8,9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: A potent full dopamine D1 agonist containing a rigid β-phenyldopamine pharmacophore

Journal of Medicinal Chemistry

Volumn 39, Issue 2, 1996, Pages 549-555

  Ghosh, Debasis ^a   Snyder, Scott E ^a   Watts, Val J ^b   Mailman, Richard B ^b   Nichols, David E ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 3 ALLYL 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DIHYDREXIDINE; DINAPSOLINE; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR STIMULATING AGENT; DOPAMINE 2 RECEPTOR; UNCLASSIFIED DRUG; ADENYLATE CYCLASE; CYCLIC AMP; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; ISOQUINOLINE DERIVATIVE; NAPHTHOL DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MALE; NONHUMAN; PARKINSON DISEASE; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL CULTURE; CHEMISTRY; CORPUS STRIATUM; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; MACACA; METABOLISM; SPRAGUE DAWLEY RAT;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ADENYLATE CYCLASE; ANIMALS; CORPUS STRIATUM; CYCLIC AMP; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; ISOQUINOLINES; MACACA MULATTA; MALE; NAPHTHOLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; TUMOR CELLS, CULTURED;

EID: 0029664618     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950707+     Document Type: Article

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