Evaluation of an experimental urodynamic platform to identify treatment effects: A randomized, placebo-controlled, crossover study in patients with overactive bladder

Neurourology and Urodynamics

Volumn 31, Issue 1, 2012, Pages 69-74

  Frenkl, Tara ^a   Railkar, Radha ^a   Shore, Neal ^b   Bailen, James ^c   Sutherland, Suzette ^d   Burke, Joanne ^a   Scott, Boyd B ^a   Ruddy, Marcella ^a   Beals, Chan ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Grand Strand Urology/Atlantic Urology Clinics   (United States)

^c PSC   (United States)

^d Metropolitan Urologic Specialists   (United States)

Author keywords

cystometrogram; overactive bladder; urodynamics; variability

Indexed keywords

TOLTERODINE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; OVERACTIVE BLADDER; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; TREATMENT DURATION; TREATMENT OUTCOME; URINE VOLUME; URODYNAMICS;

ADULT; AGED; BENZHYDRYL COMPOUNDS; COMPLIANCE; CRESOLS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MIDDLE AGED; MUSCARINIC ANTAGONISTS; PHENYLPROPANOLAMINE; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; TREATMENT OUTCOME; URINARY BLADDER; URINARY BLADDER, OVERACTIVE; URINATION; URODYNAMICS;

EID: 84856225540     PISSN: 07332467     EISSN: 15206777     Source Type: Journal    
DOI: 10.1002/nau.21094     Document Type: Article

References (16)

1. Abrams P, Artibani W, Gajewski JB, et al. Assessment of treatment outcomes in patients with overactive bladder: Importance of objective and subjective measures. Urology 2006; 68: 17-28.
2. Kuhn A, Vits K, Kuhn P, et al. Do women with urinary incontinence really know where all the toilets are? The toilet paper. Eur J Obstet Gynecol Reprod Biol 2006; 129: 65-8.
3. Schafer W, Abrams P, Liao L, et al. Good urodynamic practices: Uroflowmetry, filling cystometry, and pressure-flow studies. Neurourol Urodyn 2002; 21: 261-74.
4. Frenkl TL, Railkar R, Palcza J, et al. Variability of urodynamic parameters in patients with overactive bladder in a multicenter trial. Neurourol Urodyn 2011 (in press).
5. Brynne N, Stahl MM, Hallen B, et al. Pharmacokinetics and pharmacodynamics of tolterodine in man: A new drug for the treatment of urinary bladder overactivity. Int J Clin Pharmacol Ther 1997; 35: 287-95.
6. Olsson B, Szamosi J,. Multiple dose pharmacokinetics of a new once daily extended release tolterodine formulation versus immediate release tolterodine. Clin Pharmacokinet 2001; 40: 227-35.
7. Stahl MM, Ekstrom B, Sparf B, et al. Urodynamic and other effects of tolterodine: A novel antimuscarinic drug for the treatment of detrusor overactivity. Neurourol Urodyn 1995; 14: 647-55.
8. Jonas U, Hofner K, Madersbacher H, et al. Efficacy and safety of two doses of tolterodine versus placebo in patients with detrusor overactivity and symptoms of frequency, urge incontinence, and urgency: Urodynamic evaluation. The International Study Group. World J Urol 1997; 15: 144-51.
9. Nager CW, Albo ME, Fitzgerald MP, et al. Process for development of multicenter urodynamic studies. Urology 2007; 69: 63-7.
10. Mortensen S, Lose G, Thyssen H,. Repeatability of cystometry and pressure-flow parameters in female patients. Int Urogynecol J Pelvic Floor Dysfunct 2002; 13: 72-5.
11. Homma Y, Kondo Y, Takahashi S, et al. Reproducibility of cystometry in overactive detrusor. Eur Urol 2000; 38: 681-5.
12. Broekhuis SR, Kluivers KB, Hendriks JC, et al. Reproducibility of same session repeated cystometry and pressure-flow studies in women with symptoms of urinary incontinence. Neurourol Urodyn 2010; 29: 428-31.
13. Alloussi S, Laval K-U, Eckert R, et al. Trospium chloride (Spasmo-lyt) in patients with motor urge syndrome (detrusor instability): A double-blind randomised, multicentre, placebo controlled study. J Clin Res 1998; 1: 439-51.
14. Colli E, Parazzini F, Olivieri L, et al. Number of daytime micturitions and volume voided per micturition in the evaluation of efficacy of drugs for overactive bladder: Findings from randomized clinical trials. Eur Urol 2007; 52: 525-30.
15. Abrams P, Andersson KE,. Muscarinic receptor antagonists for overactive bladder. BJU Int 2007; 100: 987-1006.
16. Stohrer M, Bauer P, Giannetti BM, et al. Effect of trospium chloride on urodynamic parameters in patients with detrusor hyperreflexia due to spinal cord injuries. A multicentre placebo-controlled double-blind trial. Urol Int 1991; 47: 138-43.