-
1
-
-
0022378694
-
Norhalichondrin A: an antitumor polyether macrolide from a marine sponge
-
Uemura D., Takahashi K., Yamamoto T., et al. Norhalichondrin A: an antitumor polyether macrolide from a marine sponge. J Am Chem Soc 1985, 107(16):4796-4798.
-
(1985)
J Am Chem Soc
, vol.107
, Issue.16
, pp. 4796-4798
-
-
Uemura, D.1
Takahashi, K.2
Yamamoto, T.3
-
2
-
-
0022709534
-
Halichondrins-antitumor polyether macrolides from a marine sponge
-
Hirata Y., Uemura D. Halichondrins-antitumor polyether macrolides from a marine sponge. Pure Appl Chem 1986, 58(5):701-710.
-
(1986)
Pure Appl Chem
, vol.58
, Issue.5
, pp. 701-710
-
-
Hirata, Y.1
Uemura, D.2
-
3
-
-
0026356420
-
Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp.
-
Pettit G.R., Herald C.L., Boyd M.R., et al. Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp. J Med Chem 1991, 34(11):3339-3340.
-
(1991)
J Med Chem
, vol.34
, Issue.11
, pp. 3339-3340
-
-
Pettit, G.R.1
Herald, C.L.2
Boyd, M.R.3
-
4
-
-
0027195860
-
Isolation and structure of halistatin 1 from the eastern Indian Ocean marine sponge Phakellia carteri
-
Pettit G.R., Tan R., Gao F., et al. Isolation and structure of halistatin 1 from the eastern Indian Ocean marine sponge Phakellia carteri. J Org Chem 1993, 58(9):2538-2543.
-
(1993)
J Org Chem
, vol.58
, Issue.9
, pp. 2538-2543
-
-
Pettit, G.R.1
Tan, R.2
Gao, F.3
-
5
-
-
84856210698
-
-
Halichondrins: cytotoxic polyether macrolides. European Patent Office, Munich, Switzerland: Publication number EP 0 572 109 A1
-
Gravelos DG, Lake R, Blunt JW, Munro MHG, Litaudon MSP. Halichondrins: cytotoxic polyether macrolides. European Patent Office, Munich, Switzerland: Publication number EP 0 572 109 A1; 1993.
-
(1993)
-
-
Gravelos, D.G.1
Lake, R.2
Blunt, J.W.3
Munro, M.H.G.4
Litaudon, M.S.P.5
-
6
-
-
0027093080
-
Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B
-
Hamel E. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol Ther 1992, 55(1):31-51.
-
(1992)
Pharmacol Ther
, vol.55
, Issue.1
, pp. 31-51
-
-
Hamel, E.1
-
7
-
-
0026069885
-
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data
-
Bai R.L., Paull K.D., Herald C.L., Malspeis L., Pettit G.R., Hamel E. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J Biol Chem 1991, 266(24):15882-15889.
-
(1991)
J Biol Chem
, vol.266
, Issue.24
, pp. 15882-15889
-
-
Bai, R.L.1
Paull, K.D.2
Herald, C.L.3
Malspeis, L.4
Pettit, G.R.5
Hamel, E.6
-
8
-
-
0035110756
-
In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B
-
Towle M.J., Salvato K.A., Budrow J., et al. In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. Cancer Res 2001, 61(3):1013-1021.
-
(2001)
Cancer Res
, vol.61
, Issue.3
, pp. 1013-1021
-
-
Towle, M.J.1
Salvato, K.A.2
Budrow, J.3
-
9
-
-
0027518597
-
Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin
-
Luduena R.F., Roach M.C., Prasad V., Pettit G.R. Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin. Biochem Pharmacol 1993, 45(2):421-427.
-
(1993)
Biochem Pharmacol
, vol.45
, Issue.2
, pp. 421-427
-
-
Luduena, R.F.1
Roach, M.C.2
Prasad, V.3
Pettit, G.R.4
-
10
-
-
67449147109
-
A phase I study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced solid malignancies
-
Goel S., Mita A.C., Mita M., et al. A phase I study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced solid malignancies. Clin Cancer Res 2009, 15(12):4207-4212.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.12
, pp. 4207-4212
-
-
Goel, S.1
Mita, A.C.2
Mita, M.3
-
11
-
-
17344374835
-
Comparative antitumor activities of halichondrins and vinblastine against human tumor xenografts
-
Fodstad O., Breistol K., Pettit G.R., Shoemaker R.H., Boyd M.R. Comparative antitumor activities of halichondrins and vinblastine against human tumor xenografts. J Exp Ther Oncol 1996, 1(2):119-125.
-
(1996)
J Exp Ther Oncol
, vol.1
, Issue.2
, pp. 119-125
-
-
Fodstad, O.1
Breistol, K.2
Pettit, G.R.3
Shoemaker, R.H.4
Boyd, M.R.5
-
12
-
-
0026774529
-
Total synthesis of halichondrin B and norhalichondrin B
-
Aicher T.D., Buszek K.R., Fang F.G., et al. Total synthesis of halichondrin B and norhalichondrin B. J Am Chem Soc 1992, 114(8):3162-3164.
