Pycnogenol attenuates the inflammatory and nitrosative stress on joint inflammation induced by urate crystals

Free Radical Biology and Medicine

Volumn 52, Issue 4, 2012, Pages 765-774

  Peng, Yi Jen ^a   Lee, Chian Her ^b   Wang, Chih Chien ^c   Salter, Donald M ^d   Lee, Herng Sheng ^c  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Chondrocyte; Cyclooxygenase 2; interleukin 8; Nitric oxide; Pycnogenol; Synovium; Urate crystal

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PYCNOGENOL; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; URATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME SYNTHESIS; FIBROBLAST; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; NITROSATIVE STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SYNOVIUM; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, GOUTY; CELLS, CULTURED; CHONDROCYTES; CYCLOOXYGENASE 2; ENZYME ACTIVATION; FIBROBLASTS; FLAVONOIDS; HUMANS; INTERLEUKIN-8; JOINT CAPSULE; MALE; MAP KINASE SIGNALING SYSTEM; NITRIC OXIDE SYNTHASE TYPE II; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PHYSIOLOGICAL; URIC ACID;

RATTUS;

EID: 84856228802     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.12.003     Document Type: Article

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