HIV-1 down-modulates γ signaling chain of FcγR in human macrophages: A possible mechanism for inhibition of phagocytosis

Journal of Immunology

Volumn 168, Issue 6, 2002, Pages 2895-2903

  Kedzierska, Katherine ^a   Ellery, Philip ^a   Mak, Johnson ^a   Lewin, Sharon R ^a   Crowe, Suzanne M ^a   Jaworowski, Anthony ^a  

^a AIDS Pathogenesis Research Unit   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; FC RECEPTOR; HEMATOPOIETIC CELL KINASE; MESSENGER RNA; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR IMMUNITY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; MACROPHAGE FUNCTION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

EID: 0037087308     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.6.2895     Document Type: Article

References (63)

1. A monocyte chemotaxis inhibiting factor in serum of HIV-infected men shares epitopes with HIV transmembrane protein gp41
2. HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes
3. HIV-1 infection of human macrophages impairs phagocytosis and killing of Toxoplasma gondii
4. Granulocyte-macrophage colony-stimulating factor augments phagocytosis of Mycobacterium avium complex by human immunodeficiency virus type 1-infected monocytes/ macrophages in vitro and in vivo
5. nef-deleted HIV-1 inhibits phagocytosis by monocyte-derived macrophages in vitro but not by peripheral blood monocytes in vivo
6. Cytokines and HIV-1: Interactions and clinical implications
7. Role of macrophages in the pathogenesis of human immunodeficiency virus (HIV) infection
8. A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects
9. Cytoskeleton association and virion incorporation of the human immunodeficiency virus type 1 Vif protein
10. Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization
11. HIV-1 rev depolymerizes microtubules to form stable bilayered rings
12. + viruses but not for down-regulation of CD4
13. Human immunodeficiency virus type 1 nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity
14. Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family
15. p21-activated kinase 1 plays a critical role in cellular activation by Nef
16. The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein
17. Quantitative assessment of HIV-1 DNA load by coamplification of HIV-1 gag and HLA-DQ-α genes
18. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
19. Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions
20. Human immunodeficiency virus-1 env impairs Fc receptor-mediated phagocytosis via a cyclic adenosine monophosphate-dependent mechanism
21. Fc receptor biology
22. Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages
23. Tyrosine phosphorylation of the γ subunit of Fcγ receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages
24. The molecular dissection of Fcγ receptor-mediated phagocytosis
25. Determinants of the phagocytic signal mediated by the type IIIA Fcγ receptor. Fcγ RIIIA: Sequence requirements and interaction with protein-tyrosine kinases
26. Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages
27. Clustered syk tyrosine kinase domains trigger phagocytosis
28. Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor
29. Fcγ receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn
30. Conserved cytoplasmic tyrosine residues of the γ subunit are required for a phagocytic signal mediated by Fcγ RIIIA
31. Induction of phagocytosis by a protein tyrosine kinase
32. A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages
33. Involvement of phosphatidylinositol 3-kinase in Fcγ receptor signaling
34. Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages
35. FcγR mediated phagocytosis by human macrophages involves Hck, Syk, and Pyk2 and is augmented by GM-CSF
36. Quantitative immunocytofluorographic analysis of CD4 surface antigen expression and HIV infection of human peripheral blood monocyte/macrophages
37. Culture of HIV in monocytes and macrophages
38. Granulocyte-macrophage colony stimulating factor inhibits HIV-1 replication in monocyte-derived macrophages
39. A modified colorimetric method for the measurement of phagocytosis and antibody dependent cell cytotoxicity using 2,7-diaminofluorene
40. Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy
41. Quantitative analysis of hepatitis C virus RNA in liver biopsies by competitive reverse transcription and polymerase chain reaction
42. Maintenance of the Gag/Gag Pol ratio is important for human immunodeficiency virus type 1 RNA dimerization and viral infectivity
43. Role of the mononuclear phagocyte system in the immunopathogenesis of human immunodeficiency virus infection and the acquired immunodeficiency syndrome
44. Monocyte-derived macrophage function in HIV-infected subjects: In vitro modulation by rIFN-γ and rGM-CSF
45. Fc receptors expression and function in mononuclear phagocytes from AIDS patients: Modulation by IFN-γ
46. Decreased accessory cell function by human monocytic cells after infection with HIV
47. 2-microglobulin, neopterin and monocyte Fcγ receptors in opportunistic infections of HIV-positive patients
48. Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosis
49. Human immunodeficiency virus infection: Association with altered intracellular levels of cAMP and cGMP in MT-4 cells
50. Functional overlap in the src gene family: Inactivation of hck and fgr impairs natural immunity
51. Physical and functional association of Src-related protein tyrosine kinases with Fcγ RII in monocytic THP-1 cells
52. Tyrosine phosphorylation and association of Syk with Fcγ RII in monocytic THP-1 cells
53. HIV infectioninduced post-translational modification of T cell signaling molecules associated with disease progression
54. SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1
55. Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation
56. Syk tyrosine kinase is required for immunoreceptor tyrosine activation motif-dependent actin assembly
57. Paxillin
58. FcRγ chain deletion results in pleiotropbic effector cell defects
59. FcR γ-chain is essential for both surface expression and function of human FcγRI (CD64) in vivo
60. The cytoplasmic domain of human FcγRIa alters the functional properties of the FcγR·γ-chain receptor complex
61. Decreased expression of ζ molecules by T lymphocytes is correlated with disease progression in human immunodeficiency virus-infected persons
62. Human immunodeficiency virus type 2 produces a defect in CD3-γ gene transcripts similar to that observed for human immunodeficiency virus type 1
63. Toxoplasma gondii: Fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts