Theoretical implications of the biomechanical fracture threshold

Journal of Bone and Mineral Research

Volumn 23, Issue 10, 2008, Pages 1541-1547

  Keaveny, Tony M ^a,c   Bouxsein, Mary L ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biomechanics; Bone strength; Fracture risk; Osteoporosis; Treatment

Indexed keywords

ALENDRONIC ACID; PARATHYROID HORMONE;

BIOMECHANICS; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; BONE STRENGTH; CLINICAL TRIAL; DUAL ENERGY X RAY ABSORPTIOMETRY; FALLING; FEMUR; FINITE ELEMENT ANALYSIS; FORCE; HIP; HIP FRACTURE; HUMAN; OSTEOPENIA; OSTEOPOROSIS; OUTCOME ASSESSMENT; POSTMENOPAUSE; REVIEW; RISK ASSESSMENT; THEORETICAL MODEL; THERAPY EFFECT;

ABSORPTIOMETRY, PHOTON; AGED; AGED, 80 AND OVER; BIOMECHANICS; BONE DENSITY; FEMALE; HIP FRACTURES; HUMANS; MIDDLE AGED; MODELS, THEORETICAL; OSTEOPOROSIS;

EID: 52949118450     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.080406     Document Type: Review

References (47)

1. Hayes WC, Piazza SJ, Zysset PK 1991 Biomechanics of fracture risk prediction of the hip and spine by quantitative computed tomography. Radiol Clin North Am 29:1-18.
2. Myers ER, Wilson SE 1997 Biomechanics of osteoporosis and vertebral fracture. Spine 22:25S-31S.
3. Bouxsein M 2001 Biomechanics of Age-Related Fractures. In: Marcus R, Feldman D, Kelsey J (eds.) Osteoporosis, 2nd ed. Academic Press, San Diego, CA, USA, pp. 509-534.
4. Delmas PD, Seeman E 2004 Changes in bone mineral density explain little of the reduction in vertebral or nonvertebral fracture risk with anti-resorptive therapy. Bone 34:599-604.
5. Cummings SR, Karpf DB, Harris F, Genant HK, Ensrud K, LaCroix AZ, Black DM 2002 Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs. Am J Med 112:281-289.
6. Kanis JA, Borgstrom F, De Laet C, Johansson H, Johnell O, Jonsson B, Oden A, Zethraeus N, Pfleger B, Khaltaev N 2005 Assessment of fracture risk. Osteoporos Int 16:581-589.
7. McClung MR 2006 Do current management strategies and guidelines adequately address fracture risk? Bone 38:S13-S17.
8. Schuit SC, van der Klift M, Weel AE, de Laet CE, Burger H, Seeman E, Hofman A, Uitterlinden AG, van Leeuwen JP, Pols HA 2004 Fracture incidence and association with bone mineral density in elderly men and women: The Rotterdam Study. Bone 34:195-202.
9. Stone KL, Seeley DG, Lui LY, Cauley JA, Ensrud K, Browner WS, Nevitt MC, Cummings SR 2003 BMD at multiple sites and risk of fracture of multiple types: Long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res 18:1947-1954.
10. Siris ES, Chen YT, Abbott TA, Barrett-Connor E, Miller PD, Wehren LE, Berger ML 2004 Bone mineral density thresholds for pharmacological intervention to prevent fractures. Arch Intern Med 164:1108-1112.
11. Wainwright SA, Marshall LM, Ensrud KE, Cauley JA, Black DM, Hillier TA, Hochberg MC, Vogt MT, Orwoll ES 2005 Hip fracture in women without osteoporosis. J Clin Endocrinol Metab 90:2787-2793.
12. Sornay-Rendu E, Munoz F, Garnero P, Duboeuf F, Delmas PD 2005 Identification of osteopenic women at high risk of fracture: The OFELY study. J Bone Miner Res 20:1813-1819.
13. Duan Y, Duboeuf F, Munoz F, Delmas PD, Seeman E 2006 The fracture risk index and bone mineral density as predictors of vertebral structural failure. Osteoporos Int 17:54-60.
