메뉴 건너뛰기




Volumn 24, Issue 2, 2012, Pages 341-356

Deficits in Spermatogenesis but not Neurogenesis are Alleviated by Chronic Testosterone Therapy in R6/1 Huntington's Disease Mice

Author keywords

Cognition; Huntington's disease; Neurogenesis; Spermatogenesis; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; HUNTINGTIN; SODIUM CHLORIDE; TESTOSTERONE; TESTOSTERONE CIPIONATE;

EID: 84855938043     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2011.02238.x     Document Type: Article
Times cited : (27)

References (59)
  • 2
    • 33846225133 scopus 로고    scopus 로고
    • Huntington's disease
    • Walker FO. Huntington's disease. Lancet 2007; 369: 218-228.
    • (2007) Lancet , vol.369 , pp. 218-228
    • Walker, F.O.1
  • 3
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group
    • HDCRG HsDCRG.
    • HDCRG HsDCRG. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 1993;72:971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 5
    • 0034791680 scopus 로고    scopus 로고
    • Modeling Huntington's disease in cells, flies, and mice
    • Sipione S, Cattaneo E. Modeling Huntington's disease in cells, flies, and mice. Mol Neurobiol 2001; 23: 21-51.
    • (2001) Mol Neurobiol , vol.23 , pp. 21-51
    • Sipione, S.1    Cattaneo, E.2
  • 6
    • 33751282353 scopus 로고    scopus 로고
    • Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies
    • Borrell-Pages M, Zala D, Humbert S, Saudou F. Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies. Cell Mol Life Sci 2006; 63: 2642-2660.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2642-2660
    • Borrell-Pages, M.1    Zala, D.2    Humbert, S.3    Saudou, F.4
  • 8
    • 67650095269 scopus 로고    scopus 로고
    • Beyond the brain: widespread pathology in Huntington's disease
    • van der Burg JM, Bjorkqvist M, Brundin P. Beyond the brain: widespread pathology in Huntington's disease. Lancet Neurol 2009; 8: 765-774.
    • (2009) Lancet Neurol , vol.8 , pp. 765-774
    • van der Burg, J.M.1    Bjorkqvist, M.2    Brundin, P.3
  • 9
    • 48849102034 scopus 로고    scopus 로고
    • The role of neurogenesis in neurodegenerative diseases and its implications for therapeutic development
    • Abdipranoto A, Wu S, Stayte S, Vissel B. The role of neurogenesis in neurodegenerative diseases and its implications for therapeutic development. CNS Neurol Disord Drug Targets 2008; 7: 187-210.
    • (2008) CNS Neurol Disord Drug Targets , vol.7 , pp. 187-210
    • Abdipranoto, A.1    Wu, S.2    Stayte, S.3    Vissel, B.4
  • 10
    • 59249098539 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology
    • Balu DT, Lucki I. Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology. Neurosci Biobehav Rev 2009; 33: 232-252.
    • (2009) Neurosci Biobehav Rev , vol.33 , pp. 232-252
    • Balu, D.T.1    Lucki, I.2
  • 12
    • 33747602312 scopus 로고    scopus 로고
    • Hypothalamic-endocrine aspects in Huntington's disease
    • Petersen A, Bjorkqvist M. Hypothalamic-endocrine aspects in Huntington's disease. Eur J Neurosci 2006; 24: 961-967.
    • (2006) Eur J Neurosci , vol.24 , pp. 961-967
    • Petersen, A.1    Bjorkqvist, M.2
  • 15
    • 84991386183 scopus 로고    scopus 로고
    • Weight loss in Huntington's disease
    • Stoy N, McKay E. Weight loss in Huntington's disease. Ann Neurol 2000; 48: 130-131.
