Bioanalytical method development and validation of natamycin in rabbit tears and its application to ocular pharmacokinetic studies

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 5, 2011, Pages 1096-1100

  Bhatta, R S ^a   Chandasana, H ^b   Rathi, C ^b   Kumar, D ^a   Chhonker, Y S ^a   Jain, G K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b National Institute of Pharmaceutical Education and Research (NIPER)   (India)

Author keywords

Bioanalytical method; LC MS MS; Natamycin; Ocular pharmacokinetics; Rabbit tear

Indexed keywords

AMMONIUM ACETATE; AMPHOTERICIN B; DYE; LUNA CYANO; METHANOL; NATAMET; NATAMYCIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG SENSITIVITY; DRUG STABILITY; FREEZE THAWING; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MULTIPLE REACTION MONITORING; NEGATIVE ION ELECTROSPRAY; NONHUMAN; OPTIMAL DRUG DOSE; PH; PHARMACOLOGICAL PARAMETERS; PHASE SEPARATION; PRIORITY JOURNAL; RABBIT; REACTION TIME; TANDEM MASS SPECTROMETRY; TEAR FILM; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

AMPHOTERICIN B; ANIMALS; ANTIFUNGAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG MONITORING; DRUG STABILITY; MOLECULAR STRUCTURE; NATAMYCIN; OPHTHALMIC SOLUTIONS; RABBITS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; TEARS; TIME FACTORS;

EID: 78751703553     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.11.028     Document Type: Article

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