Monosomal karyotype routinely defines a poor prognosis subgroup in acute myeloid leukemia and is frequently associated with TP53 deletion

Leukemia and Lymphoma

Volumn 53, Issue 2, 2012, Pages 336-337

  Gaillard, Jean Baptiste ^a,b   Chiesa, Jean ^a,b   Reboul, Dorothée ^a,b   Arnaud, Anne ^c   Brun, Sophie ^c   Donadio, Daniel ^d   Exbrayat, Carole ^d   Wickenhauser, Stefan ^e   Bourquard, Pascal ^e   Jourdan, Eric ^e   Lavabre Bertrand, Thierry ^a,b  

^a Department of Clinical Cytology and Cytogenetics ^*  (France)

^b UNIVERSITÉ DE MONTPELLIER   (France)

^c Hematology Laboratory   (France)

^d Clinique du Parc   (France)

^e NÎMES UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ACUTE GRANULOCYTIC LEUKEMIA; CHROMOSOME 17; CHROMOSOME 17P; CHROMOSOME 18; CHROMOSOME 5; CHROMOSOME 7; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE MUTATION; HUMAN; KARYOTYPE; LETTER; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS;

ABNORMAL KARYOTYPE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; FEMALE; GENE DELETION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; MONOSOMY; PROGNOSIS; TUMOR SUPPRESSOR PROTEIN P53; YOUNG ADULT;

EID: 84856103315     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.608453     Document Type: Letter

References (15)

1. Breems DA, Van Putten WL, De Greef GE, et al. Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol 2008;26:4791-4797.
2. Medeiros BC, Othus M, Fang M, et al. Prognostic impact of monosomal karyotype in young adult anDelderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience. Blood 2010;116:2224-2228.
3. Perrot A, Luquet I, Pigneux A, et al. Dismal prognostic value of monosomal karyotype in elderly patients with acute myeloid leukemia: a GOELAMS study of 186 patients with unfavorable cytogenetic abnormalities. Blood 2011;118:679-685.
4. Patnaik MM, Hanson CA, Hodnefield JM, et al. Monosomal karyotype in myelodysplastic syndromes, with or without monosomy 7 or 5, is prognostically worse than an otherwise complex karyotype. Leukemia 2011;25:266-270.
5. Vaidya R, Caramazza D, Begna KH, et al. Monosomal karyotype in primary myelofi brosis is detrimental to both overall and leukemia-free survival. Blood 2011;117:5612-5615.
6. Grimwade D, Hills RK, Moorman AV, et al. Refi nement of cytogenetic classifi cation in acute myeloid leukemia: determination of prognostic signifi cance of rare recurring chromosomal abnormalities among 5876 younger adult patients treateDin the United Kingdom Medical Research Council trials. Blood 2010;116:354-365.
7. Seifert H, Mohr B, Thiede C, et al. The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia. Leukemia 2009;23:656-663.
8. Tang YC, Williams BR, Siegel JJ, et al. Identifi cation of aneuploidyselective antiproliferation compounds. Cell 2011;144:499-512.
9. Bowen D, Groves MJ, Burnett AK, et al. TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, anDis associated with very poor prognosis. Leukemia 2009;23:203-206.
10. Habermann JK, Brucker CA, Freitag-Wolf S, et al. Genomic instability and oncogene amplifi cations in colorectal adenomas predict recurrence and synchronous carcinoma. Mod Pathol 2011;24:542-555.
11. Jasek M, Gondek LP, Bejanyan N, et al. TP53 mutations in myeloid malignancies are either homozygous or hemizygous due to copy number-neutral loss of heterozygosity or deletion of 17p. Leukemia 2010;24:216-219.
12. Nahi H, Selivanova G, Lehmann S, et al. Mutated and nonmutated TP53 as targets in the treatment of leukaemia. Br J Haematol 2008;141:445-453. (Pubitemid 351550548)
13. Lambert JM, Gorzov P, Veprintsev DB, et al. PRIMA-1 reactivates mutant p53 by covalent binding to the core domain. Cancer Cell 2009;15:376-388.
14. Nahi H, Merup M, Lehmann S, et al. PRIMA-1 induces apoptosis in acute myeloid leukaemia cells with p53 gene deletion. Br J Haematol 2006;132:230-236. (Pubitemid 43381557)
15. Lambert JM, Moshfegh A, Hainaut P, et al. Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene 2010;29:1329-1338.