A mechanistic model for enzymatic saccharification of cellulose using continuous distribution kinetics II: Cooperative enzyme action, solution kinetics, and product inhibition

Biotechnology and Bioengineering

Volumn 109, Issue 3, 2012, Pages 676-685

  Griggs, Andrew J ^a   Stickel, Jonathan J ^a   Lischeske, James J ^a  

^a NATIONAL RENEWABLE ENERGY LABORATORY   (United States)

Author keywords

Cellulose; Enzymatic hydrolysis; Kinetics model; Polymer distribution; Substrate structure

Indexed keywords

CELLULOSE SUBSTRATES; CELLULOSIC BIOMASS; COMMERCIAL PRODUCTIONS; CONTINUOUS DISTRIBUTION KINETICS; CONVERSION RATES; CONVERSION YIELD; CURRENT LIMITATION; ENZYMATIC REACTION; ENZYMATIC SACCHARIFICATION; ENZYME ACTION; ENZYME ADSORPTION; ENZYME SYSTEMS; GLUCOSIDASE; KINETIC MODELS; KINETICS MODEL; LIQUID TRANSPORTATION; MECHANISTIC MODELS; MODEL RESULTS; NON-COOPERATIVE; ON CURRENTS; POLYMER DISTRIBUTION; PREDICTIVE MODELS; PRODUCT INHIBITION; RATE LIMITING; RENEWABLE FEEDSTOCKS; STRUCTURAL KNOWLEDGE; SUBSTRATE STRUCTURE;

ADSORPTION; CELLULOSE; ENZYMATIC HYDROLYSIS; GLUCOSE; KINETICS; SACCHARIFICATION; SUBSTRATES;

ENZYME INHIBITION;

BETA GLUCOSIDASE; CELLOBIOSE; CELLULOSE; ENZYME; GLUCAN SYNTHASE; GLUCOSE;

ADSORPTION; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; HYDROLYSIS; MOLECULAR WEIGHT; NEGATIVE FEEDBACK; SACCHARIFICATION; SOLUTION AND SOLUBILITY; STEREOCHEMISTRY;

BETA-GLUCOSIDASE; CELLULASES; CELLULOSE; CELLULOSE 1,4-BETA-CELLOBIOSIDASE; KINETICS; MODELS, THEORETICAL;

EID: 84855943677     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23354     Document Type: Article

References (26)

