Intrauterine food restriction alters the expression of uncoupling proteins in brown adipose tissue of rat newborns

Journal of Thermal Biology

Volumn 37, Issue 2, 2012, Pages 138-143

  Souza, Thais L V ^a   Coelho, Carolina T ^a   Guimarães, Paola B ^a   Goto, Eduardo M ^a   Silva, Sylvia Maria A ^a   Silva, José Antonio ^b,d   Nunes, Maria Tereza ^c,d   Ihara, Silvia S M ^a   Luz, Jacqueline ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE NOVE DE JULHO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d NONE   (Brazil)

Author keywords

Body temperature; Maternal food restriction; Thermoregulation; Uncoupling proteins; Undernutrition

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; MESSENGER RNA; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; THYROXINE; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY FAT; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; MATERNAL NUTRITION; NEWBORN; NONHUMAN; PREGNANCY; PRENATAL PERIOD; PROTEIN EXPRESSION; RAT; SKELETAL MUSCLE; THERMOREGULATION; WEIGHT REDUCTION;

ANIMALIA; RATTUS;

EID: 84856365334     PISSN: 03064565     EISSN: 18790992     Source Type: Journal    
DOI: 10.1016/j.jtherbio.2011.12.002     Document Type: Article

References (49)

1. Alvarez C., Martín M., Goya L., Bertin E., Portha B., Pascual-Leone A. Contrated impact of maternal rat food restriction on the fetal endocrine pancreas. Endocrinology 1997, 138:2267-2273.
2. Asakura H. Fetal and neonatal thermoregulation. J. Nippon Med. Sch. 2004, 71:360-370.
3. Barker D.J.P. The foetal and infant origins of inequalities in health in Britain. J. Public Health Med. 1991, 13:64-68.
4. Bartness T.J., Vaughan C.H., Song C.K. Sympathetic and sensory innervation of brown adipose tisuue. Int. J. Obes. 2010, 34:S36-S42.
5. Budge H., Edwards L., McMillen I., Bryce A., Warnes K., Pearce S., Stephenson T., Symonds M.E. Nutritional manipulation of fetal adipose tissue deposition and uncoupling protein 1 messenger RNA abundance in the sheep: differential effects of timing and duration. Biol. Reprod. 2004, 71:359-365.
6. Carmona C., Valmaseda A., Brun S., Vinas O., Mampel T., Iglesias R., Giralt M., Villaroya F. Differential regulation of uncoupling protein-2 and uncoupling protein-3 gene expression in brown adipose tissue during development and cold exposure. Biochem. Biophys. Res. Commun. 1998, 243:224-228.
7. Darras V.M., Mo,l K.A., Van der Geyten S., Kühn E.R. Control of peripheral thyroid hormone levels by activating and inactivating deiodinases. Ann. NY Acad. Sci. 1998, 839:80-86.
8. 2+ ATPase: uncoupled ATP hydrolysis and thermogenic activity. J. Biol. Chem. 2003, 278:41856-41861.
9. Divakaruni A.S., Brand M.D. The regulation and physiology of mitochondrial proton leak. Physiology 2011, 26(3):192-205.
10. Dwyer C.M., Stickland N.C. The effects of maternal undernutrition on maternal and fetal serum insulin-like growth factors, thyroid hormones and cortisol in the guinea pig. J. Dev. Physiol 1992, 18:303-313.
11. Engelbregt M.J., Van Weissenbruch M.M., Popp-Snijders C., Lips P., Delemarre-van de Waal H. Body mass index, body composition, and leptin at onset of puberty in male and female rats after intrauterine growth retardation and after early postnatal food restriction. Ped. Res 2001, 50:474-478.
12. Folch J., Lees M., Sloane-Stanley G.H.A. A simple method for isolation and purification of total lipids from animal tissue. J. Biol. Chem. 1957, 26:497-509.
13. Fowden A.L., Forhead A.J. Endocrine mechanisms of intrauterine programming. Reprodution 2004, 127:515-526.
14. Gnanalingham M.G., Giussani D.A., Sivathondan P., Forhead A.J. Chronic umbilical cord compression results in accelerated maturation of lung and brown adipose tissue in the sheep fetus during late gestation. Am. J. Physiol. Endocrinol. Metab. 2005, 289:E456-E465.
15. Gnanalingham M.G., Mostyn A., Symonds M.E., Dandrea J., Yakubu D.P., Symonds M.E., Stephenson T. Ontogeny and nutritional programming of adiposity in sheep: potential role of glucocorticoid action and uncoupling protein-2. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 289:R1407-R1415.
16. Gnanalingham M.G., Mostyn A., Gardner D.S., Stephenson T., Symonds M.E. Developmental regulation of the lung in preparation for life after birth: hormonal and nutritional manipulation of local glucocorticoid action and uncoupling protein-2. J. Endocrinol. 2006, 188:375-386.
17. Gordon C.J. Temperature Regulation in Laboratory Rodents 1993, Cambridge University, Cambridge, USA.
18. Griggio M.A., Luz J., Gorgulho A.A., Sucasas C. The influence of food restriction during different periods of pregnancy. Int. J. Food Sci. Nutr. 1997, 48:129-134.
19. Hastings M.M., Zeman F.J. Production and metabolism of thyroid hormones in protein-deficient and food- restricted pregnant rats. J. Nutr. 1979, 109:1925-1933.
