Enhanced bioreaction efficiency of a microfluidic mixer toward high-throughput and low-cost bioassays

Microfluidics and Nanofluidics

Volumn 12, Issue 1-4, 2012, Pages 143-156

  Lee, Hyun Boo ^a   Oh, Kieseok ^b   Yeo, Woon Hong ^b   Lee, Tae Rin ^a   Chang, Yoon Suk ^c   Choi, Jae Boong ^a   Lee, Kyong Hoon ^b   Kramlich, John ^b   Riley, James J ^b   Kim, Young Jin ^a   Chung, Jae Hyun ^b  

^a Sungkyunkwan University   (South Korea)

^b University of Washington   (United States)

^c Kyung Hee University   (South Korea)

Author keywords

Bio mimetic cilia; Bioreaction; Damk hler number; Microfluidic mixer

Indexed keywords

BIO-MIMETIC CILIA; BIOREACTION; BIOTIN-AVIDIN; COMPUTATIONAL STUDIES; DNA HYBRIDIZATION; FLUID MIXING; GENERAL APPROACH; HIGH-THROUGHPUT; MICRO-MIXING; MICROFLUIDIC MIXER; MICROFLUIDIC MIXERS; MICROSCALE BIOREACTORS; NUMERICAL COMPUTATIONS; REAGENT MIXING;

BIOREACTORS; CHEMICAL REACTIONS; COENZYMES; DIFFUSION; FLUIDIC DEVICES; GLYCOPROTEINS; MICROFLUIDICS; MIXERS (MACHINERY); MIXING; REACTION RATES;

BIOASSAY;

EID: 84856221598     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-011-0857-7     Document Type: Article

References (26)

