Brain-derived neurotrophic factor receptor TrkB exists as a preformed dimer in living cells

Journal of Molecular Signaling

Volumn 7, Issue , 2012, Pages

  Shen, Jianying ^a,b   Maruyama, Ichiro N ^a  

^a OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY   (Japan)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Bdnf; Chemical crosslinking; Neurotrophin receptor; Preformed homodimer; Protein fragment complementation assay

Indexed keywords

EID: 84856072855     PISSN: None     EISSN: 17502187     Source Type: Journal    
DOI: 10.1186/1750-2187-7-2     Document Type: Article

References (30)

1. Chao MV. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 2003, 4(4):299-309. 10.1038/nrn1078, 12671646.
2. Huang EJ, Reichardt LF. Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 2003, 72:609-642. 10.1146/annurev.biochem.72.121801.161629, 12676795.
3. Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 2000, 10(3):381-391. 10.1016/S0959-4388(00)00092-1, 10851172.
4. Simi A, Ibáñez CF. Assembly and activation of neurotrophic factor receptor complexes. Dev Neurobiol 2010, 70(5):323-331.
5. Brodeur GM, Minturn JE, Ho R, Simpson AM, Iyer R, Varela CR, Light JE, Kolla V, Evans AE. Trk receptor expression and inhibition in neuroblastomas. Clin Cancer Res 2009, 15(10):3244-3250. 10.1158/1078-0432.CCR-08-1815, 19417027.
6. McDonald NQ, Lapatto R, Murray-Rust J, Gunning J, Wlodawer A, Blundell TL. New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor. Nature 1991, 354(6352):411-414. 10.1038/354411a0, 1956407.
7. Radziejewski C, Robinson RC, DiStefano PS, Taylor JW. Dimeric structure and conformational stability of brain-derived neurotrophic factor and neurotrophin-3. Biochemistry 1992, 31(18):4431-4436. 10.1021/bi00133a007, 1581298.
8. Shen J, Maruyama IN. Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells. FEBS lett 2011, 585(2):295-299. 10.1016/j.febslet.2010.12.031, 21187090.
9. Daukas G, Zigmond SH. Inhibition of receptor-mediated but not fluid- phase endocytosis in polymorphonuclear leukocytes. J Cell Biol 1985, 101(5 Pt 1):1673-1679. 2113969, 4055891.
10. Heuser JE, Anderson RG. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. J Cell Biol 1989, 108(2):389-400. 10.1083/jcb.108.2.389, 2115439, 2563728.
11. Hu CD, Chinenov Y, Kerppola TK. Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation. Mol Cell 2002, 9(4):789-798. 10.1016/S1097-2765(02)00496-3, 11983170.
12. Tao RH, Maruyama IN. All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells. J Cell Sci 2008, 121(Pt 19):3207-3217.
13. Nagai T, Ibata K, Park ES, Kubota M, Mikoshiba K, Miyawaki A. A variant of yellow fluorescent protein with fast and efficient maturation for cell- biological applications. Nat Biotechnol 2002, 20(1):87-90. 10.1038/nbt0102-87, 11753368.
14. Fujiwara T, Oda K, Yokota S, Takatsuki A, Ikehara Y. Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum. J Biol Chem 1988, 263(34):18545-18552.
15. Wada I, Rindress D, Cameron PH, Ou WJ, Doherty JJ, Louvard D, Bell AW, Dignard D, Thomas DY, Bergeron JJ. SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane. J Biol Chem 1991, 266(29):19599-19610.
16. Luker KE, Smith MC, Luker GD, Gammon ST, Piwnica-Worms H, Piwnica- Worms D. Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci USA 2004, 101(33):12288-12293. 10.1073/pnas.0404041101, 514471, 15284440.
17. Milligan DL, Koshland DE. Site-directed cross-linking. Establishing the dimeric structure of the aspartate receptor of bacterial chemotaxis. J Biol Chem 1988, 263(13):6268-6275.
18. Moriki T, Maruyama H, Maruyama IN. Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain. J Mol Biol 2001, 311(5):1011-1026. 10.1006/jmbi.2001.4923, 11531336.
19. Yu X, Sharma KD, Takahashi T, Iwamoto R, Mekada E. Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling. Mol Biol Cell 2002, 13(7):2547-2557. 10.1091/mbc.01-08-0411, 117333, 12134089.
20. Clayton AH, Walker F, Orchard SG, Henderson C, Fuchs D, Rothacker J, Nice EC, Burgess AW. Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis. J Biol Chem 2005, 280(34):30392-30399. 10.1074/jbc.M504770200, 15994331.
21. Liu P, Sudhaharan T, Koh RML, Hwang LC, Ahmed S, Maryama IN, Wohland T. Investigation of the dimerization of proteins from the epidermal growth factor receptor family by single wavelength fluorescence cross-correlation spectroscopy. Biophys J 2007, 93(2):684-698. 10.1529/biophysj.106.102087, 1896234, 17468161.
22. Constantinescu SN, Keren T, Socolovsky M, Nam H, Henis YI, Lodish HF. Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc Natl Acad Sci USA 2001, 98(8):4379-4384. 10.1073/pnas.081069198, 31843, 11296286.
23. Gent J, van Kerkhof P, Roza M, Bu G, Strous GJ. Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis. Proc Natl Acad Sci USA 2002, 99(15):9858-9863. 10.1073/pnas.152294299, 125043, 12105275.
24. Brown RJ, Adams JJ, Pelekanos RA, Wan Y, McKinstry WJ, Palethorpe K, Seeber RM, Monks TA, Eidne KA, Parker MW, Waters MJ. Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol 2005, 12(9):814-821. 10.1038/nsmb977, 16116438.
25. Latz E, Verma A, Visintin A, Gong M, Sirois CM, Klein DC, Monks BG, McKnight CJ, Lamphier MS, Duprex WP, Espevik T, Golenbock DT. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol 2007, 8(7):772-779. 10.1038/ni1479, 17572678.
26. Parat M, Blanchet J, De Léan A. Role of juxtamembrane and transmembrane domains in the mechanism of natriuretic peptide receptor A activation. Biochemistry 2010, 49(22):4601-4610. 10.1021/bi901711w, 20214400.
27. Maruyama IN, Mikawa YG, Maruyama HI. A model for transmembrane signallling by the aspartate receptor based on random-cassette mutagenesis and site-directed disulfide cross-linking. J Mol Biol 1995, 253(4):530-546. 10.1006/jmbi.1995.0571, 7473732.
28. Shyu YJ, Liu H, Deng X, Hu CD. Identification of new fluorescent protein fragments for bimolecular fluorescence complementation analysis under physiological conditions. BioTechniques 2006, 40(1):61-66. 10.2144/000112036, 16454041.
29. Nakagawara A, Liu X-G, Ikegaki N, White PS, Yamashiro DJ, Nycum LM, Biegel JA, Brodeur GM. Cloning and chromosomal localization of the human Trk-B tyrosine kinase receptor gene (NTRK2). Genomics 1995, 25(2):538-546. 10.1016/0888-7543(95)80055-Q, 7789988.
30. Miyagi H, Maruyama IN. Analysis of ligand-receptor interaction on the surface of living cells by fluorescence correlation spectroscopy. Open Spectrosc J 2010, 4:28-31.