Cardiac risks associated with marathon running

Sports Health

Volumn 2, Issue 4, 2010, Pages 301-306

  Day, Sharlene M ^a   Thompson, Paul D ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b HARTFORD HOSPITAL   (United States)

Author keywords

Cardiac arrest; Exercise; Marathon; Preparticipation screening; Running; Sudden cardiac death

Indexed keywords

EID: 84856258319     PISSN: 19417381     EISSN: 19410921     Source Type: Journal    
DOI: 10.1177/1941738110373066     Document Type: Review

References (47)

1. Albert CM, Mittleman MA, Chae CU, Lee IM, Hennekens CH, Manson JE. Triggering of sudden death from cardiac causes by vigorous exertion. N Engl J Med. 2000; 343: 1355-1361.
2. Apple FS, Quist HE, Otto AP, Mathews WE, Murakami MM. Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race. Clin Chem. 2002; 48: 1097-1100.
3. Aufderheide T, Hazinski MF, Nichol G, et al. Community lay rescuer automated external defibrillation programs: key state legislative components and implementation strategies: a summary of a decade of experience for healthcare providers, policymakers, legislators, employers, and community leaders from the American Heart Association Emergency Cardiovascular Care Committee, Council on Clinical Cardiology, and Office of State Advocacy. Circulation. 2006; 113: 1260-1270.
4. Belonje A, Nangrahary M, de Swart H, Umans V. Major adverse cardiac events during endurance sports. Am J Cardiol. 2007; 99: 849-851.
5. Blair SN, Kampert JB, Kohl HW 3rd, et al. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA. 1996; 276: 205-210.
6. Chakravarty EF, Hubert HB, Lingala VB, Fries JF. Reduced disability and mortality among aging runners: a 21-year longitudinal study. Arch Intern Med. 2008; 168: 1638-1646.
7. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G. Does sports activity enhance the risk of sudden death in adolescents and young adults?. J Am Coll Cardiol. 2003; 42: 1959-1963.
8. Dawson EA, Whyte GP, Black MA, et al. Changes in vascular and cardiac function after prolonged strenuous exercise in humans. J Appl Physiol. 2008; 105: 1562-1568.
9. Fletcher GF, Balady G, Blair SN, et al. Statement on exercise: benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation. 1996; 94: 857-862.
10. Fortescue EB, Shin AY, Greenes DS, et al. Cardiac troponin increases among runners in the Boston Marathon. Ann Emerg Med. 2007; 49: 137-143, e131.
11. Fowler-Brown A, Pignone M, Pletcher M, Tice JA, Sutton SF, Lohr KN. Exercise tolerance testing to screen for coronary heart disease: a systematic review for the technical support for the U.S. Preventive Services Task Force. Ann Intern Med. 2004; 140: W9-W24.
12. Gibbons RJ, Balady GJ, Bricker JT, et al. ACC/AHA 2002 guideline update for exercise testing: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). Circulation. 2002; 106: 1883-1892.
13. Gulati M, Black HR, Shaw LJ, et al. The prognostic value of a nomogram for exercise capacity in women. N Engl J Med. 2005; 353: 468-475.
14. Gupta S, Baman T, Day SM. Cardiovascular health-part 1: pre-participation Cardiovascular Screening. Sports Health. 2009; 2: 19-28.
15. Hazinski MF, Idris AH, Kerber RE, et al. Lay rescuer automated external defibrillator ("public access defibrillation") programs: lessons learned from an international multicenter trial: advisory statement from the American Heart Association Emergency Cardiovascular Committee; the Council on Cardiopulmonary, Perioperative, and Critical Care; and the Council on Clinical Cardiology. Circulation. 2005;111:3336-3340.
16. Herrmann M, Scharhag J, Miclea M, Urhausen A, Herrmann W, Kindermann W. Post-race kinetics of cardiac troponin T and I and N-terminal pro-brain natriuretic peptide in marathon runners. Clin Chem. 2003;49:831-834.
17. Hubble KM, Fatovich DM, Grasko JM, Vasikaran SD. Cardiac troponin increases among marathon runners in the Perth Marathon: the Troponin in Marathons (TRIM) study. Med J Aust. 2009;190:91-93.
18. Jassal DS, Moffat D, Krahn J, et al. Cardiac injury markers in non-elite marathon runners. Int J Sports Med. 2009;30:75-79.
19. Kaminsky L. American College of Sports Medicine: Guidelines for Exercise Testing and Prescription. Baltimore, MD: Lippincott Williams & Wilkins 2005.
