Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells

Journal of Cellular Physiology

Volumn 227, Issue 5, 2012, Pages 2089-2096

  Zemskov, Evgeny A ^a   Mikhailenko, Irina ^a   Smith, Elizabeth P ^a   Belkin, Alexey M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; SHORT HAIRPIN RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; DOWN REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PROTO-ONCOGENE PROTEINS C-SIS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSGLUTAMINASES;

EID: 84856144414     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22938     Document Type: Article

References (44)

1. Akimov SS, Krylov D, Fleischman LF, Belkin AM. 2000. Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. J Cell Biol 148: 825-838.
2. Andrae J, Gallini R, Betsholtz C. 2008. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 22: 1276-1312.
3. Bakker EN, Buus CL, Spaan JAE, Perree J, Ganga A, Rolf TM, Sorop O, Bramsen LH, Mulvany MJ, van Bavel E. 2004. Small artery remodeling depends on tissue-type transglutaminase. Circ Res 96: 119-126.
4. Bakker EN, Pistea A, Vanbavel E. 2008. Transglutaminase in vascular biology: Relevance for vascular remodeling and atherosclerosis. J Vasc Res 22: 271-278.
5. Belkin AM, Akimov SS, Zaritskaya LS, Ratnikov BI, Deryugina EI, Strongin AY. 2001. Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion. J Biol Chem 276: 18415-18422.
6. Boucher P, Gotthardt M, Li WP, Anderson RG, Herz J. 2003. LRP: Role in vascular wall integrity and protection from atherosclerosis. Science 300: 329-332.
7. Buetow BS, Tappan KA, Crosby JR, Seifert RA, Bowen-Pope DF. 2003. Chimera analysis supports a predominant role of PDGFRbeta in promoting smooth-muscle cell chemotaxis after arterial injury. Am J Pathol 163: 979-984.
8. Cai X. 2006. Regulation of smooth muscle cells in development and vascular disease: Current therapeutic strategies. Exp Rev Cardiovasc Ther 4: 789-800.
9. Chen SH, Lin CY, Lee LT, Chang GD, Lee PP, Hung CC, Kao WT, Tsai PH, Schally AV, Hwang JJ, Lee MT. 2010. Up-regulation of fibronectin and tissue transglutaminase promotes cell invasion involving increased association with integrin and MMP expression in A431 cells. Anticancer Res 30: 4177-4186.
10. Cho BR, Kim MK, Suh DH, Hahn JH, Lee BG, Choi YC, Kwon TJ, Kim SY, Kim DJ. 2008. Increased tissue transglutaminase expression in human atherosclerotic coronary arteries. Coron Artery Dis 19: 459-468.
11. Faverman L, Mikhaylova L, Malmquist J, Nurminskaya M. 2008. Extracellular transglutaminase 2 activates beta-catenin signaling in calcifying vascular smooth muscle cells. FEBS Lett 582: 1552-1557.
12. Ferns GA, Raines EW, Sprugel KH, Motani AS, Reidy MA, Ross R. 1991. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science 253: 1129-1132.
13. Grainger DJ, Witchell CM, Weissberg PL, Metcalfe JC. 1994. Mitogens for adult rat aortic vascular smooth muscle cells in serum-free primary culture. Cardiovasc Res 28: 1238-1242.
14. Haroon ZA, Wannenburg T, Gupta M, Greenberg CS, Wallin R, Sane DC. 2001. Localization of tissue transglutaminase in human carotid and coronary artery atherosclerosis: Implications for plaque stability and progression. Lab Invest 81: 83-93.
15. Hedin U, Bottger BA, Forsberg E, Johansson S, Thyberg J. 1988. Diverse effects of fibronectin and laminin on phenotypic properties of cultured arterial smooth muscle cells. J Cell Biol 107: 307-319.
16. Heldin C-H, Westermark B. 1999. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79: 1283-1316.
17. Hellstrom M, Gerhardt H, Kalen M, Li X, Eriksson U, Wolburg H, Betsholtz C. 2001. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol 153: 543-553.
18. Holycross BJ, Blank RS, Thompson MM, Peach MJ, Owens GK. 1992. Platelet-derived growth factor-BB-induced suppression of smooth muscle cell differentiation. Circ Res 71: 1525-1532.
19. Iismaa SE, Mearns BM, Lorand L, Graham RM. 2009. Transglutaminases and disease: Lessons from genetically engineered mouse models and inherited disorders. Physiol Rev 89: 991-1023.
