Impaired phagocytosis among patients infected by the human immunodeficiency virus: Implication for a role of highly active anti-retroviral therapy

Clinical and Experimental Immunology

Volumn 167, Issue 3, 2012, Pages 499-504

  Michailidis, C ^a   Giannopoulos, G ^a   Vigklis, V ^a   Armenis, K ^a   Tsakris, A ^b   Gargalianos, P ^a  

^a G GENNIMATAS GENERAL HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Human immunodeficiency virus; Innate immunity; Oxidative burst; Phagocytosis

Indexed keywords

ANTIRETROVIRUS AGENT;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NEUTROPHIL; PHAGOCYTOSIS; PRIORITY JOURNAL; RESPIRATORY BURST; VIRUS LOAD;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, INNATE; MONOCYTES; NEUTROPHILS; PHAGOCYTOSIS; RESPIRATORY BURST; TREATMENT FAILURE; TREATMENT OUTCOME; VIRAL LOAD;

EID: 84856380035     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04526.x     Document Type: Article

References (23)

1. Engelich G, Wright DG, Hartshorn KL. Acquired disorders of phagocyte function complicating medical and surgical illnesses. Clin Infect Dis 2001; 33:2040-8.
2. Noursadeghi M, Katz DR, Miller RF. HIV-1 infection of mononuclear phagocytic cells: the case for bacterial innate immune deficiency in AIDS. Lancet Infect Dis 2006; 6:794-804.
3. Bandres JC, Trial J, Musher DM etal. Increased phagocytosis and generation of reactive oxygen products by neutrophils and monocytes of men with stage 1 human immunodeficiency virus infection. J Infect Dis 1993; 168:75-83.
4. Pos O, Stevenhagen A, Meenhorst PL etal. Impaired phagocytosis of Staphylococcus aureus by granulocytes and monocytes of AIDS patients. Clin Exp Immunol 1992; 88:23-8.
5. Pitrak DL, Bak PM, DeMarais P etal. Depressed neutrophil superoxide production in human immunodeficiency virus infection. J Infect Dis 1993; 167:1406-10.
6. Nottet HS, de Graaf L, de Vos NM etal. Phagocytic function of monocyte-derived macrophages is not affected by human immunodeficiency virus type 1 infection. J Infect Dis 1993; 168:84-91.
7. Kaplan JE, Benson C, Holmes KH etal. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. MMWR Recomm Rep 2009; 58:1-207.
8. Operator's Manual PHAGOTEST. Available at: (accessed 1 May 2011). Orpegen Pharma GmBH, Heidelberg, Germany.
9. Operator's Manual BURSTTEST. Available at: (accessed 1 May 2011). Orpegen Pharma GmBH, Heidelberg, Germany.
10. Shalekoff S, Tiemessen CT, Gray CM etal. Depressed phagocytosis and oxidative burst in polymorphonuclear leukocytes from individuals with pulmonary tuberculosis with or without human immunodeficiency virus type 1 infection. Clin Diagn Lab Immunol 1998; 5:41.
11. Covelli V, Pece S, Giuliani G etal. Pathogenetic role of phagocytic abnormalities in human virus immunodeficiency infection: possible therapeutical approaches. A review. Immunopharmacol Immunotoxicol 1997; 19:147-64.
12. Pitrak DL. Neutrophil deficiency and dysfunction in HIV-infected patients. Am J Health Syst Pharm 1999; 56 (Suppl. 5):S9-16.
13. Crowe SM, Vardaxis NJ, Kent SJ etal. HIV infection of monocyte-derived macrophages in vitro reduces phagocytosis of Candida albicans. J Leukoc Biol 1994; 56:318-27.
14. Monari C, Baldelli F, Pietrella D etal. Monocyte dysfunction in patients with acquired immunodeficiency syndrome (AIDS) versus Cryptococcus neoformans. J Infect 1997; 35:257-63.
15. Koziel H, Eichbaum Q, Kruskal BA etal. Reduced binding and phagocytosis of Pneumocystis carinii by alveolar macrophages from persons infected with HIV-1 correlates with mannose receptor downregulation. J Clin Invest 1998; 102:1332-44.
16. Kedzierska K, Churchill M, Maslin CL etal. Phagocytic efficiency of monocytes and macrophages obtained from Sydney blood bank cohort members infected with an attenuated strain of HIV-1. J Acquir Immune Defic Syndr 2003; 34:445-53.
17. Schafer V, Kreuter J, Rubsamen-Waigmann H etal. Influence of HIV-infection on the phagocytic activity of monocytes/macrophages and granulocytes. Clin Diagn Virol 1994; 1:279-87.
18. Mastroianni CM, Lichtner M, Mengoni F etal. Improvement in neutrophil and monocyte function during highly active antiretroviral treatment of HIV-1-infected patients. AIDS 1999; 13:883-90.
19. Brown EJ, Gresham HD. Phagocytosis. In: Paul WE, ed. Fundamental immunology. Philadelphia, PA: Lippincott Williams & Wilkins, 2003:1105-26.
20. Kedzierska K, Ellery P, Mak J etal. HIV-1 down-modulates gamma signaling chain of Fc gamma R in human macrophages: a possible mechanism for inhibition of phagocytosis. J Immunol 2002; 168:2895-903.
21. Kedzierska K, Azzam R, Ellery P etal. Defective phagocytosis by human monocyte/macrophages following HIV-1 infection: underlying mechanisms and modulation by adjunctive cytokine therapy. J Clin Virol 2003; 26:247-63.
22. Mazzolini J, Herit F, Bouchet J etal. Inhibition of phagocytosis in HIV-1 infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartments. Blood 2010; 115:4226-36.
23. Ryder MI, Winkler JR, Weinreb RN. Elevated phagocytosis, oxidative burst, and F-actin formation in PMNs from individuals with intraoral manifestations of HIV infection. J Acquir Immune Defic Syndr 1988; 1:346-53.