Efficacy of ASP2151, a helicase-primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo

Antiviral Research

Volumn 93, Issue 2, 2012, Pages 301-304

  Himaki, Takehiro ^a   Masui, Yumi ^a   Chono, Koji ^b   Daikoku, Tohru ^a   Takemoto, Masaya ^a   Haixia, Bo ^a   Okuda, Tomoko ^a   Suzuki, Hiroshi ^b   Shiraki, Kimiyasu ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Acyclovir; ASP2151; Helicase primase inhibitor; Herpes simplex viruses; Resistance; Thymidine kinase

Indexed keywords

AMENAMEVIR; THYMIDINE KINASE; VALACICLOVIR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; DRUG EFFICACY; DRUG SENSITIVITY; EXTERNAL EAR; FEMALE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DNA HELICASES; DNA PRIMASE; ENZYME INHIBITORS; FEMALE; HERPES SIMPLEX; HERPESVIRUS 2, HUMAN; HUMANS; MICE; MICE, INBRED BALB C; OXADIAZOLES; THYMIDINE KINASE; VIRAL PROTEINS;

HERPES; HUMAN HERPESVIRUS 2; HUMAN HERPESVIRUS 3; MUS; SIMPLEXVIRUS;

EID: 84856083032     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2011.11.015     Document Type: Article

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