Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis

Journal of Hepatology

Volumn 42, Issue 6, 2005, Pages 914-919

  Österreicher, Christoph H ^a   Datz, Christian ^a   Stickel, Felix ^b   Hellerbrand, Claus ^c   Penz, Melitta ^a   Hofer, Harald ^a   Wrba, Fritz ^a   Penner, Edward ^a   Schuppan, Detlef ^b   Ferenci, Peter ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Genetic polymorphism; Heme oxygenase 1 (HO 1); Hepatic iron concentration (HIC); Hereditary hemochromatosis; Host factors; Liver fibrosis; Myeloperoxidase (MPO); Oxidative stress; Reactive oxygen species (ROS)

Indexed keywords

FERRITIN; HEME OXYGENASE 1; IRON; MYELOPEROXIDASE;

ADULT; AGED; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; AUTOMATION; CONTROLLED STUDY; DISEASE COURSE; DNA SEQUENCE; EVOLUTION; FEMALE; FERRITIN BLOOD LEVEL; FIBROSIS; GENETIC POLYMORPHISM; GENOTYPE; HEMOCHROMATOSIS; HOMOZYGOTE; HUMAN; HUMAN TISSUE; LASER; LIVER BIOPSY; LIVER CIRRHOSIS; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; AGED; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HEMOCHROMATOSIS; HOMOZYGOTE; HUMANS; INCIDENCE; LIVER CIRRHOSIS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; OXIDATIVE STRESS; PEROXIDASE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 21044448206     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.01.023     Document Type: Article

References (45)

