Correlation of serum HE4 with tumor size and myometrial invasion in endometrial cancer

Gynecologic Oncology

Volumn 124, Issue 2, 2012, Pages 270-275

  Kalogera, Eleftheria ^a   Scholler, Nathalie ^b   Powless, Cecelia ^a   Weaver, Amy ^a   Drapkin, Ronny ^c   Li, Jinping ^a   Jiang, Shi Wen ^a   Podratz, Karl ^a   Urban, Nicole ^d   Dowdy, Sean C ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d USA   (United States)

Author keywords

Endometrial cancer; Human epididymis protein 4 (HE4); Tumor marker

Indexed keywords

HUMAN EPIDIDYMIS PROTEIN 4;

ADULT; ADVANCED CANCER; AGED; BLOOD LEVEL; CANCER GRADING; CANCER INVASION; CANCER STAGING; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOMETRIUM CANCER; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIMARY TUMOR; PRIORITY JOURNAL; TUMOR VOLUME; UTERUS CANCER;

ADULT; AGED; AGED, 80 AND OVER; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; MIDDLE AGED; MYOMETRIUM; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PILOT PROJECTS; PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 84855983043     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.10.025     Document Type: Conference Paper

References (55)

1. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics, 2010 CA Cancer J Clin 60 2010 277 300
2. E. Silverberg, C.C. Boring, and T.S. Squires Cancer statistics, 1990 CA Cancer J Clin 40 1990 9 26
3. A.G. Renehan, M. Tyson, M. Egger, R.F. Heller, and M. Zwahlen Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies Lancet 371 2008 569 578 (Pubitemid 351232031)
4. M. Fung-Kee-Fung, J. Dodge, L. Elit, H. Lukka, A. Chambers, and T. Oliver Follow-up after primary therapy for endometrial cancer: a systematic review Gynecol Oncol 101 2006 520 529 (Pubitemid 43729963)
5. S. Ginath, J. Menczer, Y. Fintsi, E. Ben-Shem, M. Glezerman, and I. Avinoach Tissue and serum CA125 expression in endometrial cancer Int J Gynecol Cancer 12 2002 372 375 (Pubitemid 34839835)
6. C.H. Hsieh, C.C. ChangChien, H. Lin, E.Y. Huang, C.C. Huang, and K.C. Lan Can a preoperative CA 125 level be a criterion for full pelvic lymphadenectomy in surgical staging of endometrial cancer? Gynecol Oncol 86 2002 28 33 (Pubitemid 34757047)
7. A.K. Sood, R.E. Buller, R.A. Burger, J.D. Dawson, J.I. Sorosky, and M. Berman Value of preoperative CA 125 level in the management of uterine cancer and prediction of clinical outcome Obstet Gynecol 90 1997 441 447 (Pubitemid 27357939)
8. M.H. Vuento, U.H. Stenman, J.P. Pirhonen, J.I. Makinen, P.J. Laippala, and T.A. Salmi Significance of a single CA 125 assay combined with ultrasound in the early detection of ovarian and endometrial cancer Gynecol Oncol 64 1997 141 146 (Pubitemid 27026972)
9. J.M. Duk, J.G. Aalders, G.J. Fleuren, and H.W. de Bruijn CA 125: a useful marker in endometrial carcinoma Am J Obstet Gynecol 155 1986 1097 1102 (Pubitemid 17176689)
10. J.M. Niloff, T.L. Klug, E. Schaetzl, V.R. Zurawski Jr. , R.C. Knapp, and R.C. Bast Jr. Elevation of serum CA125 in carcinomas of the fallopian tube, endometrium, and endocervix Am J Obstet Gynecol 148 1984 1057 1058 (Pubitemid 14136410)
11. R.E. Hawkins, K. Roberts, E. Wiltshaw, J. Mundy, and V.R. McCready The clinical correlates of serum CA125 in 169 patients with epithelial ovarian carcinoma Br J Cancer 60 1989 634 637 (Pubitemid 19251466)
12. G.J. Rustin, M. Marples, A.E. Nelstrop, M. Mahmoudi, and T. Meyer Use of CA-125 to define progression of ovarian cancer in patients with persistently elevated levels J Clin Oncol 19 2001 4054 4057 (Pubitemid 32976692)
13. G.J. Rustin, A.E. Nelstrop, M.K. Tuxen, and H.E. Lambert Defining progression of ovarian carcinoma during follow-up according to CA 125: a North Thames Ovary Group Study Ann Oncol 7 1996 361 364 (Pubitemid 26246787)
14. C. Kirchhoff, C. Osterhoff, I. Habben, and R. Ivell Cloning and analysis of mRNAs expressed specifically in the human epididymis Int J Androl 13 1990 155 167 (Pubitemid 20116937)
15. C. Kirchhoff, I. Habben, R. Ivell, and N. Krull A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors Biol Reprod 45 1991 350 357
