Vascular smooth muscle cell-derived adiponectin: A paracrine regulator of contractile phenotype

Journal of Molecular and Cellular Cardiology

Volumn 52, Issue 2, 2012, Pages 474-484

  Ding, Min ^a,b   Carrão, Ana Catarina ^b   Wagner, Robert J ^a   Xie, Yi ^b   Jin, Yu ^b   Rzucidlo, Eva M ^a   Yu, Jun ^b   Li, Wei ^b   Tellides, George ^b   Hwa, John ^a,b   Aprahamian, Tamar R ^c   Martin, Kathleen A ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adiponectin; Autocrine; Contractile phenotype; Contractile proteins; Paracrine; Vascular smooth muscle

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADIPONECTIN; ALPHA SMOOTH MUSCLE ACTIN; CALDESMON; CALNEXIN; CALPONIN; CELL MARKER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 2; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MYOSIN HEAVY CHAIN; NEUTRALIZING ANTIBODY; PROTEIN KINASE B; PROTEIN NOGO B; ROSIGLITAZONE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR GATA 6; TRANSGELIN; UNCLASSIFIED DRUG;

ACTA2 GENE; ANIMAL CELL; AORTA MEDIA; ARTERY MUSCLE; ARTICLE; AUTOCRINE EFFECT; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CNN GENE; CONTROLLED STUDY; CORONARY ARTERY; CULTURE MEDIUM; ENDOPLASMIC RETICULUM; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; MYH11 GENE; NONHUMAN; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SMOOTH MUSCLE FIBER; TGLN GENE; VASCULAR SMOOTH MUSCLE;

ADIPONECTIN; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ENDOPLASMIC RETICULUM; FEMALE; GENE EXPRESSION; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PARACRINE COMMUNICATION; PPAR GAMMA; PROTEIN TRANSPORT; THIAZOLIDINEDIONES;

MUS;

EID: 84855996178     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.09.008     Document Type: Article

References (62)

