The German Infant Nutritional Intervention Study (GINI) for the preventive effect of hydrolysed infant formulas in infants at high risk for allergic diseases. Design and selected results;Die German Infant Nutritional Intervention Study (GINI) zur präventiven wirkung von hydrolysatnahrungen bei kindern mit allergierisiko. Design und ausgewählte ergebnisse

Allergologie

Volumn 35, Issue 1, 2012, Pages 32-43

  Von Berg, A ^a   Filipiak Pittroff, B ^a   Kramer U ^b   Link, E ^b   Heinrich, J ^c   Koletzko, S ^d   Grubl A ^e   Hoffmann, U ^e   Beckmann, C ^a   Reinhardt, D ^f   Bauer, C P ^e   Wichmann, E ^c   Berdel, D ^a  

^a Marien Hospital   (Germany)

^b IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f NONE

Author keywords

Birth cohort; Double blind, randomised intervention study; Hypoallergenic infant formula; Primary allergy prevention; Prospective

Indexed keywords

CASEIN HYDROLYSATE; PROTEIN HYDROLYSATE;

ALLERGIC DISEASE; ARTIFICIAL MILK; ASTHMA; ATOPIC DERMATITIS; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; FAMILY HISTORY; GERMAN INFANT NUTRITIONAL INTERVENTION STUDY; HUMAN; INCIDENCE; INFANT; INTERVENTION STUDY; MEDICAL HISTORY; MILK; OBSERVATIONAL STUDY; OBSTETRICS; PROPHYLAXIS; PROSPECTIVE PAYMENT; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; REVIEW; RHINOCONJUNCTIVITIS; SELF REPORT; SIBLING;

EID: 84856069186     PISSN: 03445062     EISSN: None     Source Type: Journal    
DOI: 10.5414/ALX01462     Document Type: Review

References (31)