    • (2000) Ann Neurol , vol.48 , pp. 130-131
    • Stoy, N.1    McKay, E.2
  • 16
    • 16344368831 scopus 로고    scopus 로고
    • Plasma testosterone in male patients with Huntington's disease: relations to severity of illness and dementia
    • Markianos M, Panas M, Kalfakis N, Vassilopoulos D. Plasma testosterone in male patients with Huntington's disease: relations to severity of illness and dementia. Ann Neurol 2005; 57: 520-525.
    • (2005) Ann Neurol , vol.57 , pp. 520-525
    • Markianos, M.1    Panas, M.2    Kalfakis, N.3    Vassilopoulos, D.4
  • 18
    • 40749098073 scopus 로고    scopus 로고
    • Gonadal hormone modulation of neurogenesis in the dentate gyrus of adult male and female rodents
    • Galea LA. Gonadal hormone modulation of neurogenesis in the dentate gyrus of adult male and female rodents. Brain Res Rev 2008; 57: 332-341.
    • (2008) Brain Res Rev , vol.57 , pp. 332-341
    • Galea, L.A.1
  • 19
    • 77954024451 scopus 로고    scopus 로고
    • A local autocrine axis in the testes that regulates spermatogenesis
    • Cheng CY, Mruk DD. A local autocrine axis in the testes that regulates spermatogenesis. Nat Rev Endocrinol 2010; 6: 380-395.
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 380-395
    • Cheng, C.Y.1    Mruk, D.D.2
  • 21
    • 34547790231 scopus 로고    scopus 로고
    • Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats
    • Spritzer MD, Galea LA. Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats. Dev Neurobiol 2007; 67: 1321-1333.
    • (2007) Dev Neurobiol , vol.67 , pp. 1321-1333
    • Spritzer, M.D.1    Galea, L.A.2
  • 23
    • 60549103857 scopus 로고    scopus 로고
    • The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease
    • Gil JM, Rego AC. The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease. Brain Res Rev 2009; 59: 410-431.
    • (2009) Brain Res Rev , vol.59 , pp. 410-431
    • Gil, J.M.1    Rego, A.C.2
  • 24
    • 0034078621 scopus 로고    scopus 로고
    • Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice
    • Dellu F, Contarino A, Simon H, Koob GF, Gold LH. Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice. Neurobiol Learn Mem 2000; 73: 31-48.
    • (2000) Neurobiol Learn Mem , vol.73 , pp. 31-48
    • Dellu, F.1    Contarino, A.2    Simon, H.3    Koob, G.F.4    Gold, L.H.5
  • 25
    • 34548279774 scopus 로고    scopus 로고
    • Systemically delivered Erythropoietin transiently enhances adult hippocampal neurogenesis
    • Ransome MI, Turnley AM. Systemically delivered Erythropoietin transiently enhances adult hippocampal neurogenesis. J Neurochem 2007; 102: 1953-1965.
    • (2007) J Neurochem , vol.102 , pp. 1953-1965
    • Ransome, M.I.1    Turnley, A.M.2
  • 26
    • 55249095553 scopus 로고    scopus 로고
    • Growth hormone signaling and hippocampal neurogenesis: insights from genetic models
    • Ransome MI, Turnley AM. Growth hormone signaling and hippocampal neurogenesis: insights from genetic models. Hippocampus 2008; 18: 1034-1050.
    • (2008) Hippocampus , vol.18 , pp. 1034-1050
    • Ransome, M.I.1    Turnley, A.M.2
  • 28
    • 0042921188 scopus 로고    scopus 로고
    • Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release
    • Li H, Wyman T, Yu ZX, Li SH, Li XJ. Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release. Hum Mol Genet 2003; 12: 2021-2030.
    • (2003) Hum Mol Genet , vol.12 , pp. 2021-2030
    • Li, H.1    Wyman, T.2    Yu, Z.X.3    Li, S.H.4    Li, X.J.5
  • 29
    • 17044416878 scopus 로고    scopus 로고
    • Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2
    • Ransome MI, Turnley AM. Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2. Neuroscience 2005; 132: 673-687.
