Potent antibacterial activity of Y-754, a novel benzimidazole compound with selective action against Helicobacter pylori

Journal of Infection and Chemotherapy

Volumn 10, Issue 2, 2004, Pages 90-96

  Iwao, Eiji ^a   Yamamoto, Katsuhiro ^a   Yokoyama, Yoshito ^a   Hirayama, Fumihiro ^a   Haga, Keiichiro ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Antibacterial activity; Benzimidazole; Helicobacter pylori; Mongolian gerbil

Indexed keywords

2 [3 METHYL 4 [2 [2 (2,2,2 TRIFLUOROETHOXY)ETHYLTHIO] 2 PYRIDYL]METHYLTHIO] 1H BENZIMIDAZOLE; AMOXICILLIN; ANTIBIOTIC AGENT; CLARITHROMYCIN; METRONIDAZOLE; UNCLASSIFIED DRUG; Y 754;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; ERADICATION THERAPY; GENE MUTATION; GERBIL; HELICOBACTER PYLORI; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTIC ULCER; STOMACH INJURY; STOMACH MUCOSA;

EID: 2342599768     PISSN: 1341321X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10156-004-0299-1     Document Type: Article

References (19)

1. Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroenterology 1989;96:615-25.
2. Blaser MJ. Helicobacter pylori: its role in disease. Clin Infect Dis 1992;15:386-91.
3. Nomura A, Stemmermann GN, Chyou PH, Kato I, Perez-Perez GI, Blaser MJ. Helicobacterpylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 1991;325:1132-6.
4. Lambert T, Megraud F, Gerbaud G, Courvalin P. Susceptibility of Campylobacter pyloridis to 20 antimicrobial agents. Antimicrob Agents Chemother 1986;30:510-1.
5. The European Helicobacterpylori Study Group (EHPSG): current European concepts in the management of Helicobacter pylori infection. The Maastricht consensus report. Gut 1997;41:8-13.
6. American Digestive Health Foundation: the report of the digestive health initiative SM international update conference on Helicobacter pylori. Gastroenterology 1997;113(Suppl 6):S4-8.
7. Asaka M, Sugiyama T, Kato M, Satoh K, Kuwayama H, Fukuda Y, et al. A multicenter, double-blind study on triple therapy with lansoprazole, amoxicillin and clarithromycin for eradication of Helicobacterpylori in Japanese peptic ulcer patients. Helicobacter 2001;6:254-61.
8. Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow ED, Blackbourn SJ, et al. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet 1988;11:1437-42.
9. Rauws EAJ, Tytgat GNJ. Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 1990;335:1233-5.
10. Goddard AF, Logan RPH. Antimicrobial resistance and Helicobacter pylori. J Antimicrob Chemother 1996;37:639-43.
11. Kato M, Yamaoka Y, Kim JJ, Reddy R, Asaka M, Kashima K, et al. Regional differences in metronidazole resistance and increasing clarithromycin resistance among Helicobacter pylori isolates from Japan. Antimicrob Agents Chemother 2000;44:2214-6.
12. Miwa H, Nagahara A, Sato K, Ohkura R, Murai T, Shimizu H, et al. Efficacy of 1 week omeprazole or lansoprazole-amoxycillin-clarithromycin therapy for Helicobacter pylori infection in the Japanese population. J Gastroenterol Hepatol 1999;14:317-21.
13. Hirayama F, Takagi S, Yokoyama Y, Iwao E, Ikeda Y. Establishment of gastric Helicobacter pylori infection in Mongolian gerbils. J Gastroenterol 1996;31(Suppl 9):24-8.
14. Hirayama F, Takagi S, Kusuhara H, Iwao E, Yokoyama Y, Ikeda Y. Induction of gastric ulcer and intestinal metaplasia in Mongolian gerbils infected with Helicobacter pylori. J Gastroenterol 1996;31:755-7.
15. Honda S, Fujioka T, Tokieda M, Gotoh T, Nishizono A, Nasu M. Gastric ulcer, atrophic gastritis, and intestinal metaplasia caused by Helicobacter pylori infection in Mongolian gerbils. Scand J Gastroenterol 1998;33:454-60.
16. Ikeno T, Ota H, Sugiyama A, Ishida K, Katsuyama T, Genta RM, et al. Helicobacterpylori-induced chronic active gastritis, intestinal metaplasia, and gastric ulcer in Mongolian gerbils. Am J Pathol 1999;154:951-60.
17. Honda S, Fujioka T, Tokieda M, Satoh R, Nishizono A, Nasu M. Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils. Cancer Res 1998;58:4255-9.
18. Iwao E, Yokoyama Y, Yamamoto K, Hirayama F, Haga K. In vitro and in vivo anti-Helicobacter pylori activity of Y-904, a new fluoroquinolone. J Chemother Infect 2003;9:165-71.
19. Rautelin H, Seppala K, Renkonen OV, Vainio U, Kosunen TU. Role of metronidazole resistance in therapy of Helicobacterpylori infections. Antimicrob Agents Chemother 1992;36:163-6.