The role of magnesium in type 2 diabetes: A brief based-clinical review

Magnesium Research

Volumn 24, Issue 4, 2011, Pages 156-162

  Rodríguez Morán, Martha ^a   Simental Mendía, Luis E ^a   Galván, Graciela Zambrano ^a,b   Guerrero Romero, Fernando ^a  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^b University of Durango   (Mexico)

Author keywords

Epidemiological studies; Magnesium; Randomized controlled clinical trials; Type 2 diabetes

Indexed keywords

MAGNESIUM; MAGNESIUM ASPARTATE; MAGNESIUM CHLORIDE; MAGNESIUM CITRATE; MAGNESIUM OXIDE; PYROGLUTAMATE MAGNESIUM;

COCHRANE LIBRARY; DIET SUPPLEMENTATION; DIETARY INTAKE; DISEASE COURSE; EMBASE; GLUCOSE METABOLISM; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; MEDLINE; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; RISK REDUCTION; SYSTEMATIC REVIEW;

DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; EPIDEMIOLOGIC STUDIES; HUMANS; MAGNESIUM; MAGNESIUM DEFICIENCY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; UNITED STATES;

EID: 84856137867     PISSN: 09531424     EISSN: 19524021     Source Type: Journal    
DOI: 10.1684/mrh.2011.0299     Document Type: Review

References (46)