    • (2005) Neuroscience , vol.132 , pp. 673-687
    • Ransome, M.I.1    Turnley, A.M.2
  • 30
    • 70049087121 scopus 로고    scopus 로고
    • Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide-treated rats
    • Winnall WR, Muir JA, Liew S, Hirst JJ, Meachem SJ, Hedger MP. Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide-treated rats. Int J Androl 2009; 32: 542-555.
    • (2009) Int J Androl , vol.32 , pp. 542-555
    • Winnall, W.R.1    Muir, J.A.2    Liew, S.3    Hirst, J.J.4    Meachem, S.J.5    Hedger, M.P.6
  • 31
    • 39249084983 scopus 로고    scopus 로고
    • Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice
    • Nithianantharajah J, Barkus C, Murphy M, Hannan AJ. Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice. Neurobiol Dis 2008; 29: 490-504.
    • (2008) Neurobiol Dis , vol.29 , pp. 490-504
    • Nithianantharajah, J.1    Barkus, C.2    Murphy, M.3    Hannan, A.J.4
  • 32
    • 0037196872 scopus 로고    scopus 로고
    • The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis
    • Kee N, Sivalingam S, Boonstra R, Wojtowicz JM. The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis. J Neurosci Methods 2002; 115: 97-105.
    • (2002) J Neurosci Methods , vol.115 , pp. 97-105
    • Kee, N.1    Sivalingam, S.2    Boonstra, R.3    Wojtowicz, J.M.4
  • 34
    • 61749091464 scopus 로고    scopus 로고
    • Modification of androgen receptor function by IGF-1 signaling implications in the mechanism of refractory prostate carcinoma
    • Yanase T, Fan W. Modification of androgen receptor function by IGF-1 signaling implications in the mechanism of refractory prostate carcinoma. Vitam Horm 2009; 80: 649-666.
    • (2009) Vitam Horm , vol.80 , pp. 649-666
    • Yanase, T.1    Fan, W.2
  • 36
    • 0031895775 scopus 로고    scopus 로고
    • The proliferation of spermatogonia in normal and pathological human seminiferous epithelium: an immunohistochemical study using monoclonal antibodies against Ki-67 protein and proliferating cell nuclear antigen
    • Steger K, Aleithe I, Behre H, Bergmann M. The proliferation of spermatogonia in normal and pathological human seminiferous epithelium: an immunohistochemical study using monoclonal antibodies against Ki-67 protein and proliferating cell nuclear antigen. Mol Hum Reprod 1998; 4: 227-233.
    • (1998) Mol Hum Reprod , vol.4 , pp. 227-233
    • Steger, K.1    Aleithe, I.2    Behre, H.3    Bergmann, M.4
  • 38
    • 0027370351 scopus 로고
    • Testosterone administration increases insulin-like growth factor-I levels in normal men
    • Hobbs CJ, Plymate SR, Rosen CJ, Adler RA. Testosterone administration increases insulin-like growth factor-I levels in normal men. J Clin Endocrinol Metab 1993; 77: 776-779.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 776-779
    • Hobbs, C.J.1    Plymate, S.R.2    Rosen, C.J.3    Adler, R.A.4
  • 39
    • 0019163929 scopus 로고
    • Characterization of a specific receptor for somatomedin C (SM-C) on cultured human lymphocytes: evidence that SM-C modulates homologous receptor concentration
    • Rosenfeld RG, Hintz RL. Characterization of a specific receptor for somatomedin C (SM-C) on cultured human lymphocytes: evidence that SM-C modulates homologous receptor concentration. Endocrinology 1980; 107: 1841-1848.
    • (1980) Endocrinology , vol.107 , pp. 1841-1848
    • Rosenfeld, R.G.1    Hintz, R.L.2
  • 40
    • 0026717790 scopus 로고
    • Effect of testosterone on insulin-like growth factor-I (IGF-I) and IGF-I receptor gene expression in the hypophysectomized rat
    • Phillip M, Palese T, Hernandez ER, Roberts CT Jr, LeRoith D, Kowarski AA. Effect of testosterone on insulin-like growth factor-I (IGF-I) and IGF-I receptor gene expression in the hypophysectomized rat. Endocrinology 1992; 130: 2865-2870.
