Intrathecal administration of triptolide, a T lymphocyte inhibitor, attenuates chronic constriction injury-induced neuropathic pain in rats

Brain Research

Volumn 1436, Issue , 2012, Pages 122-129

  Hu, Jin Yu ^a   Li, Chang Lin ^a   Wang, Ying Wei ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Neuropathic pain; Rat; T lymphocyte; Triptolide

Indexed keywords

BETA ACTIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA; TRIPTOLIDE; TUMOR NECROSIS FACTOR ALPHA;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERALGESIA; LATENT PERIOD; LOCOMOTION; MALE; MOTOR DYSFUNCTION; NERVE INJURY; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SCIATIC NERVE; SPINAL CORD; SPRAGUE DAWLEY RAT; T LYMPHOCYTE ACTIVATION; TREATMENT OUTCOME; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHRONIC PAIN; DITERPENES; EPOXY COMPOUNDS; HYPERALGESIA; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; NEURALGIA; PHENANTHRENES; RATS; SPINAL CORD INJURIES; T-LYMPHOCYTES; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 84856022478     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.11.051     Document Type: Article

References (38)

1. G.J. Bennett, and Y.K. Xie A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man Pain 33 1988 87 107
2. L. Cao, and J.A. DeLeo CNS-infiltrating CD4 T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain Eur. J. Immunol. 38 2008 448 458
3. M.A. Chan, J.E. Kohlmeier, M. Branden, M. Jung, and S.H. Benedict Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506 Phytother. Res. 13 1999 464 467 (Pubitemid 29445761)
4. S.R. Chaplan, F.W. Bach, J.W. Pogrel, J.M. Chung, and T.L. Yaksh Quantitative assessment of tactile allodynia in the rat paw J. Neurosci. Methods 53 1994 55 63 (Pubitemid 24238751)
5. W.C. Covey, T.A. Ignatowski, A.E. Renauld, P.R. Knight, N.D. Nader, and R.N. Spengler Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain Reg. Anesth. Pain Med. 27 2002 357 366 (Pubitemid 34787388)
6. J.G. Cui, S. Holmin, T. Mathiesen, B.A. Meyerson, and B. Linderoth Possible role of inflammatory mediators in tactile hypersensitivity in rat Pain 88 2000 239 248
7. J.A. DeLeo, F.Y. Tanga, and V.L. Tawfik Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia Neuroscientist 10 2004 40 52 (Pubitemid 38112699)
8. N.B. Finnerup, S.H. Sindrup, and T.S. Jensen The evidence for pharmacological treatment of neuropathic pain Pain 150 2010 573 581
9. K. Hargreaves, R. Dubner, F. Brown, C. Flores, and J. Joris A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia Pain 32 1988 77 88
10. P. Hu, and E.M. McLachlan Macrophage and lymphocyte invasion of dorsal root ganglia after peripheral nerve lesions in the rat Neuroscience 112 2002 23 38 (Pubitemid 34603495)
11. P.N. Huynh, A.P. Hikim, and C. Wang Long-term effects of triptolide on spermatogenesis, epididymal sperm function, and fertility in male rats J. Androl. 21 2000 689 699
12. H.P. Kim, J. Imbert, and W.J. Leonard Both integrated and differential regulation of components of the IL-2/IL-2 receptor system Cytokine Growth Factor Rev. 17 2006 349 366 (Pubitemid 44604346)
13. T.M. Kiviharju, P.S. Lecane, R.G. Sellers, and D.M. Peehl Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells Clin. Cancer Res. 8 2002 2666 2674 (Pubitemid 34856355)
14. C.T. Kuo, M.L. Veselits, and J.M. Leiden A transcriptional regulator of singlepositive T cell quiescence and survival Science 277 1997 1986 1990 (Pubitemid 27449139)
15. J.X. Lin, and W.J. Leonard Signaling from the IL-2 receptor to the nucleus Cytokine Growth Factor Rev. 8 1997 313 332 (Pubitemid 28201656)
16. Q. Liu, T. Chen, G. Chen, X. Shu, A. Sun, P. Ma, L. Lu, and X. Cao Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K Akt and NF-kappa B pathways Mol. Immunol. 44 2007 2686 2696 (Pubitemid 46240316)
17. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(- Delta Delta C(T)) method Methods 25 2001 402 408 (Pubitemid 34164012)
18. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the folin phenol reagent Biol. Chem. 193 1951 265 275
19. H. Lu, M. Hachida, S. Enosawa, X.K. Li, S. Suzuki, and H. Koyanagi Immunosuppressive effect of triptolide in vitro Transplant. Proc. 31 1999 2056 2057 (Pubitemid 29376525)
20. A. Ma, R. Koka, and P. Burkett Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis Annu. Rev. Immunol. 24 2006 657 679
21. G. Moalem, K. Xu, and L. Yu T lymphocytes play a role in neuropathic following peripheral nerve injury in rats Neuroscience 129 2004 767 777 (Pubitemid 39487128)
22. G. Moalem-Taylor, H.N. Allbutt, M.D. Iordanova, and D.J. Tracey Pain hypersensitivity in rats with experimental autoimmune neuritis: an animal model of human inflammatory demyelinating neuropathy Brain Behav. Immun. 21 2007 699 710 (Pubitemid 46829765)
23. C.E. Orhan, A. Onal, and S. Ulker Antihyperalgesic and antiallodynic effect of sirolimus in neuropathic pain and the role of cytokines in this effect Neurosci. Lett. 481 2010 17 20
24. D. Qiu, and P.N. Kao Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook F Drugs 4 2003 1 18 (Pubitemid 37062640)
25. D. Qiu, G. Zhao, Y. Aoki, L. Shi, A. Uyei, S. Nazarian, J.C. Ng, and P.N. Kao Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kB transcriptional activation J. Biol. Chem. 274 1999 13443 13450
26. V. Raghavendra, M.D. Rutkowski, and J.A. DeLeo The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats J. Neurosci. 22 2002 9980 9989 (Pubitemid 35332883)
27. E. Serfling, A. Avots, and M. Neumann The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation Biochim. Biophys. Acta 1263 3 1995 181 200
28. W.H. Shen, C.Y. Zhang, and G.Y. Zhang Antioxidants attenuate reperfusion injury after global brain ischemia through inhibiting nuclear factor-kappa B activity in rats Acta Pharmacol. Sin. 24 2003 1125 1130
29. K. Smith The interleukin 2 receptor Annu. Rev. Cell. Biol. 5 397 1989 1989
30. C. Sommer, and J.M. Schroder HLA-DR expression in peripheral neuropathies: the role of Schwann cells, resident and hematogenous macrophages, and endoneurial fibroblasts Acta Neuropathol. 89 1995 63 71
31. R.V. Storkson, A. Kjorsvik, A. Tjolsen, and K. Hole Lumbar catheterization of the spinal subarachnoid space in the rat J. Neurosci. Methods 65 1996 167 172 (Pubitemid 26132817)
32. S.M. Sweitzer, W.F. Hickey, M.D. Rutkowski, J.L. Pahl, and J.A. DeLeo Focal peripheral nerve injury induces leukocyte trafficking into the central nervous system: potential relationship to neuropathic pain Pain 100 2002 163 170 (Pubitemid 35305133)
33. M.A. Thacker, A.K. Clark, F. Marchand, and S.B. McMahon Pathophysiology of peripheral neuropathic pain: immune cells and molecules Anesth. Analg. 105 2007 838 847 (Pubitemid 47300869)
34. C. Toth, J.A. Martinez, W.Q. Liu, J. Diggle, G.F. Guo, N. Ramji, R. Mi, A. Hoke, and D.W. Zochodne Local erythropoietin signaling enhances regeneration in peripheral axons Neuroscience 154 2008 767 783
35. L.R. Watkins, and S.F. Maier Beyond neurons: evidence that immune and glial cells contribute to pathological pain states Physiol. Rev. 82 2002 981 1011
36. Y. Yang, Z. Liu, E. Tolosa, J. Yang, and L. Li Triptolide induces apoptotic death of T lymphocyte Immunopharmacology 40 1998 139 149 (Pubitemid 28439168)
37. K.J. Zhu, Q.Y. Shen, H. Cheng, X.H. Mao, L.M. Lao, and L.L. Hao Triptolide affects the differentiation, maturation and function of human dendritic cells Int. Immunopharmacol. 5 2005 1415 1426 (Pubitemid 40813298)
38. M. Zimmermann Pathobiology of neuropathic pain Eur. J. Pharmacol. 429 2001 23 37 (Pubitemid 33043979)