1. Hopkins T.A., Ouchi N., Shibata R., Walsh K. Adiponectin actions in the cardiovascular system. Cardiovasc Res 2007 Apr 1, 74(1):11-18.
2. Okamoto Y., YA, Nishida M., Muraguchi M., Ouchi N., Takahashi M., et al. An Adipocyte-Derived Plasma Protein, Adiponectin, Adheres to Injured Vascular Walls. Horm Metab Res 2000, 32:47-50.
3. Dzielinska Z., Januszewicz A., Wiecek A., Demkow M., Makowiecka-Ciesla M., Prejbisz A., et al. Decreased plasma concentration of a novel anti-inflammatory protein-adiponectin-in hypertensive men with coronary artery disease. Thromb Res 2003 Jun 15, 110(5-6):365-369.
4. Yaturu S., Bridges J.F., Subba Reddy D.R. Decreased levels of plasma adiponectin in prediabetes, Type 2 diabetes and coronary artery disease. Med Sci Monit 2006 Jan, 12(1):CR17-20.
5. Kumada M., Kihara S., Sumitsuji S., Kawamoto T., Matsumoto S., Ouchi N., et al. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003 Jan 1, 23(1):85-89.
6. Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 2000, 96(5):1723-1732. 2000 September 1.
7. Hotta K., Funahashi T., Bodkin N.L., Ortmeyer H.K., Arita Y., Hansen B.C., et al. Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys. Diabetes 2001, 50(5):1126-1133. 2001 May 1.
8. Yamauchi T., Kamon J., Waki H., Imai Y., Shimozawa N., Hioki K., et al. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 2003, 278(4):2461-2468. 2003 January 24.
9. Chen H., Montagnani M., Funahashi T., Shimomura I., Quon M.J. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 2003, 278(45):45021-45026. 2003 November 7.
10. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001, 7(8):941-946.
11. Berg A.H., Combs T.P., Du X., Brownlee M., Scherer P.E. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001, 7(8):947-953.
12. Maeda N., Shimomura I., Kishida K., Nishizawa H., Matsuda M., Nagaretani H., et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002, 8(7):731-737.
13. Matsuzawa Y. Establishment of a concept of visceral fat syndrome and discovery of adiponectin. Proc Jpn Acad Ser B Phys Biol Sci 2010, 86(2):131-141.
14. Maeda N., Shimomura I., Kishida K., Nishizawa H., Matsuda M., Nagaretani H., et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002 Jul, 8(7):731-737.
15. Matsuda M., Shimomura I., Sata M., Arita Y., Nishida M., Maeda N., et al. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem 2002 Oct 4, 277(40):37487-37491.
16. Kato H., Kashiwagi H., Shiraga M., Tadokoro S., Kamae T., Ujiie H., et al. Adiponectin acts as an endogenous antithrombotic factor. Arterioscler Thromb Vasc Biol 2006 Jan, 26(1):224-230.
17. Ohashi K., Kihara S., Ouchi N., Kumada M., Fujita K., Hiuge A., et al. Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension 2006 Jun, 47(6):1108-1116.
18. Shibata R., Sato K., Pimentel D.R., Takemura Y., Kihara S., Ohashi K., et al. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med 2005 Oct, 11(10):1096-1103.
19. Okui H., Hamasaki S., Ishida S., Kataoka T., Orihara K., Fukudome T., et al. Adiponectin is a better predictor of endothelial function of the coronary artery than HOMA-R, body mass index, immunoreactive insulin, or triglycerides. Int J Cardiol 2008 May 7, 126(1):53-61.
20. Scherer P.E., Williams S., Fogliano M., Baldini G., Lodish H.F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995, 270(45):26746-26749. 1995 November 10.
21. Maeda K., Okubo K., Shimomura I., Funahashi T., Matsuzawa Y., Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 1996 Apr 16, 221(2):286-289.
22. Wang Y., Lam K.S., Yau M.H., Xu A. Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J 2008 Feb 1, 409(3):623-633.
23. Shetty S., Kusminski C.M., Scherer P.E. Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies. Trends Pharmacol Sci 2009 May, 30(5):234-239.
24. Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003, 423(6941):762-769.
25. Hug C., Wang J., Ahmad N.S., Bogan J.S., Tsao T.S., Lodish H.F. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci USA 2004 Jul 13, 101(28):10308-10313.
26. Denzel M.S., Scimia M.C., Zumstein P.M., Walsh K., Ruiz-Lozano P., Ranscht B. T-cadherin is critical for adiponectin-mediated cardioprotection in mice. J Clin Invest 2010 Dec 1, 120(12):4342-4352.
27. Martin K.A., Rzucidlo E.M., Merenick B.L., Fingar D.C., Brown D.J., Wagner R.J., et al. The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation. Am J Physiol Cell Physiol 2004 Mar, 286(3):C507-C517.
28. Martin K.A., Merenick B.L., Ding M., Fetalvero K.M., Rzucidlo E.M., Kozul C.D., et al. Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling. J Biol Chem 2007 Dec 7, 282(49):36112-36120.
29. Fetalvero K.M., Shyu M., Nomikos A.P., Chiu Y.F., Wagner R.J., Powell R.J., et al. The prostacyclin receptor induces human vascular smooth muscle cell differentiation via the protein kinase A pathway. Am J Physiol Heart Circ Physiol 2006 Apr, 290(4):H1337-H1346.
30. Banga A., Bodles A.M., Rasouli N., Ranganathan G., Kern P.A., Owens R.J. Calcium is involved in formation of high molecular weight adiponectin. Metab Syndr Relat Disord 2008 Summer, 6(2):103-111.
31. Ding M., Xie Y., Wagner R.J., Jin Y., Carrao A.C., Liu L.S., et al. Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4. Arterioscler Thromb Vasc Biol 2011 Jun, 31(6):1403-1410.
32. Takaoka M., Suzuki H., Shioda S., Sekikawa K., Saito Y., Nagai R., et al. Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue. Arterioscler Thromb Vasc Biol 2010, 30(8):1576-1582. 2010 August 1.
33. Kitta Y., Takano H., Nakamura T., Kodama Y., Umetani K., Fujioka D., et al. Low adiponectin levels predict late in-stent restenosis after bare metal stenting in native coronary arteries. Int J Cardiol 2008 Dec 17, 131(1):78-82.
