Prevalence and Prognostic Significance of the Presence of Esophageal Varices in Patients With Hepatocellular Carcinoma

Clinical Gastroenterology and Hepatology

Volumn 4, Issue 11, 2006, Pages 1378-1384

  Giannini, Edoardo Giovanni ^a   Risso, Domenico ^a   Testa, Roberto ^a   Trevisani, Franco ^b   Di Nolfo, Maria Anna ^c   Del Poggio, Paolo ^d   Benvegnù, Luisa ^e   Ludovico Rapaccini, Gian ^f   Farinati, Fabio ^e   Zoli, Marco ^b   Borzio, Franco ^g   Caturelli, Eugenio ^h  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c BOLOGNINI HOSPITAL   (Italy)

^d TREVIGLIO HOSPITAL   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

^f CATHOLIC UNIVERSITY   (Italy)

^g FATEBENEFRATELLI HOSPITAL   (Italy)

^h BELCOLLE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BLEEDING; CALCULATION; CANCER CENTER; CANCER MORTALITY; CANCER SURVIVAL; CAUSE OF DEATH; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; ESOPHAGUS VARICES; EVALUATION; FEMALE; FOLLOW UP; HUMAN; ITALY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PATIENT REFERRAL; PREVALENCE; PROGNOSIS; RISK FACTOR; STATISTICAL SIGNIFICANCE;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; ESOPHAGEAL AND GASTRIC VARICES; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMANS; ITALY; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREVALENCE; PROGNOSIS; REGISTRIES; REGRESSION ANALYSIS; RISK FACTORS; SURVIVAL ANALYSIS;

EID: 33750811257     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2006.08.011     Document Type: Article

References (42)