14. Duan Y, Seeman E, Turner CH 2001 The biomechanical basis of vertebral body fragility in men and women. J Bone Miner Res 16:2276-2283.
15. Yang RS, Lin HJ, Chieng PU, Liu TK, Tsai KS 2005 Estimated risk score for spine fracture in the specific bending activity of normal Taiwanese men and women. Spine 30:2288-2292.
16. Riggs BL, Melton LJ III, Robb RA, Camp JJ, Atkinson EJ, Oberg AL, Rouleau PA, McCollough CH, Khosla S, Bouxsein ML 2006 Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures. J Bone Miner Res 21:315-323.
17. Bouxsein ML, Melton LJ III, Riggs BL, Muller J, Atkinson EJ, Oberg AL, Robb RA, Camp JJ, Rouleau PA, McCollough CH, Khosla S 2006 Age- and sex-specific differences in the factor of risk for vertebral fracture: A population-based study using QCT. J Bone Miner Res 21:1475-1482.
18. Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ 2003 The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 349:1207-1215.
19. Black DM, Bilezikian JP, Ensrud KE, Greenspan SL, Palermo L, Hue T, Lang TF, McGowan JA, Rosen CJ 2005 One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis. N Engl J Med 353:555-565.
20. van den Kroonenberg AJ, Hayes WC, McMahon TA 1995 Dynamic models for sideways falls from standing height. J Biomech Eng 117:309-318.
21. van den Kroonenberg AJ, Hayes WC, McMahon TA 1996 Hip impact velocities and body configurations for voluntary falls from standing height. J Biomech 29:807-811.
22. Robinovitch SN, Hayes WC, McMahon TA 1991 Prediction of femoral impact forces in falls on the hip. J Biomech Eng 113:366-374.
23. Keyak JH 2001 Improved prediction of proximal femoral fracture load using nonlinear finite element models. Med Eng Phys 23:165-173.
24. Cody DD, Gross GJ, Hou FJ, Spencer HJ, Goldstein SA, Fyhrie DP 1999 Femoral strength is better predicted by finite element models than QCT and DXA. J Biomech 32:1013-1020.
25. Crawford RP, Rosenberg WS, Keaveny TM 2003 Quantitative computed tomography-based finite element models of the human lumbar vertebral body: Effect of element size on stiffness, damage, and fracture strength predictions. J Biomech Eng 125:434-438.
26. Crawford RP, Brouwers J, Keaveny TM 2004 Accurate prediction of vertebral strength using voxel-based non-linear finite element models. Trans Orthop Res Soc 29:1123.
27. Buckley JM, Loo K, Motherway J 2007 Comparison of quantitative computed tomography-based measures in predicting vertebral compressive strength. Bone 40:767-774.
28. Bessho M, Ohnishi I, Matsuyama J, Matsumoto T, Imai K, Nakamura K 2007 Prediction of strength and strain of the proximal femur by a CT-based finite element method. J Biomech 40:1745-1753.
29. Imai K, Ohnishi I, Bessho M, Nakamura K 2006 Nonlinear finite element model predicts vertebral bone strength and fracture site. Spine 31:1789-1794.
30. Liebschner MA, Kopperdahl DL, Rosenberg WS, Keaveny TM 2003 Finite element modeling of the human thoracolumbar spine. Spine 28:559-565.
31. Lotz JC, Cheal EJ, Hayes WC 1991 Fracture prediction for the proximal femur using finite element models: Part II-Nonlinear analysis. J Biomech Eng 113:361-365.
32. Faulkner KG, Cann CE, Hasegawa BH 1991 Effect of bone distribution on vertebral strength: Assessment with patient-specific nonlinear finite element analysis. Radiology 179:669-674.