20. Johnson KA, Polewski M, Terkeltaub RA. 2008. Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells. Circ Res 102: 529-537.
21. Kozaki K, Kaminski WE, Tang J, Hollenbach S, Lindahl P, Sullivan C, Yu JC, Abe K, Martin PJ, Ross R, Betsholtz C, Giese NA, Raines EW. 2002. Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice. Am J Pathol 161: 1395-1407.
22. Kumar A, Lindner V. 1997. Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow. Arterioscler Thromb Vasc Biol 17: 2238-2244.
23. Lai TS, Liu Y, Li W, Greenberg CS. 2007. Identification of two GTP-independent alternatively spliced forms of tissue transglutaminase in human leukocytes, vascular smooth muscle, and endothelial cells. FASEB J 21: 4131-4143.
24. Lehti K, Rose NF, Valavaara S, Weiss SJ, Keski-Oja J. 2009. MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing. J Cell Sci 122: 126-135.
25. Levitzki A. 2005. PDGF receptor kinase inhibitors for the treatment of restenosis. Cardiovasc Res 65: 581-586.
26. Lindner V, Fingerle J, Reidy M. 1993. Mouse model of arterial injury. Circ Res 73: 792-796.
27. Lo CS, Tamaroglio T, Zhang J. 1995. Regulation of fibronectin by platelet-derived growth factors in cultured rat thoracic aortic smooth muscle cells. J Biomed Sci 2: 63-69.
28. Lorand L, Graham RM. 2003. Transglutaminases: Crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol 4: 140-156.
29. Matlung HL, van Bavel E, van den Akker J, de Vries CJ, Bakker EN. 2010. Role of trans-glutaminases in cuff-induced atherosclerotic lesion formation in femoral arteries of ApoE3 Leiden mice. Atherosclerosis 213: 77-84.
30. Nelson PR, Yamamura S, Kent KC. 1997. Platelet-derived growth factor and extracellular matrix proteins provide a synergistic stimulus for human vascular smooth muscle cell migration. J Vasc Surg 26: 104-112.
31. Owens GK, Kumar MS, Wamhoff BR. 2004. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84: 767-801.
32. Owens GK. 2007. Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity. Novartis Found Symp 283: 174-191.
33. Pistea A, Bakker EN, Spaan JA, Hardeman MR, van Rooijen N, van Bavel E. 2008. Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: Role of transglutaminases. J Vasc Res 45: 271-278.
34. Raines EW. 2004. PDGF and cardiovascular disease. Cytokine Growth Factor Rev 15: 237-254.
35. Sane DC, Kontos JL, Greenberg CS. 2007. Roles of transglutaminases in vascular and cardiac diseases. Front Biosci 12: 2530-2545.
36. Sano H, Sudo T, Yokode M, Murayama T, Kataoka H, Takakura N, Nishikawa S, Nishikawa SI, Kita T. 2001. Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice. Circulation 103: 2955-2960.
37. Santhanam L, Tuday EC, Webb AK, Dowzicky P, Kim JH, Oh YJ, Sikka G, Kuo M, Halushka MK, Macgregor AM, Dunn J, Gutbrod S, Yin D, Shoukas A, Nyhan D, Flavahan NA, Belkin AM, Berkowitz DE. 2010. Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness. Circ Res 107: 117-125.
38. Sundberg C, Rubin K. 1998. Stimulation of β1 integrins on fibroblasts induces PDGF independent phosphorylation of PDGF β-receptors. J Cell Biol 132: 741-752.
39. Thomas-Ecker S, Lindecke A, Hatzmann W, Kaltschmidt C, Zanker KS, Dittmar T. 2007. Alteration in the gene expression pattern of primary monocytes after adhesion to endothelial cells. Proc Natl Acad Sci USA 104: 5539-5544.
40. Vantler M, Caglayan E, Zimmermann WH, Baumer AT, Rosenkranz S. 2005. Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important. J Biol Chem 280: 14168-14176.
41. Yoshida T, Owens GK. 2005. Molecular determinants of vascular smooth muscle cell diversity. Circ Res 96: 280-291.
42. Zemskov EA, Janiak A, Hang J, Waghray A, Belkin AM. 2006. The role of tissue transglutaminase in cell-matrix interactions. Front Biosci 11: 1057-1076.
43. Zemskov EA, Mikhailenko I, Strickland DK, Belkin AM. 2007. Cell-surface transglutaminase undergoes internalization and lysosomal degradation: An essential role of LRP1. J Cell Sci 120: 3188-3199.
44. Zemskov EA, Loukinova E, Mikhailenko I, Coleman RA, Strickland DK, Belkin AM. 2009. Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase. J Biol Chem 284: 16693-16703.