Pro- and anti-angiogenic factors in human skeletal muscle in response to acute exercise and training

Journal of Physiology

Volumn 590, Issue 3, 2012, Pages 595-606

  Hoier, B ^a   Nordsborg, N ^a   Andersen, S ^a   Jensen, L ^a   Nybo, L ^a   Bangsbo, J ^a   Hellsten, Y ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; CITRATE SYNTHASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE B; MESSENGER RNA; THROMBOSPONDIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

ADULT; AEROBIC EXERCISE; ANGIOPOIETIN 2 GENE; ARTICLE; CAPILLARY DENSITY; CAPILLARY PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDURANCE TRAINING; EXERCISE INTENSITY; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; INTERSTITIAL FLUID; MALE; MUSCLE BIOPSY; MUSCLE EXERCISE; MUSCLE LEVEL; NEGATIVE FEEDBACK; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; REST; SKELETAL MUSCLE; TISSUE INHIBITOR OF METALLOPROTEINASE 1 GENE; TRANSCRIPTION REGULATION; UPREGULATION; VASTUS LATERALIS MUSCLE;

ADULT; ANGIOGENESIS INDUCING AGENTS; ANGIOGENESIS INHIBITORS; ANGIOPOIETIN-1; ANGIOPOIETIN-2; CELL PROLIFERATION; EXERCISE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MATRIX METALLOPROTEINASE 9; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTOR, TIE-2; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; THROMBOSPONDIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE-1; VASCULAR ENDOTHELIAL GROWTH FACTOR A; YOUNG ADULT;

EID: 84856346072     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.216135     Document Type: Article

References (35)

