A randomized controlled trial of emergency treatment of bleeding esophageal varices in cirrhosis for hepatocellular carcinoma

American Journal of Surgery

Volumn 203, Issue 2, 2012, Pages 182-190

  Orloff, Marshall J ^a   Isenberg, Jon I ^a   Wheeler, Henry O ^a   Haynes, Kevin S ^a   Jinich Brook, Horacio ^a   Rapier, Roderick ^a   Vaida, Florin ^a   Hye, Robert J ^a   Orloff, Susan L ^b  

^a UCSD MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Bleeding esophageal varices; Cirrhosis; Emergency portacaval shunt; Endoscopic sclerotherapy; Hepatocellular carcinoma (HCC); Screening for HCC

Indexed keywords

ALPHA FETOPROTEIN;

ADULT; ARTICLE; CANCER PATIENT; CANCER STAGING; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ECHOGRAPHY; EMERGENCY TREATMENT; ENDOSCOPIC SCLEROTHERAPY; ESOPHAGUS VARICES BLEEDING; FEMALE; FOLLOW UP; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCREENING; SHUNTING;

CARCINOMA, HEPATOCELLULAR; EARLY DETECTION OF CANCER; EMERGENCY TREATMENT; ESOPHAGEAL AND GASTRIC VARICES; ESOPHAGOSCOPY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMANS; KAPLAN-MEIER ESTIMATE; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PORTACAVAL SHUNT, SURGICAL; QUALITY OF LIFE; SCLEROTHERAPY; SURVIVAL RATE;

EID: 84856098216     PISSN: 00029610     EISSN: 18791883     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2011.02.007     Document Type: Article

References (40)

