Small amygdala high aggression? the role of the amygdala in modulating aggression in healthy subjects

World Journal of Biological Psychiatry

Volumn 13, Issue 1, 2012, Pages 75-81

  Matthies, Swantje ^a   Rsch, Nicolas ^a   Weber, Matthias ^a   Lieb, Klaus ^a,b   Philipsen, Alexandra ^a   Tuescher, Oliver ^a   Ebert, Dieter ^a   Hennig, Jrgen ^a   Van Elst, Ludger Tebartz ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Aggression; Amygdala; Healthy volunteers; MRI; Volumetry

Indexed keywords

ADULT; AGGRESSION; AMYGDALOID NUCLEUS; ARTICLE; BRAIN SCINTISCANNING; CLINICAL ASSESSMENT; CORRELATION ANALYSIS; FEMALE; HUMAN; MENTAL DISEASE; MORPHOMETRICS; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PSYCHOMETRY;

ADULT; AGGRESSION; AMYGDALA; FEMALE; GERMANY; HUMANS; MAGNETIC RESONANCE IMAGING; NEUROIMAGING; ORGAN SIZE; PSYCHIATRIC STATUS RATING SCALES;

EID: 84855971487     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2010.541282     Document Type: Article

References (52)

1. Adolphs R, Tranel D, Damasio H, Damasio AR. 1995. Fear and the human amygdala. J Neurosci 15:5879-5891.
2. Adolphs R, Gosselin F, Buchanan TW, Tranel D, Schyns P, Damasio AR. 2005. A mechanism for impaired fear recognition after amygdala damage. Nature 433:68-72. (Pubitemid 40101144)
3. Amaral DG, Price JL, Pitkänen A, Carmichael ST. 1992. Anatomical organization of the primate amygdaloid complex. In: Aggleton JP, editor. The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction. New York: Wiley-Liss. p 1-66.
4. Archer J. 1991. The infl uence of testosterone on human aggression. Br J Psychol 82:1-28.
5. Beck AT, Steer RA. 1987. Beck Depression Inventory Manual. San Antonio, TX: The Psychological Corporation.
6. Brierley B, Shaw P, David AS. 2002. The human amygdala: a systematic review and meta-analysis of volumetric magnetic resonance imaging. Brain Res Rev 39:84-105. (Pubitemid 34666988)
7. Cendes F, Andermann F, Gloor P, Evans A, Jones-Gotman M, Watson C, et al. 1993a. MRI volumetric measurement of amygdala and hippocampus in temporal lobe epilepsy. Neurology 43:719-725. (Pubitemid 23121963)
8. Cendes F, Leproux F, Melanson D, Ethier R, Evans A, Peters T, et al. 1993b. MRI of amygdala and hippocampus in temporal lobe epilepsy. J Comput Assist Tomogr 17:206-210. (Pubitemid 23086435)
9. Coccaro EF, Berman ME, Kavoussi RJ. 1997. Assessment of life history of aggression: development and psychometric characteristics. Psychiatry Res 73:147-157. (Pubitemid 28088171)
10. Coccaro EF, Beresford B, Minar P, Kaskow J, Geracioti T. 2007a. CSF testosterone: relationship to aggression, impulsivity, and venturesomeness in adult males with personality disorder. J Psychiatr Res 41:488-492. (Pubitemid 46227442)
11. Coccaro EF, McCloskey MS, Fitzgerald DA, Phan KL, Coccaro EF, McCloskey MS, et al. 2007b. Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggression. Biol Psychiatry 62:168-178. (Pubitemid 46963248)
12. Cushing BS, Perry A, Musatov S, Ogawa S, Papademetriou E. 2008. Estrogen receptors in the medial amygdala inhibit the expression of male prosocial behavior. J Neurosci 28: 10399-10403.
13. Davidson RJ, Putnam KM, Larson CL. 2000. Dysfunction in the neural circuitry of emotion regulation-a possible prelude to violence. Science 289:591-594. (Pubitemid 30622056)
14. Derogatis LR, Cleary PA. 1977. Factorial invariance across gender for the primary symptom dimensions of the SCL-90. Br J Soc Clin Psychol 16:347-356.
15. Drevets WC. 2000. Neuroimaging studies of mood disorders. Biol Psychiatry 48:813-829.