33. Keaveny TM, Hoffmann PF, Singh M, Palermo L, Bilezikian JP, Greenspan SL, Black DM 2008 Femoral bone strength and its relation to cortical and trabecular changes after treatment with PTH, alendronate, and their combination as assessed by finite element analysis of quantitative CT scans. J Bone Miner Res (in press).
34. Greenspan SL, Maitland-Ramsey L, Myers E 1996 Classification of osteoporosis in the elderly is dependent on site-specific analysis. Calcif Tissue Int 58:409-414.
35. Faulkner KG, von Stetten E, Miller P 1999 Discordance in patient classification using T-scores. J Clin Densitom 2:343-350.
36. Melton LJ, Riggs BL, Keaveny TM, Achenbach SJ, Hoffmann PF, Camp JJ, Rouleau PA, Bouxsein ML, Amin S, Atkinson EJ, Robb RA, Khosla S 2007 Structural determinants of vertebral fracture risk. J Bone Miner Res 22:1885-1892.
37. Karsdal MA, Qvist P, Christiansen C, Tanko LB 2006 Optimising antiresorptive therapies in postmenopausal women: Why do we need to give due consideration to the degree of suppression? Drugs 66:1909-1918.
38. Delmas PD, Genant HK, Crans GG, Stock JL, Wong M, Siris E, Adachi JD 2003 Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: Results from the MORE trial. Bone 33:522-532.
39. Black DM, Thompson DE, Bauer DC, Ensrud K, Musliner T, Hochberg MC, Nevitt MC, Suryawanshi S, Cummings SR 2000 Fracture risk reduction with alendronate in women with osteoporosis: The Fracture Intervention Trial. FIT Research Group. J Clin Endocrinol Metab 85:4118-4124.
40. Chesnut IC, Skag A, Christiansen C, Recker R, Stakkestad JA, Hoiseth A, Felsenberg D, Huss H, Gilbride J, Schimmer RC, Delmas PD 2004 Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J Bone Miner Res 19:1241-1249.
41. Felsenberg D, Miller P, Armbrecht G, Wilson K, Schimmer RC, Papapoulos SE 2005 Oral ibandronate significantly reduces the risk of vertebral fractures of greater severity after 1, 2, and 3 years in postmenopausal women with osteoporosis. Bone 37:651-654.
42. Reginster JY, Seeman E, De Vernejoul MC, Adami S, Compston J, Phenekos C, Devogelaer JP, Curiel MD, Sawicki A, Goemaere S, Sorensen OH, Felsenberg D, Meunier PJ 2005 Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab 90:2816-2822.
43. Kanis JA, Oden A, Johnell O, Johansson H, De Laet C, Brown J, Burckhardt P, Cooper C, Christiansen C, Cummings S, Eisman JA, Fujiwara S, Gluer C, Goltzman D, Hans D, Krieg MA, La Croix A, McCloskey E, Mellstrom D, Melton LJ III, Pols H, Reeve J, Sanders K, Schott AM, Silman A, Torgerson D, van Staa T, Watts NB, Yoshimura N 2007 The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int 18:1033-1046.
44. Black DM, Steinbuch M, Palermo L, Dargent-Molina P, Lindsay R, Hoseyni MS, Johnell O 2001 An assessment tool for predicting fracture risk in postmenopausal women. Osteoporos Int 12:519-528.
45. Burger H, de Laet CE, Weel AE, Hofman A, Pols HA 1999 Added value of bone mineral density in hip fracture risk scores. Bone 25:369-374.
46. Taylor BC, Schreiner PJ, Stone KL, Fink HA, Cummings SR, Nevitt MC, Bowman PJ, Ensrud KE 2004 Long-term prediction of incident hip fracture risk in elderly white women: Study of osteoporotic fractures. J Am Geriatr Soc 52:1479-1486.
47. Bouxsein ML, Szulc P, Munoz F, Thrall E, Sornay-Rendu E, Delmas PD 2007 Contribution of trochanteric soft tissues to fall force estimates, the factor of risk and prediction of hip fracture risk. J Bone Miner Res 22:825-831.