A ferrocene-based reagent for the conjugation and quantification of reactive metabolites

Analytical and Bioanalytical Chemistry

Volumn 402, Issue 1, 2012, Pages 461-471

  Jahn, Sandra ^a   Lohmann, Wiebke ^a   Bomke, Susanne ^a   Baumann, Anne ^a   Karst, Uwe ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Electrochemistry; Ferrocene label; Liquid chromatography; Mass spectrometry; Oxidative metabolism; Reactive metabolites

Indexed keywords

ADDUCT FORMATION; ANTIMALARIAL AGENT; CLOZAPINE; DERIVATIZATIONS; EFFECTIVE TRAPPING AGENTS; FERROCENES; FLOW-THROUGH CELLS; GLUTATHIONES; MASS SPECTROMETRIC DETECTION; MODEL SUBSTANCE; OXIDATIVE METABOLISM; REACTIVE METABOLITES; RETENTION TIME; REVERSED PHASE; THIOL GROUPS; TRAPPING AGENT; TRIPEPTIDE;

BIOMOLECULES; CHEMICAL REACTIONS; ELECTROCHEMISTRY; ELECTROSPRAY IONIZATION; INDUCTIVELY COUPLED PLASMA; IONIZATION POTENTIAL; IRON COMPOUNDS; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLITES; ORGANOMETALLICS; PHYSIOLOGY;

METABOLISM;

AMODIAQUINE; ANTIMALARIAL AGENT; CLOZAPINE; FERROCENE; FERROUS ION; GLUTATHIONE; NEUROLEPTIC AGENT; PROPIONIC ACID DERIVATIVE;

ARTICLE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION; LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY;

AMODIAQUINE; ANTIMALARIALS; ANTIPSYCHOTIC AGENTS; CHROMATOGRAPHY, LIQUID; CLOZAPINE; FERROUS COMPOUNDS; GLUTATHIONE; PROPIONATES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84856200176     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-5388-2     Document Type: Article

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