-
(1992)
J Am Chem Soc
, vol.114
, Issue.8
, pp. 3162-3164
-
-
Aicher, T.D.1
Buszek, K.R.2
Fang, F.G.3
-
14
-
-
79955887466
-
Eribulin mesilate, a halichondrin B analogue, in the treatment of breast cancer
-
Mani S., Swami U. Eribulin mesilate, a halichondrin B analogue, in the treatment of breast cancer. Drugs Today (Barc) 2010, 46(9):641-653.
-
(2010)
Drugs Today (Barc)
, vol.46
, Issue.9
, pp. 641-653
-
-
Mani, S.1
Swami, U.2
-
15
-
-
23144433687
-
The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth
-
Jordan M.A., Kamath K., Manna T., et al. The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth. Mol Cancer Ther 2005, 4(7):1086-1095.
-
(2005)
Mol Cancer Ther
, vol.4
, Issue.7
, pp. 1086-1095
-
-
Jordan, M.A.1
Kamath, K.2
Manna, T.3
-
16
-
-
51049119664
-
Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase
-
Okouneva T., Azarenko O., Wilson L., Littlefield B.A., Jordan M.A. Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase. Mol Cancer Ther 2008, 7(7):2003-2011.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.7
, pp. 2003-2011
-
-
Okouneva, T.1
Azarenko, O.2
Wilson, L.3
Littlefield, B.A.4
Jordan, M.A.5
-
17
-
-
33751102419
-
Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin
-
Dabydeen D.A., Burnett J.C., Bai R., et al. Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin. Mol Pharmacol 2006, 70(6):1866-1875.
-
(2006)
Mol Pharmacol
, vol.70
, Issue.6
, pp. 1866-1875
-
-
Dabydeen, D.A.1
Burnett, J.C.2
Bai, R.3
-
18
-
-
4143052665
-
Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389
-
Kuznetsov G., Towle M.J., Cheng H., et al. Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389. Cancer Res 2004, 64(16):5760-5766.
-
(2004)
Cancer Res
, vol.64
, Issue.16
, pp. 5760-5766
-
-
Kuznetsov, G.1
Towle, M.J.2
Cheng, H.3
-
19
-
-
84856209595
-
-
F.D.A. U. S. Food and Drug Administration. Retreived on 16.11.10.
-
F.D.A. U. S. Food and Drug Administration. Retreived on 16.11.10. http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/201532lbl.pdf.
-
-
-
-
20
-
-
84856235764
-
-
U. S. National Institutes of Health Retreived on 13.11.10.
-
U. S. National Institutes of Health Retreived on 13.11.10. http://clinicaltrials.gov/ct2/results%3Fterm=e7389.
-
-
-
-
21
-
-
84856213938
-
-
National Cancer Institute Drug Dictionary - Definition of eribulin mesylate. Retreived on 13.11.10.
-
National Cancer Institute Drug Dictionary - Definition of eribulin mesylate. Retreived on 13.11.10. http://www.cancer.gov/drugdictionary/%3FCdrID=257773.
-
-
-
-
22
-
-
35648961242
-
Eribulin mesilate
-
Wang Y., Serradell N., Bolos J., Rosa E. Eribulin mesilate. Drugs Future 2007, 32(8):681-698.
-
(2007)
Drugs Future
, vol.32
, Issue.8
, pp. 681-698
-
-
Wang, Y.1
Serradell, N.2
Bolos, J.3
Rosa, E.4
-
23
-
-
84856213935
-
-
Product information, USA, Eisai Inc.
-
Product information, USA, Eisai Inc.
-
-
-
-
24
-
-
84856235765
-
-
National Cancer Institute, Division of Cancer Treatment and Diagnosis - Featured Agents. Retreived on 13.11.10.
-
National Cancer Institute, Division of Cancer Treatment and Diagnosis - Featured Agents. Retreived on 13.11.10. http://dctd.cancer.gov/FeaturedAgents/pdfs/E7389SolicitationMarch2005.pdf.
-
-
-
-
25
-
-
84856225987
-
E7389, a novel antimicrotubule agent with potent p53-independent induction of p27, Bcl2 phosphorylation and cytotoxicity in nonsmall cell lung cancer (NSCLC)
-
[abstr 2804]
-
Kimura T., Synold T., Mahaffey C.M., et al. E7389, a novel antimicrotubule agent with potent p53-independent induction of p27, Bcl2 phosphorylation and cytotoxicity in nonsmall cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2003, 22. [abstr 2804].
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Kimura, T.1
Synold, T.2
Mahaffey, C.M.3
-
26
-
-
35648953764
-
Comparison of the relative efficacies and toxicities of halichondrin B analogues
-
[abst C230]
-
Alley M.C., Smith A.C., Donohue S.J., Schweikart K.M., Newman D.J., Tomaszewski J.E. Comparison of the relative efficacies and toxicities of halichondrin B analogues. 17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther 2005, [abst C230].
-
(2005)
17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther
-
-
Alley, M.C.1
Smith, A.C.2
Donohue, S.J.3
Schweikart, K.M.4
Newman, D.J.5
Tomaszewski, J.E.6
-
27
-
-
35648990744
-
Synergestic combinations of E7389 (halichondrin B analogue) with conventional agaents:In vitro median effect analysis in cell lines with potential clinical implications
-
[abst 6055]
-
Budman D.R., Calabro A., Littlefield BA Synergestic combinations of E7389 (halichondrin B analogue) with conventional agaents:In vitro median effect analysis in cell lines with potential clinical implications. 27th Annu San Antonio Breast Cancer Symp 2004, [abst 6055].
