Estrogen receptors in the medial amygdala inhibit the expression of male prosocial behavior

Journal of Neuroscience

Volumn 28, Issue 41, 2008, Pages 10399-10403

  Cushing, Bruce S ^a,b   Perry, Adam ^b   Musatov, Sergei ^c,d   Ogawa, Sonoko ^e   Papademetriou, Eros ^b  

^a UNIVERSITY OF AKRON   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c Neurologix Inc   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

^e UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Aggression; Amygdala; Estrogen receptor ; Microtus ochrogaster; Transfection; Viral vector

Indexed keywords

ESTROGEN RECEPTOR ALPHA;

AMYGDALOID NUCLEUS; ARTICLE; BEHAVIORAL SCIENCE; CONTROLLED STUDY; FEMALE; IMMUNOREACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOCIAL BEHAVIOR; VOLE; ANIMAL; ANIMAL BEHAVIOR; ARVICOLINAE; DECISION MAKING; GENETIC TRANSFECTION; GENETICS; HUMAN; INHIBITION (PSYCHOLOGY); METABOLISM; PHYSIOLOGY; SEXUAL BEHAVIOR; SEXUAL DEVELOPMENT; UPREGULATION;

AMYGDALA; ANIMALS; ARVICOLINAE; BEHAVIOR, ANIMAL; CHOICE BEHAVIOR; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; INHIBITION (PSYCHOLOGY); MALE; SEX CHARACTERISTICS; SEXUAL BEHAVIOR, ANIMAL; SOCIAL BEHAVIOR; TRANSFECTION; UP-REGULATION;

EID: 55249103453     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1928-08.2008     Document Type: Article

References (36)

