Comprehensive use of cardiopulmonary exercise testing identifies adults with congenital heart disease at increased mortality risk in the medium term

Circulation

Volumn 125, Issue 2, 2012, Pages 250-259

  Inuzuka, Ryo ^a,b   Diller, Gerhard Paul ^a,b   Borgia, Francesco ^a   Benson, Leah ^a   Tay, Edgar L W ^a   Alonso Gonzalez, Rafael ^a   Silva, Margarida ^a   Charalambides, Menelaos ^a   Swan, Lorna ^c   Dimopoulos, Konstantinos ^a,b   Gatzoulis, Michael A ^a,b  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c NONE

Author keywords

exercise test; heart defects, congenital; oxygen consumption; prognosis

Indexed keywords

CARBON DIOXIDE;

ADULT; ARTICLE; CARDIOPULMONARY EXERCISE TEST; CONGENITAL HEART DISEASE; CYANOSIS; FEMALE; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; OXYGEN CONSUMPTION; PEAK OXYGEN CONSUMPTION; PRIORITY JOURNAL;

ADULT; CYANOSIS; EXERCISE TEST; HEART DEFECTS, CONGENITAL; HEART FUNCTION TESTS; HEART RATE; HUMANS; MIDDLE AGED; OXYGEN CONSUMPTION; PROGNOSIS; PULMONARY VENTILATION; RESPIRATORY FUNCTION TESTS; RETROSPECTIVE STUDIES; RISK; SURVIVAL ANALYSIS;

EID: 84856117360     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.058719     Document Type: Article

References (47)