1. Alexander DD, Cabana MD. Partially hydrolyzed 100% whey protein infant formula and reduced risk of atopic dermatitis: a meta-analysis. J Pediatr Gastroenterol Nutr. 2010; 50: 422-430. PubMed
2. American Academy of Pediatrics CoN. Hypoallergenic infant formulas. Pediatrics. 2000; 106: 236-347.
3. AWMF-S3 Leitlinie Allergiprävention. http:// www.uni-duesseldorf.de/ AWMF/11/061-016.htm.
4. von Berg A, Koletzko S, Grübl A, Filipiak-Pittroff B, Wichmann HE, Bauer CP, Reinhardt D, Berdel D; German Infant Nutritional Intervention Study Group. The effect of hydrolyzed cow's milk formula for allergy prevention in the first year of life: the German Infant Nutritional Intervention Study, a randomized double-blind trial. J Allergy Clin Immunol. 2003; 111: 533-540. doi:10.1067/ mai.2003.101 PubMed
5. von Berg A, Koletzko S, Filipiak-Pittroff B, Laubereau B, Grübl A, Wichmann HE, Bauer CP, Reinhardt D, Berdel D; German Infant Nutritional Intervention Study Group. Certain hydrolyzed formulas reduce the incidence of atopic dermatitis but not that of asthma: three-year results of the German Infant Nutritional Intervention Study. J Allergy Clin Immunol. 2007; 119: 718-725. doi:10.1016/j.jaci.2006.11.017 PubMed (Pubitemid 46335815)
6. von Berg A, Filipiak-Pittroff B, Krämer U, Link E, Bollrath C, Brockow I, Koletzko S, Grübl A, Heinrich J, Wichmann HE, Bauer CP, Reinhardt D, Berdel D; GINIplus study group. Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI). J Allergy Clin Immunol. 2008; 121: 1442-1447. doi:10.1016/j.jaci.2008.04.021 PubMed (Pubitemid 351787357)
7. von Berg A, Krämer U, Link E, Bollrath C, Heinrich J, Brockow I, Koletzko S, Grübl A, Filipiak- Pittroff B, Wichmann HE, Bauer CP, Reinhardt D, Berdel D; GINIplus study group. Impact of early feeding on childhood eczema: development after nutritional intervention compared with the natural course - the GINIplus study up to the age of 6 years. Clin Exp Allergy. 2010; 40: 627-636. Published online January 14, 2010 PubMed.
8. Brandt PLP, Vlieg-Boerstra BJ, Dubois AEJ. Dietary prevention of allergic diseases in children: are current recommendations really based on good evidence? Pediatr Allergy Immunol. 2007; 18: 475-479. PubMed doi:10.1111/j.1399- 3038.2007.00541.x
9. 100% whey-protein partially hydrolyzed infant formula and reduced risk of atopic dermatitis, food and drug administration; 2011 available from http://www.fda.gov/Food/LabelingNutrition/ LabelClaims/QualifiedHealthClaims/ucm 256731.htm.
10. Filipiak B, Zutavern A, Koletzko S, von Berg A, Brockow I, Grübl A, Berdel D, Reinhardt D, Bauer CP, Wichmann HE, Heinrich J; GINI-Group. Solid food introduction in relation to eczema: results from a four-year prospective birth cohort study. J Pediatr. 2007; 151: 352-358. doi:10.1016/j. jpeds.2007.05.018 PubMed
11. Halken S, Hansen KS, Jacobsen HP, Estmann A, Faelling AE, Hansen LG, Kier SR, Lassen K, Lintrup M, Mortensen S, Ibsen KK, Osterballe O, Høst A. Comparison of a partially hydrolyzed infant formula with two extensively hydrolyzed formulas for allergy prevention: a prospective, randomized study. Pediatr Allergy Immunol. 2000; 11: 149-161. doi:10.1034/j.1399- 3038.2000.00081.x PubMed
12. Hays T, Wood RA. A systematic review of the role of hydrolyzed infant formulas in allergy prevention. Arch Pediatr Adolesc Med. 2005; 159: 810- 816. doi:10.1001/archpedi.159.9.810 PubMed
13. Høst A, Koletzko B, Dreborg S, Muraro A, Wahn U, Aggett P, Bresson JL, Hernell O, Lafeber H, Michaelsen KF, Micheli JL, Rigo J, Weaver L, Heymans H, Strobel S, Vandenplas Y. Dietary products used in infants for treatment and prevention of food allergy. Joint Statement of the European Society for Paediatric Allergology and Clinical Immunology (ESPACI) Committee on Hypoallergenic Formulas and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Committee on Nutrition. Arch Dis Child. 1999; 81: 80-84. doi:10.1136/adc.81.1.80 PubMed (Pubitemid 29307465)
14. Katz Y, Rajuan N, Goldberg MR, Eisenberg E, Heyman E, Cohen A, Leshno M. Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy. J Allergy Clin Immunol. 2010; 126: 77-82, e1. doi:10.1016/j. jaci.2010.04.020 PubMed
15. Koletzko S, Filipiak-Pittroff B, von Berg A, Grübl A, Heinrich J, Krämer U, Wichmann HE, Bauer CP, Reinhardt D, Berdel D; German Infant Nutritional Intervention Study Group. Letter to the Editor: Supplementation with cow's milk at birth is not recommended. J Allergy Clin Immunol. 2011; 127: 836-838.