1. Benoit H, Jordan M, Wagner H & Wagner PD (1999). Effect of NO, vasodilator prostaglandins, and adenosine on skeletal muscle angiogenic growth factor gene expression. J Appl Physiol 86, 1513-1518.
2. Breen EC, Johnson EC, Wagner H, Tseng HM, Sung LA & Wagner PD (1996). Angiogenic growth factor mRNA responses in muscle to a single bout of exercise. J Appl Physiol 81, 355-361.
3. Egginton S (2009). Invited review: activity-induced angiogenesis. Pflugers Arch 457, 963-977.
4. Gavin TP, Ruster RS, Carrithers JA, Zwetsloot KA, Kraus RM, Evans CA, Knapp DJ, Drew JL, McCartney JS, Garry JP & Hickner RC (2007). No difference in the skeletal muscle angiogenic response to aerobic exercise training between young and aged men. J Physiol 585 231-239.
5. Gustafsson T, Bodin K, Sylven C, Gordon A, Tyni-Lenne R & Jansson E (2001). Increased expression of VEGF following exercise training in patients with heart failure. Eur J Clin Invest 31, 362-366.
6. Gustafsson T, Knutsson A, Puntschart A, Kaijser L, Nordqvist AC, Sundberg CJ & Jansson E (2002). Increased expression of vascular endothelial growth factor in human skeletal muscle in response to short-term one-legged exercise training. Pflugers Arch 444, 752-759.
7. Gustafsson T, Rundqvist H, Norrbom J, Rullman E, Jansson E & Sundberg CJ (2007). The influence of physical training on angiopoietin and VEGF-A systems in human skeletal muscle. J Appl Physiol 103, 1012-1020.
8. Hansen AH, Nielsen JJ, Saltin B & Hellsten Y (2010). Exercise training normalizes skeletal muscle vascular endothelial growth factor levels in patients with essential hypertension. J Hypertens 28, 1176-1185.
9. Hansen AH, Nyberg M, Bangsbo J, Saltin B & Hellsten Y (2011). Exercise training alters the balance between vasoactive compounds in skeletal muscle of individuals with essential hypertension. Hypertension 58, 943-949.
10. Hoffner L, Nielsen JJ, Langberg H & Hellsten Y (2003). Exercise but not prostanoids enhance levels of vascular endothelial growth factor and other proliferative agents in human skeletal muscle interstitium. J Physiol 550, 217-225.
11. Hoier B, Rufener N, Bojsen-Moller J, Bangsbo J & Hellsten Y (2010). The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle. J Physiol 588, 3833-3845.
12. Jansson PA, Veneman T, Nurjhan N & Gerich J (1994). An improved method to calculate adipose tissue interstitial substrate recovery for microdialysis studies. Life Sci 54, 1621-1624.
13. Jensen L, Bangsbo J & Hellsten Y (2004a). Effect of high intensity training on capillarization and presence of angiogenic factors in human skeletal muscle. J Physiol 557, 571-582.
14. Jensen L, Pilegaard H, Neufer PD & Hellsten Y (2004b). Effect of acute exercise and exercise training on VEGF splice variants in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol 287, R397-R402.
15. Kendall RL & Thomas KA (1993). Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci U S A 90, 10705-10709.
16. Kendall RL, Wang G & Thomas KA (1996). Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem Biophys Res Commun 226, 324-328.
17. Lawler J (1986). The structural and functional properties of thrombospondin. Blood 67, 1197-1209.
18. Lawler J (2000). The functions of thrombospondin-1 and -2. Curr Opin Cell Biol 12, 634-640.
19. Lloyd PG, Prior BM, Yang HT & Terjung RL (2003). Angiogenic growth factor expression in rat skeletal muscle in response to exercise training. Am J Physiol Heart Circ Physiol 284, H1668-H1678.
20. Lundby C, Nordsborg N, Kusuhara K, Kristensen KM, Neufer PD & Pilegaard H (2005). Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsies. Eur J Appl Physiol 95, 351-360.
21. Malek MH & Olfert IM (2009). Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and exercise capacity in mice. Exp Physiol 94, 749-760.
22. Nordsborg N, Mohr M, Pedersen LD, Nielsen JJ, Langberg H & Bangsbo J (2003). Muscle interstitial potassium kinetics during intense exhaustive exercise: effect of previous arm exercise. Am J Physiol Regul Integr Comp Physiol 285, R143-R148.
23. Olfert IM, Breen EC, Gavin TP & Wagner PD (2006). Temporal thrombospondin-1 mRNA response in skeletal muscle exposed to acute and chronic exercise. Growth Factors 24, 253-259.
24. Olfert IM, Howlett RA, Wagner PD & Breen EC (2010). Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis. Am J Physiol Regul Integr Comp Physiol 299, R1059-R1067.
25. Pilegaard H, Ordway GA, Saltin B & Neufer PD (2000). Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol Endocrinol Metab 279, E806-E814.
26. Pilegaard H, Saltin B & Neufer PD (2003). Exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle. J Physiol 546, 851-858.
27. Placanica G, Migliau G, Nasso G, Rosso R, Tallarico D & Migliau G (1999). Short-term effect of exercise on platelet factor 4 in normal subjects and in patients with coronary artery disease. Cardiologia 44, 993-996.
28. Rivilis I, Milkiewicz M, Boyd P, Goldstein J, Brown MD, Egginton S, Hansen FM, Hudlicka O & Haas TL (2002). Differential involvement of MMP-2 and VEGF during muscle stretch- versus shear stress-induced angiogenesis. Am J Physiol Heart Circ Physiol 283, H1430-H1438.
29. Rullman E, Rundqvist H, Wagsater D, Fischer H, Eriksson P, Sundberg CJ, Jansson E & Gustafsson T (2007). A single bout of exercise activates matrix metalloproteinase in human skeletal muscle. J Appl Physiol 102, 2346-2351.
30. Ryan NA, Zwetsloot KA, Westerkamp LM, Hickner RC, Pofahl WE & Gavin TP (2006). Lower skeletal muscle capillarization and VEGF expression in aged vs. young men. J Appl Physiol 100, 178-185.
31. Scheller D & Kolb J (1991). The internal reference technique in microdialysis: a practical approach to monitoring dialysis efficiency and to calculating tissue concentration from dialysate samples. J Neurosci Methods 40, 31-38.
32. Tsurumi Y, Murohara T, Krasinski K, Chen D, Witzenbichler B, Kearney M, Couffinhal T & Isner JM (1997). Reciprocal relation between VEGF and NO in the regulation of endothelial integrity. Nat Med 3, 879-886.
33. Wagner PD, Olfert IM, Tang K & Breen EC (2006). Muscle-targeted deletion of VEGF and exercise capacity in mice. Respir Physiol Neurobiol 151, 159-166.
34. Williams JL, Cartland D, Hussain A & Egginton S (2006a). A differential role for nitric oxide in two forms of physiological angiogenesis in mouse. J Physiol 570, 445-454.
35. Williams JL, Weichert A, Zakrzewicz A, Da Silva-Azevedo L, Pries AR, Baum O & Egginton S (2006b). Differential gene and protein expression in abluminal sprouting and intraluminal splitting forms of angiogenesis. Clin Sci (Lond) 110, 587-595.