1. Nieminen HP, Jokinen EV, Sairanen HI. Causes of late deaths after pediatric cardiac surgery: A population-based study. J Am Coll Cardiol. 2007;50:1263-1271. (Pubitemid 47405126)
2. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, van Dijk AP, Vliegen HW, Grobbee DE, Mulder BJ. Mortality in adult congenital heart disease. Eur Heart J. 2010;31:1220-1229.
3. Warnes CA, Williams RG, Bashore TM, Child JS, Connolly HM, Dearani JA, del Nido P, Fasules JW, Graham TP Jr, Hijazi ZM, Hunt SA, King ME, Landzberg MJ, Miner PD, Radford MJ, Walsh EP, Webb GD. ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines on the Management of Adults With Congenital Heart Disease). Circulation. 2008;118:e714-e833.
4. Diller GP, Dimopoulos K, Okonko D, Li W, Babu-Narayan SV, Broberg CS, Johansson B, Bouzas B, Mullen MJ, Poole-Wilson PA, Francis DP, Gatzoulis MA. Exercise intolerance in adult congenital heart disease: Comparative severity, correlates, and prognostic implication. Circulation. 2005;112:828-835. (Pubitemid 41170068)
5. Diller GP, Dimopoulos K, Okonko D, Uebing A, Broberg CS, Babu- Narayan S, Bayne S, Poole-Wilson PA, Sutton R, Francis DP, Gatzoulis MA. Heart rate response during exercise predicts survival in adults with congenital heart disease. J Am Coll Cardiol. 2006;48:1250-1256. (Pubitemid 44345139)
6. Dimopoulos K, Okonko DO, Diller GP, Broberg CS, Salukhe TV, Babu- Narayan SV, Li W, Uebing A, Bayne S, Wensel R, Piepoli MF, Poole- Wilson PA, Francis DP, Gatzoulis MA. Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival. Circulation. 2006;113:2796-2802. (Pubitemid 44305291)
7. Francis DP, Shamim W, Davies LC, Piepoli MF, Ponikowski P, Anker SD, Coats AJ. Cardiopulmonary exercise testing for prognosis in chronic heart failure: Continuous and independent prognostic value from VE/VCO(2) slope and peak VO(2). Eur Heart J. 2000;21:154-161. (Pubitemid 30072630)
8. Wasserman K, Hansen JE, Sue DY, Stringer WW, Whipp BJ. Principles of Exercise Testing and Interpretation. 4th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2005.
9. Clark AL, Poole-Wilson PA, Coats AJ. Relation between ventilation and carbon dioxide production in patients with chronic heart failure. J Am Coll Cardiol. 1992;20:1326-1332.
10. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol. 1986;60: 2020-2027. (Pubitemid 16066969)
11. Wasserman K, McIlroy MB. Detecting the threshold of anaerobic metabolism in cardiac patients during exercise. Am J Cardiol. 1964;14: 844-852.
12. Wasserman K, Stringer WW, Casaburi R, Koike A, Cooper CB. Determination of the anaerobic threshold by gas exchange: Biochemical considerations, methodology and physiological effects. Z Kardiol. 1994; 83(suppl 3):1-12. (Pubitemid 24256088)
13. Balady GJ, Arena R, Sietsema K, Myers J, Coke L, Fletcher GF, Forman D, Franklin B, Guazzi M, Gulati M, Keteyian SJ, Lavie CJ, Macko R, Mancini D, Milani RV. Clinician's guide to cardiopulmonary exercise testing in adults: A scientific statement from the American Heart Association. Circulation. 2010;122:191-225.
14. Heagerty PJ, Lumley T, Pepe MS. Time-dependent ROC curves for censored survival data and a diagnostic marker. Biometrics. 2000;56: 337-344. (Pubitemid 30422619)
15. Bewick V, Cheek L, Ball J. Statistics review 13: Receiver operating characteristic curves. Crit Care. 2004;8:508-512. (Pubitemid 40073688)
16. Ishwaran H, Kogalur U, Blackstone E, Lauer M. Random survival forests. Ann Appl Stat. 2008;3:841-860.
17. Ishwaran H, Kogalur U. Random survival forests for R. R News. 2007; 7:25-31.
18. Ishwaran H, Kogalur U, Gorodeski EZ, Minn AJ, Lauer MS. Highdimensional variable selection for survival data. J Am Stat Assoc. 2010; 105:205-217.
19. R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria; 2006.
20. Rigby RA, Stasinopoulos DM. Generalized additive models for location, scale and shape. Appl Stat. 2005;54:507-554. (Pubitemid 40659551)
21. Gitt AK, Wasserman K, Kilkowski C, Kleemann T, Kilkowski A, Bangert M, Schneider S, Schwarz A, Senges J. Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death. Circulation. 2002;106:3079-3084. (Pubitemid 35440292)
22. Chua TP, Clark AL, Amadi AA, Coats AJ. Relation between chemosensitivity and the ventilatory response to exercise in chronic heart failure. J Am Coll Cardiol. 1996;27:650-657. (Pubitemid 26080387)
23. Clark AL, Gatzoulis MA, Redington AN. Ventilatory responses to exercise in adults after repair of tetralogy of Fallot. Br Heart J. 1995;73: 445-449.
24. Rhodes J, Dave A, Pulling MC, Geggel RL, Marx GR, Fulton DR, Hijazi ZM. Effect of pulmonary artery stenoses on the cardiopulmonary response to exercise following repair of tetralogy of Fallot. Am J Cardiol. 1998;81:1217-1219.
25. Scott AC, Davies LC, Coats AJ, Piepoli M. Relationship of skeletal muscle metaboreceptors in the upper and lower limbs with the respiratory control in patients with heart failure. Clin Sci (Lond). 2002; 102:23-30. (Pubitemid 34177797)
