The effects of intrauterine undernutrition on pancreas ghrelin and insulin expression in neonate rats

Journal of Endocrinology

Volumn 194, Issue 1, 2007, Pages 121-129

  Wang, Xiumin ^a   Liang, Li ^a   Du, Lizhong ^a  

^a CHILDREN S HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GLUCOSE; INSULIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH WEIGHT; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; DIET RESTRICTION; FEMALE; FETAL MALNUTRITION; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; LOW BIRTH WEIGHT; MATERNAL NUTRITION; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS; PANCREAS ISLET BETA CELL; PREGNANCY; PRIORITY JOURNAL; PROGENY; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RAT; RNA ANALYSIS; STATISTICAL SIGNIFICANCE;

ANIMAL NUTRITION PHYSIOLOGY; ANIMALS; ANIMALS, NEWBORN; BLOOD GLUCOSE; FEMALE; FETAL NUTRITION DISORDERS; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; MICROSCOPY, CONFOCAL; PEPTIDE HORMONES; PREGNANCY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 34547429975     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/JOE-07-0057     Document Type: Article

References (38)

1. Adeghate E & Ponery AS 2002a Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats. Journal of Neuroendocrinology 14 555-560.
2. Adeghate F & Parvez H 2002b Mechanism of ghrelin-evoked glucagon secretion from the pancreas of diabetic rats. Neuro Endocrinology Letters 23 432-436
3. Arantes VC, Teixeira VP Reis MA, Latorraca MQ Leite AR, Carneiro EM, Yamada AT & Boschero AC 2002 Expression of PDX-1 is reduced in pancreatic islets from pups of rat darns fed a low protein diet during gestation and lactation. Journal of Nutrition 132 3030-3035.
4. Barker DJ 1993 Fetal origins of coronary heart disease. British Heart Journal 69 195-196.
5. Boujendar S, Arany E, Hill D, Remacle C & Reusens B 2003 Taurine supplementation of a low protein diet fed to rat dams normalizes the vascularization of the fetal endocrine pancreas. Journal of Nutrition 133 2820-2825.
6. Chanome JP & Wong AC 2004 Ghrelin gene expression is markedly higher in fecal pancreas compared with fecal stomach: effect of maternal fasting. Endocrinology 145 3813-3820.
7. Chanoine JP, Wong AC & Barrios V 2006 Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas. Hormone Research 66 81-88.
8. Dahri S, Snoeck A, Reusens-Billen B, Remacle C & Hoet JJ 1991 Islet function in offspring of mothers on low-protein diet during gestation. Diabetes 40 115-120.
9. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K & Nakazato M 2000 Gbrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141 4255-4261.
10. Desai M, Crowther NJ, Lucas A & Hales CN 1996 Organ-selective growth in the offspring of protem-restricted mothers. British Journal of Nutrition 76 591-603.
11. Farquhar J, Heiman M, Wong AC, Wach R, Chessex P & Chanoine JP 2003 Elevated umbilical cord ghrelin concentrations in small for gestational age neonates. Journal of Clinical Endocrinology and Metabolism 88 4324-4327.
12. Fuglsang J, Sandager P, Moller N, Fisker S, Frystyk J & Ovesen P 2006 Peripartum maternal and foetal ghrelin, growth hormones, IGFs and insulin interrelations. Clinical Endocrinology 64 502-509.
13. Garofano A, Czernichow P & Breant B 1997 In utero undernutrition impairs rat beta-cell development. Diabetologia 40 1231-1234.
14. Garofano A, Czernichow P & Breanc B 1998 Beta-cell mass and proliferation following late fetal and early postnatal malnutrition in the rat. Diabetologia 41 1114-1120.
15. Gualillo O, Caminos E, Blanco M, Garcia-caballero T, Kojima M, Kangawa K, Dieguez C & Casanueva FF 2001 Ghrelin, a novel placental-derived hormone. Endocrinology 142 788-794.
16. Hayashida T, Nakahara, K, Mondal MS, Date Y, Nakazato M, Kojima M, Kangawa K & Murakami N 2002 Ghrelin in neonatal rats: distribution in stomach and its possible role. Journal of Endocrinology 17 239-245.
17. Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G & Serup P 2005 Generic determinants of pancreatic epsilon-cell development. Developmental Biology 286 217-224.