-
(2004)
27th Annu San Antonio Breast Cancer Symp
-
-
Budman, D.R.1
Calabro, A.2
Littlefield, B.A.3
-
28
-
-
70350231755
-
Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin
-
Kuznetsov G., TenDyke K., Towle M.J., et al. Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin. Mol Cancer Ther 2009, 8(10):2852-2860.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.10
, pp. 2852-2860
-
-
Kuznetsov, G.1
TenDyke, K.2
Towle, M.J.3
-
29
-
-
84856213153
-
In vivo efficacy of E7389, a synthetic analogue of the marine sponge antitubulin agent halichondrin B, against human tumor xenografts under monotherapy and combination therapy conditions
-
2nd ed., [abst 2749]
-
Towle M.J., Agoulnik S., Kuznetsov G., et al. In vivo efficacy of E7389, a synthetic analogue of the marine sponge antitubulin agent halichondrin B, against human tumor xenografts under monotherapy and combination therapy conditions. Proc Am Assoc Cancer Res (AACR) 2003, 44(2nd ed.). [abst 2749].
-
(2003)
Proc Am Assoc Cancer Res (AACR)
, vol.44
-
-
Towle, M.J.1
Agoulnik, S.2
Kuznetsov, G.3
-
30
-
-
84856223816
-
Assessment of neuropathy-inducing effects of eribulin mesylate versus paclitaxel and ixabepilone in mice
-
[abstract 137P], Abstract Book of the 35th ESMO Congress Milan
-
Wozniak K.M., Lapidus R.G., Wu Y., et al. Assessment of neuropathy-inducing effects of eribulin mesylate versus paclitaxel and ixabepilone in mice. Ann Oncol 2010, 21(Suppl. 8):viii42-viii62. [abstract 137P].
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 8
-
-
Wozniak, K.M.1
Lapidus, R.G.2
Wu, Y.3
-
31
-
-
84856213936
-
Interaction of [3H]halichondrin B with tubulin
-
[abst 5570]
-
Bai R., Hamel E Interaction of [3H]halichondrin B with tubulin. Proc Am Assoc Cancer Res 2009, [abst 5570].
-
(2009)
Proc Am Assoc Cancer Res
-
-
Bai, R.1
Hamel, E.2
-
32
-
-
35649008589
-
E7389 and ER-076349, synthetic halichondrin B analogs, suppress centromere dynamics in concert with mitotic block
-
[abst 5436]
-
Okouneva T., Wilson L., Littlefield B.A., Jordan M.A. E7389 and ER-076349, synthetic halichondrin B analogs, suppress centromere dynamics in concert with mitotic block. Proc Am Assoc Cancer Res (AACR) 2001, 45. [abst 5436].
-
(2001)
Proc Am Assoc Cancer Res (AACR)
, vol.45
-
-
Okouneva, T.1
Wilson, L.2
Littlefield, B.A.3
Jordan, M.A.4
-
33
-
-
35648962108
-
E7389, a synthetic analog of halichondrin B, suppresses microtubule dynamics in living MCF7 cells by a novel mechanism
-
[abst LB-43]
-
Kamath K., Okouneva T., Miller H., et al. E7389, a synthetic analog of halichondrin B, suppresses microtubule dynamics in living MCF7 cells by a novel mechanism. Proc Am Assoc Cancer Res (AACR) 2003, 44(2nd ed.). [abst LB-43].
-
(2003)
Proc Am Assoc Cancer Res (AACR)
, vol.44
, Issue.2
-
-
Kamath, K.1
Okouneva, T.2
Miller, H.3
-
34
-
-
76749127634
-
Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability
-
Smith J.A., Wilson L., Azarenko O., et al. Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. Biochemistry 2010, 49(6):1331-1337.
-
(2010)
Biochemistry
, vol.49
, Issue.6
, pp. 1331-1337
-
-
Smith, J.A.1
Wilson, L.2
Azarenko, O.3
-
35
-
-
84856210701
-
Eribulin (E7389) binds to 13 saturable sites at microtubule ends to inhibit microtubule dynamics
-
[abst 1408]
-
Smith J., Wilson L., Zhu X., Lewis B., Littlefield B., Jordan M.A. Eribulin (E7389) binds to 13 saturable sites at microtubule ends to inhibit microtubule dynamics. 99th AACR Annual Meeting 2008, [abst 1408].
-
(2008)
99th AACR Annual Meeting
-
-
Smith, J.1
Wilson, L.2
Zhu, X.3
Lewis, B.4
Littlefield, B.5
Jordan, M.A.6
-
36
-
-
69049106647
-
Macromolecular interaction of halichondrin B analogues eribulin (E7389) and ER-076349 with tubulin by analytical ultracentrifugation
-
Alday P.H., Correia J.J. Macromolecular interaction of halichondrin B analogues eribulin (E7389) and ER-076349 with tubulin by analytical ultracentrifugation. Biochemistry 2009, 48(33):7927-7938.
