Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, part 2

Journal of Medicinal Chemistry

Volumn 45, Issue 19, 2002, Pages 4300-4309

  Carcanague, Daniel ^a   Shue, Youe Kong ^a   Wuonola, Mark A ^a   Uria Nickelsen, Maria ^a   Joubran, Camil ^a   Abedi, Joseph K ^a   Jones, Jeanette ^a   Kühler, Thomas C ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[(2 PYRIDYL)METHYL]THIO] 1H BENZIMIDAZOLE; 2 [[3 [(1H BENZIMIDAZOL 2 YLSULFANYL)METHYL] 2 METHYLPHENYL]SULFANYL]ETHYL CARBAMATE; 2 [[3 [(1H BENZIMIDAZOL 2 YLSULFANYL)METHYL]PHENYL]SULFANYL] 1 ETHANOL; AMIDE; AMINE; BENZIMIDAZOLE DERIVATIVE; CARBAMIC ACID DERIVATIVE; CARBOXYLIC ACID; CLARITHROMYCIN; ISOCYANIC ACID DERIVATIVE; METRONIDAZOLE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANAEROBIC BACTERIUM; ANTIBIOTIC RESISTANCE; ARTICLE; CHROMATOGRAPHY; DILUTION; DRUG SYNTHESIS; HELICOBACTER PYLORI; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

ANIMALS; ANTI-BACTERIAL AGENTS; BENZIMIDAZOLES; COLONY COUNT, MICROBIAL; DRUG RESISTANCE, BACTERIAL; FEMALE; HELICOBACTER PYLORI; KINETICS; MICE; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037068474     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020868v     Document Type: Article

References (21)

1. Helicobacter pylori infection
2. Helicobacter pylori: Its role in disease
3. Campylobacter pylori and peptic ulcer disease
4. A comparative study of the rod and coccoid forms of Campylobacter jejuni ATCC 29428
5. Factors affecting growth and susceptibility testing of Helicobacter pylori in liquid media
6. Antimicrobial susceptibility testing of Helicobacter pylori. Comparison of E-test, broth microdilution, and disk diffusion for ampicillin, clarithromycin, and metronidazole
7. The susceptibility of Helicobacter pylori to 12 antimicrobial agents, omeprazole and bismuth salts
8. Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti Helicobacter pylori agents, part 1
9. Omeprazole plus one or two antibiotics to eradicate H. pylori
10. Evaluation of various multi-drug eradication regimens for Helicobacter pylori
11. Antimicrobial resistance and Helicobacter pylori
12. Metronidazole resistance significantly affects eradication of H. pylori infection
13. Treatment of Helicobacter pylori infection: A review of the world literature
14. Antimicrobial resistance and Helicobacter pylori
15. Pre and posttreatment clarithromycin resistance of Helicobacter pylori strains: A key factor of treatment failure
16. Prevalence of Helicobacter pylori resistance to metronidazole, clarithromycin, amoxycillin, tetracycline and trovafloxacin in The Netherlands
17. Rapid increase in the prevalence of metronidazole-resistant Helicobacter pylori in The Netherlands
18. Kill kinetics of antimicrobial agents against Helicobacter pylori
19. Chemical information management in drug discovery: Optimizing the computational and combinatorial interfaces