Ionic residues of human serum transferrin affect binding to the transferrin receptor and iron release

Biochemistry

Volumn 51, Issue 2, 2012, Pages 686-694

  Steere, Ashley N ^a   Miller, Brendan F ^a   Roberts, Samantha E ^a   Byrne, Shaina L ^a,d   Chasteen, N Dennis ^b   Smith, Valerie C ^c   MacGillivray, Ross T A ^c   Mason, Anne B ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b University of New Hampshire   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE SUBSTITUTION; DELIVERY PROCESS; ENDOSOMAL PH; ENDOSOMES; HUMAN SERUM TRANSFERRIN; HUMAN SERUM TRANSFERRIN (HTF); IRON RELEASE; MODELING STUDIES; NANOMOLAR AFFINITY; PH SENSITIVE; TRANSFERRIN RECEPTORS;

AMINO ACIDS; BODY FLUIDS; IRON;

IRON COMPOUNDS;

ALANINE; MONOMER; TRANSFERRIN RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOTINYLATION; CELL DIVISION; CELL SURFACE; ENDOSOME; HUMAN; HUMAN CELL; IRON TRANSPORT; MUTANT; NONHUMAN; PH; PRIORITY JOURNAL; RECEPTOR BINDING; STOICHIOMETRY; SUBSTITUTION REACTION; TRANSFERRIN BLOOD LEVEL;

HUMANS; HYDROGEN-ION CONCENTRATION; IRON; KINETICS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, TRANSFERRIN; SOLUBILITY; TRANSFERRIN;

EID: 84855943314     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201661g     Document Type: Article

References (18)

1. Williams, J. and Moreton, K. (1980) The distribution of iron between the metal-binding sites of transferrin human serum Biochem. J. 185, 483-488 (Pubitemid 10112316)
2. Huebers, H., Josephson, B., Huebers, E., Csiba, E., and Finch, C. (1981) Uptake and release of iron from human transferrin Proc. Natl. Acad. Sci. U.S.A. 78, 2572-2576 (Pubitemid 11067249)
3. Zak, O. and Aisen, P. (1986) Nonrandom distribution of iron in circulating human transferrin Blood 68, 157-161 (Pubitemid 16033623)
4. Lawrence, C. M., Ray, S., Babyonyshev, M., Galluser, R., Borhani, D. W., and Harrison, S. C. (1999) Crystal structure of the ectodomain of human transferrin receptor Science 286, 779-782
5. Mason, A. B., Byrne, S. L., Everse, S. J., Roberts, S. E., Chasteen, N. D., Smith, V. C., Macgillivray, R. T., Kandemir, B., and Bou-Abdallah, F. (2009) A loop in the N-lobe of human serum transferrin is critical for binding to the transferrin receptor as revealed by mutagenesis, isothermal titration calorimetry, and epitope mapping J. Mol. Recognit. 22, 521-529
6. Wally, J., Halbrooks, P. J., Vonrhein, C., Rould, M. A., Everse, S. J., Mason, A. B., and Buchanan, S. K. (2006) The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding J. Biol. Chem. 281, 24934-24944 (Pubitemid 44274264)
7. Dautry-Varsat, A., Ciechanover, A., and Lodish, H. F. (1983) pH and the recycling of transferrin during receptor-mediated endocytosis Proc. Natl. Acad. Sci. U.S.A. 80, 2258-2262 (Pubitemid 13097167)
8. Cheng, Y., Zak, O., Aisen, P., Harrison, S. C., and Walz, T. (2004) Structure of the human transferrin receptor-transferrin complex Cell 116, 565-576 (Pubitemid 38264433)
9. Sakajiri, T., Yamamura, T., Kikuchi, T., and Yajima, H. (2009) Computational structure models of apo and diferric transferrin-transferrin receptor complexes Protein J. 28, 407-414
10. Eckenroth, B. E., Steere, A. N., Chasteen, N. D., Everse, S. J., and Mason, A. B. (2011) How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH Proc. Natl. Acad. Sci. U.S.A. 108, 13089-13094
11. Byrne, S. L., Chasteen, N. D., Steere, A. N., and Mason, A. B. (2010) The unique kinetics of iron-release from transferrin: The role of receptor, lobe-lobe interactions and salt at endosomal pH J. Mol. Biol. 396, 130-140
12. Giannetti, A. M., Snow, P. M., Zak, O., and Bjorkman, P. J. (2003) Mechanism for multiple ligand recognition by the human transferrin receptor PLoS Biol. 1, 341-350
13. Mason, A. B., He, Q. Y., Halbrooks, P. J., Everse, S. J., Gumerov, D. R., Kaltashov, I. A., Smith, V. C., Hewitt, J., and MacGillivray, R. T. (2002) Differential effect of a His tag at the N- and C-termini: Functional studies with recombinant human serum transferrin Biochemistry 41, 9448-9454 (Pubitemid 34810020)
14. Steere, A. N., Byrne, S. L., Chasteen, N. D., Smith, V. C., MacGillivray, R. T., and Mason, A. B. (2010) Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin J. Biol. Inorg. Chem. 15, 1341-1352
15. Byrne, S. L., Leverence, R., Klein, J. S., Giannetti, A. M., Smith, V. C., MacGillivray, R. T., Kaltashov, I. A., and Mason, A. B. (2006) Effect of glycosylation on the function of a soluble, recombinant form of the transferrin receptor Biochemistry 45, 6663-6673 (Pubitemid 43825367)
16. Mason, A. B., He, Q. Y., Adams, T. E., Gumerov, D. R., Kaltashov, I. A., Nguyen, V., and MacGillivray, R. T. (2001) Expression, purification, and characterization of recombinant nonglycosylated human serum transferrin containing a C-terminal hexahistidine tag Protein Expression Purif. 23, 142-150 (Pubitemid 32930990)
17. Masunov, A. and Lazaridis, T. (2003) Potentials of mean force between ionizable amino acid side chains in water J. Am. Chem. Soc. 125, 1722-1730 (Pubitemid 36232567)
18. Delano, W. L. (2002) The PyMOL Molecular Graphics System, DeLano Scientific, San Carlos, CA.