-
(2009)
Biochemistry
, vol.48
, Issue.33
, pp. 7927-7938
-
-
Alday, P.H.1
Correia, J.J.2
-
37
-
-
33744979610
-
Sensitivity to halichondrin analog E7389 and hemiasterlin analog E7974 correlates with ßIII tubulin isotype expression in human breast cancer cell lines
-
Part I of II, 2005 ASCO Annual Meeting Proceedings
-
Agoulnik S., Kuznetsov G., Tendyke K., et al. Sensitivity to halichondrin analog E7389 and hemiasterlin analog E7974 correlates with ßIII tubulin isotype expression in human breast cancer cell lines. J Clin Oncol 2005, 23(16S):2012. Part I of II.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 S
, pp. 2012
-
-
Agoulnik, S.1
Kuznetsov, G.2
Tendyke, K.3
-
38
-
-
75549087583
-
Class III beta-tubulin expression and in vitro resistance to microtubule targeting agents
-
Stengel C., Newman S.P., Leese M.P., Potter B.V., Reed M.J., Purohit A. Class III beta-tubulin expression and in vitro resistance to microtubule targeting agents. Br J Cancer 2010, 102(2):316-324.
-
(2010)
Br J Cancer
, vol.102
, Issue.2
, pp. 316-324
-
-
Stengel, C.1
Newman, S.P.2
Leese, M.P.3
Potter, B.V.4
Reed, M.J.5
Purohit, A.6
-
39
-
-
68549083516
-
Vinorelbine induces beta3-tubulin gene expression through an AP-1 Site
-
Saussede-Aim J., Matera E.L., Herveau S., Rouault J.P., Ferlini C., Dumontet C. Vinorelbine induces beta3-tubulin gene expression through an AP-1 Site. Anticancer Res 2009, 29(8):3003-3009.
-
(2009)
Anticancer Res
, vol.29
, Issue.8
, pp. 3003-3009
-
-
Saussede-Aim, J.1
Matera, E.L.2
Herveau, S.3
Rouault, J.P.4
Ferlini, C.5
Dumontet, C.6
-
40
-
-
38549161093
-
Is class III beta-tubulin a predictive factor in patients receiving tubulin-binding agents?
-
Seve P., Dumontet C. Is class III beta-tubulin a predictive factor in patients receiving tubulin-binding agents?. Lancet Oncol 2008, 9(2):168-175.
-
(2008)
Lancet Oncol
, vol.9
, Issue.2
, pp. 168-175
-
-
Seve, P.1
Dumontet, C.2
-
41
-
-
33745000162
-
A phase I pharmacokinetic and target validation study of the novel anti-tubulin agent E7389: a California Cancer Consortium trial
-
2005 ASCO Annual Meeting Proceedings
-
Synold T.W., Morgan R.J., Newman E.M., et al. A phase I pharmacokinetic and target validation study of the novel anti-tubulin agent E7389: a California Cancer Consortium trial. J Clin Oncol 2005, 23(16S):3036.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 S
, pp. 3036
-
-
Synold, T.W.1
Morgan, R.J.2
Newman, E.M.3
-
42
-
-
35648971301
-
Human pharmacokinetics of E7389 (Halichondrin B analog), a novel anti-microtubule agent undergoing phase I investigation in the California Cancer Consortium (CCC)
-
[abstr 575]
-
Synold T.W., Lawrence J., Xi B., Colevas A.D., Lewis M.D., Doroshow JH Human pharmacokinetics of E7389 (Halichondrin B analog), a novel anti-microtubule agent undergoing phase I investigation in the California Cancer Consortium (CCC). Proc Am Soc Clin Oncol 2003, 22. [abstr 575].
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Synold, T.W.1
Lawrence, J.2
Xi, B.3
Colevas, A.D.4
Lewis, M.D.5
Doroshow, J.H.6
-
43
-
-
67449123315
-
Phase I study of eribulin mesylate administered once every 21days in patients with advanced solid tumors
-
Tan A.R., Rubin E.H., Walton D.C., et al. Phase I study of eribulin mesylate administered once every 21days in patients with advanced solid tumors. Clin Cancer Res 2009, 15(12):4213-4219.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.12
, pp. 4213-4219
-
-
Tan, A.R.1
Rubin, E.H.2
Walton, D.C.3
-
44
-
-
67449159949
-
A phase I study of eribulin mesylate (E7389) in patients with refractory cancers
-
[abst 446]
-
Minami H., Mukohara T., Nagai S., Mukai H., Namiki M. A phase I study of eribulin mesylate (E7389) in patients with refractory cancers. Eur J Cancer Suppl 2008, 6:140. [abst 446].
-
(2008)
Eur J Cancer Suppl
, vol.6
, pp. 140
-
-
Minami, H.1
Mukohara, T.2
Nagai, S.3
Mukai, H.4
Namiki, M.5
-
45
-
-
79551555821
-
Eribulin mesylate pharmacokinetics in patients with hepatic impairment
-
2010 ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Witteveen P., Marchetti S., Mergui-Roelvink M., et al. Eribulin mesylate pharmacokinetics in patients with hepatic impairment. J Clin Oncol 2010, 28(15 Suppl.):2582.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
, pp. 2582
-
-
Witteveen, P.1
Marchetti, S.2
Mergui-Roelvink, M.3
-
46
-
-
80455138386
-
Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole
-
[abstract 574]
-
Devriese L.A., Wanders J., Jenner A., et al. Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole. Abstract presented at the EORTC-NCI-AACR Symposium 2010, [abstract 574].
