A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis

Journal of Hepatology

Volumn 56, Issue 2, 2012, Pages 426-432

  Nahon, Pierre ^a,b   Sutton, Angela ^a,c   Rufat, Pierre ^d   Charnaux, Nathalie ^a,c   Mansouri, Abdellah ^b   Moreau, Richard ^b   Ganne Carrié, Nathalie ^a   Grando Lemaire, Véronique ^a   N'Kontchou, Gisle ^a   Trinchet, Jean Claude ^a   Pessayre, Dominique ^b   Beaugrand, Michel ^a  

^a HÔPITAL JEAN VERDIER   (France)

^b INSERM   (France)

^c UNIVERSITÉ PARIS 13   (France)

^d ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

Anti oxidant system; Liver cancer; Single nucleotide polymorphisms; Viral hepatitis

Indexed keywords

ALANINE; ANTIVIRUS AGENT; CATALASE; GLUTATHIONE PEROXIDASE 1; LEUCINE; MANGANESE SUPEROXIDE DISMUTASE; MYELOPEROXIDASE; PROLINE; VALINE;

ADULT; ALLELE; ANTIVIRAL THERAPY; ARTICLE; CANCER RISK; DEATH; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS CARCINOGENESIS;

AMINO ACID SUBSTITUTION; CARCINOMA, HEPATOCELLULAR; CATALASE; FEMALE; GENETIC VARIATION; GENOTYPE; GLUTATHIONE PEROXIDASE; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PEROXIDASE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RISK FACTORS; SUPEROXIDE DISMUTASE;

EID: 84855956113     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.08.010     Document Type: Article

References (29)

1. M. Korenaga, T. Wang, Y. Li, L.A. Showalter, T. Chan, and J. Sun Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production J Biol Chem 280 2005 37481 37488 (Pubitemid 41642356)
2. H.E. Boudreau, S.U. Emerson, A. Korzeniowska, M.A. Jendrysik, and T.L. Leto Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: a new contributor to HCV-induced oxidative stress J Virol 83 2009 12934 12946
3. N.S. de Mochel, S. Seronello, S.H. Wang, C. Ito, J.X. Zheng, and T.J. Liang Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection Hepatology 52 2010 47 59
4. K. Bedard, and K.H. Krause The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology Physiol Rev 87 2007 245 313 (Pubitemid 46209993)
5. S.J. Klebanoff Myeloperoxidase: friend and foe J Leukoc Biol 77 2005 598 625 (Pubitemid 40628741)
6. E.H. Sarsour, M.G. Kumar, L. Chaudhuri, A.L. Kalen, and P.C. Goswami Redox control of the cell cycle in health and disease Antioxid Redox Signal 11 2009 2985 3011
7. J.F. Turrens Mitochondrial formation of reactive oxygen species J Physiol 552 2003 335 344 (Pubitemid 37321833)
8. Nathan C, Ding A. SnapShot: Reactive Oxygen Intermediates (ROI). Cell 2010;140:951-951, e952.
9. S.A. Weitzman, A.B. Weitberg, E.P. Clark, and T.P. Stossel Phagocytes as carcinogens: malignant transformation produced by human neutrophils Science 227 1985 1231 1233 (Pubitemid 15142011)
10. H. Wiseman, and B. Halliwell Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer Biochem J 313 1996 17 29 (Pubitemid 26013419)
11. K. Machida, K.T. Cheng, V.M. Sung, S. Shimodaira, K.L. Lindsay, and A.M. Levine Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes Proc Natl Acad Sci USA 101 2004 4262 4267 (Pubitemid 38405917)
12. J.Y. Choi, M.L. Neuhouser, M.J. Barnett, C.C. Hong, A.R. Kristal, and M.D. Thornquist Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort Carcinogenesis 29 2008 964 970 (Pubitemid 351982241)
13. Y.J. Hu, and A.M. Diamond Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium Cancer Res 63 2003 3347 3351 (Pubitemid 36735893)
14. W.F. Reynolds, E. Chang, D. Douer, E.D. Ball, and V. Kanda An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia Blood 90 1997 2730 2737 (Pubitemid 27413483)
15. A. Sutton, P. Nahon, D. Pessayre, P. Rufat, A. Poire, and M. Ziol Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis Cancer Res 66 2006 2844 2852
16. A. Sutton, A. Imbert, A. Igoudjil, V. Descatoire, S. Cazanave, and D. Pessayre The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability Pharmacogenet Genomics 15 2005 311 319 (Pubitemid 40676552)
17. L. Forsberg, L. Lyrenas, U. de Faire, and R. Morgenstern A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels Free Radic Biol Med 30 2001 500 505 (Pubitemid 32162956)
18. J.M. Llovet, J. Fuster, and J. Bruix The Barcelona approach: diagnosis, staging, and treatment of hepatocellular carcinoma Liver Transpl 10 2004 S115 120
19. C.H. Osterreicher, C. Datz, F. Stickel, C. Hellerbrand, M. Penz, and H. Hofer Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis J Hepatol 42 2005 914 919 (Pubitemid 40693209)
20. P. Nahon, A. Sutton, P. Rufat, M. Ziol, H. Akouche, and C. Laguillier Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis Hepatology 50 2009 1484 1493
21. E.J. Heathcote Prevention of hepatitis C virus-related hepatocellular carcinoma Gastroenterology 127 2004 S294 302
22. J. Choi, K.J. Lee, Y. Zheng, A.K. Yamaga, M.M. Lai, and J.H. Ou Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells Hepatology 39 2004 81 89 (Pubitemid 38461470)
23. P. Nahon, A. Sutton, D. Pessayre, P. Rufat, F. Degoul, and N. Ganne-Carrie Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma, and death Clin Gastroenterol Hepatol 3 2005 292 298 (Pubitemid 40568736)
24. C. Fillebeen, and K. Pantopoulos Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells J Hepatol 53 2010 995 999
25. P. Nahon, A. Sutton, P. Rufat, M. Ziol, G. Thabut, and P.O. Schischmanoff Liver iron, HFE gene mutations, and hepatocellular carcinoma occurrence in patients with cirrhosis Gastroenterology 134 2008 102 110 (Pubitemid 350309327)
26. J.M. Pullar, M.C. Vissers, and C.C. Winterbourn Glutathione oxidation by hypochlorous acid in endothelial cells produces glutathione sulfonamide as a major product but not glutathione disulfide J Biol Chem 276 2001 22120 22125
27. M.C. Vissers, A.C. Carr, and A.L. Chapman Comparison of human red cell lysis by hypochlorous and hypobromous acids: insights into the mechanism of lysis Biochem J 330 1998 131 138 (Pubitemid 28075731)
28. J.I. Kang Jr., and L.C. Sowers Examination of hypochlorous acid-induced damage to cytosine residues in a CpG dinucleotide in DNA Chem Res Toxicol 21 2008 1211 1218 (Pubitemid 351967385)
29. N. Gungor, R.W. Godschalk, D.M. Pachen, F.J. Van Schooten, and A.M. Knaapen Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase Faseb J 21 2007 2359 2367 (Pubitemid 47230666)