18. Hofman PL, Regan F, Jackson WE, Jefferies C, Knight DB, Robinson EM & Cutfield WS 2004 Premature birth and later insulin resistance. New England Journal of Medicine 351 2179-2186.
19. Holemans K, Aerts L & Van Assche FA 2003 Fetal growth restriction and consequences for the offspring in animal models. Journal of the Society for Gynecologic Investigation 10 392-399.
20. Katsuki A, Urakawa H, Gabazza EC, Murashima S, Nakatani K, Togashi K, Yano Y, Adachi Y & Sumida Y 2004 Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus. European Journal of Endocrinoloqy 151 573-577.
21. Kitamura S, Yokota I, Hosoda H, Kotani Y, Matsuda J, Naito E, Ito M, Kangawa K & Kuroda Y 2003 Ghrelin concentration in cord and neonatal blood: relation to fetal growth and energy balance. Journal of Clinical Endocrinology and Metabolism 88 5473-5477.
22. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 656-660.
23. Langley SC, Browne RE & Jackson AA 1994 Altered glucose tolerance in rats exposed to maternal low protein diets in utero. Comparative Biochemistry and Physiology. Physiology 109 223-229.
24. Mozid AM, Tringali G, Forshing ME, Hendricks MS, Ajodhas, Edwards R, Navarra P, Grossman AB & Korbonits M 2003 ghrelin in released from rat hypothalamic explants and stimulates corricots opin releasing hormone and arginrim-vasopressin. Hormone and metabolic Research 35 455-459.
25. Oliver MH Hawkins P & Harding JE 2005 Periconceptional undernutrition alters growth trajectory and metabolic and endocrine responses to fasting in late-gestation fetal sheep. Pediatric Research 57 591-598.
26. Park KS, Kim SK, Kim MS, Cho EY, Lee JH, Lee KU, Pak YK & Lee HK 2003 Fetal and early postnatal protein malnutrition cause long-term changes in rat liver and muscle mitochondria. Journal of Nutrition 133 3085-3090.
27. Prado CL, Pugh-Bernard AE, Elghazi L, Sosj-Pineda B & Sussel L 2004 Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. PNAS 101 2924-2929.
28. Shi SR, Cote RJ & Taylor CR 1997 Antigen retrieval immunohistochemistry: past. present and future. Journal of Histochemistry and Cytochemistry 45 327-343.
29. Shuto Y, Shibasaki T, Wada K, Parhar I, Kamegai J, Sugihara H, Oikawa S & Wakabayashi I 2001 Generation of polyclonal antiserum against the growth hormone secretagogue receptor (GHS-R): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach of rats. Life Sciences 68 991-996.
30. Snoeck A, Remacle C, Reusens B & Hoetjj 1990 Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas. Biology of the Neonate 57 107-118.
31. Sparre T, Reusens B, Cherif H, Larsen MR, Roepstorff P, Fey SJ, Mose Larsen P, Remacle C & Nerup J 2003 Intrauterine programming offetal islet gene expression in rats-effects of maternal protein restriction during gestation revealed by proteome analysis. Diabetologia 46 1497-1511.
32. Toshinai K, Mondal MS, Nakazato M, Date Y, Murakami N, Kojima M, Kangawa K & Matsukura S 2001 Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochemical and Biophysical Research Communications 281 1220-1225.
33. Volante M, Allia E, Gugliotta P, Funaro A, Broglio F, Deghenghi R, Muccioli G, Ghigo E & Papotti M 2002a Expression ofghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. Journal of Clinical Endocrinology and 'Metabolism 87 1300-1308.
34. Volante M, Fulcheri E, Allia E, Cerrato M, Pucci A & Papotti M 2002b Ghrelin expression in fetal, infant, and adult human lung. Journal of Histochemistry and Cytochemistry 50 1013-1021.
35. Vuguin P, Raab E, Liu B, Barzilai N & Simmons R 2004 Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation. Diabetes 53 2617-2621
36. Wjerup N & Sundler F 2005 Ultrastructure ofislet ghrelin cells in the human tetus. Cell and Tissue Research 319 423-428.
37. Wierup N, Svensson FE Mulder H & Sundler F 2002 The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regulatory Peptides 107 63-669.
38. Wierup N, Yang S, McEvilly RJ, Mulder H & Sundler F 2004 Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells. Journal of Histochemistry and Cytochemistry 52 301-31O.