1. Andric P, Meyer AS, Jensen PA, Dam-Johansen K. 2010. Reactor design for minimizing product inhibition during enzymatic lignocellulose hydrolysis: I. significance and mechanism of cellobiose and glucose inhibition on cellulolytic enzymes. Biotechnol Adv 28(3):308-324.
2. Bansal P, Hall M, Realff MJ, Lee JH, Bommarius AS. 2009. Modeling cellulase kinetics on lignocellulosic substrates. Biotechnol Adv 27(6):833-848.
3. Beckham G, Matthews J, Peters B, Bomble Y, Himmel ME, Crowley M. 2011. Molecular-level origins of biomass recalcitrance. J Phys Chem B 115(14):4118-4127.
4. Bezerra R, Dias A. 2004. Discrimination among eight modified Michaelis-Menten kinetic models of cellulose hydrolysis with a large range of substrate/enzyme ratios. Appl Biochem Biotechnol 112:173-184.
5. Bommarius AS, Katona A, Cheben SE, Patel AS, Ragauskas AJ, Knudson K, Pu Y. 2008. Cellulase kinetics as a function of cellulose pretreatment. Metab Eng 10(6):370-381.
6. Foust T, Wooley R, Sheehan J, Wallace R, Ibsen K, Dayton D, Himmel M, Ashworth J, McCormick R, Melendez M, Hess J, Kenney K, Wright C, Radtke C, Perlack R, Mielenz J, Wang M, Synder S, Werpy T. 2007. A national laboratory market and technology assessment of the 30x30 scenario. Tech Rep NREL/TP-510-40942, National Renewable Energy Laboratory (NREL), Idaho National Laboratory (INL), Oak Ridge National Laboratory (ORNL), Argonne National Laboratory (ANL), and Pacific Northwest National Laboratory (PNNL).
7. Griggs AJ, Stickel JJ, Lischeske JJ. 2011. A mechanistic model for enzymatic saccharification of cellulose using continuous distribution kinetics I: Depolymerization by EGI and CBHI. Biotechnol Bioeng DOI: 10.1002/bit.23355.
8. Hall M, Bansal P, Lee J, Realff M, Bommarius A. 2010. Cellulose crystallinity - a key predictor of the enzymatic hydrolysis rate. FEBS J 277:1571-1582.
9. Igarashi K, Koivula A, Wada M, Kimura S, Penttila M, Samejima M. 2009. High speed atomic force microscopy visualizes processive movement of Trichoderma reesei cellobiohydrolase I on crystalline cellulose. J Biol Chem 284(52):36186-36190.
10. Jalak J, Valjamae P. 2010. Mechanism of initial rapid rate retardation in cellobiohydrolase catalyzed cellulose hydrolysis. Biotechnol Bioeng 106(6):871-883.
11. Jeoh T, Ishizawa C, Davis M, Himmel M, Adney W, Johnson D. 2007. Cellulase digestibility of pretreated biomass is limited by cellulose accessibility. Biotechnol Bioeng 98(1):112-122.
12. Kleman-Leyer KM, SiikaAho M, Teeri TT, Kirk TK. 1996. The cellulases endoglucanase I and cellobiohydrolase II of Trichoderma reesei act synergistically to solubilize native cotton cellulose but not to decrease its molecular size. Appl Environ Microbiol 62(8):2883-2887.
13. Levine SE, Fox JM, Blanch HW, Clark DS. 2010. A mechanistic model of the enzymatic hydrolysis of cellulose. Biotechnol Bioeng 107(1):37-51.
14. Linder M, Teeri T. 1996. The cellulose-binding domain of major cellobiohydrolase of Trichoderma reesei exhibits true reversibility and a high exchange rate on crystalline cellulose. Proc Natl Acad Sci USA 93:12251-12255.
15. Linder M, Teeri T. 1997. The roles and function of cellulose-binding domains. J Biotechnol 57:15-28.
16. Medve J, Karlsson J, Lee D, Tjerneld F. 1998. Hydrolysis of microcrystalline cellulose by cellobiohydrolase I and endoglucanase II from Trichoderma reesei: Adsorption, sugar production pattern, and synergism of the enzymes. Biotechnol Bioeng 59(5):621-634.
17. Pala H, Mota M, Gama F. 2007. Enzymatic depolymerisation of cellulose. Carbohydr Polym 68:101-108.
18. Ritter SK. 2011. Race to the pump. Chem Eng News 89(7):11-12 14-17.
19. Roche CM, Dibble CJ, Stickel JJ. 2009. Laboratory-scale method for enzymatic saccharification of lignocellulosic biomass at high-solids loadings. Biotechnol Biofuels 2:28.
20. Srisodsuk M, Kleman-Leyer K, Keranen S, Kirk TK, Teeri TT. 1998. Modes of action on cotton and bacterial cellulose of a homologous endoglucanase-exoglucanase pair from Trichoderma reesei. Eur J Biochem 251(3):885-892.
21. Tu MB, Chandra RP, Saddler JN. 2007. Evaluating the distribution of cellulases and the recycling of free cellulases during the hydrolysis of lignocellulosic substrates. Biotechnol Prog 23(2):398-406.
22. Valjamae P, Sild V, Nutt A, Petterson G, Johansson G. 1999. Acid hydrolysis of bacterial cellulose reveals different modes of synergistic action between cellobiohydrolase I and endoglucanase I. Eur J Biochem 266:327-334.
23. Wyman CE. 2007. What is (and is not) vital to advancing cellulosic ethanol. Trends Biotechnol 25(4):153-157.
24. Yeh A, Huang Y, Chen S. 2010. Effect of particle size on the rate of enzymatic hydrolysis of cellulose. Carbohydr Polym 79:192-199.
25. Zhang YHP, Lynd LR. 2004. Towards an aggregated understanding of enzymatic hydrolysis of cellulose: Noncomplexed cellulase systems. Biotechnol Bioeng 88(7):797-824.
26. Zhou W, Xu Y, Schuttler HB. 2010. Cellulose hydrolysis in evolving substrate morphologies III: Time-scale analysis. Biotechnol Bioeng 107(2):224-234.