Ectopic fat deposition and the metabolic syndrome in obese children and adolescents

Hormone Research

Volumn 71, Issue SUPPL. 1, 2009, Pages 2-7

  Cali, Anna M G ^a   Caprio, Sonia ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Insulin resistance; Metabolic syndrome; Obesity

Indexed keywords

FAT; INSULIN; LIPID;

ABDOMINAL SUBCUTANEOUS FAT; ADOLESCENT; ADULT; ANTHROPOMETRY; BLOOD PRESSURE MEASUREMENT; BODY FAT DISTRIBUTION; BODY MASS; CHILD; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE SEVERITY; FATTY LIVER; FEMALE; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LEAN BODY WEIGHT; LIPID BLOOD LEVEL; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SUBCUTANEOUS FAT;

ADIPOSE TISSUE; ADOLESCENT; BODY FAT DISTRIBUTION; CASE-CONTROL STUDIES; CHILD; FEMALE; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; MALE; METABOLIC SYNDROME X; OBESITY; PREVALENCE;

EID: 58549101476     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000178028     Document Type: Conference Paper

References (20)

1. Ogden CL, Flegal KM: Prevalence and trends in overweight among U.S. children and adolescents, 1999-2000. JAMA 2002;288:1728-1732.
2. Rosenbloom AL, Joe JR, Young RS, Winter WE: Emerging epidemic of type 2 diabetes in youth. Diabetes Care 1999;22:345-354.
3. Arslanian S: Type 2 diabetes in children: clinical aspects and risk factors. Horm Res 2002;57(suppl 1):19-28.
4. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH: Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med 2003;157:821-827.
5. Reaven GM: Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988;37:1595-1607.
6. Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK: Cardiovascular risk factors in confirmed prediabetic individuals: does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 1990;263:2893-2899.
7. Abbasi F, Brown BW Jr, Lamendola C, McLaughlin T, Reaven GM: Relationship between obesity, insulin resistance, and coronary heart disease risk. J Am Coll Cardiol 2002;40:937-943.
8. Despres JP: Is visceral obesity the cause of the metabolic syndrome? Ann Med 2006;38:52-63.
9. Pouliot MC, Despres JP, Nadeau A, Moorjani S, Prud'Homme D, Lupien PJ, Tremblay A, Bouchard C: Visceral obesity in men. Associations with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes 1992;41:826-834.
10. Wajchenberg BL: Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000;21:697-738.
11. Hegele RA, Joy TR, Al-Attar S, Rutt BK: Thematic review series: adipocyte biology. Lipodystrophies: windows on adipose biology and metabolism. J Lipid Res 2007;48:1433-1444.
12. Simha V, Garg A: Lipodystrophy: lessons in lipid and energy metabolism. Curr Opin Lipidol 2006;17:162-169.
13. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S: Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004;350:2362-2374.
14. Shaibi GQ, Goran MI: Examining metabolic syndrome definitions in overweight Hispanic youth: a focus on insulin resistance. J Pediatr 2008;152:171-176.
15. Lee S, Bacha F, Gungor N, Aslanian S: Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers. J Pediatr 2008;152:177-184.
16. Sinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K, Savoye M, Rieger V, Taksali S, Barbetta G, Sherwin RS, Caprio S: Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002;346:802-810.
17. Matsuda M, DeFronzo RA: Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462-1470.
18. Taksali S, Caprio S, Dziura J, Dufour S, Cali AMG, Goodman T, Papademetris X, Burgert T, Pierpont B, Savoye M, Shaw M, Seyal A, Weiss R: High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic syndrome. Diabetes 2008;57:367-371.
19. Burgert TS, Taksali SE, Dziura J, Goodman TR, Yeckel CW, Papademetris X, Constable RT, Weiss R, Tamborlane WV, Savoye M, Seyal AA, Caprio S: Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat. J Clin Endocrinol Metab 2006;91:4287-4294.
20. Fishbein MH, Gardner KG, Potter CJ, Schmalbrock P, Smith MA: Introduction of fast MR imaging in the assessment of hepatic steatosis. Magn Reson Imaging 1997;15:287-293.