1. Lopez Martinez J, Sanchez Castilla M, Garcia de Lorenzo y Mateos A, Culebras Fernandez JM. Magnesium: metabolism and requirements. Nutr Hosp 1997; 12: 4-14.
2. Grubbs RD, Maguire ME. Magnesium as a regulatory cation: criteria and evaluation. Magnesium 1987, 6, 113-127.
3. Garfinkel D, Garfinkel L. Magnesium and regulation of carbohydrate metabolism at the molecular level. Magnesium 1988; 7: 249-61.
4. Paolisso G, Scheen A, D'Onofrio F, Lefèbvre P. Magnesium and glucose homeostasis. Diabetologia 1990, 33, 511-4.
5. Paolisso G, Barbagallo M. Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. Am J Hypertens 1997, 10, 346-55.
6. Laughlin MR, Thompson D. The regulatory role for magnesium in glycolytic flux of the human erythrocyte. J Biol Chem 1996; 271: 28977-83.
7. Otto M, Heinrich R, Kuhn B, Jacobasch G. A mathematical model for the influence of fructose 6-phosphate, ATP, potassium, ammonium and magnesium on the phosphofructokinase from rat erythrocytes. Eur J Biochem 1974; 49: 169-78.
8. Guerrero-Romero F, Rodríguez-Morán M. Relationship between serum magnesium levels and C-reactive protein concentration, in non-diabetic, non-hypertensive obese subjects. Int J Obes Relat Metab Disord 2002; 26: 469-74.
9. Song Y, Li TY, van Dam RM, Manson JE, Hu FB. Magnesium intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women. Am J Clin Nutr 2007; 85: 1068-74.
10. Guerrero-Romero F, Rodríguez-Morán M. Hypomagnesemia, oxidative stress, inflammation, and metabolic syndrome. Diabetes Metab Res Rev 2006; 22: 471-6.
11. Kim DJ, Xun P, Liu K, et al. Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. Diabetes Care 2010; 33: 2604-10.
12. Rosolova H, Mayer O Jr, Reaven G. Effect of variations in plasma magnesium concentration on resistance to insulin-mediated glucose disposal in nondiabetic subjects. J Endocrinol Metab 1997, 82, 3783-5.
13. Huerta MG, Roemmich JN, Kington ML, et al. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care 2005; 28: 1175-81.
14. Guerrero-Romero F, Rodríguez-Morán M. Low serum Magnesium levels and Metabolic Syndrome. Acta Diabetológica 2002, 39, 209-213.
15. Rosolova H, Mayer O Jr, Reaven GM. Insulinmediated glucose disposal is decreased in normal subjects with relatively low plasma magnesium concentrations. Metabolism 2000, 49, 418-20.
16. Kao WH, Folsom AR, Nieto FJ, Mo JP, Watson RL, Brancati FL. Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the Atherosclerosis Risk in Communities Study. Arch Intern Med 1999; 159: 2151-9.
17. Rumawas ME, McKeown NM, Rogers G, Meigs JB, Wilson PW, Jacques PF. Magnesium intake is related to improved insulin homeostasis in the framingham offspring cohort. J Am Coll Nutr 2006; 25: 486-92.
18. Barbagallo M, Dominguez LJ. Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Arch Biochem Biophys 2007; 458: 40-7.
19. Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. Failure of -cell function for compensate variation in insulin sensitivity in the hypomagnesemic subjects Magnesium Res 2009; 22: 151-6.
20. Rodríguez-Morán M, Guerrero-Romero F. Insulin secretion is decreased in non-diabetic individuals with hypomagnesemia. Diabetes Metab Res Rev 2011 Apr 12. doi: 10.1002/dmrr.1206. [Epub ahead of print].
21. Guerrero-Romero F, Rodríguez-Morán M. Magnesium improves the beta-cell function to compensate variation of insulin sensitivity: double-blind, randomized clinical trial. Eur J Clin Invest 2011; 41:405-410.
22. Ma J, Folsom AR, Melnick SL, et al. Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. Atherosclerosis Risk in Communities Study. J Clin Epidemiol 1995; 48: 927-40.
23. Bo S, Milanesio N, Schiavone C, et al. Magnesium and trace element intake after a lifestyle intervention. Nutrition 2011; 27: 108-10.
24. Hopping BN, Erber E, Grandinetti A, Verheus M, Kolonel LN, Maskarinec G. Dietary fiber, magnesium, and glycemic load alter risk of type 2 diabetes in a multiethnic cohort in Hawaii. J Nutr 2010; 140: 68-74.
25. Shi ZM, Hu XS, Yuan BJ, Gibson R, Dai Y, Garg M. Association between magnesium: iron intake ratio and diabetes in Chinese adults in Jiangsu Province. Diabet Med 2008; 25: 1164-70.
26. McKeown NM, Jacques PF, Zhang XL, Juan W, Sahyoun NR. Dietary magnesium intake is related to metabolic syndrome in older Americans. Eur J Nutr 2008; 47: 210-6.
27. Ma B, Lawson AB, Liese AD, Bell RA, Mayer- Davis EJ. Dairy, magnesium, and calcium intake in relation to insulin sensitivity: approaches to modeling a dose-dependent association. Am J Epidemiol 2006; 164: 449-58.
28. Lopez-Ridaura R, Willett WC, Rimm EB, Liu S, Stampfer MJ, Manson JE, Hu FB. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care 2004; 27: 134-40.
29. He K, Liu K, Daviglus ML, et al. Magnesium intake and incidence of metabolic syndrome among young adults. Circulation. 2006; 113: 1675-82.
30. Kirii K, Iso H, Date C, Fukui M, Tamakoshi A, JACC Study Group. Magnesium intake and risk of selfreported type 2 diabetes among Japanese. J Am Coll Nutr 2010; 29: 99-106.
31. Schulze MB, Schulz M, Heidemann C, Schienkiewitz A, Hoffmann K, Boeing H. Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch Intern Med 2007; 167: 956-65.
32. Nanri A, Mizoue T, Noda M, et al. Japan Public Health Center-based Prospective Study Group. Magnesium intake and type II diabetes in Japanese men and women: the Japan Public Health Center- based Prospective Study. Eur J Clin Nutr 2010; 64: 1244-7.
33. King DE, Mainous AG 3rd, Geesey ME, Ellis T. Magnesium intake and serum C-reactive protein levels in children. Magnes Res 2007; 20: 32-6.
34. Song Y, Manson JE, Buring JE, Liu S. Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women. Diabetes Care 2004; 27: 59-65.
35. Mooren FC, Krüger K, Völker K, Golf SW, Wadepuhl M, Kraus A. Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial. Diabetes Obes Metab 2011; 13: 281-4.
36. Guerrero-Romero F, Tamez-Perez HE, González-González G, Salinas-Martínez AM, Montes-Villarreal J, Treviño-Ortiz JH, Rodríguez-Morán M. Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab 2004; 30: 253-8.
37. Chacko SA, Sul J, Song Y, et al. Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. Am J Clin Nutr 2011; 93: 463-73.
38. Paolisso G, Sgambato S, Gambardella A, et al. Daily magnesium supplements improve glucose handling in elderly subjects. Am J Clin Nutr 1992; 55: 1161-7.
39. Rodríguez-Morán M, Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care 2003; 26: 1147-52.
40. Paolisso G, Scheen A, Cozzolino D, et al. Changes in glucose turnover parameters and improvement of glucose oxidation after 4-week magnesium administration in elderly noninsulin-dependent (type II) diabetic patients. J Clin Endocrinol Metab 1994; 78: 1510-4.
41. Purvis JR, Cummings DM, Landsman P, et al. Effect of oral magnesium supplementation on selected cardiovascular risk factors in non-insulin-dependent diabetics. Arch Fam Med 1994; 3: 503-8.
42. De Lordes Lima M, Cruz T, Pousada JC, Rodrigues LE, Barbosa K, Canguçu V. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care 1998; 21:682-6.
43. Johnsen SP, Husted SE, Ravn HB, Stødkilde-Jørgensen H, Peltz-Andresen E, Christensen CK. supplementation to patients with type II diabetes. Ugeskr Laeger 1999; 161: 945-8.
44. De Valk HW, Verkaaik R, van Rijn HJ, Geerdink RA, Struyvenberg A. Oral magnesium supplementation in insulin-requiring Type 2 diabetic patients. Diabet Med 1998; 15: 503-7.
45. Gullestad L, Jacobsen T, Dolva LO. Effect of magnesium treatment on glycemic control and metabolic parameters in NIDDM patients. Diabetes Care 1994; 17: 460-1.
46. Barbagallo M, Dominguez LJ. Magnesium and aging. Curr Pharm Des 2010; 16: 832-9.