In vitro antiplasmodial activity of indole alkaloids from the stem bark of Geissospermum vellosii

Journal of Ethnopharmacology

Volumn 139, Issue 2, 2012, Pages 471-477

  Mbeunkui, Flaubert ^a   Grace, Mary H ^a   Lategan, Carmen ^b   Smith, Peter J ^b   Raskin, Ilya ^c   Lila, Mary Ann ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Antiplasmodial activity; Apocynaceae; Geissospermum vellosii; Indole alkaloids; Malaria

Indexed keywords

CHLOROQUINE; EMETINE; GEISSOLOSIMINE; GEISSOSCHIZOLINE; GEISSOSPERMINE; GEISSOSPERMUM VELLOSII EXTRACT; INDOLE ALKALOID; METHANOL; PLANT EXTRACT; UNCLASSIFIED DRUG; VELLOSIMINOL;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; BARK; COUNTER CURRENT CHROMATOGRAPHY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; FEMALE; GEISSOSPERMUM VELLOSII; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; IN VITRO STUDY; MASS SPECTROMETRY; MEDICINAL PLANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; APOCYNACEAE; CELL SURVIVAL; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLE ALKALOIDS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLANT BARK; PLANTS, MEDICINAL; PLASMODIUM FALCIPARUM;

APOCYNACEAE; GEISSOSPERMUM; PLASMODIUM FALCIPARUM;

EID: 84856012987     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.11.036     Document Type: Article

References (32)