20. Knebel F, Schimke I, Schroeckh S, et al. Myocardial function in older male amateur marathon runners: assessment by tissue Doppler echocardiography, speckle tracking, and cardiac biomarkers. J Am Soc Echocardiogr. 2009;22:803-809.
21. Kokkinos P, Myers J, Kokkinos JP, et al. Exercise capacity and mortality in black and white men. Circulation. 2008;117:614-622.
22. La Gerche A, Connelly KA, Mooney DJ, MacIsaac AI, Prior DL. Biochemical and functional abnormalities of left and right ventricular function after ultraendurance exercise. Heart (British Cardiac Society). 2008;94:860-866.
23. Maron BJ. Sudden death in young athletes. N Engl J Med. 2003;349:1064-1075.
24. Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO. Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980-2006. Circulation. 2009;119:1085-1092.
25. Maron BJ, Poliac LC, Roberts WO. Risk for sudden cardiac death associated with marathon running. J Am Coll Cardiol. 1996;28:428-431.
26. Maron BJ, Shirani J, Poliac LC, Mathenge R, Roberts WC, Mueller FO. Sudden death in young competitive athletes: clinical, demographic, and pathological profiles. JAMA. 1996;276:199-204.
27. Mingels A, Jacobs L, Michielsen E, Swaanenburg J, Wodzig W, van Dieijen-Visser M. Reference population and marathon runner sera assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and I assays. Clin Chem. 2009;55:101-108.
28. Mittleman MA, Maclure M, Tofler GH, Sherwood JB, Goldberg RJ, Muller JE; for Determinants of Myocardial Infarction Onset Study Investigators. Triggering of acute myocardial infarction by heavy physical exertion: protection against triggering by regular exertion. N Engl J Med. 1993;329:1677-1683.
29. Mousavi N, Czarnecki A, Kumar K, et al. Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. Am J Cardiol. 2009;103:1467-1472.
30. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793-801.
31. Neilan TG, Januzzi JL, Lee-Lewandrowski E, et al. Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston Marathon. Circulation. 2006;114:2325-2333.
32. Parker-Pope T. A marathon run in the slow lane. New York Times. November 3, 2009:D1.
33. Redelmeier DA, Greenwald JA. Competing risks of mortality with marathons: retrospective analysis. BMJ. 2007;335:1275-1277.
34. Roberts WO, Maron BJ. Evidence for decreasing occurrence of sudden cardiac death associated with the marathon. J Am Coll Cardiol. 2005;46:1373-1374.
35. Sahlen A, Gustafsson TP, Svensson JE, et al. Predisposing factors and consequences of elevated biomarker levels in long-distance runners aged > or = 55 years. Am J Cardiol. 2009;104:1434-1440.
36. Siscovick DS, Weiss NS, Fletcher RH, Lasky T. The incidence of primary cardiac arrest during vigorous exercise. N Engl J Med. 1984;311:874-877.
37. Sui X, LaMonte MJ, Laditka JN, et al. Cardiorespiratory fitness and adiposity as mortality predictors in older adults. JAMA. 2007;298:2507-2516.
38. Thompson PD, Buchner D, Pina IL, et al. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation. 2003;107:3109-3116.
39. Thompson PD, Franklin BA, Balady GJ, et al. Exercise and acute cardiovascular events placing the risks into perspective: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism and the Council on Clinical Cardiology. Circulation. 2007;115:2358-2368.
40. Thompson PD, Stern MP, Williams P, Duncan K, Haskell WL, Wood PD. Death during jogging or running: a study of 18 cases. JAMA. 1979;242:1265-1267.
41. Tunstall Pedoe D. Sudden death and sport: preventable or inevitable. Br J Sports Med. 1984;18:293-294.
42. Tunstall Pedoe DS. Marathon cardiac deaths: the London experience. Sports Med. 2007;37:448-450.
43. Van Camp SP, Bloor CM, Mueller FO, Cantu RC, Olson HG. Nontraumatic sports death in high school and college athletes. Med Sci Sports Exerc. 1995;27:641-647.
44. Virmani R, Burke AP, Farb A, Kark JA. Causes of sudden death in young and middle-aged competitive athletes. Cardiol Clin. 1997;15:439-466.
45. Virmani R, Robinowitz M. Cardiac pathology and sports medicine. Hum Pathol. 1987;18:493-501.
46. Whang W, Manson JE, Hu FB, et al. Physical exertion, exercise, and sudden cardiac death in women. JAMA. 2006;295:1399-1403.
47. Willich SN, Lewis M, Lowel H, Arntz HR, Schubert F, Schroder R; for the Triggers and Mechanisms of Myocardial Infarction Study Group. Physical exertion as a trigger of acute myocardial infarction. N Engl J Med. 1993;329:1684-1690.