16. A. Clauss, H. Lilja, and A. Lundwall The evolution of a genetic locus encoding small serine proteinase inhibitors Biochem Biophys Res Commun 333 2005 383 389 (Pubitemid 40848302)
17. L. Bingle, S.S. Cross, A.S. High, W.A. Wallace, D. Rassl, and G. Yuan WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung Respir Res 7 2006 61
18. D. Bouchard, D. Morisset, Y. Bourbonnais, and G.M. Tremblay Proteins with whey-acidic-protein motifs and cancer Lancet Oncol 7 2006 167 174 (Pubitemid 43159503)
19. H.M. Kluger, D. Chelouche Lev, Y. Kluger, M.M. McCarthy, G. Kiriakova, R.L. Camp, D.L. Rimm, and J.E. Price Using a xenograft model of human breast cancer metastasis to find genes associated with clinically aggressive disease Cancer Res 65 2005 5578 5587 (Pubitemid 40911158)
20. U. Westin, M. Nystrom, I. Ljungcrantz, B. Eriksson, and K. Ohlsson The presence of elafin, SLPI, IL1-RA and STNFalpha RI in head and neck squamous cell carcinomas and their relation to the degree of tumour differentiation Mediators Inflamm 11 2002 7 12 (Pubitemid 34252541)
21. J. Yang, J. Zhu, D. Sun, and A. Ding Suppression of macrophage responses to bacterial lipopolysaccharide (LPS) by secretory leukocyte protease inhibitor (SLPI) is independent of its anti-protease function Biochim Biophys Acta 1745 2005 310 317 (Pubitemid 41330785)
22. N. Yoshida, H. Egami, J. Yamashita, E. Takai, Y. Tamori, and N. Fujino Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung Oncol Rep 9 2002 495 501
23. M.T. Galgano, G.M. Hampton, and H.F. Frierson Jr. Comprehensive analysis of HE4 expression in normal and malignant human tissues Mod Pathol 19 2006 847 853 (Pubitemid 43780455)
24. R. Drapkin, H.H. von Horsten, Y. Lin, S.C. Mok, C.P. Crum, and W.R. Welch Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas Cancer Res 65 2005 2162 2169 (Pubitemid 40490123)
25. M.E. Schaner, D.T. Ross, G. Ciaravino, T. Sorlie, O. Troyanskaya, and M. Diehn Gene expression patterns in ovarian carcinomas Mol Biol Cell 14 2003 4376 4386 (Pubitemid 37444641)
26. I. Hellstrom, and K.E. Hellstrom SMRP and HE4 as biomarkers for ovarian carcinoma when used alone and in combination with CA125 and/or each other Adv Exp Med Biol 622 2008 15 21
27. I. Hellstrom, J. Raycraft, M. Hayden-Ledbetter, J.A. Ledbetter, M. Schummer, and M. McIntosh The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma Cancer Res 63 2003 3695 3700 (Pubitemid 36793054)
28. C.D. Hough, C.A. Sherman-Baust, E.S. Pizer, F.J. Montz, D.D. Im, and N.B. Rosenshein Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer Cancer Res 60 2000 6281 6287
29. K. Ono, T. Tanaka, T. Tsunoda, O. Kitahara, C. Kihara, and A. Okamoto Identification by cDNA microarray of genes involved in ovarian carcinogenesis Cancer Res 60 2000 5007 5011
30. M. Schummer, W.V. Ng, R.E. Bumgarner, P.S. Nelson, B. Schummer, and D.W. Bednarski Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas Gene 238 1999 375 385 (Pubitemid 29446174)
31. V. Shridhar, J. Lee, A. Pandita, S. Iturria, R. Avula, and J. Staub Genetic analysis of early- versus late-stage ovarian tumors Cancer Res 61 2001 5895 5904 (Pubitemid 32769109)
32. J.B. Welsh, P.P. Zarrinkar, L.M. Sapinoso, S.G. Kern, C.A. Behling, and B.J. Monk Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer Proc Natl Acad Sci U S A 98 2001 1176 1181 (Pubitemid 32121206)
33. R.G. Moore, A.K. Brown, M.C. Miller, S. Skates, W.J. Allard, and T. Verch The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass Gynecol Oncol 108 2008 402 408 (Pubitemid 351174295)
34. L. DeSouza, J. Grigull, S. Ghanny, V. Dubé, A. Romaschin, and T. Colgan Endometrial carcinoma biomarker discovery and verification using differentially tagged clinical samples with multidimensional liquid chromatography and tandem mass spectrometry Mol Cell Proteomics 6 2007 1170
35. H. Li, L. DeSouza, S. Ghanny, W. Li, A. Romaschin, and T. Colgan Identification of candidate biomarker proteins released by human endometrial and cervical cancer cells using two-dimensional liquid chromatography/tandem mass spectrometry J Proteome Res 6 2007 2615 2622 (Pubitemid 47122356)