-
(2010)
Abstract presented at the EORTC-NCI-AACR Symposium
-
-
Devriese, L.A.1
Wanders, J.2
Jenner, A.3
-
47
-
-
79551561542
-
Phase IB study of eribulin mesylate in combination with carboplatin in patients with advanced solid tumors
-
[abst 2589], 2010 ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Swami U., Petrylak D.P., Raftopoulos H., et al. Phase IB study of eribulin mesylate in combination with carboplatin in patients with advanced solid tumors. J Clin Oncol 2010, 28(15 Suppl.). [abst 2589].
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Swami, U.1
Petrylak, D.P.2
Raftopoulos, H.3
-
48
-
-
79955884288
-
Population pharmacokinetics (PPK) of eribulin mesylate in patients with locally advanced or metastatic breast cancer (MBC)
-
[abst 2524], 2009 ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Jansen M., Vernaz-Gris M., DesJardins C., et al. Population pharmacokinetics (PPK) of eribulin mesylate in patients with locally advanced or metastatic breast cancer (MBC). J Clin Oncol 2009, 27(15S). [abst 2524].
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Jansen, M.1
Vernaz-Gris, M.2
DesJardins, C.3
-
50
-
-
0030758777
-
Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization
-
Giannakakou P., Sackett D.L., Kang Y.K., et al. Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization. J Biol Chem 1997, 272(27):17118-17125.
-
(1997)
J Biol Chem
, vol.272
, Issue.27
, pp. 17118-17125
-
-
Giannakakou, P.1
Sackett, D.L.2
Kang, Y.K.3
-
51
-
-
47549112107
-
Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4
-
Zhang Z.Y., King B.M., Pelletier R.D., Wong Y.N. Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4. Cancer Chemother Pharmacol 2008, 62(4):707-716.
-
(2008)
Cancer Chemother Pharmacol
, vol.62
, Issue.4
, pp. 707-716
-
-
Zhang, Z.Y.1
King, B.M.2
Pelletier, R.D.3
Wong, Y.N.4
-
52
-
-
0030749549
-
Accelerated titration designs for phase I clinical trials in oncology
-
Simon R., Rubinstein L., Arbuck S.G., Christian M.C., Freidlin B., Collins J. Accelerated titration designs for phase I clinical trials in oncology. J Natl Cancer Inst 1997, 89(15):1138-1147.
-
(1997)
J Natl Cancer Inst
, vol.89
, Issue.15
, pp. 1138-1147
-
-
Simon, R.1
Rubinstein, L.2
Arbuck, S.G.3
Christian, M.C.4
Freidlin, B.5
Collins, J.6
-
53
-
-
78649646076
-
Phase I and pharmacokinetic (PK) study of eribulin (E7389) in patients (pts) with renal dysfunction (RD) and advanced urothelial cancer (UC): a California Cancer Consortium Trial
-
[abst 2527]
-
Synold T.W., Tsao-Wei D.D., Quinn D.I., et al. Phase I and pharmacokinetic (PK) study of eribulin (E7389) in patients (pts) with renal dysfunction (RD) and advanced urothelial cancer (UC): a California Cancer Consortium Trial. J Clin Oncol 2010, 28(Suppl.):7s. [abst 2527].
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Synold, T.W.1
Tsao-Wei, D.D.2
Quinn, D.I.3
-
54
-
-
77952696144
-
Phase I study of E7389/gemcitabine combination in patients with advanced solid tumors
-
[abstr e13509]
-
Goel R., Chen E., Welch S., et al. Phase I study of E7389/gemcitabine combination in patients with advanced solid tumors. J Clin Oncol 2009, 27(Suppl.). [abstr e13509].
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Goel, R.1
Chen, E.2
Welch, S.3
-
55
-
-
77957594393
-
Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine
-
Cortes J., Vahdat L., Blum J.L., et al. Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine. J Clin Oncol 2010, 28(25):3922-3928.
-
(2010)
J Clin Oncol
, vol.28
, Issue.25
, pp. 3922-3928
-
-
Cortes, J.1
Vahdat, L.2
Blum, J.L.3
-
56
-
-
67649908927
-
Phase II study of eribulin mesylate, a halichondrin B analog, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
-
Vahdat L.T., Pruitt B., Fabian C.J., et al. Phase II study of eribulin mesylate, a halichondrin B analog, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2009, 27(18):2954-2961.
-
(2009)
J Clin Oncol
, vol.27
, Issue.18
, pp. 2954-2961
-
-
Vahdat, L.T.1
Pruitt, B.2
Fabian, C.J.3
-
57
-
-
79551553908
-
Efficacy and safety of eribulin in Japanese patients (pts) with advanced breast cancer
-
2010 ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Iwata H., Aogi K., Masuda N., et al. Efficacy and safety of eribulin in Japanese patients (pts) with advanced breast cancer. J Clin Oncol 2010, 28(15 Suppl.):1081.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
, pp. 1081
-
-
Iwata, H.1
Aogi, K.2
Masuda, N.3
-
58
-
-
84856210703
-
The place for eribulin in the treatment of metastatic breast cancer
-
Nov 23 [Epub ahead of print]
-
Gradishar W.J. The place for eribulin in the treatment of metastatic breast cancer. Curr Oncol Rep 2010, Nov 23 [Epub ahead of print].