    • (1992) Endocrinology , vol.130 , pp. 2865-2870
    • Phillip, M.1    Palese, T.2    Hernandez, E.R.3    Roberts Jr, C.T.4    LeRoith, D.5    Kowarski, A.A.6
  • 41
    • 58149496792 scopus 로고    scopus 로고
    • Endocrine regulation of cognition and neuroplasticity: our pursuit to unveil the complex interaction between hormones, the brain, and behaviour
    • Galea LA, Uban KA, Epp JR, Brummelte S, Barha CK, Wilson WL, Lieblich SE, Pawluski JL. Endocrine regulation of cognition and neuroplasticity: our pursuit to unveil the complex interaction between hormones, the brain, and behaviour. Can J Exp Psychol 2008; 62: 247-260.
    • (2008) Can J Exp Psychol , vol.62 , pp. 247-260
    • Galea, L.A.1    Uban, K.A.2    Epp, J.R.3    Brummelte, S.4    Barha, C.K.5    Wilson, W.L.6    Lieblich, S.E.7    Pawluski, J.L.8
  • 44
    • 0035996825 scopus 로고    scopus 로고
    • Cocaine-induced locomotor activity is enhanced by exogenous testosterone
    • Martinez-Sanchis S, Aragon CM, Salvador A. Cocaine-induced locomotor activity is enhanced by exogenous testosterone. Physiol Behav 2002; 76: 605-609.
    • (2002) Physiol Behav , vol.76 , pp. 605-609
    • Martinez-Sanchis, S.1    Aragon, C.M.2    Salvador, A.3
  • 46
    • 0035125829 scopus 로고    scopus 로고
    • The anabolic-androgenic steroid nandrolone decanoate affects the density of dopamine receptors in the male rat brain
    • Kindlundh AM, Lindblom J, Bergstrom L, Wikberg JE, Nyberg F. The anabolic-androgenic steroid nandrolone decanoate affects the density of dopamine receptors in the male rat brain. Eur J Neurosci 2001; 13: 291-296.
    • (2001) Eur J Neurosci , vol.13 , pp. 291-296
    • Kindlundh, A.M.1    Lindblom, J.2    Bergstrom, L.3    Wikberg, J.E.4    Nyberg, F.5
  • 47
    • 0037707819 scopus 로고    scopus 로고
    • Chronic administration with nandrolone decanoate induces alterations in the gene-transcript content of dopamine D(1)- and D(2)-receptors in the rat brain
    • Kindlundh AM, Lindblom J, Nyberg F. Chronic administration with nandrolone decanoate induces alterations in the gene-transcript content of dopamine D(1)- and D(2)-receptors in the rat brain. Brain Res 2003; 979: 37-42.
    • (2003) Brain Res , vol.979 , pp. 37-42
    • Kindlundh, A.M.1    Lindblom, J.2    Nyberg, F.3
  • 48
    • 20144379127 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease
    • Pineda JR, Canals JM, Bosch M, Adell A, Mengod G, Artigas F, Ernfors P, Alberch J. Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease. J Neurochem 2005; 93: 1057-1068.
    • (2005) J Neurochem , vol.93 , pp. 1057-1068
    • Pineda, J.R.1    Canals, J.M.2    Bosch, M.3    Adell, A.4    Mengod, G.5    Artigas, F.6    Ernfors, P.7    Alberch, J.8
  • 49
    • 0029895292 scopus 로고    scopus 로고
    • Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease
    • Weeks RA, Piccini P, Harding AE, Brooks DJ. Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease. Ann Neurol 1996; 40: 49-54.