26. Troutman WB, Barstow TJ, Galindo AJ, Cooper DM. Abnormal dynamic cardiorespiratory responses to exercise in pediatric patients after Fontan procedure. J Am Coll Cardiol. 1998;31:668-673. (Pubitemid 28144136)
27. Wasserman K, Zhang YY, Gitt A, Belardinelli R, Koike A, Lubarsky L, Agostoni PG. Lung function and exercise gas exchange in chronic heart failure. Circulation. 1997;96:2221-2227. (Pubitemid 27425826)
28. Wensel R, Georgiadou P, Francis DP, Bayne S, Scott AC, Genth-Zotz S, Anker SD, Coats AJ, Piepoli MF. Differential contribution of dead space ventilation and low arterial pCO2 to exercise hyperpnea in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2004;93:318-323. (Pubitemid 38167428)
29. Tabet JY, Beauvais F, Thabut G, Tartiere JM, Logeart D, Cohen-Solal A. A critical appraisal of the prognostic value of the VE/VCO2 slope in chronic heart failure. Eur J Cardiovasc Prev Rehabil. 2003;10: 267-272. (Pubitemid 37433491)
30. Arena R, Humphrey R, Peberdy MA. Prognostic ability of VE/VCO2 slope calculations using different exercise test time intervals in subjects with heart failure. Eur J Cardiovasc Prev Rehabil. 2003;10:463-468. (Pubitemid 39127680)
31. Mancini DM, Eisen H, Kussmaul W, Mull R, Edmunds LH Jr, Wilson JR. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation. 1991;83:778-786.
32. Fredriksen PM, Veldtman G, Hechter S, Therrien J, Chen A, Warsi MA, Freeman M, Liu P, Siu S, Thaulow E, Webb G. Aerobic capacity in adults with various congenital heart diseases. Am J Cardiol. 2001; 87:310-314. (Pubitemid 32144872)
33. Mezzani A, Corra U, Bosimini E, Giordano A, Giannuzzi P. Contribution of peak respiratory exchange ratio to peak VO2 prognostic reliability in patients with chronic heart failure and severely reduced exercise capacity. Am Heart J. 2003;145:1102-1107. (Pubitemid 36688264)
34. Sietsema KE, Cooper DM, Perloff JK, Rosove MH, Child JS, Canobbio MM, Whipp BJ, Wasserman K. Dynamics of oxygen uptake during exercise in adults with cyanotic congenital heart disease. Circulation. 1986;73:1137-1144. (Pubitemid 16080525)
35. Sietsema KE. Cyanotic congenital heart disease: Dynamics of oxygen uptake and ventilation during exercise. J Am Coll Cardiol. 1991;18: 322-323.
36. Rhodes J, Curran TJ, Camil L, Rabideau N, Fulton DR, Gauthier NS, Gauvreau K, Jenkins KJ. Impact of cardiac rehabilitation on the exercise function of children with serious congenital heart disease. Pediatrics. 2005;116:1339-1345. (Pubitemid 46061099)
37. Dua JS, Cooper AR, Fox KR, Graham Stuart A. Physical activity levels in adults with congenital heart disease. Eur J Cardiovasc Prev Rehabil. 2007;14:287-293. (Pubitemid 46650085)
38. Giardini A. Generalised myopathy in young adults with congenital heart disease. Heart. 2011;97:1115-1116.
39. Greutmann M, Le TL, Tobler D, Biaggi P, Oechslin EN, Silversides CK, Granton JT. Generalised muscle weakness in young adults with congenital heart disease. Heart. 2011;97:1164-1168.
40. Lauer MS, Okin PM, Larson MG, Evans JC, Levy D. Impaired heart rate response to graded exercise: Prognostic implications of chronotropic incompetence in the Framingham Heart Study. Circulation. 1996;93: 1520-1526.
41. Lauer MS, Francis GS, Okin PM, Pashkow FJ, Snader CE, Marwick TH. Impaired chronotropic response to exercise stress testing as a predictor of mortality. JAMA. 1999;281:524-529. (Pubitemid 29081305)
42. Davos CH, Francis DP, Leenarts MF, Yap SC, Li W, Davlouros PA, Wensel R, Coats AJ, Piepoli M, Sreeram N, Gatzoulis MA. Global impairment of cardiac autonomic nervous activity late after the Fontan operation. Circulation. 2003;108(suppl 1):II-180 -II-185. (Pubitemid 37099951)
43. Colucci WS, Ribeiro JP, Rocco MB, Quigg RJ, Creager MA, Marsh JD, Gauthier DF, Hartley LH. Impaired chronotropic response to exercise in patients with congestive heart failure: Role of postsynaptic beta-adrenergic desensitization. Circulation. 1989;80:314-323. (Pubitemid 19195740)
44. Ellestad MH. Chronotropic incompetence: The implications of heart rate response to exercise (compensatory parasympathetic hyperactivity?). Circulation. 1996;93:1485-1487. (Pubitemid 26115410)
45. Khan MN, Pothier CE, Lauer MS. Chronotropic incompetence as a predictor of death among patients with normal electrograms taking beta blockers (metoprolol or atenolol). Am J Cardiol. 2005;96: 1328-1333. (Pubitemid 41505419)
46. Pillutla P, Shetty KD, Foster E. Mortality associated with adult congenital heart disease: Trends in the US population from 1979 to 2005. Am Heart J. 2009;158:874-879.
47. Silka MJ, Hardy BG, Menashe VD, Morris CD. A population-based prospective evaluation of risk of sudden cardiac death after operation for common congenital heart defects. J Am Coll Cardiol. 1998;32:245-251. (Pubitemid 28351069)