1. A. Pietrangelo Hereditary hemochromatosis - a new look at an old disease N Engl J Med 350 2004 2383 2397
2. B.R. Bacon, L.W. Powell, P.C. Adams, T.F. Kresina, and J.H. Hoofnagle Molecular medicine and hemochromatosis: at the crossroads Gastroenterology 116 1999 193 207
3. Z.J. Bulaj, R.S. Ajioka, J.D. Phillips, B.A. LaSalle, L.B. Jorde, and L.M. Griffen Disease-related conditions in relatives of patients with hemochromatosis N Engl J Med 343 2000 1529 1535
4. J.K. Olynyk, D.J. Cullen, S. Aquilia, E. Rossi, L. Summerville, and L.W. Powell A population-based study of the clinical expression of the hemochromatosis gene N Engl J Med 341 1999 718 724
5. E. Beutler, V.J. Felitti, J.A. Koziol, N.J. Ho, and T. Gelbart Penetrance of 845G→A (C282Y) HFE hereditary haemochromatosis mutation in the USA Lancet 359 2002 211 218
6. J.C. Barton, W.W. Shih, R. Sawada-Hirai, R.T. Acton, L. Harmon, and C. Rivers Genetic and clinical description of hemochromatosis probands and heterozygotes: evidence that multiple genes linked to the major histocompatibility complex are responsible for hemochromatosis Blood Cells Mol Dis 23 1997 135 145
7. C. Mura, J.B. Nousbaum, P. Verger, M.T. Moalic, O. Raguenes, and A.Y. Mercier Phenotype-genotype correlation in haemochromatosis subjects Hum Genet 101 1997 271 276
8. L.M. Fletcher, J.L. Dixon, D.M. Purdie, L.W. Powell, and D.H. Crawford Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis Gastroenterology 122 2002 281 289
9. A. Piperno, S. Fargion, R. D'Alba, L. Roffi, A.L. Fracanzani, and L. Vecchi Liver damage in Italian patients with hereditary hemochromatosis is highly influenced by hepatitis B and C virus infection J Hepatol 16 1992 364 368
10. L.W. Powell, V. Nathan Subramaniam, and T.R. Yapp Haemochromatosis in the new millenium J Hepatol 32 2000 48 62
11. A. Pietrangelo Metals, oxidative stress, and hepatic fibrogenesis Semin Liver Dis 16 1996 13 30
12. C.C. Winterbourn, M.C. Vissers, and A.J. Kettle Myeloperoxidase Curr Opin Hematol 7 2000 53 58
13. B. Junge, Y. Carrion, C. Bosco, M. Galleano, S. Puntarulo, and G. Tapia Effects of iron overload and lindane intoxication in relation to oxidative stress, Kupffer cell function, and liver injury in the rat Toxicol Appl Pharmacol 170 2001 23 28
14. K.E. Brown, E.M. Brunt, and J.W. Heinecke Immunohistochemical detection of myeloperoxidase and its oxidation products in Kupffer cells of human liver Am J Pathol 159 2001 2081 2088
15. F.J. Piedrafita, R.B. Molander, G. Vansant, E.A. Orlova, M. Pfahl, and W.F. Reynolds An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element J Biol Chem 271 1996 14412 14420
16. W.F. Reynolds, E. Chang, D. Douer, E.D. Ball, and V. Kanda An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia Blood 90 1997 2730 2737
17. R. Tenhunen, H.S. Marver, and R. Schmid The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase Proc Natl Acad Sci USA 61 1968 748 755
18. S.H. Vincent Oxidative effects of heme and porphyrins on proteins and lipids Semin Hematol 26 1989 105 113
19. S. Immenschuh, and G. Ramadori Gene regulation of heme oxygenase-1 as a therapeutic target Biochem Pharmacol 60 2000 1121 1128
20. A.M. Choi, and J. Alam Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury Am J Respir Cell Mol Biol 15 1996 9 19
21. P.J. Lee, J. Alam, G.W. Wiegand, and A.M. Choi Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia Proc Natl Acad Sci USA 93 1996 10393 10398
22. K.D. Poss, and S. Tonegawa Heme oxygenase 1 is required for mammalian iron reutilization Proc Natl Acad Sci USA 94 1997 10919 10924
23. A. Yachie, Y. Niida, T. Wada, N. Igarashi, H. Kaneda, and T. Toma Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency J Clin Invest 103 1999 129 135
24. B.M. Choi, H.O. Pae, Y.M. Kim, and H.T. Chung Nitric oxide-mediated cytoprotection of hepatocytes from glucose deprivation-induced cytotoxicity: involvement of heme oxygenase-1 Hepatology 374 2003 810 823
25. G. Sass, M.C. Soares, K. Yamashita, S. Seyfried, W.H. Zimmermann, and T. Eschenhagen Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice Hepatology 38 2003 909 918
26. L. Li, P. Grenard, J.T. Nhieu, B. Julien, A. Mallat, and A. Habib Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts Gastroenterology 125 2003 460 469
27. C.L. Wei, K.H. Lee, H.E. Khoo, and W.M. Hon Expression of haem oxygenase in cirrhotic rat liver J Pathol 199 2003 324 334
28. M. Rizzardini, M. Zappone, P. Villa, P. Gnocchi, M. Sironi, and L. Diomede Kupffer cell depletion partially prevents hepatic heme oxygenase 1 messenger RNA accumulation in systemic inflammation in mice: role of interleukin-1beta Hepatology 27 1998 703 710
29. C.D. Ferris, S.R. Jaffrey, A. Sawa, M. Takahashi, S.D. Brady, and R.K. Barrow Haem oxygenase-1 prevents cell death by regulating cellular iron Nat Cell Biol 1 1999 152 157
30. S.F. Llesuy, and M.L. Tomaro Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage Biochim Biophys Acta 1223 1994 9 14
31. T. Kimpara, A. Takeda, K. Watanabe, Y. Itoyama, S. Ikawa, and M. Watanabe Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease Hum Genet 100 1997 145 147
32. N. Yamada, M. Yamaya, S. Okinaga, K. Nakayama, K. Sekizawa, and S. Shibahara Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema Am J Hum Genet 66 2000 187 195
33. M. Schillinger, M. Exner, W. Mlekusch, H. Domanovits, K. Huber, and C. Mannhalter Heme oxygenase-1 gene promoter polymorphism is associated with abdominal aortic aneurysm Thromb Res 106 2002 131 136
34. L. Kazemi-Shirazi, C. Datz, T. Maier-Dobersberger, K. Kaserer, F. Hackl, and C. Polli The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C Gastroenterology 116 1999 127 134
35. K. Ishak, A. Baptista, L. Bianchi, F. Callea, J. De Groote, and F. Gudat Histological grading and staging of chronic hepatitis J Hepatol 22 1995 696 699
36. W.F. Reynolds, K. Patel, S. Pianko, L.M. Blatt, J.J. Nicholas, and J.G. McHutchison A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection Genes Immun 3 2002 345 349
37. R. Moirand, P.C. Adams, V. Bicheler, P. Brissot, and Y. Deugnier Clinical features of genetic hemochromatosis in women compared with men Ann Intern Med 127 1997 105 110
38. R. Bataller, K.E. North, and D.A. Brenner Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal Hepatology 37 2003 493 503
39. E. Albanis, and S.L. Friedman Hepatic fibrosis. Pathogenesis and principles of therapy Clin Liver Dis 5 2001 315 334 v-vi
40. G.A. Ramm, D.H. Crawford, L.W. Powell, N.I. Walker, L.M. Fletcher, and J.W. Halliday Hepatic stellate cell activation in genetic haemochromatosis. Lobular distribution, effect of increasing hepatic iron and response to phlebotomy J Hepatol 26 1997 584 592
41. H. Tsukamoto, and S.C. Lu Current concepts in the pathogenesis of alcoholic liver injury Fed Am Soc Exp Biol J 15 2001 1335 1349
42. G. Poli Pathogenesis of liver fibrosis: role of oxidative stress Mol Aspects Med 21 2000 49 98
43. V. Paradis, P. Mathurin, M. Kollinger, F. Imbert-Bismut, F. Charlotte, and A. Piton In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features J Clin Pathol 50 1997 401 406
44. K. Washington, K. Wright, Y. Shyr, E.B. Hunter, S. Olson, and D.S. Raiford Hepatic stellate cell activation in nonalcoholic steatohepatitis and fatty liver Hum Pathol 31 2000 822 828
45. J.P. Ioannidis, E.E. Ntzani, T.A. Trikalinos, and D.G. Contopoulos-Ioannidis Replication validity of genetic association studies Nat Genet 29 2001 306 309