34. Moldoveanu E., Mut-Vitcu B., Tanaseanu G.R., Marta D.S., Manea G., Kosaka T., et al. Low basal levels of circulating adiponectin in patients undergoing coronary stenting predict in-stent restenosis, independently of basal levels of inflammatory markers: lipoprotein associated phospholipase A2, and myeloperoxidase. Clin Biochem 2008 Dec, 41(18):1429-1433.
35. Scherer P.E., Williams S., Fogliano M., Baldini G., Lodish H.F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995 Nov 10, 270(45):26746-26749.
36. Pineiro R., Iglesias M.J., Gallego R., Raghay K., Eiras S., Rubio J., et al. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett 2005 Sep 26, 579(23):5163-5169.
37. Krause M.P., Liu Y., Vu V., Chan L., Xu A., Riddell M.C., et al. Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function. Am J Physiol Cell Physiol 2008, 295(1):C203-C212. 2008 July 1.
38. Berner H.S., Lyngstadaas S.P., Spahr A., Monjo M., Thommesen L., Drevon C.A., et al. Adiponectin and its receptors are expressed in bone-forming cells. Bone 2004 Oct, 35(4):842-849.
39. Caminos J.E., Nogueiras R., Gallego R., Bravo S., Tovar S., Garcia-Caballero T., et al. Expression and regulation of adiponectin and receptor in human and rat placenta. J Clin Endocrinol Metab 2005 Jul, 90(7):4276-4286.
40. Rodriguez-Pacheco F., Martinez-Fuentes A.J., Tovar S., Pinilla L., Tena-Sempere M., Dieguez C., et al. Regulation of pituitary cell function by adiponectin. Endocrinology 2007 Jan, 148(1):401-410.
41. Yoda-Murakami M., Taniguchi M., Takahashi K., Kawamata S., Saito K., Choi-Miura N.H., et al. Change in expression of GBP28/adiponectin in carbon tetrachloride-administrated mouse liver. Biochem Biophys Res Commun 2001 Jul 13, 285(2):372-377.
42. Maresh J.G., Shohet R.V. In vivo endothelial gene regulation in diabetes. Cardiovasc Diabetol 2008, 7:8.
43. Singer C.A., Salinthone S., Baker K.J., Gerthoffer W.T. Synthesis of immune modulators by smooth muscles. Bioessays 2004 Jun, 26(6):646-655.
44. Acevedo L., Yu J., Erdjument-Bromage H., Miao R.Q., Kim J.E., Fulton D., et al. A new role for Nogo as a regulator of vascular remodeling. Nat Med 2004 Apr, 10(4):382-388.
45. Iwaki M., Matsuda M., Maeda N., Funahashi T., Matsuzawa Y., Makishima M., et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 2003, 52(7):1655-1663. 2003 July 1.
46. Rasouli N., Yao-Borengasser A., Varma V., Spencer H.J., McGehee R.E., Peterson C.A., et al. Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans. Arterioscler Thromb Vasc Biol 2009, 29(9):1328-1335. 2009 September 1.
47. Goldstein B.J., Scalia R.G., Ma X.L. Protective vascular and myocardial effects of adiponectin. Nat Clin Pract Cardiovasc Med 2009 Jan, 6(1):27-35.
48. Amin R.H., Mathews S.T., Camp H.S., Ding L., Leff T. Selective activation of PPAR{gamma} in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance. Am J Physiol Endocrinol Metab 2010, 298(1):E28-E37. 2010 January 1.
49. Arita Y., Kihara S., Ouchi N., Takahashi M., Maeda K., Miyagawa J., et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999, 257(1):79-83.
50. Piñeiro R., Iglesias M.J., Gallego R., Raghay K., Eiras S., Rubio J., et al. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett 2005, 579(23):5163-5169.
51. Wang Y., Lau W.B., Gao E., Tao L., Yuan Y., Li R., et al. Cardiomyocyte-derived adiponectin is biologically active in protecting against myocardial ischemia-reperfusion injury. Am J Physiol Endocrinol Metab 2010, 298(3):E663-E670. 2010 March 1.
52. Amin R.H., Mathews S.T., Alli A., Leff T. Endogenously produced adiponectin protects cardiomyocytes from hypertrophy by a PPARγ-dependent autocrine mechanism. Am J Physiol Heart Circ Physiol 2010, 299(3):H690-H698. 2010 September 1.
53. Liu Y., Chewchuk S., Lavigne C., Brule S., Pilon G., Houde V., et al. Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes, and regulation by rosiglitazone treatment. Am J Physiol Endocrinol Metab 2009 Sep, 297(3):E657-E664.
54. Shinoda Y., Yamaguchi M., Ogata N., Akune T., Kubota N., Yamauchi T., et al. Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 2006 Sep 1, 99(1):196-208.
55. Wang Y., Lau W.B., Gao E., Tao L., Yuan Y., Li R., et al. Cardiomyocyte-derived adiponectin is biologically active in protecting against myocardial ischemia-reperfusion injury. Am J Physiol Endocrinol Metab 2010 Mar, 298(3):E663-E670.
56. Ouedraogo R., Wu X., Xu S.-Q., Fuchsel L., Motoshima H., Mahadev K., et al. Adiponectin Suppression of High-Glucose-Induced Reactive Oxygen Species in Vascular Endothelial Cells. Diabetes June 2006, 55(6):1840-1846.
57. Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 2002 Jun 18, 105(24):2893-2898.
58. Law R.E., Goetze S., Xi X.P., Jackson S., Kawano Y., Demer L., et al. Expression and function of PPARgamma in rat and human vascular smooth muscle cells. Circulation 2000 Mar 21, 101(11):1311-1318.
59. Zhang L., Xie P., Wang J., Yang Q., Fang C., Zhou S., et al. Impaired peroxisome proliferator-activated receptor-γ contributes to phenotypic modulation of vascular smooth muscle cells during hypertension. J Biol Chem 2010, 285(18):13666-13677. 2010 April 30.
60. Nawrocki A.R., Rajala M.W., Tomas E., Pajvani U.B., Saha A.K., Trumbauer M.E., et al. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 2006 Feb 3, 281(5):2654-2660.
61. Li P., Shibata R., Unno K., Shimano M., Furukawa M., Ohashi T., et al. Evidence for the importance of adiponectin in the cardioprotective effects of pioglitazone. Hypertension 2010 Jan, 55(1):69-75.
62. Thomas G.D. Neural control of the circulation. Adv Physiol Educ 2011 Mar, 35(1):28-32.