16. Emsley RA, Paster L. 1985. Lipoid proteinosis presenting with neuropsychiatric manifestations. J Neurol Neurosurg Psychiatry 48:1290-1292. (Pubitemid 16229414)
17. Franke GH. 1992. Eine weitere Ü berprüfung der Symptom-Check-Liste (SCL-90-R) als Forschungsinstrument. Diagnos-tica 38:160-167.
18. Frodl T, Meisenzahl EM, Zetzsche T, Born C, Jager M, Groll C, et al. 2003. Larger amygdala volumes in fi rst depressive episode as compared to recurrent major depression and healthy control subjects. Biol Psychiatry 53:338-344. (Pubitemid 36173963)
19. Izquierdo A, Suda RK, Murray EA. 2005. Comparison of the effects of bilateral orbital prefrontal cortex lesions and amygdala lesions on emotional responses in rhesus monkeys. J Neurosci 25:8534-8542. (Pubitemid 41324739)
20. Kalin NH, Shelton SE, Davidson RJ, Kelley AE. 2001. The primate amygdala mediates acute fear but not the behavioral and physiological components of anxious temperament. J Neurosci 21:2067-2074. (Pubitemid 32221389)
21. Kiehl KA, Smith AM, Hare RD, Mendrek A, Forster BB, Brink J, et al. 2001. Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biol Psychiatry 50:677-684. (Pubitemid 33043770)
22. Kleinert R, Cervos-Navarro J, Kleinert G, Walter GF, Steiner H. 1987. Predominantly cerebral manifestation in Urbach-Wiethe's syndrome (lipoid proteinosis cutis et mucosae): a clinical and pathomorphological study. Clin Neuropathol 6:43-45. (Pubitemid 17019420)
23. Kluver H, Bucy PC. 1939. Preliminary analysis of functions of the temporal lobes in monkeys. Arch Neurol Psychiatry 42: 979-1000.
24. Laux L, Glanzmann P, Schaffner P, Spielberger CD. 1981. Das State-Trait-Angst-Inventar (STAI). Weinheim: Beltz Verlagsgesellschaft.
25. Lehrl S. 2005. Mehrfachwahl-Wortschatz-Intelligenztest MWT-B. Balingen: Spitta.
26. Lehrl S, Triebig G, Fischer B. 1995. Multiple choice vocabulary test MWT as a valid and short test to estimate premorbid intelligence. Acta Neurol Scand 91:335-345.
27. Lemieux L, Liu RS, Duncan JS. 2000. Hippocampal and cerebel-lar volumetry in serially acquired MRI volume scans. Magn Reson Imaging 18:1027-1033.
28. Manuck SB, Flory JD, McCaffery JM, Matthews KA, Mann JJ, Muldoon MF. 1998. Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology 19:287-299. (Pubitemid 28491338)
29. Markowitsch HJ, Calabrese P, Wurker M, Durwen HF, Kessler J, Babinsky R, et al. 1994. The amygdala's contribution to memory-a study on two patients with Urbach-Wiethe disease. Neuroreport 5:1349-1352. (Pubitemid 24219229)
30. Newton FH, Rosenberg RN, Lampert PW, O'Brien JS. 1971. Neurologic involvement in Urbach-Wiethe's disease (lipoid proteinosis). A clinical, ultrastructural, and chemical study. Neurology 21:1205-1213.
31. Oldfield RC. 1971. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97-113.
32. Raine A, Meloy JR, Bihrle S, Stoddard J, LaCasse L, Buchsbaum MS. 1998. Reduced prefrontal and increased subcortical brain functioning assessed using positron emission tomography in predatory and affective murderers. Behav Sci Law 16:319-332. (Pubitemid 28451316)
33. Rüsch N, Weber M, Il ' yasov K, Lieb K, Ebert D, Hennig J, Tebartz van Elst L. 2007. Inferior frontal white matter microstructure and patterns of psychopathology in women with borderline personality disorder and comorbid attention defi cit hyperactiv-ity disorder. NeuroImage 35:738-747. (Pubitemid 46400549)
34. Saver JL, Salloway SP, Devinsky O, Bear DM. 1996. Neuropsy-chiatry of aggression. In: Fogel BS, Schiffer RB, RAo SM, editors. Neuropsychiatry. Baltimore, MD: William & Wilkins. p. 523-548.