1. J.Q. Araujo, J.A. Lima, A.C. Pinto, R.B. de Alencastro, and M.G. Albuquerque Docking of the alkaloid geissospermine into acetylcholinesterase: a natural scaffold targeting the treatment of Alzheimer's disease Journal of Molecular Modeling 17 2011 1401 1412
2. Beljanski, M., 1994. Flavopereirine-based pharmaceutical composition for treatment of HIV infection. Patent family written in French. PCT Int. Appl. p. 33.
3. S. Bertani, G. Bourdy, I. Landau, J.C. Robinson, P. Esterre, and E. Deharo Evaluation of French Guiana traditional antimalarial remedies Journal of Ethnopharmacology 98 2005 45 54 (Pubitemid 40349166)
4. H. Budzikiewicz, J.M. Wilson, C. Djerassi, J. Levy, J. LeMen, and M.M. Janot Mass spectrometry in structural and stereochemical problems. XIX. Akuammicine and related alkaloids Tetrahedron 19 1963 1265 1276
5. A. Chiaroni, C. Riche, M. Pais, and R. Goutarel Alcaloides indoliques CIV: structure cristalline de la geissospermine Tetrahedron Letters 51 1976 4729 4730
6. A. Chiaroni, and C. Riche Structure and stereochemistry of indole alkaloids. 5. Structure of geissospermine Acta Crystallographica. Section B 35 1979 1820 1825
7. R.S. Costa, J.A. Lima, A.C. Pinto, and M.S. Rocha Fracão de extrato de Geissospermum vellosii reverte a amnésia induzida por escopolamina em camundongos Federacão de Sociedades de Biologia Experimental Abstracts 2006 13075
8. N.P. Dos Santos Passando da doutrina à prática: Ezequiel Corrêa dos Santos ea farmácia nacional Química Nova 4 2007 1038 1045
9. N.P. Dos Santos, A.C. Pinto, and R.B. Alencastro Theodoro Peckolt, farmacêutico do Brasil Imperial Quimica Nova 21 1998 666 670
10. 13C NMR analysis of geissospermine and its indole alkaloid monomer fragments Tetrahedron Letters 19 1978 1235 1238
11. M.H. Grace, C. Lategan, F. Mbeunkui, R. Graziose, P.J. Smith, I. Raskin, and M.A. Lila Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana Natural Product Communication 5 2010 1869 1872
12. R. Graziose, T. Rathinasabapathy, C. Lategan, A. Poulev, P.J. Smith, M. Grace, M.A. Lila, and I. Raskin Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L Journal of Ethnopharmacology 133 2011 26 30
13. N.A. Hughes, and H. Rapoport Flavopereirine, an alkaloid from Geissospermum vellosii Journal of the American Chemical Society 80 1958 1604 1609
14. J.A. Lima, R.S. Costa, R.A. Epifanio, N.G. Castro, M.S. Rocha, and A.C. Pinto Geissospermum vellosii stembark: anticholinesterase activity and improvement of scopolamine-induced memory deficits Pharmacology, Biochemistry, and Behavior 92 2009 508 513
15. M.T. Makler, J.M. Ries, J.A. Williams, J.E. Bancroft, R.C. Piper, B.L. Gibbins, and D.J. Hinrichs Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity American Journal of Tropical Medicine and Hygiene 48 1993 739 741 (Pubitemid 23238452)
16. R.H.F. Manske, and H.L. Holmes The Alkaloids Chemistry and Physiology 1952 Academic Press Inc. New York
17. F. Mbeunkui, M.H. Grace, C. Lategan, P.J. Smith, I. Raskin, and M.A. Lila Isolation and identification of antiplasmodial N-alkylamides from Spilanthes acmella flowers using centrifugal partition chromatography and ESI-IT-TOF-MS Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 879 2011 1886 1892
18. W. Milliken Traditional antimalarial medicine in Roaramia, Brazil Economic Botany 51 1997 212 237 (Pubitemid 27416032)
19. M.S. Morales-Rios, and P. Joseph-Nathan NMR studies of indoles and their N-carboalkoxy derivatives Magnetic Resonance in Chemistry 25 1987 911 918
20. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 65 1983 55 63 (Pubitemid 14203433)
21. V. Munoz, M. Sauvain, G. Bourdy, J. Callapa, S. Bergeron, I. Rojas, J.A. Bravo, L. Balderrama, B. Ortiz, A. Gimenez, and E. Deharo A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part I. Evaluation of the antimalarial activity of plants used by the Chacobo Indians Journal of Ethnopharmacology 69 2000 127 137 (Pubitemid 30016027)
22. J.F. Norton Atlas of Medicinal Plants of Middle America 1981 C Thomas Springfield, IL
23. G. Peckolt As dez árvores genuinamente brasileiras mais úteis na medicina Revista da Flora Medicinal 9 1942 453 470
24. H. Rapoport, T.P. Onak, N.A. Hughes, and M.G. Reinecke Alkaloids of Geissospermum vellosii Journal of the American Chemical Society 80 1958 1601 1604
25. H. Rapoport, and R.E. Moore Alkaloids of Geissospermum vellosii. Isolation and structure determinations of vellosimine, vellosiminol, and geissolosimine Journal of Organic Chemistry 27 1962 2981 2985
26. R.G. Ridley Planting the seeds of new antimalarial drugs Science 285 1999 1502 1503 (Pubitemid 29420566)
27. C.F. Spencer, F.R. Koniuszy, E.F. Rogers, J. Shavel, N.R. Easton, E.A. Kaczka, F.A. Kuehl, R.F. Phillips, A. Walti, K. Folkers, C. Malanga, and A.O. Seeler Surgery of plants for antimalarial activity Lloydia 10 1947 145 147
28. J.C. Steele, N.C. Veitch, G.C. Kite, M.S. Simmonds, and D.C. Warhurst Indole and beta-carboline alkaloids from Geissospermum sericeum Journal of Natural Products 65 2002 85 88 (Pubitemid 34118822)
29. W. Trager, and J.B. Jensen Human malaria parasites in continuous culture Science 193 1976 673 675
30. E. Tyihák, and D. Vágujfalvi Dragendorff reactions for visualization of amino acids and amino acid derivatives separated by paper or thin-layer chromatography Journal of Chromatography 49 1970 343 348
31. N.J. White Drug resistance in malaria British Medical Bulletin 54 1998 703 715 (Pubitemid 28477205)
32. World Health Organization World Malaria Report 2009 2009