Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, cellular proliferation, haze, and long-term keratocyte density in rabbits

Journal of Refractive Surgery

Volumn 22, Issue 6, 2006, Pages 562-574

  Netto, Marcelo V ^a,b   Mohan, Rajiv R ^a   Sinha, Sunilima ^a   Sharma, Ajay ^a   Gupta, Pankaj C ^a   Wilson, Steven E ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BALANCED SALT SOLUTION; DNA FRAGMENT; KI 67 ANTIGEN; MITOMYCIN C;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DENSITY; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA; CORNEA CELL; CORNEA OPACITY; FEMALE; FOLLOW UP; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MYOFIBROBLAST; NICK END LABELING; NONHUMAN; PHOTOREFRACTIVE KERATECTOMY; PRIORITY JOURNAL; SLIT LAMP;

EID: 33745221665     PISSN: 1081597X     EISSN: None     Source Type: Journal    
DOI: 10.3928/1081-597x-20060601-08     Document Type: Article

References (41)

1. Rajan MS, Jaycock P, O'Brart D, Nystrom HH, Marshall J. A long-term study of photorefractive keratectomy; 12-year follow-up. Ophthalmology. 2004;111:1813-1824.
2. El-Maghraby A, Salah T, Waring GO III, Klyce SD, Ibrahim O. Randomized bilateral comparison of excimer laser in situ keratomileusis and photorefractive keratectomy for 2.50 to 8.00 diopters of myopia. Ophthalmology. 1999;106:447-457.
3. Hersh PS, Stulting RD, Steinert RF, Waring GO III, Thompson KP, O'Connell M, Doney K, Schein OD. Results of phase III excimer laser photorefractive keratectomy for myopia. The Summit PRK Study Group. Ophthalmology. 1997;104:1535-1553.
4. Mohan RR, Hutcheon AE, Choi R, Hong J, Lee J, Mohan RR, Ambrosio R Jr, Zieske JD, Wilson SE. Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK. Exp Eye Res. 2003;76:71-87.
5. Moller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV. Corneal haze development after PRK is regulated by volume of stromal tissue removal. Cornea. 1998;17:627-639.
6. Vinciguerra P, Azzolini M, Airaghi P, Radice P, De Molfetta V. Effect of decreasing surface and interface irregularities after photorefractive keratectomy and laser in situ keratomileusis on optical and functional outcomes. J Refract Surg. 1998;14:S199-S203.
7. Netto MV, Mohan RR, Sinha S, Sharma A, Dupps W, Wilson SE. Stromal haze, myofibroblasts, and surface irregularity after PRK. Exp Eye Res. 2006;82:788-797.
8. Kaji Y, Amano S, Oshika T, Obata H, Ohashi T, Sakai H, Shirasawa E, Tsuru T, Yamashita H. Effect of anti-inflammatory agents on corneal wound-healing process after surface excimer laser keratectomy. J Cataract Refract Surg. 2000;26:426-431.
9. Thom SB, Myers JS, Rapuano CJ, Eagle RC Jr, Siepser SB, Gomes JA. Effect of topical anti-transforming growth factor-beta on corneal stromal haze after photorefractive keratectomy in rabbits. J Cataract Refract Surg. 1997;23:1324-1330.
10. Furukawa H, Nakayasu K, Gotoh T, Watanabe Y, Takano T, Ishikawa T, Kanai A. Effect of topical tranilast and corticosteroids on subepithelial haze after photorefractive keratectomy in rabbits. J Refract Surg. 1997;13:S457-S458.
11. Lohmann CP, Marshall J. Plasmin- and plasminogen-activator inhibitors after excimer laser photorefractive keratectomy: new concept in prevention of postoperative myopic regression and haze. Refract Corneal Surg. 1993;9:300-302.
12. Galm U, Hager MH, Van Lanen SG, Ju J, Thorson JS, Shen B. Antitumor antibiotics: bleomycin, enediynes, and mitomycin. Chem Rev. 2005;105:739-758.
13. Fujita T, Tamura T, Yamada H, Yamamoto A, Muranishi S. Pharmacokinetics of mitomycin C (MMC) after intraperitoneal administration of MMC-gelatin gel and its anti-tumor effects against sarcoma-180 bearing mice. J Drug Target. 1997;4:289-296.
14. Jampel HD. Effect of brief exposure to mitomycin C on viability and proliferation of cultured human Tenon's capsule fibroblasts. Ophthalmology. 1992;99:1471-1476.
15. Nuyts RM, Pels E, Greve EL. The effects of 5-fluorouracil and mitomycin C on the corneal endothelium. Curr Eye Res. 1992;11:565-570.
16. Wu KY, Hong SJ, Huang HT, Lin CP, Chen CW. Toxic effects of mitomycin-C on cultured corneal keratocytes and endothelial cells. J Ocul Pharmacol Ther. 1999;15:401-411.