-
(2010)
Curr Oncol Rep
-
-
Gradishar, W.J.1
-
59
-
-
45349107525
-
Phase II study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced non-small cell lung cancer (NSCLC)
-
2007 ASCO Annual Meeting Proceedings Part I
-
Spira A.I., Iannotti N.O., Savin M.A., et al. Phase II study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007, 25(18S):7546.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
, pp. 7546
-
-
Spira, A.I.1
Iannotti, N.O.2
Savin, M.A.3
-
60
-
-
76649124132
-
A phase II study of the halichondrin B analog, E7389, in patients (pts) with advanced non-small cell lung cancer (NSCLC) previously treated with a taxane. A California Consortium/University of Pittsburgh/University of Chicago NCI/CTEP sponsored trial. 2009 ASCO Annual Meeting
-
[abstr 8056]
-
Gitlitz B.J., Davies A.M., Belani C.P., et al. A phase II study of the halichondrin B analog, E7389, in patients (pts) with advanced non-small cell lung cancer (NSCLC) previously treated with a taxane. A California Consortium/University of Pittsburgh/University of Chicago NCI/CTEP sponsored trial. 2009 ASCO Annual Meeting. J Clin Oncol 2009, 27(Suppl.):15s. [abstr 8056].
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Gitlitz, B.J.1
Davies, A.M.2
Belani, C.P.3
-
61
-
-
79959285684
-
Phase II study of eribulin mesylate (E7389) in patients (pts) with metastatic castration-resistant prostate cancer (CRPC) stratified by prior taxane therapy
-
[abstract No. 166]
-
de Bono J.S., Maroto P., Calvo E., et al. Phase II study of eribulin mesylate (E7389) in patients (pts) with metastatic castration-resistant prostate cancer (CRPC) stratified by prior taxane therapy. 2009 ASCO Genitourinary Cancers Symposium 2009, [abstract No. 166].
-
(2009)
2009 ASCO Genitourinary Cancers Symposium
-
-
de Bono, J.S.1
Maroto, P.2
Calvo, E.3
-
62
-
-
35748985009
-
The Prostate Cancer Clinical Trials Working Group (PCCTWG) consensus criteria for phase II clinical trials for castration-resistant prostate cancer
-
2007 ASCO Annual Meeting Proceedings Part I
-
Scher H.I., Halabi S., Tannock I., et al. The Prostate Cancer Clinical Trials Working Group (PCCTWG) consensus criteria for phase II clinical trials for castration-resistant prostate cancer. J Clin Oncol 2007, 25(18S):5057.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
, pp. 5057
-
-
Scher, H.I.1
Halabi, S.2
Tannock, I.3
-
63
-
-
84856236087
-
ECOG 5805: a phase II study of eribulin mesylate (E7389) in patients (pts) with metastatic castration-resistant prostate cancer (CRPC)
-
2010 ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Stein M.N., Chen Y., Hudes G.R., Carducci M.A., Tan W., DiPaola RS ECOG 5805: a phase II study of eribulin mesylate (E7389) in patients (pts) with metastatic castration-resistant prostate cancer (CRPC). J Clin Oncol 2010, 28(15 Suppl.):4556.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
, pp. 4556
-
-
Stein, M.N.1
Chen, Y.2
Hudes, G.R.3
Carducci, M.A.4
Tan, W.5
DiPaola, R.S.6
-
64
-
-
84856235763
-
-
E7389 in Treating Patients With Recurrent Ovarian Epithelial PPC, or Fallopian Tube Cancer.
-
E7389 in Treating Patients With Recurrent Ovarian Epithelial PPC, or Fallopian Tube Cancer. http://clinicaltrials.gov/ct2/show/NCT00334893.
-
-
-
-
65
-
-
84856235525
-
Eribulin mesylate (halichondrin B Analog E7389) in platinum-resistant epithelial ovarian cancer (PR-EOC): a CTEP-sponsored phase II study. 2009 ASCO Annual Meeting
-
[abstr 5561]
-
Hensley M.L., Kravetz S., Sima C., et al. Eribulin mesylate (halichondrin B Analog E7389) in platinum-resistant epithelial ovarian cancer (PR-EOC): a CTEP-sponsored phase II study. 2009 ASCO Annual Meeting. J Clin Oncol 2009, 27(Suppl.):15s. [abstr 5561].
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Hensley, M.L.1
Kravetz, S.2
Sima, C.3
-
66
-
-
78650050500
-
Activity of eribulin mesylate (E7389) in patients with soft tissue sarcoma (STS): Phase II studies of the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC 62052)
-
2010 ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Schoffski P., Ray-Coquard I.L., Cioffi A., et al. Activity of eribulin mesylate (E7389) in patients with soft tissue sarcoma (STS): Phase II studies of the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC 62052). J Clin Oncol 2010, 28(15S):10031.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
, pp. 10031
-
-
Schoffski, P.1
Ray-Coquard, I.L.2
Cioffi, A.3
-
67
-
-
70449723914
-
A phase II study of Halichondrin B analog eribulin mesylate (E7389) as second-line therapy for patients with advanced pancreatic cancer
-
2009 ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Moore M.J., Tang P., Renouf D., et al. A phase II study of Halichondrin B analog eribulin mesylate (E7389) as second-line therapy for patients with advanced pancreatic cancer. J Clin Oncol 2009, 27(15S):e15634.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Moore, M.J.1
Tang, P.2
Renouf, D.3
-
68
-
-
84856210704
-
-
E7389 in Treating Patients With Locally Advanced or Metastatic Cancer of the Urothelium and Kidney Dysfunction.