1. Grace N.D. Diagnosis and treatment of gastrointestinal bleeding secondary to portal hypertension. American College of Gastroenterology Practice Parameters Committee. Am J Gastroenterol 92 (1997) 1081-1091
2. Jensen D.M. Endoscopic screening for varices in cirrhosis: findings, implications, and outcomes. Gastroenterology 122 (2002) 1620-1630
3. Talwalkar J.A., and Kamath P.S. Influence of recent advances in clinical management on clinical outcomes of cirrhosis. Mayo Clin Proc 80 (2005) 1501-1508
4. Benvegnù L., Gios M., Boccato S., et al. Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications. Gut 53 (2004) 744-749
5. Llovet J.M., Brù C., and Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 19 (1999) 329-338
6. Bruix J., and Llovet J.M. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 35 (2002) 519-524
7. Hassoun Z., and Gores G.J. Treatment of hepatocellular carcinoma. Clin Gastroenterol Hepatol 1 (2003) 10-18
8. Bruix J., Castells A., Bosch J., et al. Surgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressure. Gastroenterology 111 (1996) 1018-1022
9. Degos F., Christidis C., Ganne-Carrie N., et al. Hepatitis C virus related cirrhosis: time to occurrence of hepatocellular carcinoma and death. Gut 47 (2000) 131-136
10. Pompili M., Rapaccini G.L., Covino M., et al. Prognostic factors for survival in patients with compensated cirrhosis and small hepatocellular carcinoma after percutaneous ethanol injection. Cancer 92 (2001) 126-135
11. Ueno S., Tanabe G., Nuruki K., et al. Prognosis of hepatocellular carcinoma associated with Child class B and C cirrhosis in relation to treatment: a multivariate analysis of 411 patients at a single center. J Hepatobiliary Pancreat Surg 9 (2002) 469-477
12. Mazzanti R., Arena U., Pantaleo P., et al. Survival and prognostic factors in patients with hepatocellular carcinoma treated by percutaneous ethanol injection. Can J Gastroenterol 18 (2004) 611-618
13. Bruix J., Sherman M., Llovet J.M., et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL Conference. J Hepatol 35 (2001) 421-430
14. Bruix J., and Sherman M. Management of hepatocellular carcinoma. Hepatology 42 (2005) 1208-1236
15. Commissione "Epatocarcinoma" dell'Associazione Italiana per lo Studio del Fegato. Epatocarcinoma: Linee Guida per la Diagnosi e la Terapia (1998), Tipografia Moderna, Bologna 235-268
16. Pugh R.N., Murray-Lyon I.M., Dawson J.L., et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60 (1973) 646-649
17. Mazzaferro V., Regalia E., Doci R., et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 334 (1996) 693-699
18. Trevisani F., De Notariis S., Rapaccini G., et al. Semiannual and annual surveillance of cirrhotic patients for hepatocellular carcinoma: effects on cancer stage and patient survival (Italian experience). Am J Gastroenterol 97 (2002) 734-744
19. Llovet J.M. Evidence-based medicine in the treatment of hepatocellular carcinoma. J Gastroenterol Hepatol 17 (2002) S428-S433
20. Stroffolini T., Andreone P., Andriulli A., et al. Characteristics of hepatocellular carcinoma in Italy. J Hepatol 29 (1998) 944-952
21. Chalasani N., Imperiale T.F., Ismail A., et al. Predictors of large esophageal varices in patients with cirrhosis. Am J Gastroenterol 94 (1999) 3285-3291
22. Zaman A., Hapke R., Flora K., et al. Factors predicting the presence of esophageal varices or gastric varices in patients with advanced liver disease. Am J Gastroenterol 94 (1999) 3292-3296
23. Giannini E., Botta F., Borro P., et al. Platelet count spleen/diameter ratio: proposal and validation of a non-invasive parameter to predict the presence of oesophageal varices in patients with liver cirrhosis. Gut 52 (2003) 1200-1205
24. Tanaka R., Itoshima T., and Nagashima H. Follow-up study of 582 liver cirrhosis patients. Liver 7 (1987) 316-324
25. Fattovich G., Giustina G., Degos F., et al. Moribidity and mortality in compensated cirrhosis C: a retrospective follow-up study of 384 patients. Gastroenterology 112 (1997) 463-742
26. Wong J.B., McQuillan G.M., McHutchison J.G., et al. Estimating future hepatitis C morbidity, mortality, and costs in the United States. Am J Public Health 90 (2000) 1562-1569
27. The Cancer of the Liver Italian Program (CLIP) Investigators. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients. Hepatology 28 (1998) 751-755
28. Chevret S., Trinchet J.C., Mathieu D., et al. A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. J Hepatol 31 (1999) 133-141
29. Leung T.W., Tang A.M., Zee B., et al. Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients. Cancer 94 (2002) 1760-1769
30. Kudo M., Chung H., Haji S., et al. Validation of a new prognostic staging system for hepatocellular carcinoma: the JIS score compared with the CLIP score. Hepatology 40 (2004) 1396-1405
31. Talwalkar J.A., and Gores G.J. Diagnosis and staging of hepatocellular carcinoma. Gastroenterology 127 (2004) S126-S132
32. Sala M., Forner A., Varela M., et al. Prognostic prediction in patients with hepatocellular carcinoma. Semin Liver Dis 25 (2005) 171-180
33. Bruix J., Sala M., and Llovet J.M. Chemoembolization for hepatocellular carcinoma. Gastroenterology 127 Suppl 1 (2004) S179-S188
34. Llovet J.M., Real M.I., Montana X., and Barcelona Clinic Liver Cancer Group. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomized controlled trial. Lancet 359 (2002) 1734-1739
35. Chan A.O., Yuen M.F., Hui C.K., et al. A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma. Cancer 94 (2002) 1747-1752
36. Calvet X., Bruix J., Bru C., et al. Natural history of hepatocellular carcinoma in Spain. Five years' experience in 249 cases. J Hepatol 10 (1990) 311-317
37. Rabe C., Pilz T., Klostermann C., et al. Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma. World J Gastroenterol 7 (2001) 208-215
38. Lerose R., Molinari R., Rocchi E., et al. Prognostic features and survival of hepatocellular carcinoma in Italy: impact of stage of disease. Eur J Cancer 37 (2001) 239-245
39. Lang B.H., Poon R.T., Fan S.T., et al. Outcomes of patients with hepatocellular carcinoma presenting with variceal bleeding. Am J Gastroenterol 99 (2004) 2158-2165
40. Zaman A., Boyer-Quick J., and De Garmo P. Trends in endoscopic screening for varices in cirrhotics: four years of data from a national endoscopic database (CORI-Clinical Outcomes Research Initiative) (abstr). Hepatology 36 Suppl S (2002) 714A
41. Arguedas M.R., McGuire B.M., Fallon M.B., et al. The use of screening and preventive therapies for gastroesophageal varices in patients referred for evaluation of orthotopic liver transplantation. Am J Gastroenterol 96 (2001) 833-837
42. de Franchis R., Pascal J.P., Ancona E., et al. Definitions, methodology and therapeutic strategies in portal hypertension. A Consensus Development Workshop, Baveno, Lake Maggiore, Italy, April 5 and 6, 1990. J Hepatol 15 (1992) 256-261