Analogues of doxanthrine reveal differences between the dopamine D 1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines

European Journal of Medicinal Chemistry

Volumn 48, Issue , 2012, Pages 97-107

  Cueva, Juan Pablo ^a   Chemel, Benjamin R ^b   Juncosa Jr , Jose I ^c   Lill, Markus A ^d   Watts, Val J ^d   Nichols, David E ^d  

^a Quimique Cía Ltda   (Ecuador)

^b FOREST AND RANGELAND ECOSYSTEM SCIENCE CENTER   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d PURDUE UNIVERSITY   (United States)

Author keywords

Agonist; Dihydrexidine; Dopamine D 1 receptor; Doxanthrine

Indexed keywords

11 METHYL 2,3 DIHYDROXY 6A,7,8,12B TETRAHYDRO 6H CHROMEN[3,4 C]ISOQUINOLINE HYDROBROMIDE; 2 (4 ETHYLPHENYL) 4,4 DIMETHYLOXAZOLINE; 2 (4 TRIFLUOROMETHYLPHENYL) 4,4 DIMETHYLOXAZOLINE; 2,3 DIHYDROXY 11 ETHYL 6A,7,8,12B TETRAHYDRO 6H CHROMEN[3,4 C]ISOQUINOLINE HYDROBROMIDE; 2,3 METHYLENEDIOXY 11 ETHYL 6A,12B DIHYDRO 6H CHROMEN[3,4 C]ISOQUINOLIN 8 ONE; 2,3 METHYLENEDIOXY 11 FLUORO 6A,12B DIHYDRO 6H CHROMEN[3,4 C]ISOQUINOLIN 8 ONE; 2,3 METHYLENEDIOXY 11 METHYL 6A,12B DIHYDRO 6H CHROMEN[3,4 C]ISOQUINOLIN 8 ONE; 2,3 METHYLENEDIOXY 11 METHYL 6A,7,8,12B TETRAHYDRO 6H CHROMEN[3,4 C]ISOQUINOLINE; 2,3 METHYLENEDIOXY 6A,12B DIHYDRO 6H THIOCHROMEN[3,4 C]ISOQUINOLINE; 2,3 METHYLENEDIOXY 6A,7,8,12B TETRAHYDRO 6H THIOCHROMEN[3,4 C]ISOQUINOLINE; 3 NITRO 2H 6,7 METHYLENEDIOXYCHROMENE; 3 NITRO 2H 6,7 METHYLENEDIOXYTHIOCHROMENE; 4 [2 (4,4 DIMETHYL OXAZOLIN 2 YL) 5 ETHYLPHENYL] 6,7 METHYLENEDIOXY 3 NITROCHROMAN; 4 [2 (4,4 DIMETHYL OXAZOLIN 2 YL) 5 TRIFLUOROMETHYLPHENYL] 6,7 METHYLENEDIOXY 3 NITROCHROMAN; 4 [2 (4,4 DIMETHYLOXAZOLIN 2 YL) 5 FLUOROPHENYL] 6,7 METHYLENEDIOXY 3 NITROCHROMAN; 4 [2 (4,4 DIMETHYLOXAZOLIN 2 YL) 5 METHYLPHENYL] 6,7 METHYLENEDIOXY 3 NITROCHROMAN; 6 (O DIMETHYLTHIOCARBAMOYL) 1,3 BENZODIOXOLE; 6 (S DIMETHYLTHIOCARBAMOYL) 1,3 BENZODIOXOLE; 6 HYDROXYBENZO[1,3]DIOXOLE 5 CARBOXALDEHYDE; 9H BIS([1,3]DIOXOLO[4,5B:4',5' I])XANTHYLIUM CHLORIDE; CHROMAN DERIVATIVE; CHROMANOISOQUINOLINE DERIVATIVE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOXANTHRINE DERIVATIVE; HEXAHYDROBENZO[A]PHENANTHRIDINE DERIVATIVE; ISOQUINOLINE DERIVATIVE; PHENANTHRIDINE DERIVATIVE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN;

ANIMALS; CORPUS STRIATUM; DOPAMINE AGONISTS; ISOQUINOLINES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PHENANTHRIDINES; RECEPTORS, DOPAMINE D1; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 84856007599     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.11.039     Document Type: Article

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