1. J.M. Llovet, A. Burroughs, J. Bruix Hepatocellular carcinoma Lancet 362 2003 1907 1917 (Pubitemid 37518510)
2. H.B. El-Serag Should we screen for hepatocellular carcinoma in patients with cirrhosis? If so, in whom and how? AGA Perspect 6 2010 20 21
3. H.B. El-Serag, A.C. Mason Rising incidence of hepatocellular carcinoma in the United States N Engl J Med 340 1999 745 750 (Pubitemid 29114292)
4. H.B. El-Serag, K.L. Rudolph Hepatocellular carcinoma: epidemiology and molecular carcinogenesis Gastroenterology 132 2007 2557 2576 (Pubitemid 46890874)
5. F.X. Bosch, J. Ribes, M. Diaz Primary liver cancer: worldwide incidence and trends Gastroenterology 127 2004 S5 S16
6. J. Bruix, L. Boix, M. Sala Focus on hepatocellular carcinoma Cancer Cell 5 2004 215 219 (Pubitemid 38402113)
7. G. Fattovich, T. Stroffolini, I. Zagni Hepatocellular carcinoma in cirrhosis: incidence and risk factors Gastroenterology 127 2004 S35 S50
8. L. Benvegnu, M. Gios, S. Boccato Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications Gut 53 2004 744 749 (Pubitemid 38561455)
9. F. Degos, C. Christidis, N. Ganne-Carrie Hepatitis C virus related cirrhosis: time to occurrence of hepatocellular carcinoma and death Gut 47 2000 131 136 (Pubitemid 30430422)
10. A. Sangiovanni, E. Del Ninno, P. Fasani Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance Gastroenterology 1265 2004 1005 1014 (Pubitemid 38451172)
11. M.J. Orloff, J.I. Isenberg, H.O. Wheeler Randomized trial of emergency endoscopic sclerotherapy versus emergency portacaval shunt for acutely bleeding esophageal varices in cirrhosis J Am Coll Surg 209 2009 25 45
12. M.J. Orloff, J.I. Isenberg, H.O. Wheeler Portal-systemic encephalopathy in a randomized controlled trial of endoscopic sclerotherapy versus emergency portacaval shunt treatment of acutely bleeding esophageal varices in cirrhosis Ann Surg 250 2009 598 610
13. D. Moher, K.F. Schulz, D. Altman The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials JAMA 285 2001 1987 1991 (Pubitemid 32366951)
14. D.G. Altman, K.F. Schulz, D. Moher The revised CONSORT statement for reporting randomized trials: explanation and elaboration Ann Intern Med 134 2001 663 694 (Pubitemid 32322245)
15. K. Ikeda, S. Saitoh, I. Koida A multivariate analysis of risk factors for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis Hepatology 18 1993 47 53 (Pubitemid 23193616)
16. L. Bolondi, S. Sofia, S. Siringo Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis Gut 48 2001 251 259 (Pubitemid 32141852)
17. C.-H. Chen, J.-C. Sheu, G.-T. Huang Characteristics of hepatocellular carcinoma presenting with variceal bleeding J Gastroenterol Hepatol 13 1998 170 174 (Pubitemid 28137917)
18. B.H. Lang, R.T. Poon, S.T. Fan Outcomes of patients with hepatocellular carcinoma presenting with variceal bleeding Am J Gastroenterol 99 2004 2158 2165 (Pubitemid 39524707)
19. E.G. Giannini, D. Rizzo, R. Testa Prevalence and prognostic significance of the presence of esophageal varices in patients with hepatocellular carcinoma Clin Gastro Hepatol 4 2006 1378 1384 (Pubitemid 44781090)
20. J.A. Marrero, Z. Feng, Y. Wang Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma Gastroenterology 137 2009 110 118
21. J. Bruix, M. Sherman Management of hepatocellular carcinoma Hepatology 42 2005 1208 1236 (Pubitemid 43112690)
22. F. Trevisani, P.E. D'Intino, A.M. Morselli-Labate Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status J Hepatol 34 2001 570 575 (Pubitemid 32328514)
23. D. Pateron, N. Ganne, J.C. Trinchet Prospective study of screening for hepatocellular carcinoma in Caucasian patients with cirrhosis J Hepatol 20 1994 65 71 (Pubitemid 24043087)
24. M. Sherman Alphafetoprotein: an obituary J Hepatol 34 2001 603 605 (Pubitemid 32328519)
25. C. Bartolozzi, R. Lencioni, D. Caramella Small hepatocellular carcinoma: detection with US, CT, MR imaging, DSA, and lipiodol-CT Acta Radiol 37 1996 69 74 (Pubitemid 126710079)
26. A. Singal, M.L. Volk, A. Waljee Meta-analysis: surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis Aliment Pharmacol Ther 30 2009 37 47
27. K. Takayasu, N. Moriyama, Y. Muramatsu The diagnosis of small hepatocellular carcinomas: efficacy of various imaging procedures in 100 patients AJR Am J Roentgenol 155 1990 49 54 (Pubitemid 20218673)
28. W.J. Miller, R.L. Baron, G.D. Dodd III Malignancies in patients with cirrhosis: CT sensitivity and specificity in 200 consecutive transplant patients Radiology 193 1994 645 650 (Pubitemid 24366929)
29. C. Bartolozzi, R. Lencioni C. Bartolozzi, R. Lencioni, Liver malignancies 1999 Springer-Verlag Berlin
30. K. Kobayashi, T. Sugimoto, H. Makino Screening methods for early detection of hepatocellular carcinoma Hepatology 5 1985 1100 1105 (Pubitemid 16222276)
31. S. Saab, D. Ly, J. Nieto Hepatocellular carcinoma screening in patients waiting for liver transplantation: a decision analytic model Liver Transpl 9 2003 672 681 (Pubitemid 36874452)
32. M. Gambarin-Gelwan, D.C. Wolf, R. Shapiro Sensitivity of commonly available screening tests in detecting hepatocellular carcinoma in cirrhotic patients undergoing liver transplantation Am J Gastroenterol 95 2000 1535 1538 (Pubitemid 30396316)
33. H. Oka, A. Tamori, T. Kuroki Prospective study of alpha-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma Hepatology 19 1994 61 66
34. G.D. Dodd III, W.J. Miler, R.L. Baron Detection of malignant tumors in end-stage cirrhotic livers: efficacy of sonography as a screening technique AJR Am J Roentgenol 159 1992 727 733
35. M.J. Orloff, J.I. Isenberg, H.O. Wheeler Liver transplantation in a randomized controlled trial of emergency treatment of acutely bleeding esophageal varices in cirrhosis Transplant Proc 42 2010 4101 4108
36. R.H. Hauboldt, S.G. Hanson, G.R. Bernstein 2008 U.S. organ and tissue transplant cost estimates and discussion Milliman Res Rep 2008 1 17 April
37. D. Sorbi, C.J. Gostout, D. Peura An assessment of the management of acute bleeding varices: a multicenter prospective member-based study Am J Gastroenterol 98 2003 2424 2434 (Pubitemid 37448752)
38. J.E. Krige, J.M. Shaw, P.C. Bornman The evolving role of endoscopic treatment of esophageal varices Wld J Surg 29 2005 966 973 (Pubitemid 41605754)
39. I.M. Gralnek, D.M. Jensen, T.O.G. Kovacs The economic impact of esophageal variceal hemorrhage: cost-effectiveness implications of endoscopic therapy Hepatology 29 1999 44 50 (Pubitemid 29023984)
40. C.K. Triantos, J. Goulis, D. Patch An evaluation of emergency sclerotherapy of varices in randomized trials: looking the needle in the eye Endoscopy 38 2006 797 808 (Pubitemid 44314634)