Improvement of cerebral metabolism mediated by Ro5-4864 is associated with relief of intracranial pressure and mitochondrial protective effect in experimental Brain injury

Pharmaceutical Research

Volumn 28, Issue 11, 2011, Pages 2945-2953

  Soustiel, Jean F ^a   Vlodavsky, Eugene ^b   Milman, Felix ^a   Gavish, Moshe ^a   Zaaroor, Menashe ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

18 kDa translocator protein; Intracranial pressure; Microdialysis; Mitochondria; Traumatic brain injury

Indexed keywords

4' CHLORODIAZEPAM; CARRIER PROTEIN; GLUCOSE; GLYCEROL; LACTIC ACID; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN INJURY; BRAIN METABOLISM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG MECHANISM; ELECTRON MICROSCOPY; EX VIVO STUDY; EXPERIMENTAL RAT; IN VIVO STUDY; INTRACRANIAL PRESSURE MONITORING; MALE; MICRODIALYSIS; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; WATER CONTENT;

ANIMALS; BENZODIAZEPINONES; BRAIN; BRAIN EDEMA; BRAIN INJURIES; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; INTRACRANIAL PRESSURE; MALE; MICRODIALYSIS; MITOCHONDRIA; NEUROLOGIC EXAMINATION; PROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84856232945     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0463-0     Document Type: Article

References (39)