    • (1996) Ann Neurol , vol.40 , pp. 49-54
    • Weeks, R.A.1    Piccini, P.2    Harding, A.E.3    Brooks, D.J.4
  • 51
    • 1842524121 scopus 로고    scopus 로고
    • Neural aromatization accelerates the acquisition of spatial memory via an influence on the songbird hippocampus
    • Oberlander JG, Schlinger BA, Clayton NS, Saldanha CJ. Neural aromatization accelerates the acquisition of spatial memory via an influence on the songbird hippocampus. Horm Behav 2004; 45: 250-258.
    • (2004) Horm Behav , vol.45 , pp. 250-258
    • Oberlander, J.G.1    Schlinger, B.A.2    Clayton, N.S.3    Saldanha, C.J.4
  • 52
    • 33745287880 scopus 로고    scopus 로고
    • Male hormonal contraception: concept proven, product in sight?
    • Matthiesson KL, McLachlan RI. Male hormonal contraception: concept proven, product in sight? Hum Reprod Update 2006; 12: 463-482.
    • (2006) Hum Reprod Update , vol.12 , pp. 463-482
    • Matthiesson, K.L.1    McLachlan, R.I.2
  • 55
    • 0035143822 scopus 로고    scopus 로고
    • Differential regulation of gonadotropin secretion by testosterone in the human male: absence of a negative feedback effect of testosterone on follicle-stimulating hormone secretion
    • Hayes FJ, DeCruz S, Seminara SB, Boepple PA, Crowley WF Jr. Differential regulation of gonadotropin secretion by testosterone in the human male: absence of a negative feedback effect of testosterone on follicle-stimulating hormone secretion. J Clin Endocrinol Metab 2001; 86: 53-58.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 53-58
    • Hayes, F.J.1    DeCruz, S.2    Seminara, S.B.3    Boepple, P.A.4    Crowley Jr, W.F.5
  • 56
    • 0029787431 scopus 로고    scopus 로고
    • Testosterone withdrawal promotes stage-specific detachment of round spermatids from the rat seminiferous epithelium
    • O'Donnell L, McLachlan RI, Wreford NG, de Kretser DM, Robertson DM. Testosterone withdrawal promotes stage-specific detachment of round spermatids from the rat seminiferous epithelium. Biol Reprod 1996; 55: 895-901.
    • (1996) Biol Reprod , vol.55 , pp. 895-901
    • O'Donnell, L.1    McLachlan, R.I.2    Wreford, N.G.3    de Kretser, D.M.4    Robertson, D.M.5
  • 57
    • 0028080879 scopus 로고
    • Testosterone promotes the conversion of round spermatids between stages VII and VIII of the rat spermatogenic cycle
    • O'Donnell L, McLachlan RI, Wreford NG, Robertson DM. Testosterone promotes the conversion of round spermatids between stages VII and VIII of the rat spermatogenic cycle. Endocrinology 1994; 135: 2608-2614.
    • (1994) Endocrinology , vol.135 , pp. 2608-2614
    • O'Donnell, L.1    McLachlan, R.I.2    Wreford, N.G.3    Robertson, D.M.4
  • 58
    • 77149133396 scopus 로고    scopus 로고
    • Spermatogonial stem cells in higher primates: are there differences from those in rodents?
    • Hermann BP, Sukhwani M, Hansel MC, Orwig KE. Spermatogonial stem cells in higher primates: are there differences from those in rodents? Reproduction 2010; 139: 479-493.
    • (2010) Reproduction , vol.139 , pp. 479-493
    • Hermann, B.P.1    Sukhwani, M.2    Hansel, M.C.3    Orwig, K.E.4
  • 59
    • 45549084972 scopus 로고    scopus 로고
    • Aromatase in the brain: not just for reproduction anymore
    • Garcia-Segura LM. Aromatase in the brain: not just for reproduction anymore. J Neuroendocrinol 2008; 20: 705-712.
    • (2008) J Neuroendocrinol , vol.20 , pp. 705-712
    • Garcia-Segura, L.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.