1. JG Bai CL Chang JH Chung KH Lee 2007 Shadow edge lithography for nanoscale patterning and manufacturing Nanotechnology 18 405307 10.1088/0957-4484/18/40/405307 (Pubitemid 47479661)
2. M Berg K Undisz R Thiericke P Zimmermann T Moore C Posten 2001 Evaluation of liquid handling conditions in microplates J Biomol Screen 6 1 47 56 (Pubitemid 32172444)
3. AN Brooks TJR Hughes 1982 Streamline upwind Petrov-Galerkin formulations for convection dominated flows with particular emphasis on the incompressible Navier-Stokes equations Comput Meth Appl Mech Eng 32 199 259 10.1016/0045-7825(82)90071-8 0497.76041 679322
4. SR Chary RK Jain 1989 Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching Proc Natl Acad Sci USA 86 14 5385 5389 10.1073/pnas.86.14.5385 (Pubitemid 19185554)
5. HC Feldman M Sigurdson CD Meinhart 2007 AC electrothermal enhancement of heterogeneous assays in microfluidics Lab Chip 7 11 1553 1559 10.1039/b706745c (Pubitemid 350013183)
6. B He BJ Burke X Zhang R Zhang FE Regnier 2001 A picoliter-volume mixer for microfluidic analytical systems Anal Chem 73 9 1942 1947 10.1021/ac000850x (Pubitemid 32862398)
7. KT Kunas ET Papoutsakis 1990 Damage mechanisms of suspended animal cells in agitated bioreactors with and without entrainment Biotechnol Bioeng 36 5 476 483 10.1002/bit.260360507 (Pubitemid 20283272)
8. MP Larvor L Djavadiohaniance B Nall ME Goldberg 1994 Measurement of the dissociation rate constant of antigen/antibody complexes in solution by enzyme-linked immunosorbent assay J Immunol Methods 170 2 167 175 10.1016/0022-1759(94)90392-1 (Pubitemid 24122506)
9. TR Lee K Oh JH Chung YS Chang JB Choi G Yagawa YJ Kim 2011 Resonant behavior and microfluidic manipulation of silicone cilia due to an added mass effect Soft Matter 7 9 4325 4334 10.1039/c0sm01294g
10. NZ Li CH Hsu A Folch 2005 Parallel mixing of photolithograpically defined nanoliter volumes using elastomeric microvalve arrays Electrophoresis 26 19 3758 3764 10.1002/elps.200500171 (Pubitemid 41512028)
11. CH Lin LM Fu YS Chien 2004 Microfluidic T-form mixer utilizing switching electroosmotic flow Anal Chem 76 18 5265 5272 10.1021/ac0494782 (Pubitemid 39249406)
12. CH Lin CH Tsai CW Pan LM Fu 2007 Rapid circular microfluidic mixer utilizing unbalanced driving force Biomed Microdevices 9 1 43 50 10.1007/s10544-006-9009-3 (Pubitemid 46050128)
13. BR Lutz J Chen DT Schwartz 2003 Microfluidics without microfabrication Proc Natl Acad Sci USA 100 8 4395 4398 10.1073/pnas.0831077100 (Pubitemid 36457740)
14. BR Lutz J Chen DT Schwartz 2006 Characterizing homogeneous chemistry using well-mixed microeddies Anal Chem 78 5 1606 1612 10.1021/ac051646i (Pubitemid 43346299)
15. E Mitre M Schulze GA Cumme F Rossler T Rausch H Rhode 2007 Turbo-mixing in microplate J Biomol Screen 12 3 361 369 10.1177/1087057106297565 (Pubitemid 46514665)
16. K Oh J Chung S Devasia JJ Riley 2009 Bio-mimetic silicone cilia for microfluidic manipulation Lab Chip 9 11 1561 1566 10.1039/b817409a
17. K Oh B Smith S Devasia JJ Riley J Chung 2010 Characterization of mixing performance for bio-mimetic silicone cilia Microfluid Nanofluid 9 4 645 655 10.1007/s10404-010-0578-3
18. Y Okahata N Kawase K Niikura F Ohtake H Furusawa Y Ebra 1998 Kinetic measurements of DNA hybridization on an oligonucleotide-immobilized 27-MHz quartz crystal microbalance Anal Chem 70 7 1288 1296 10.1021/ac970584w (Pubitemid 128669440)
19. AS Piatek S Tyagi AC Pol A Telenti LP Miller FR Kramer D Alland 1998 Molecular beacon sequence analysis for detecting drug resistance in Mycobacterium tuberculosis Nat Biotechnol 16 4 359 363 10.1038/nbt0498-359 (Pubitemid 28164656)
20. MA Stremler FR Haselton H Aref 2004 Designing for chaos: application of chaotic advection at the microscle Philos Trans R Soc London Ser A 362 1818 1019 1036 10.1098/rsta.2003.1360 2107644 (Pubitemid 38652645)
21. AD Stroock SKW Dertinger A Ajdari I Mezic HA Stone GM Whitesides 2002 Chaotic mixer for microchannels Science 295 5555 647 651 10.1126/science.1066238 (Pubitemid 34111816)
22. JR Thiagarajah JK Kim M Magzoub AS Verkman 2006 Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching Nat Methods 3 275 280 10.1038/nmeth863
23. L Walling N Carramanzana C Schulz T Romig M Johnson 2007 Mixing in 384-well plates: issues, measurements, and solutions Assay Drug Dev Technol 5 2 265 275 10.1089/adt.2006.042 (Pubitemid 46684913)
24. JR Wayment JM Harris 2009 Biotin-avidin binding kinetics measured by single-molecule imaging Anal Chem 81 1 336 342 10.1021/ac801818t
25. JT Yang KJ Huang YC Lin 2005 Geometric effects on fluid mixing in passive grooved micromixers Lab Chip 5 1140 1147 10.1039/b500972c (Pubitemid 41453005)
26. WH Yeo JH Chung YL Liu KH Lee 2009 Size-specific concentration of Dna To a nanostructured tip using dielectrophoresis and capillary action J Phys Chem B 113 31 10849 10858 10.1021/jp900618t