1. Jaggi JL, Obrist WD, Gennarelli TA, Langfitt TW. Relationship of early cerebral blood flow and metabolism to outcome in acute head injury. J Neurosurg. 1990;72:176-82. (Pubitemid 20087704)
2. Obrist WD, Langfitt TW, Jaggi JL, Cruz J, Gennarelli TA. Relationship to intracranial hypertension. J Neurosurg. 1984;61:241-53.
3. Bouma GJ, Muizelaar JP, Bandoh K, Marmarou A. Blood pressure and intracranial pressure-volume dynamics in severe head injury: relationship with cerebral blood flow. J Neurosurg. 1992;77:15-9.
4. Chieregato A, Tanfani A, Compagnone C, Turrini C, Sarpieri F, Ravaldini M, et al. Global cerebral blood flow and CPP after severe head injury: a xenon-CT study. Intensive Care Med. 2007;33:856-62. (Pubitemid 46675333)
5. Soustiel JF, Sviri GE. Monitoring of cerebral metabolism: nonischemic impairment of oxidative metabolism following severe traumatic brain injury. Neurol Res. 2007;29:654-60. (Pubitemid 350086061)
6. Vespa P, Bergsneider M, Hattori N, Wu HM, Huang SC, Martin NA, et al. Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study. J Cereb Blood Flow Metab. 2005;25:763-74. (Pubitemid 40705611)
7. Soustiel JF, Mahamid E, Chistyakov A, Shik V, Benenson R, Zaaroor M. Comparison of moderate hyperventilation and mannitol for control of intracranial pressure control in patients with severe traumatic brain injury-a study of cerebral blood flow and metabolism. Acta Neurochir (Wien). 2006;148:845-51. (Pubitemid 44126078)
8. Soustiel JF, Sviri GE, Mahamid E, Shik V, Abeshaus S, Zaaroor M. Cerebral blood flow and metabolism following decompressive craniectomy for control of increased intracranial pressure. Neurosurgery. 2010;67:65-72. discussion 72.
9. Merenda A, Bullock R. Clinical treatments for mitochondrial dysfunctions after brain injury. Curr Opin Crit Care. 2006;12:90-6.
10. Robertson CL, Soane L, Siegel ZT, Fiskum G. The potential role of mitochondria in pediatric traumatic brain injury. Dev Neurosci. 2006;28:432-46. (Pubitemid 44310509)
11. Xiong Y, Gu Q, Peterson PL, Muizelaar JP, Lee CP. Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury. J Neurotrauma. 1997;14:23-34. (Pubitemid 27100278)
12. Galluzzi L, Blomgren K, Kroemer G. Mitochondrial membrane permeabilization in neuronal injury. Nat Rev Neurosci. 2009;10:481-94.
13. Mazzeo AT, Beat A, Singh A, Bullock MR. The role of mitochondrial transition pore, and its modulation, in traumatic brain injury and delayed neurodegeneration after TBI. Exp Neurol. 2009;218:363-70.
14. Soustiel JF, Larisch S. Mitochondrial damage: a target for new therapeutic horizons. Neurotherapeutics. 2010;7:13-21.
15. Braestrup C, Squires RF. Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding. Proc Natl Acad Sci USA. 1977;74:3805-9. (Pubitemid 8189972)
16. McEnery MW, Snowman AM, Trifiletti RR, Snyder SH. Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA. 1992;89:3170-4.
17. Decaudin D. Peripheral benzodiazepine receptor and its clinical targeting. Anticancer Drugs. 2004;15:737-45. (Pubitemid 39281296)
18. Soustiel JF, Zaaroor M, Vlodavsky E, Veenman L, Weizman A, Gavish M. Neuroprotective effect of Ro5-4864 following brain injury. Exp Neurol. 2008;214:201-8.
19. Palzur E, Vlodavsky E, Mulla H, Arieli R, Feinsod M, Soustiel JF. Hyperbaric oxygen therapy for reduction of secondary brain damage in head injury: an animal model of brain contusion. J Neurotrauma. 2004;21:41-8. (Pubitemid 38141801)
20. Soustiel JF, Palzur E, Vlodavsky E, Veenman L, Gavish M. The effect of oxygenation level on cerebral post-traumatic apoptotsis is modulated by the 18-kDa translocator protein (also known as peripheral-type benzodiazepine receptor) in a rat model of cortical contusion. Neuropathol Appl Neurobiol. 2008;34:412-23.
21. Vlodavsky E, Palzur E, Soustiel JF. Hyperbaric oxygen therapy reduces neuroinflammation and expression of matrix metalloproteinase-9 in the rat model of traumatic brain injury. Neuropathol Appl Neurobiol. 2006;32:40-50.
22. Lees GJ. Effects of anaesthetics, anticonvulsants and glutamate antagonists on kainic acid-induced local and distal neuronal loss. J Neurol Sci. 1992;108:221-8.
23. Nakamoto Y, Watabe S, Shiotani T, Yoshii M. Peripheral-type benzodiazepine receptors in association with epileptic seizures in EL mice. Brain Res. 1996;717:91-8. (Pubitemid 26153440)
24. Shiotani T, Nakamoto Y, Watabe S, Yoshii M, Nabeshima T. Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors. Brain Res. 2000;859:255-61. (Pubitemid 30136096)
25. Soustiel JF, Glenn TC, Shik V, Boscardin J, Mahamid E, Zaaroor M. Monitoring of cerebral blood flow and metabolism in traumatic brain injury. J Neurotrauma. 2005;22:955-65. (Pubitemid 41362062)
26. Shohami E, Novikov M, Bass R. Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat. Brain Res. 1995;674:55-62.
27. Prins ML, Fujima LS, Hovda DA. Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury. J Neurosci Res. 2005;82:413-20. (Pubitemid 41552492)
28. Lifshitz J, Friberg H, Neumar RW, Raghupathi R, Welsh FA, Janmey P, et al. Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus. J Cereb Blood Flow Metab. 2003;23:219-31. (Pubitemid 36188460)
29. Johnston AJ, Steiner LA, Coles JP, Chatfield DA, Fryer TD, Smielewski P, et al. Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury. Crit Care Med. 2005;33:189-95. discussion 255-187. (Pubitemid 40116556)
30. Belli A, Sen J, Petzold A, Russo S, Kitchen N, Smith M. Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study. Acta Neurochir (Wien). 2008;150:461-9. discussion 470.
31. Enblad P, Valtysson J, Andersson J, Lilja A, Valind S, Antoni G, et al. Simultaneous intracerebral microdialysis and positron emission tomography in the detection of ischemia in patients with subarachnoid hemorrhage. J Cereb Blood Flow Metab. 1996;16:637-44. (Pubitemid 26227073)
32. Hillered L, Persson L, Nilsson P, Ronne-Engstrom E, Enblad P. Continuous monitoring of cerebral metabolism in traumatic brain injury: a focus on cerebral microdialysis. Curr Opin Crit Care. 2006;12:112-8.
33. Hlatky R, Valadka AB, Goodman JC, Robertson CS. Evolution of brain tissue injury after evacuation of acute traumatic subdural hematomas. Neurosurgery. 2004;55:1318-23. discussion 1324. (Pubitemid 39612875)
34. Langemann H, Mendelowitsch A, Landolt H, Alessandri B, Gratzl O. Experimental and clinical monitoring of glucose by microdialysis. Clin Neurol Neurosurg. 1995;97:149-55.
35. Valtysson J, Persson L, Hillered L. Extracellular ischaemia markers in repeated global ischaemia and secondary hypoxaemia monitored by microdialysis in rat brain. Acta Neurochir (Wien). 1998;140:387-95. (Pubitemid 28256547)
36. Bazan Jr NG, Rakowski H. Increased levels of brain free fatty acids after electroconvulsive shock. Life Sci. 1970;9:501-7.
37. Gercken G, Brauning C. Quantitative determination of hydrolysis products of phospholipids in the ischaemic rat brain. Pflugers Arch. 1973;344:207-15.
38. Chan PH, Longar S, Fishman RA. Phospholipid degradation and edema development in cold-injured rat brain. Brain Res. 1983;277:329-37. (Pubitemid 13023957)
39. Veiga S, Azcoitia I, Garcia-Segura LM. Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity. J Neurosci Res. 2005;80:129-37. (Pubitemid 40577301)