35. Siebert M, Markowitsch HJ, Bartel P. 2003. Amygdala, affect and cognition: evidence from 10 patients with Urbach-Wiethe disease. Brain 126:2627-2637. (Pubitemid 37463082)
36. Spielberger CD, Gorsuch RL, Lushene RE. 1970. Manual for the State-Trait-Anxiety-Inventory. Palo Alto, CA: Consulting Psychologists Press.
37. Staut CC, Naidich TP. 1998. Urbach-Wiethe disease (Lipoid proteinosis). Pediatr Neurosurg 28:212-214. (Pubitemid 28402000)
38. Sterzer P, Stadler C, Poustka F, Kleinschmidt A. 2007. A structural neural defi cit in adolescents with conduct disorder and its association with lack of empathy. Neuroimage 37:335-342. (Pubitemid 47068977)
39. Streiner DL. 1995. Learning how to differ: agreement and reliability statistics in psychiatry. Can J Psychiatry 40:60-66.
40. Tebartz van Elst L, Woermann FG, Lemieux L, Trimble MR. 1999. Amygdala enlargement in dysthmia-a volumetric study of patients with temporal lobe epilepsy. Biol Psychiatry. 46(12):1614-23. (Pubitemid 30001603)
41. Tebartz van Elst L, Woermann F, Lemieux L, Trimble MR. 2000a. Increased amygdala volumes in female and depressed humans. A quantitative magnetic resonance imaging study. Neurosci Lett 281:103-106. (Pubitemid 30125876)
42. Tebartz van Elst L, Woermann FG, Lemieux L, Thompson PJ, Trimble MR. 2000b. Affective aggression in patients with temporal lobe epilepsy: a quantitative MRI study of the amygdala. Brain 123:234-243. (Pubitemid 30055148)
43. Tebartz van Elst L, Ebert D, Trimble MR. 2001. Dual brain pathology in patients with affective aggression. Arch Gen Psychiatry 58:1187-1188.
44. Tebartz van Elst L, Baeumer D, Lemieux L, Woermann F, Koepp MJ, Krishnamoorthy E, et al. 2002a. Amygdala abnormalities in psychosis of epilepsy. A magnetic resonance imaging study in patients with temporal lobe epilepsy. Brain 125:140-149. (Pubitemid 34084043)
45. Tebartz van Elst L, Juengling FD, Kassubek J, Schmidtke K, Thiel T, Ebert D, et al. 2002b. On the role of quantitative brain imaging in the differential diagnosis of speech disorders. Psychiatry Clin Neurosci 56:111-115. (Pubitemid 34130629)
46. Tebartz van Elst L, Thiel T, Hesslinger B, Geiger E, Haegele K, Lemieux L, et al. 2003. Frontolimbic brain abnormalities in patients with borderline personality disorder. A volumetric MRI study. Biol Psychiatry 54:163-171. (Pubitemid 36859776)
47. Tebartz van Elst L, Ludaescher P, Thiel T, Buchert M, Hesslinger B, Bohus M, et al. 2007. Evidence of disturbed amygdalar energy metabolism in patients with borderline personality disorder. Neurosci Lett 417:36-41. (Pubitemid 46517846)
48. Thornton HB, Nel D, Thornton D, van Honk J, Baker GA, Stein DJ. 2008. The neuropsychiatry and neuropsychology of lipoid proteinosis. J Neuropsychiatry Clin Neurosci 20:86-92. (Pubitemid 351295033)
49. Tranel D, Gullickson G, Koch M, Adolphs R. 2006. Altered experience of emotion following bilateral amygdala damage. Cogn Neuropsychiatry 11:219-232. (Pubitemid 46291896)
50. Trimble MR, Tebartz van Elst L. 1999. On some clinical implications of the ventral striatum and the extended amygdala. Investigations of aggression. Ann NY Acad Sci 877: 638-644. (Pubitemid 29351883)
51. Urbach E, Wiethe C. 1929. Lipidosis cutis et mucosae. Virchows Arch Pathol Anat Physiol Klin Med 273:285-319.
52. Watson C, Andermann F, Gloor P, Jones-Gotman M, Peters T, Evans A, et al. 1992. Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology 42:1743-1750.