-
E7389 in Treating Patients With Locally Advanced or Metastatic Cancer of the Urothelium and Kidney Dysfunction. http://clinicaltrials.gov/ct2/show/NCT00365157.
-
-
-
-
69
-
-
78649667759
-
Phase II study of eribulin (E7389) in patients (pts) with advanced urothelial cancer (UC)-Final report: A California Cancer Consortium-led NCI/CTEP-sponsored trial
-
2010 ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Quinn D.I., Aparicio A., Tsao-Wei D.D., et al. Phase II study of eribulin (E7389) in patients (pts) with advanced urothelial cancer (UC)-Final report: A California Cancer Consortium-led NCI/CTEP-sponsored trial. J Clin Oncol 2010, 28(15 Suppl.):4539.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
, pp. 4539
-
-
Quinn, D.I.1
Aparicio, A.2
Tsao-Wei, D.D.3
-
70
-
-
79959925153
-
Phase II evaluation of eribulin mesylate (E7389, NSC 707389) in patients with metastatic or recurrent squamous cell carcinoma of the head and neck: Southwest Oncology Group trial S0618
-
Arnold S.M., Moon J., Williamson S.K., et al. Phase II evaluation of eribulin mesylate (E7389, NSC 707389) in patients with metastatic or recurrent squamous cell carcinoma of the head and neck: Southwest Oncology Group trial S0618. Invest New Drugs 2009.
-
(2009)
Invest New Drugs
-
-
Arnold, S.M.1
Moon, J.2
Williamson, S.K.3
-
71
-
-
77950475001
-
Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer
-
Twelves C., Cortes J., Vahdat L.T., Wanders J., Akerele C., Kaufman P.A. Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer. Clin Breast Cancer 2010, 10(2):160-163.
-
(2010)
Clin Breast Cancer
, vol.10
, Issue.2
, pp. 160-163
-
-
Twelves, C.1
Cortes, J.2
Vahdat, L.T.3
Wanders, J.4
Akerele, C.5
Kaufman, P.A.6
-
72
-
-
77955893812
-
A phase III study (EMBRACE) of eribulin mesylate versus treatment of physician's choice in patients with locally recurrent or metastatic breast cancer previously treated with an anthracycline and a taxane
-
Twelves C., Loesch D., Blum J.L., et al. A phase III study (EMBRACE) of eribulin mesylate versus treatment of physician's choice in patients with locally recurrent or metastatic breast cancer previously treated with an anthracycline and a taxane. ASCO Meeting Abstracts 2010, CRA1004.
-
(2010)
ASCO Meeting Abstracts
-
-
Twelves, C.1
Loesch, D.2
Blum, J.L.3
-
73
-
-
84855653860
-
Eribulin Mesylate (E7389) vs. Treatment of Physician's Choice (TPC) in Patients (Pts) with Metastatic Breast Cancer (MBC): Subgroup Analyses from the EMBRACE Study
-
viii96-viii121, Abstract 2750, presented at the ESMO Congress
-
Twelves C., Akerele C., Wanders J., Cortes J. Eribulin Mesylate (E7389) vs. Treatment of Physician's Choice (TPC) in Patients (Pts) with Metastatic Breast Cancer (MBC): Subgroup Analyses from the EMBRACE Study. Ann Oncol 2010, 21(Suppl. 8). viii96-viii121.
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 8
-
-
Twelves, C.1
Akerele, C.2
Wanders, J.3
Cortes, J.4
-
74
-
-
84856210697
-
Second generation eribulin analogs: efficacy against multi-drug resistant tumors and brain tumors
-
[abstract nr 2704]
-
Narayan S., Carlson E., Cheng H., et al. Second generation eribulin analogs: efficacy against multi-drug resistant tumors and brain tumors. Proc Am Assoc Cancer Res 2009, [abstract nr 2704].
-
(2009)
Proc Am Assoc Cancer Res
-
-
Narayan, S.1
Carlson, E.2
Cheng, H.3
-
75
-
-
77955448465
-
Analysis of overall survival from a phase III study of ixabepilone plus capecitabine versus capecitabine in patients with MBC resistant to anthracyclines and taxanes
-
Hortobagyi G., Gomez H., Li R., et al. Analysis of overall survival from a phase III study of ixabepilone plus capecitabine versus capecitabine in patients with MBC resistant to anthracyclines and taxanes. Breast Cancer Res Treat 2010, 122(2):409-418.
-
(2010)
Breast Cancer Res Treat
, vol.122
, Issue.2
, pp. 409-418
-
-
Hortobagyi, G.1
Gomez, H.2
Li, R.3
-
76
-
-
36849071808
-
Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment
-
Thomas E.S., Gomez H.L., Li R.K., et al. Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. J Clin Oncol 2007, 25(33):5210-5217.