17. Kang SG, Chung H, Yoo YD, Lee JG, Choi YI, Yu YS. Mechanism of growth inhibitory effect of mitomycin-C on cultured human retinal pigment epithelial cells: apoptosis and cell cycle arrest. Curr Eye Res. 2001;22:174-181.
18. Watanabe J, Sawaguchi S, Fukuchi T, Abe H, Zhou L. Effects of mitomycin C on the expression of proliferating cell nuclear antigen after filtering surgery in rabbits. Graefes Arch Clin Exp Ophthalmol. 1997;235:234-240.
19. Majmudar PA, Forstot SL, Dennis RF, Nirankari VS, Damiano RE, Brenart R, Epstein RJ. Topical mitomycin-C for subepithelial fibrosis after refractive corneal surgery. Ophthalmology. 2000;107:89-94.
20. Talamo JH, Gollamudi S, Green WR, De La Cruz Z, Filatov V, Stark WJ. Modulation of corneal wound healing after excimer laser keratomileusis using topical mitomycin C and steroids. Arch Ophthalmol. 1991;109:1141-1146.
21. Carones F, Vigo L, Scandola E, Vacchini L. Evaluation of the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy. J Cataract Refract Surg. 2002;28:2088-2095.
22. Helena MC, Baerveldt F, Kim WJ, Wilson SE. Keratocyte apoptosis after corneal surgery. Invest Ophthalmol Vis Sci. 1998;39:276-283.
23. Zieske JD, Wasson M. Regional variation in distribution of EGF receptor in developing and adult corneal epithelium. J Cell Sci. 1993;106:145-152.
24. Fantes FE, Hanna KD, Waring GO III, Pouliquen Y, Thompson KP, Savoldelli M. Wound healing after excimer laser keratomileusis (photorefractive keratectomy) in monkeys. Arch Ophthalmol. 1990;108:665-675.
25. Maltseva O, Folger P, Zekaria D, Petridou S, Masur SK. Fibroblast growth factor reversal of the corneal myofibroblast phenotype. Invest Ophthalmol Vis Sci. 2001;42:2490-2495.
26. Siganos DS, Katsanevaki VJ, Pallikaris IG. Correlation of subepithelial haze and refractive regression 1 month after photorefractive keratectomy for myopia. J Refract Surg. 1999;15:338-342.
27. Shah SS, Kapadia MS, Meisler DM, Wilson SE. Photorefractive keratectomy using the summit SVS Apex laser with or without astigmatic keratotomy. Cornea. 1998;17:508-516.
28. Stramer BM, Zieske JD, Jung JC, Austin JS, Fini ME. Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes. Invest Ophthalmol Vis Sci. 2003;44:4237-4246.
29. Camellin M. Laser epithelial keratomileusis for myopia. J Refract Surg. 2003;19:666-670.
30. Pallikaris IG, Katsanevaki VJ, Kalyvianaki MI, Naoumidi II. Advances in subepithelial excimer refractive surgery techniques: epi-LASIK. Curr Opin Ophthalmol. 2003;14:207-212.
31. Kervick G. Subepithelial scarring after laser-assisted subepithelial keratectomy. J Cataract Refract Surg. 2005;31:647-648.
32. Netto MV, Mohan RR, Ambrosio R Jr, Hutcheon AE, Zieske JD, Wilson SE. Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy. Cornea. 2005;24:509-522.
33. Taneri S, Zieske JD, Azar DT. Evolution, techniques, clinical outcomes, and pathophysiology of LASEK: review of the literature. Surv Ophthalmol. 2004;49:576-602.
34. Anderson NJ, Beran RF, Schneider TL. Epi-LASEK for the correction of myopia and myopic astigmatism. J Cataract Refract Surg. 2002;28:1343-1347.
35. Schipper I, Suppelt C, Gebbers JO. Mitomycin C reduces scar formation after excimer laser (193 nm) photorefractive keratectomy in rabbits. Eye. 1997;11:649-655.
36. Gambato C, Ghirlando A, Moretto E, Busato F, Midena E. Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes. Ophthalmology. 2005;112:208-218.
37. Kim TI, Tchah H, Lee SA, Sung K, Cho BJ, Kook MS. Apoptosis in keratocytes caused by mitomycin C. Invest Ophthalmol Vis Sci. 2003;44:1912-1917.
38. Jester JV, Petroll WM, Barry PA, Cavanagh HD. Expression of alpha-smooth muscle (alpha-SM) actin during corneal stromal wound healing. Invest Ophthalmol Vis Sci. 1995;36:809-819.
39. Jester JV, Petroll WM, Cavanagh HD. Corneal stromal wound healing in refractive surgery: the role of myofibroblasts. Prog Retin Eye Res. 1999;18:311-356.
40. Maldonado MJ. Intraoperative MMC after excimer laser surgery for myopia. Ophthalmology. 2002;109:826-828.
41. Erie JC, Patel SV, McLaren JW, Hodge DO, Bourne WM. Keratocyte density in the human cornea after photorefractive keratectomy. Arch Ophthalmol. 2003;121:770-776.