Effect of TGFβ and PDGF-B blockade on corneal myofibroblast development in mice

Experimental Eye Research

Volumn 93, Issue 6, 2011, Pages 810-817

  Singh, V ^a   Santhiago, M R ^a   Barbosa, F L ^a   Agrawal, V ^a   Singh, N ^b   Ambati, B K ^b   Wilson, S E ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Alpha smooth muscle actin; Cornea; Corneal opacity; Corneal wound healing; Gene delivery; Myofibroblasts; Platelet derived growth factor; Transforming growth factor beta; Vimentin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CYTOKINE; GROWTH FACTOR RECEPTOR; PLATELET DERIVED GROWTH FACTOR B; TRANSFORMING GROWTH FACTOR BETA; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CORNEA; IMMUNOCYTOCHEMISTRY; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL;

ACTINS; ANIMALS; CELLS, CULTURED; CORNEA; CORNEAL OPACITY; CORNEAL SURGERY, LASER; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FEMALE; GENE THERAPY; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MYOFIBROBLASTS; PROTO-ONCOGENE PROTEINS C-SIS; TIME FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; VIMENTIN;

EID: 84855941741     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.09.012     Document Type: Article

References (28)

1. Barbosa F.L., Chaurasia S.S., Cutler A., Asosingh K., Kaur H., de Medeiros F.W., Agrawal V., Wilson S.E. Corneal myofibroblast generation from bone marrow-derived cells. Exp. Eye Res. 2010, 91:92-96.
2. Chaurasia S.S., Kaur H., Medeiros F.W., Smith S.D., Wilson S.E. Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury. Exp. Eye Res. 2009, 89:133-139.
3. Desmouliere A. Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol. Int. 1995, 19:471-476.
4. Direkze N.C., Forbes S.J., Brittan M., Hunt T., Jeffery R., Preston S.L., Poulsom R., Hodivala-Dilke K., Alison M.R., Wright N.A. Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice. Stem Cells 2003, 21:514-520.
5. Fantes F.E., Hanna K.D., Waring G.O., Pouliquen Y., Thompson K.P., Savoldelli M. Wound healing after excimer laser keratomi-leusis (photorefractive keratectomy) in monkeys. Arch. Ophthalmol. 1990, 108:665-675.
6. Funderburgh J.L., Mann M.M., Funderburgh M.L. Keratocyte phenotype mediates proteoglycan structure: a role for fibroblasts in corneal fibrosis. J.Biol. Chem. 2003, 278:45629-45637.
7. Imanishi J., Kamiyama K., Iguchi I., Kita M., Sotozono C., Kinoshita S. Growth factors: importance in wound healing and maintenance of transparency of the cornea. Prog. Retin. Eye Res. 2000, 19:113-129.
8. Jester J.V., Barry-Lane P.A., Petroll W.M., Olsen D.R., Cavanagh H.D. Inhibition of corneal fibrosis by topical application of blocking antibodies to TGF beta in the rabbit. Cornea 1997, 16:177-187.
9. Jester J.V., Huang J., Barry-Lane P.A., Kao W.W., Petroll W.M., Cavanagh H.D. Transforming growth factor (beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly. Invest. Ophthalmology. Vis. Sci. 1999, 40:1959-1967.
10. Jester J.V., Moller-Pedersen T., Huang J., Sax C.M., Kays W.T., Cavangh H.D., Petroll W.M., Piatigorsky J. The cellular basis of corneal transparency: evidence for corneal crystallins. J. Cell Sci. 1999, 112:613-622.
11. Kaur H., Chaurasia S.S., Medeiros F.W., Agrawal V., Salomao M.Q., Singh N., Ambati B.K., Wilson S.E. Corneal stroma PDGF blockade and myofibroblast development. Exp. Eye Res. 2009, 88:960-965.
12. Kim W.J., Helena M.C., Mohan R.R., Wilson S.E. Changes in corneal morphology associated with chronic epithelial injury. Invest. Ophthalmology. Vis. Sci. 1999, 40:35-42.
13. Kim W.J., Mohan R.R., Mohan R.R., Wilson S.E. Effect of PDGF, IL-1 alpha, and BMP2/4 on corneal fibroblast chemotaxis: expression of the platelet-derived growth factor system in the cornea. Invest. Ophthalmology. Vis. Sci. 1999, 40:1364-1372.
14. Kivelä T., Uusitalo M. Structure, development and function of cytoskeletal elements in non-neuronal cells of the human eye. Prog. Retin. Eye Res. 1998, 17:385-428.
15. Lee Y.C., Wang I.J., Hu F.R., Kao W.W. Immunohistochemical study of subepithelial haze after phototherapeutic keratectomy. J.Refract. Surg. 2001, 17:334-341.
16. Masur S.K., Dewal H.S., Dinh T.T., Erenburg I., Petridou S. Myofibroblasts differentiate from fibroblasts when plated at low density. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:4219-4223.
17. Mimura T., Amano S., Yokoo S., Uchida S., Usui T., Yamagami S. Isolation and distribution of rabbit keratocyte precursors. Mol. Vis. 2008, 14:197-203.
18. Mohan R.R., Hutcheon A.E.K., Choi R., Hong J., Lee J., Mohan R.R., Ambrósio R., Zieske J.D., Wilson S.E. Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK. Exp. Eye Res. 2003, 76:71-87.
19. Mohan R.R., Stapleton W.M., Sinha S., Netto M.V., Wilson S.E. Anovel method for generating corneal haze in anterior stroma of the mouse eye with the excimer laser. Exp. Eye Res. 2008, 86:235-240.
20. Netto M.V., Mohan R.R., Sinha S., Sharma A., Dupps W., Wilson S.E. Stromal haze, myofibroblasts, and surface irregularity after PRK. Exp. Eye Res. 2006, 82:788-797.
21. Netto M.V., Mohan R.R., Sinha S., Sharma A., Gupta P.C., Wilson S.E. Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, proliferation, haze, and keratocyte density. J.Refract. Surg. 2006, 22:562-574.
22. Novo E., di Bonzo L.V., Cannito S., Colombatto S., Parola M. Hepatic myofibroblasts: a heterogeneous population of multifunctional cells in liver fibrogenesis. Int. J. Biochem. Cell Biol. 2009, 41:2089-2093.
23. Saika S., Yamanaka O., Sumioka T., Okada Y., Miyamoto T., Shirai K., Kitano A., Tanaka S. Transforming growth factor beta signal transduction: a potential target for maintenance/restoration of transparency of the cornea. Eye Contact Lens 2010, 36:286-289.
24. Shephard P., Martin G., Smola-Hess S., Brunner G., Krieg T., Smola H. Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1. Am. J. Pathol. 2004, 164:2055-2066.
25. Tandon A., Tovey J.C., Sharma A., Gupta R., Mohan R.R. Role of transforming growth factor beta in corneal function, biology and pathology. Curr. Mol. Med. 2010, 10:565-578.
26. Wilson S.E., He Y.-G., Weng J., Li Q., McDowall A.W., Vital M., Chwang E.L. Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing. Exp. Eye Res. 1996, 62:325-328.
27. Wilson S.E., Schultz G.S., Chegini N., Weng J., He Y.G. Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea. Exp. Eye Res. 1994, 59:63-71.
28. Zhang H.Y., Phan S.H. Inhibition of myofibroblast apoptosis by transforming growth factor beta(1). Am. J. Respir. Cell Mol. Biol. 1999, 21:658-665.