36. R.G. Moore, A.K. Brown, M.C. Miller, D. Badgwell, Z. Lu, and W.J. Allard Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus Gynecol Oncol 110 2008 196 201
37. E. Bignotti, M. Ragnoli, L. Zanotti, S. Calza, M. Falchetti, and S. Lonardi Diagnostic and prognostic impact of serum HE4 detection in endometrial carcinoma patients Br J Cancer 104 2011 1418 1425
38. J.N. Bakkum-Gamez, A. Mariani, S.C. Dowdy, A.L. Weaver, M.E. McGree, and W.A. Cliby Podratz KC 2011 The impact of surgical guidelines and periodic quality assessment on the staging of endometrial cancer Gynecol Oncol
39. N. Scholler, K.A. Lowe, L.A. Bergan, A.V. Kampani, V. Ng, and R.M. Forrest Use of yeast-secreted in vivo biotinylated recombinant antibodies (Biobodies) in bead-based ELISA Clin Cancer Res 14 2008 2647 2655
40. E.P. Beck, M. Wagner, L. Anselmino, F. Xu, R.C. Bast Jr. , and W. Jaeger Is OVX1 a suitable marker for endometrial cancer? Gynecol Oncol 65 1997 291 296 (Pubitemid 27216943)
41. P.L. Cherchi, S. Dessole, G.A. Ruiu, G. Ambrosini, M. Farina, and G. Capobianco The value of serum CA 125 and association CA 125/CA 19-9 in endometrial carcinoma Eur J Gynaecol Oncol 20 1999 315 317 (Pubitemid 30113736)
42. H. Hareyama, N. Sakuragi, S. Makinoda, and S. Fujimoto Serum and tissue measurements of CA72-4 in patients with endometrial carcinoma J Clin Pathol 49 1996 967 970 (Pubitemid 27273805)
43. G. Olt, J. Soper, S. Ramakrishnan, F. Xu, A. Berchuck, and D. Clarke-Pearson Preoperative evaluation of macrophage colony-stimulating factor levels in patients with endometrial cancer Am J Obstet Gynecol 174 1996 1316 1319 (Pubitemid 26131154)
44. N. Takeshima, Y. Shimizu, S. Umezawa, Y. Hirai, J.T. Chen, and I. Fujimoto Combined assay of serum levels of CA125 and CA19-9 in endometrial carcinoma Gynecol Oncol 54 1994 321 326 (Pubitemid 24301907)
45. M. Kamei, S. Yamashita, K. Tokuishi, T. Hashioto, T. Moroga, and S. Suehiro HE4 expression can be associated with lymph node metastases and disease-free survival in breast cancer Anticancer Res 30 2010 4779 4783
46. A. Mariani, S.C. Dowdy, G.L. Keeney, M.G. Haddock, T.G. Lesnick, and K.C. Podratz Predictors of vaginal relapse in stage I endometrial cancer Gynecol Oncol 97 2005 820 827 (Pubitemid 40824652)
47. A. Mariani, M.J. Webb, L. Galli, and K.C. Podratz Potential therapeutic role of para-aortic lymphadenectomy in node-positive endometrial cancer Gynecol Oncol 76 2000 348 356 (Pubitemid 30131506)
48. A. Mariani, M.J. Webb, G.L. Keeney, G. Aletti, and K.C. Podratz Predictors of lymphatic failure in endometrial cancer Gynecol Oncol 84 2002 437 442 (Pubitemid 34211872)
49. A. Mariani, M.J. Webb, G.L. Keeney, M.G. Haddock, G. Calori, and K.C. Podratz Low-risk corpus cancer: is lymphadenectomy or radiotherapy necessary? Am J Obstet Gynecol 182 2000 1506 1519 (Pubitemid 30437424)
50. A. Mariani, M.J. Webb, G.L. Keeney, T.G. Lesnick, and K.C. Podratz Surgical stage I endometrial cancer: predictors of distant failure and death Gynecol Oncol 87 2002 274 280 (Pubitemid 36034647)
51. P. Benedetti Panici, S. Basile, F. Maneschi, A. Alberto Lissoni, M. Signorelli, and G. Scambia Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial J Natl Cancer Inst 100 2008 1707 1716
52. H. Kitchener, A.M. Swart, Q. Qian, C. Amos, and M.K. Parmar Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study Lancet 373 2009 125 136
53. I. Ben-Shachar, K.M. Vitellas, and D.E. Cohn The role of MRI in the conservative management of endometrial cancer Gynecol Oncol 93 2004 233 237 (Pubitemid 38429576)
54. Y. Nakao, M. Yokoyama, K. Hara, Y. Koyamatsu, M. Yasunaga, and Y. Araki MR imaging in endometrial carcinoma as a diagnostic tool for the absence of myometrial invasion Gynecol Oncol 102 2006 343 347 (Pubitemid 44041647)
55. A. Sebastianelli, M.C. Renaud, J. Gregoire, M. Roy, and M. Plante Preoperative CA 125 tumour marker in endometrial cancer: correlation with advanced stage disease J Obstet Gynaecol Can 32 2010 856 860