Vitamin B 12 and folic acid levels as therapeutic target in preserving bone mineral density (BMD) of older men

Archives of Gerontology and Geriatrics

Volumn 54, Issue 3, 2012, Pages 469-472

  Naharci, Ilkin ^a   Bozoglu, Ergun ^a   Karadurmus, Nuri ^a   Emer, Ozdes ^a   Kocak, Necmettin ^a   Kilic, Selim ^a   Doruk, Huseyin ^a   Serdar, Muhittin ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Bone mineral density; Folic acid; The bone status in older men; Vitamin B 12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID;

AGE; AGED; ALCOHOL CONSUMPTION; ANALYSIS OF VARIANCE; ANATOMICAL VARIATION; ARTICLE; BODY MASS; BONE DENSITY; CONTROLLED STUDY; EXERCISE; FEMUR NECK; HUMAN; MAJOR CLINICAL STUDY; MALE; OSTEOLYSIS; OSTEOPENIA; OSTEOPOROSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SMOKING; VITAMIN BLOOD LEVEL;

AGED; AGED, 80 AND OVER; ALCOHOL DRINKING; BODY MASS INDEX; BONE DENSITY; BONE DISEASES, METABOLIC; EXERCISE; FEMUR; FOLIC ACID; HUMANS; MALE; RETROSPECTIVE STUDIES; SMOKING; VITAMIN B 12;

EID: 84856041440     PISSN: 01674943     EISSN: 18726976     Source Type: Journal    
DOI: 10.1016/j.archger.2011.06.009     Document Type: Article

References (25)

1. 12 to bone mineral density of postmenopausal women. Bone 2003, 33:956-959.
2. 12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation. Bone 2008, 42:314-320.
3. Carmel R., Lau K.H., Baylink D.J., Saxena S., Singer F.R. Cobalamin and osteoblast-specific proteins. N. Engl. J. Med. 1988, 319:70-75.
4. Center J., Nguyen T., Schneider D., Sambrook P.N., Eisman J.A. Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 1999, 353:878-882.
5. 12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J. Bone Miner. Res. 2005, 20:921-929.
6. Gjesdal G.C., Vollset S.E., Ueland P.M., Refsum H., Drevon C.A., Gjessing H.K., Tell G.S. Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Arch. Intern. Med. 2006, 166:88-94.
7. Herbert V. Folic acid. Modern Nutrition in Health and Disease 1999, 433-446. Lippincott Williams & Wilkins, Baltimore. 9th ed. A. Ross (Ed.).
8. Herrmann M., Stanger O., Paulweber B., Hufnagl C., Herrmann W. Folate supplementation does not affect biochemical markers of bone turnover. Clin. Lab. 2006, 52:131-136.
9. Herrmann M., Schmidt J., Umanskaya N., Colaianni G., Al Marrawi F., Widmann T., Zallone A., Wildemann B., Herrmann W. Stimulation of osteoclast activity by low B-vitamin concentrations. Bone 2007, 41:584-591.
10. 12 deficiency does not alter bone quality in rats. J. Bone Miner. Res. 2009, 24:589-596.
11. 12 vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial. Stroke 2009, 40:730-736. BVAIT Research Group.
12. Johnell O. The socioeconomic burden of fractures: today and in the 21st century. Am. J. Med. 1997, 103:20-26.
13. Kannus P., Parkkari J., Sievanen H., Heinonen A., Vuori I., Järvinen M. Epidemiology of hip fractures. Bone 1996, 18:57-63.
14. 12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells. Metabolism 1996, 45:1443-1446.
15. McLean R.R., Jacques P.F., Selhub J., Fredman L., Tucker K.L., Samelson E.J., Kiel D.P., Cupples L.A., Hannan M.T. Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women. J. Clin. Endocrinol. Metab. 2008, 93:2206-2212.
16. Morris M.S., Jacques P.F., Selhub J. Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone 2005, 37:234-242.
17. Nguyen T.V., Eisman J.A., Kelly P.J., Sambrook P.N. Risk factors for osteoporotic fractures in elderly men. Am. J. Epidemiol. 1996, 144:255-263.
18. Schrier, S.L., 2010. Diagnosis and treatment of vitamin B12 and folic acid deficiency. In: Rose, B.D. (Ed), UpToDate Online 18.1.
19. 12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia. Eur. J. Endocrinol. 2004, 151:483-489.
20. Stone K.L., Bauer D.C., Sellmeyer D., Cummings S.R. Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: a prospective study. J. Clin. Endocrinol. Metab. 2004, 89:1217-1221.
21. Tanriover M.D., Oz S.G., Tanriover A., Kilicarslan A., Turkmen E., Guven G.S., Saracbasi O., Tokgozoglu M., Sozen T. Hip fractures in a developing country: osteoporosis frequency, predisposing factors and treatment costs. Arch. Gerontol. Geriatr. 2010, 50:e13-e18.
22. Trombetti A., Herrmann F., Hoffmeyer P., Schurch M.A., Bonjour J.P., Rizzoli R. Survival and potential years of life lost after hip fracture in men and age-matched women. Osteoporos. Int. 2002, 13:731-737.
23. 12 is associated with lower BMD: the Framingham Osteoporosis Study. J. Bone Miner. Res. 2005, 20:152-158.
24. Vaes B.L., Lute C., Blom H.J., Bravenboer N., de Vries T.J., Everts V., Dhonukshe-Rutten R.A., Müller M., de Groot L.C., Steegenga W.T. Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid. Calcif. Tissue Int. 2009, 84:413-422.
25. Van Staa T.P., Dennison E.M., Leufkens H.G., Cooper C. Epidemiology of fractures in England and Wales. Bone 2001, 29:517-522.