1. Cho MM, DeVries AC, Williams JR, Carter CS (1999) The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster). Behav Neurosci 113:1071-1079.
2. Clark KR, Liu X, McGrath JP, Johnson PR (1999) Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses. Hum Gene Ther 10:1031-1039.
3. Cooke BM, Stokas MR, Woolley CS (2007) Morphological sex differences and laterality in the prepubertal medial amygdala. J Comp Neurol 501:904-915.
4. Cushing BS, Kramer KM (2005a) Microtines: a model system for studying the evolution and regulation of social monogamy. Acta Theriol Sin 25:182-199.
5. Cushing BS, Kramer KM (2005b) Mechanisms underlying epigenetic effects of early social experience: the role of neuropeptides and steroids. Neurosci Biobehav Rev 29:1089-1115.
6. Cushing BS, Wynne-Edwards KE (2006) Estrogen receptor alpha distribution in male rodents is associated with social organization. J Comp Neurol 494:595-605.
7. Cushing BS, Okorie U, Young LJ (2003) The effects of early exposure of testosterone on the subsequent response of adult male prairie voles to arginine vasopressin. J Neuroendocrinol 15:1021-1026.
8. Cushing BS, Razzoli M, Murphy AZ, Epperson PM, Le WW, Hoffman GE (2004) Intraspecific variation in estrogen receptor alpha and the expression of male sociosexual behavior in two populations of prairie voles. Brain Res 1016:247-254.
9. DeVries AC, DeVries MB, Taymans SE, Carter CS (1996) The effects of stress on social preferences are sexually dimorphic in prairie voles. Proc Natl Acad Sci U S A 93:11980-11984.
10. De Vries GJ, Villalba C (1997) Brain sexual dimorphism and sex differences in parental and other social behaviors. Ann N Y Acad Sci 807:273-286.
11. Ferguson JN, Aldag JM, Insel TR, Young LJ (2001) Oxytocin in the medial amygdala is essential for social recognition in the mouse. J Neurosci 21:8278-8285.
12. Fink S, Excoffier L, Heckel G (2006) Mammalian monogamy is not controlled by a single gene. Proc Natl Acad Sci U S A 103:10955-10960.
13. Floresco SB, Ghods-Sharifi S (2007) Amygdala-prefrontal cortical circuitry regulates effort-based decision making. Cereb Cortex 17:251-260.
14. Hammock EA, Young LJ (2004) Functional microsatellite polymorphism associated with divergent social structure in vole species. Mol Biol Evo 21:1057-1063.
15. Hammock EA, Lim MM, Nair HP, Young LJ (2005) Association of vasopressin 1a receptor levels with a regulatory microsatellite and behavior. Genes Brain Behav 4:289-301.
16. Hnatczuk OC, Lisciotto CA, Don Carlos LL, Carter CS, Morrell JI (1994) Estrogen and progesterone receptor immunoreactivity (ER-IR and PR-IR) in specific brain areas of the prairie vole (Microtus ochrogaster) is altered by sexual receptivity and genetic sex. J Neuroendocrinol 6:89-100.
17. Insel TR, Young LJ (2001) The neurobiology of social attachment. Nat Rev Neurosci 2:129-136.
18. Keverne KB, Curley JP (2004) Vasopressin, oxytocin and social behaviour. Curr Opin Neurobiol 14:777-783.
19. Kramer KM, Simmons JL, Freeman DA (2008) Photoperiod alters central distribution of estrogen receptor α in brain regions that regulate aggression. Horm Behav 53:358-365.
20. Krezel W, Dupont S, Krust A, Chambon P, Chapman PF (2001) Increased anxiety and synaptic plasticity in estrogen receptor β-deficient mice. Proc Natl Acad Sci U S A 98:12278-12282.
21. Kudwa AE, Bodo C, Gustafsson JA, Rissman EF (2005) A previously uncharacterized role for estrogen receptor beta: defeminization of male brain and behavior. Proc Natl Acad Sci U S A 102:4608-4612.
22. Lim MM, Insel TR, Young LJ (2001) The ventral pallidum in the monogamous prairie vole: neuroanatomy and activity. Horm Behav 39:336-337.
23. Liu Y, Curtis JT, Wang ZX (2001) Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster). Behav Neurosci 115:910-919.
24. Lonstein JS, Rood BD, De Vries GJ (2002) Parental responsiveness is feminized after neonatal castration in virgin male prairie voles, but not masculinized by perinatal testosterone in virgin females. Horm Behav 41:80-87.
25. Moy SS, Nadler JJ, Perez A, Barbaro RP, Johns JM, Magnuson TR, Piven J, Crawley JN (2004) Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice. Genes Brain Behav 3:287-302.
26. Musatov S, Chen W, Pfaff DW, Kaplitt MG, Ogawa S (2006) RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors. Proc Natl Acad Sci U S A 103:10456-10460.
27. Nair HP, Young LJ (2006) Vasopressin and pair-bond formation: genes to brain to behavior. Physiology 21:146-152.
28. Newman SW (1999) The medial extended amygdala in male reproductive behavior. A node in the mammalian social behavior network. Ann N Y Acad Sci 877:242-257.
29. Ogawa S, Washburn TF, Taylor J, Lubahn DB, Korach KS, Pfaff DW (1998) Modifications of testosterone-dependent behaviors by estrogen receptor-alpha gene disruption in male mice. Endocrinology 139:5058-5069.
30. Paxinos G, Franklin KB (2001) The mouse brain in stereotaxic coordinates, Ed 2. San Diego: Academic.
31. Sheehan T, Paul M, Amaral E, Numan MJ, Numan M (2001) Evidence that the medial amygdala projects to the anterior/ventromedial hypothalamic nuclei to inhibit maternal behavior in rats. Neuroscience 106:341-356.
32. Trainor BC, Greiwe KM, Nelson RJ (2006) Individual differences in estrogen receptor a in select brain nuclei are associated with individual differences in aggression. Horm Behav 50:338-345.
33. Wersinger SR, Sannen K, Villalba C, Lubahn DB, Rissman EF, De Vries GJ (1997) Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene. Horm Behav 32:176-183.
34. Young LJ, Wang ZX (2004) The neurobiology of pair bonding. Nat Neurosci 7:1048-1054.
35. Young LJ, Nilsen R, Waymire KG, MacGregor GR, Insel TR (1999) Increased affiliative response to vasopressin in mice expressing the vasopressin receptor from a monogamous vole. Nature 400:766-768.
36. Young LJ, Murphy-Young AZ, Hammock EA (2005) Anatomy and neurochemistry of the pair bond. J Comp Neurol 493:51-57.