20. Herrera E., López-Soldado I., Limones M., Amusquivar E., Ramos M.P. Experimental models for studying perinatal lipid metabolism. Long-term effects of perinatal undernutrition. Adv. Exp.Med. Biol. 2005, 569:95-108.
21. Himms-Hagen J. Brown adipose tissue metabolism and thermogenesis. Ann. Rev. Nutr. 1985, 5:69-94.
22. Ježek P. Possible physiological roles of mitochondrial uncoupling proteins - UCPn. Int. J. Biochem. Cell Biol. 2002, 34:1190-1206.
23. Kind K., Roberts C., Sohlstrom A. Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288:R119-R126.
24. Koletzko B., Aggett P.J., Bindels J.G., Bung P., Ferré P., Gil A., Lentze M.J., Roberfroid M., Strobel S. Growth, development and differentiation: a functional food science approach. Br. J. Nutr. 1998, 1:S5-S45.
25. Ledesma A., de Lacoba M.G., Rial E. The mitochondrial uncoupling proteins. Genome. Biol. 2002, 3(12). REVIEWS 3015.1-3015.9.
26. Leshner A.L., Litwin V.A. A simple method for carcass analysis. Physiol. Behav. 1972, 9:282-289.
27. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta C (t)) method. Methods 2001, 25:402-408.
28. Luz J., Griggio M.A. Food restriction and refeeding in growing rats. Comp. Biochem. Physiol. 1991, 99A:477-480.
29. Luz J., Griggio M.A. Distribution of energy between food-restricted dams and offspring. Ann. Nutr. Metab. 1996, 40:165-174.
30. Luz J., Griggio M.A., Vieira L.V. Impact of maternal food restriction on cold-induced thermogenesis in the offspring. Biol. Neonate 2003, 84:252-258.
31. Mahajan S.D., Aalinkeel R., Singh S., Shah P., Gupta N., Kouchupillai N. Thyroid hormone dysregulation in intrauterine growth retardation associated with maternal malnutrition and/or anemia. Horm. Metab. Res. 2005, 37:633-640.
32. Martín M., Fernández E., Pascual-Leone A.M., Escrivá F., Alvarez C. Protein calorie restriction has opposite effects on glucose metabolism and insulin gene expression in fetal and adult rat endocrine pancreas. Am. J. Physiol. Endocrinol. Metab. 2004, 286:542-550.
33. Martín M., Serradas P., Ramos S., Fernández E., Goya L., Gangnerau M.N., Lacorne M., Pascual-Leone A., Escrivá F., Portha B., Alvarez C. Protein-caloric food restriction affects insulin-like growth factor system in fetal Wistar rat. Endocrinology 2005, 146:1364-1371.
34. Mericq V., Ong K., Bazaes R., Pena V., Avila A., Salazar T., Soto N., Iniguez G., Dunger D.B. Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children. Diabetologia 2005, 48:2609-2624.
35. Mostyn A., Keisler D., Webb R., Stephenson T., Symonds M. The role of leptin in the transition from fetus to neonate. Proc. Nutr. Soc. 2001, 60:187-194.
36. Desai M., Gayle D., Babu J., Ross M. Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition. Am. J. Physiol. RegulIntegr. Comp. Physiol. 2005, 288:R91-R96.
37. Nazarova L.A. The thermogenic characteristics in the early ontogeny of rats developing normally and under conditions of decreased uterine-placental blood circulation. Ross Fiziol. Zh. Im. I. M. Sexhenova 1993, 79:68-74.
38. Nazarova L.A., Petrova O.P. Thermoregulatory reaction in the rabbit fetuses developing under the reduced utero-placental blood flow. Ross Fiziol. Zh. Im. I. M. Sexhenova 1999, 85:1070-1074.
39. Oberkotter L.V., Rasmussen K.M. Changes in plasma thyroid hormone concentrations in chronically food-restricted female rats and their offspring during suckling. J. Nutr. 1992, 122:435-441.
40. Passadore M.D., Griggio M.A., Nunes M.T., Luz J. Effects of ageing on the energy balance of food-restricted rats. Acta Physiol. Scand. 2004, 181:193-198.
41. Richard D., Carpenter A.C., Doré G., Ouellet V., Picard F. Determinants of brown adipocyte development and thermogenesis. Int. J. Obes. 2010, 34:S59-S66.
42. Richard D., Picard F. Brown fat biology and thermogenesis. Front. Biosci. 2011, 16:1233-1260.
43. Rosenberg A. The IUGR newborn. Semin. Peronatol. 2008, 32:219-224.
44. Ross M.G., Beall M.H. Adult sequelae of intrauterine growth restriction. Semin. Peronatol. 2008, 32:213-218.
45. Roth G.S., Handy A.M., Mattison J.A., Tilmont E.M., Ingram D.K., Lane M.A. Effects of dietary caloric restriction and aging on thyroid hormones of rhesus monkeys. Horm. Metab. Res. 2002, 34:278-382.
46. Symonds M., Mostyn A., Pearce S. Endocrine and nutritional regulation of fetal adipose tissue development. J. Endocrinol. 2003, 179:293-299.
47. Symonds M., Phillips I., Anthony R. Prolactin receptor gene expression and foetal adipose tissue. J. Neuroendocrinol. 1998, 10:885-890.
48. Wang X., Liang L., Du L. The effects of intrauterine undernutrition on pancreas ghrelin and insulin expression in neonate rats. J. Endocrinol. 2007, 194:121-129.
49. Yuen B.S., Owens P.C., McFarlane J.R. Circulating leptin concentrations are positively related to leptin messenger RNA expression in the adipose tissue of fetal sheep in the pregnant ewe fed at or below maintenance energy requirements during late gestation. Biol. Reprod. 2002, 67:911-916.