-
(2007)
J Clin Oncol
, vol.25
, Issue.33
, pp. 5210-5217
-
-
Thomas, E.S.1
Gomez, H.L.2
Li, R.K.3
-
77
-
-
77954752064
-
Randomized Phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
-
Sparano J.A., Vrdoljak E., Rixe O., et al. Randomized Phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2010, 28(20):3256-3263.
-
(2010)
J Clin Oncol
, vol.28
, Issue.20
, pp. 3256-3263
-
-
Sparano, J.A.1
Vrdoljak, E.2
Rixe, O.3
-
78
-
-
33847138943
-
Gemcitabine plus vinorelbine versus vinorelbine monotherapy in patients with metastatic breast cancer previously treated with anthracyclines and taxanes: final results of the phase III Spanish Breast Cancer Research Group (GEICAM) trial
-
Martín M., Ruiz A., Muñoz M., et al. Gemcitabine plus vinorelbine versus vinorelbine monotherapy in patients with metastatic breast cancer previously treated with anthracyclines and taxanes: final results of the phase III Spanish Breast Cancer Research Group (GEICAM) trial. Lancet Oncol 2007, 8(3):219-225.
-
(2007)
Lancet Oncol
, vol.8
, Issue.3
, pp. 219-225
-
-
Martín, M.1
Ruiz, A.2
Muñoz, M.3
-
79
-
-
0029092360
-
Randomized comparison of vinorelbine and melphalan in anthracycline-refractory advanced breast cancer
-
Jones S., Winer E., Vogel C., et al. Randomized comparison of vinorelbine and melphalan in anthracycline-refractory advanced breast cancer. J Clin Oncol 1995, 13(10):2567-2574.
-
(1995)
J Clin Oncol
, vol.13
, Issue.10
, pp. 2567-2574
-
-
Jones, S.1
Winer, E.2
Vogel, C.3
-
80
-
-
33750935337
-
Phase III trial comparing three doses of docetaxel for second-line treatment of advanced breast cancer
-
Harvey V., Mouridsen H., Semiglazov V., et al. Phase III trial comparing three doses of docetaxel for second-line treatment of advanced breast cancer. J Clin Oncol 2006, 24(31):4963-4970.
-
(2006)
J Clin Oncol
, vol.24
, Issue.31
, pp. 4963-4970
-
-
Harvey, V.1
Mouridsen, H.2
Semiglazov, V.3
-
81
-
-
77954700380
-
Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2 - negative metastatic breast cancer
-
Miles D.W., Chan A., Dirix L.Y., et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2 - negative metastatic breast cancer. J Clin Oncol 2010, 28(20):3239-3247.
-
(2010)
J Clin Oncol
, vol.28
, Issue.20
, pp. 3239-3247
-
-
Miles, D.W.1
Chan, A.2
Dirix, L.Y.3
-
82
-
-
77953350010
-
Docetaxel versus docetaxel alternating with gemcitabine as treatments of advanced breast cancer: final analysis of a randomised trial
-
Joensuu H., Sailas L., Alanko T., et al. Docetaxel versus docetaxel alternating with gemcitabine as treatments of advanced breast cancer: final analysis of a randomised trial. Ann Oncol 2010, 21(5):968-973.
-
(2010)
Ann Oncol
, vol.21
, Issue.5
, pp. 968-973
-
-
Joensuu, H.1
Sailas, L.2
Alanko, T.3
-
83
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller K., Wang M., Gralow J., et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007, 357(26):2666-2676.
-
(2007)
N Engl J Med
, vol.357
, Issue.26
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
-
84
-
-
43249115659
-
Randomized Phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 Nonoverexpressors: final results of cancer and leukemia group B Protocol 9840
-
Seidman A.D., Berry D., Cirrincione C., et al. Randomized Phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 Nonoverexpressors: final results of cancer and leukemia group B Protocol 9840. J Clin Oncol 2008, 26(10):1642-1649.
-
(2008)
J Clin Oncol
, vol.26
, Issue.10
, pp. 1642-1649
-
-
Seidman, A.D.1
Berry, D.2
Cirrincione, C.3
-
85
-
-
0032809977
-
Initial paclitaxel improves outcome compared with CMFP combination chemotherapy as front-line therapy in untreated metastatic breast cancer
-
Bishop J.F., Dewar J., Toner G.C., et al. Initial paclitaxel improves outcome compared with CMFP combination chemotherapy as front-line therapy in untreated metastatic breast cancer. J Clin Oncol 1999, 17(8):2355-2364.
-
(1999)
J Clin Oncol
, vol.17
, Issue.8
, pp. 2355-2364
-
-
Bishop, J.F.1
Dewar, J.2
Toner, G.C.3
-
86
-
-
32944482677
-
Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
-
Gradishar W.J., Tjulandin S., Davidson N., et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol 2005, 23(31):7794-7803.
-
(2005)
J Clin Oncol
, vol.23
, Issue.31
, pp. 7794-7803
-
-
Gradishar, W.J.1
Tjulandin, S.2
Davidson, N.3
-
87
-
-
84856209594
-
-
National Comprehensive Cancer Network Clinical Practice Guidelines In Oncology. Retrieved on 18.02.11.
-
National Comprehensive Cancer Network Clinical Practice Guidelines In Oncology. Retrieved on 18.02.11. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp.
-
-
-
|