Evidence of dependence of lipoprotein(a) on triglyceride and high-density lipoprotein metabolism

Journal of Clinical Lipidology

Volumn 6, Issue 1, 2012, Pages 27-32

  Konerman, Matthew ^a   Kulkarni, Krishnaji ^b   Toth, Peter P ^c   Jones, Steven R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Atherotech Inc   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

HDL; Lipoprotein(a); Metabolism; Triglycerides; VLDL

Indexed keywords

BILE ACID SEQUESTRANT; EZETIMIBE; FIBRIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN A; LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN; NICOTINIC ACID; TRIACYLGLYCEROL;

ADULT; ARTICLE; CELL SURFACE; CORONARY ARTERY DISEASE; DYSLIPIDEMIA; FEMALE; HUMAN; LIPOPROTEIN METABOLISM; MAJOR CLINICAL STUDY; MALE; METABOLIC CAPACITY; PRACTICE GUIDELINE; PRIMARY PREVENTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SECONDARY PREVENTION; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; CHOLESTEROL; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDIES; DYSLIPIDEMIAS; HUMANS; HYPOLIPIDEMIC AGENTS; LINEAR MODELS; LIPOPROTEIN(A); LIPOPROTEINS, HDL; MIDDLE AGED; MULTIVARIATE ANALYSIS; PERIPHERAL ARTERIAL DISEASE; TRIGLYCERIDES;

EID: 84856228821     PISSN: 19332874     EISSN: 18764789     Source Type: Journal    
DOI: 10.1016/j.jacl.2011.08.004     Document Type: Article

References (26)

1. E.J. Schaefer, M.E. Herman, J.J. Jenner, and L.J. Seman Lipoprotein(a): a pleotropic risk factor for cardiovascular disease P.O. Kwiterovich Jr. The Johns Hopkins Textbook of Dyslipidemia vol. 18 2010 Lippincott Williams & Wilkins Philadelphia 222 229
2. J. Genest Jr., J.L. Jenner, and J.R. McNamara Prevalence of lipoprotein(a) [Lp(a)] excess in coronary artery disease Am J Cardiol 67 1991 1039 1145
3. F. Kronenberg, M.F. Kronenberg, and S. Kiechl Role of lipoprotein (a) and apolipoprotein(a) phenotype in atherogenesis. Prospective results from the Bruneck study Circulation 100 1999 1154 1160 (Pubitemid 29426589)
4. 2 activity, and 10-year cardiovascular outcome. Prospective results from the Bruneck study Arterioscler Thromb Vasc Biol 27 2007 1788 1795 (Pubitemid 47207175)
5. S. Tsimikas, E.S. Brilakis, and E.R. Miller Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease N Engl J Med 353 2005 46 57 (Pubitemid 41007806)
6. P.R. Kamstrup, A. Tybjaerg-Hansen, R. Steffensen, and B.G. Nordestgaard Genetically elevated lipoprotein(a) and increased risk of myocardial infarction JAMA 301 2009 2331 2339
7. F. Paultre, T.A. Pearson, and H. Weil High levels of Lp(a) with a small apo(a) isoform are associated with coronary artery disease in African-American and White men Arterioscler Thromb Vasc Biol 20 2000 2619 2624
8. 2 in atherosclerosis and cardiovascular disease Arterioscler Thromb Vasc Biol 27 2007 2094 2099 (Pubitemid 350287235)
9. L.J. Seman, C. DeLuca, and J.L. Jenner Lipoprotein(a)-cholesterol and coronary heart disease in the Framingham Heart Study Clin Chem 45 1999 1039 1046 (Pubitemid 29340541)
10. N. Rifai, J. Ma, F.M. Sacks, P.M. Ridker, W.J. Hernandez, M.J. Stampfer, and S.M. Marcovina Apolipoprotein(a) size and lipoprotein(a) concentration and future risk of angina pectoris with evidence of severe coronary atherosclerosis in men: the physicians' health study Clin Chem 50 2004 1364 1371 (Pubitemid 38970643)
11. E. Boerwinkle, C.C. Leffert, J. Lin, C. Lackner, G. Chiesa, and H.H. Hobbs Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations J Clin Invest 90 1990 52 60
12. R. Clarke, J.F. Peden, and J.C. Hopewell Genetic variants associated with Lp(a) lipoprotein level and coronary disease N Engl J Med 361 2009 2518 2528
13. K.M. Argraves, K.F. Kozarsky, J.T. Fallon, P.C. Harpel, and D.K. Strickland The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor J Clin Invest 1997 2170 2181 (Pubitemid 27500138)
14. D.L. Rainwater, M.J. Ludwig, S.M. Haffner, and J.L. Vandeberg Lipid and lipoprotein factors associated with variation in Lp(a) density Arterioscler Thromb Vasc Biol 15 1995 313 319
15. F. Nassir, D.K. Bonen, and N.O. Davidson Apolipoprotein(a) synthesis and secretion from hepatoma cells is coupled to triglyceride synthesis and secretion J Biol Chem 273 1998 17793 17800 (Pubitemid 28355123)
16. H.H. Hobbs, and A.L. White Lipoprotein(a): intrigues and insights Curr Opin Lipidol 10 1999 225 236 (Pubitemid 29405913)
17. J.W. Gaubatz, R.C. Hoogeveen, and A.S. Hoffman Isolation, quantitation, and characterization of a stable complex formed by Lp(a) binding to triglyceride-rich lipoproteins J Lipid Res 42 2001 2058 2068 (Pubitemid 34001055)
18. T. Tholstrup, and S. Samman Postprandial lipoprotein(a) is affected differently by specific individual dietary fatty acids in healthy young men J Nutr 134 2004 2550 2555 (Pubitemid 39315254)
19. T.P. Bersot, T.L. Innerarity, R.E. Pitas, S.C. Rall, K.H. Weisgraber, and R.W. Mahley Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein(a) and that cause lipid accumulation in macrophages J Clin Invest 77 1986 622 630 (Pubitemid 16037665)
20. J.P. Werba, O. Safa, G. Gianfranceschi, S. Michelagnoli, C.R. Sirtori, and G. Franceschini Plasma triglycerides and lipoprotein(a): inverse relationship in a hyperlipidemic Italian population Atherosclerosis 101 1993 203 211 (Pubitemid 23214233)
21. W.J. McConathy, V.N. Trieu, E. Koren, C.S. Wang, and C.C. Corder Triglyceride-rich lipoprotein interactions with Lp(a) Chem Phys Lipids 67 1994 105 113 (Pubitemid 24054467)
22. J.S. Cohn, C.W. Lam, D.R. Sullivan, and W.J. Hensley Plasma lipoprotein distribution of apolipoprotein(a) in the fed and fasted states Atherosclerosis 90 1991 59 66
23. W. Bartens, D.J. Rader, G. Talley, and H.B. Brewer Jr. Decreased plasma levels of lipoprotein(a) in patients with hypertriglyceridemia Atherosclerosis 108 1994 149 157 (Pubitemid 24265887)
24. L.M. Gatto, D.R. Sullivan, and S. Samman Postprandial effects of dietary trans fatty acids on apolipoprotein(a) and cholesteryl ester transfer Am J Clin Nutr 77 2003 1119 1124 (Pubitemid 44858425)
25. C. Sandholzer, G. Feussner, and G. Utermann Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. No evidence for a triglyceride-rich precursor of lipoprotein(a) J Clin Invest 90 1992 1958 1965
26. C.P. Cannon, S. Shah, and H.M. Dansky Safety of anacetrapib in patients with or at high risk for coronary heart disease N Engl J Med 363 2010 2406 2415