16. Koletzko S, Filipiak-Pittroff B, Koletzko B, von Berg A, Krämer U, Berdel D, Heinrich J; GINI study group. Letter to the Editor: No reason to change the current guidelines on allergy prevention J Allergy Clin Immunol.accepted.
17. Laubereau B, Brockow I, Zirngibl A, Koletzko S, Gruebl A, von Berg A, Filipiak-Pittroff B, Berdel D, Bauer CP, Reinhardt D, Heinrich J, Wichmann HE; GINI Study Group. Effect of breast-feeding on the development of atopic dermatitis during the first 3 years of life - results from the GINIbirth cohort study. J Pediatr. 2004; 144: 602-607. doi:10.1016/j.jpeds.2003.12.029 PubMed (Pubitemid 38594760)
18. Lowe AJ, Hosking CS, Bennett CM, Allen KJ, Axelrad C, Carlin JB, Abramson MJ, Dharmage SC, Hill DJ. Effect of a partially hydrolyzed whey infant formula at weaning on risk of allergic disease in high-risk children: A randomized controlled trial. J Allergy Clin Immunol. 2011; 128: 360-365 e4. Epub 2011 Jun 22.
19. Mertens J, Stock S, Lüngen M, von Berg A, Krämer U, Filipiak-Pittroff B, Heinrich J, Koletzko S, Grübl A, Wichmann HE, Bauer CP, Reinhardt D, Berdel D, Gerber A. Is prevention of atopic eczema with hydrolysed formulas costeffective? An application of results of the GINIstudy to the German situation. Abstract 3rd EAPS Congress, Copenhagen, Oct. 25th 2010.
20. Muraro A, Dreborg S, Halken S, Høst A, Niggemann B, Aalberse R, Arshad SH, Berg Av A, Carlsen K, Duschén K, Eigenmann P, Hill D, Jones C, Mellon M, Oldeus G, Oranje A, Pascual C, Prescott S, Sampson H, Svartengren M et al. Dietary prevention of allergic diseases in infants and small children. Part I: immunologic background and criteria for hypoallergenicity. Pediatr Allergy Immunol. 2004; 15: 103-111. doi:10.1046/j.1399-3038.2003.00129.x PubMed (Pubitemid 38480777)
21. Oldaeus G, Anjou K, Björkstén B, Moran JR, Kjellman NI. Extensively and partially hydrolysed infant formulas for allergy prophylaxis. Arch Dis Child. 1997; 77: 4-10. doi:10.1136/ adc.77.1.4 PubMed
22. Osborn DA, Sinn J. Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants. Cochrane Database Syst Rev. 2006; CD003664 PubMed.
23. Rzehak P, Sausenthaler S, Koletzko S, Reinhardt D, von Berg A, Krämer U, Berdel D, Bollrath C, Grübl A, Bauer CP, Wichmann HE, Heinrich J; for the GINI-plus Study Group. Long-term effects of hydrolyzed protein infant formulas on growth - extended follow-up to 10 y of age: results from the German Infant Nutritional Intervention (GINI) study. Am J Clin Nutr. 2011; 94: 1803S-1807S. doi:10.3945/ajcn.110.000679Epub ahead of print PubMed.
24. Sausenthaler S, Koletzko S, Koletzko B, Reinhardt D, Krämer U, von Berg A, Berdel D, Bauer CP, Grübl A, Wichmann HE, Heinrich J; GINIplus study group. Effect of hydrolysed formula feeding on taste preferences at 10 years. Data from the German Infant Nutritional Intervention Program Plus Study. Clin Nutr. 2010; 29: 304-306. doi:10.1016/j.clnu.2010.01.007 PubMed
25. Schoetzau A, Gehring U, Wichmann HE. Prospective cohort studies using hydrolysed formulas for allergy prevention in atopy-prone newborns: a systematic review. Eur J Pediatr. 2001; 160: 323- 332. doi:10.1007/PL00008442 PubMed
26. Schoetzau A, Gehring U, Franke K, Grübl A, Koletzko S, von Berg A, Berdel D, Reinhardt D, Bauer CP, Wichmann HE; Gini Study Group. Maternal compliance with nutritional recommendations in an allergy preventive programme. Arch Dis Child. 2002; 86: 180-184. doi:10.1136/ adc.86.3.180 PubMed
27. Smith R. Investigating the previous studies of a fraudulent author. BMJ. 2005; 331: 288-291. doi:10.1136/bmj.331.7511.288 PubMed (Pubitemid 41097915)
28. Stein RTD, Sherrill D, Morgan WJ, Holberg CJ, Halonen M, Taussig LM, Wright AL, Martinez FD. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999; 354: 541-545. doi:10.1016/S0140- 6736(98)10321-5 PubMed
29. Szajewska H, Horvath A. A meta-analysis of the evidencefor a partially hydrolyzed 100% whey formula for the prevention of allergic diseases. Curr Med Res Opin. 2010; 26: 423-437.
30. Vandenplas Y, Hauser B, Van den Borre C, Clybouw C, Mahler T, Hachimi-Idrissi S, Deraeve L, Malfroot A, Dab I. The long-term effect of a partial whey hydrolysate formula on the prophylaxis of atopic disease. Eur J Pediatr. 1995; 154: 488- 494. doi:10.1007/BF02029362 PubMed
31. Zeiger RS. Food allergen avoidance in the prevention of food allergy in infants and children. Pediatrics. 2003; 111: 1662-1671. PubMed (Pubitemid 36681525)