Daam2 Is Required for Dorsal Patterning via Modulation of Canonical Wnt Signaling in the Developing Spinal Cord

Developmental Cell

Volumn 22, Issue 1, 2012, Pages 183-196

  Lee, Hyun Kyoung ^a   Deneen, Benjamin ^a,b  

^a CENTER FOR CELL AND GENE THERAPY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN2 PROTEIN; BETA CATENIN; DAAM2 PROTEIN; DVL3 PROTEIN; FRIZZLED PROTEIN; PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BIOCHEMISTRY; EMBRYO; GAIN OF FUNCTION MUTATION; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MICROARRAY ANALYSIS; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD DEVELOPMENT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AXIN PROTEIN; BLOTTING, WESTERN; BODY PATTERNING; CELL COMMUNICATION; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CHICK EMBRYO; CHICKENS; COS CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; KIDNEY; MICE; MICROFILAMENT PROTEINS; ORGANOGENESIS; PHOSPHOPROTEINS; SPINAL CORD; WNT SIGNALING PATHWAY;

EID: 84855913455     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2011.10.025     Document Type: Article

References (43)

1. Alberts A.S. Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domain. J.Biol. Chem. 2001, 276:2824-2830.
2. Alvarez-Medina R., Cayuso J., Okubo T., Takada S., Martí E. Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression. Development 2008, 135:237-247.
3. Bilic J., Huang Y.L., Davidson G., Zimmermann T., Cruciat C.M., Bienz M., Niehrs C. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 2007, 316:1619-1622.
4. Briscoe J., Pierani A., Jessell T.M., Ericson J. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell 2000, 101:435-445.
5. Chang J., Sonoyama W., Wang Z., Jin Q., Zhang C., Krebsbach P.H., Giannobile W., Shi S., Wang C.Y. Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J.Biol. Chem. 2007, 282:30938-30948.
6. Chen H.J., Lin C.M., Lin C.S., Perez-Olle R., Leung C.L., Liem R.K. The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 2006, 20:1933-1945.
7. Chizhikov V.V., Millen K.J. Control of roof plate formation by Lmx1a in the developing spinal cord. Development 2004, 131:2693-2705.
8. DasGupta R., Fuchs E. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 1999, 126:4557-4568.
9. Deneen B., Ho R., Lukaszewicz A., Hochstim C.J., Gronostajski R.M., Anderson D.J. The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron 2006, 52:953-968.
10. Dickinson M.E., Krumlauf R., McMahon A.P. Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development 1994, 120:1453-1471.
11. Ding Y., Xi Y., Chen T., Wang J.Y., Tao D.L., Wu Z.L., Li Y.P., Li C., Zeng R., Li L. Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J.Cell Biol. 2008, 182:865-872.
12. Ericson J., Rashbass P., Schedl A., Brenner-Morton S., Kawakami A., van Heyningen V., Jessell T.M., Briscoe J. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 1997, 90:169-180.
13. Graham V., Khudyakov J., Ellis P., Pevny L. SOX2 functions to maintain neural progenitor identity. Neuron 2003, 39:749-765.
14. Gray R.S., Bayly R.D., Green S.A., Agarwala S., Lowe C.J., Wallingford J.B. Diversification of the expression patterns and developmental functions of the dishevelled gene family during chordate evolution. Dev. Dyn. 2009, 238:2044-2057.
15. Habas R., Kato Y., He X. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell 2001, 107:843-854.
16. Ikeya M., Lee S.M.K., Johnson J.E., McMahon A.P., Takada S. Wnt signalling required for expansion of neural crest and CNS progenitors. Nature 1997, 389:966-970.
17. Jessell T.M. Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat. Rev. Genet. 2000, 1:20-29.
18. Kida Y., Shiraishi T., Ogura T. Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system. Brain Res. Dev. Brain Res. 2004, 153:143-150.
19. Kim C.H., Oda T., Itoh M., Jiang D., Artinger K.B., Chandrasekharappa S.C., Driever W., Chitnis A.B. Repressor activity of Headless/Tcf3 is essential for vertebrate head formation. Nature 2000, 407:913-916.
20. Kishida S., Yamamoto H., Hino S., Ikeda S., Kishida M., Kikuchi A. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol. Cell. Biol. 1999, 19:4414-4422.
21. Lassiter R.N.T., Dude C.M., Reynolds S.B., Winters N.I., Baker C.V.H., Stark M.R. Canonical Wnt signaling is required for ophthalmic trigeminal placode cell fate determination and maintenance. Dev. Biol. 2007, 308:392-406.
22. Liem K.F., Tremml G., Roelink H., Jessell T.M. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 1995, 82:969-979.
23. Liu A., Niswander L.A. Bone morphogenetic protein signalling and vertebrate nervous system development. Nat. Rev. Neurosci. 2005, 6:945-954.
24. Liu T., DeCostanzo A.J., Liu X., Wang Hy, Hallagan S., Moon R.T., Malbon C.C. G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway. Science 2001, 292:1718-1722.
25. Lupo G., Harris W.A., Lewis K.E. Mechanisms of ventral patterning in the vertebrate nervous system. Nat. Rev. Neurosci. 2006, 7:103-114.
26. Lyuksyutova A.I., Lu C.C., Milanesio N., King L.A., Guo N., Wang Y., Nathans J., Tessier-Lavigne M., Zou Y. Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling. Science 2003, 302:1984-1988.
27. MacDonald B.T., Tamai K., He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 2009, 17:9-26.
28. Megason S.G., McMahon A.P. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 2002, 129:2087-2098.
29. Muroyama Y., Fujihara M., Ikeya M., Kondoh H., Takada S. Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev. 2002, 16:548-553.
30. Rothbächer U., Laurent M.N., Deardorff M.A., Klein P.S., Cho K.W., Fraser S.E. Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J. 2000, 19:1010-1022.
31. Schlessinger K., Hall A., Tolwinski N. Wnt signaling pathways meet Rho GTPases. Genes Dev. 2009, 23:265-277.
32. Schwarz-Romond T., Metcalfe C., Bienz M. Dynamic recruitment of axin by Dishevelled protein assemblies. J.Cell Sci. 2007, 120:2402-2412.
33. Schwarz-Romond T., Fiedler M., Shibata N., Butler P.J., Kikuchi A., Higuchi Y., Bienz M. The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. Nat. Struct. Mol. Biol. 2007, 14:484-492.
34. Tetsu O., McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999, 398:422-426.
35. Villa P., Kaufmann S.H., Earnshaw W.C. Caspases and caspase inhibitors. Trends Biochem. Sci. 1997, 22:388-393.
36. Wallingford J.B., Habas R. The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. Development 2005, 132:4421-4436.
37. Weernink P.A., Meletiadis K., Hommeltenberg S., Hinz M., Ishihara H., Schmidt M., Jakobs K.H. Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42. J.Biol. Chem. 2004, 279:7840-7849.
38. Wehrli M., Dougan S.T., Caldwell K., O'Keefe L., Schwartz S., Vaizel-Ohayon D., Schejter E., Tomlinson A., DiNardo S. arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 2000, 407:527-530.
39. Wei Y.J., Sun H.Q., Yamamoto M., Wlodarski P., Kunii K., Martinez M., Barylko B., Albanesi J.P., Yin H.L. Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP. J.Biol. Chem. 2002, 277:46586-46593.
40. Wodarz A., Nusse R. Mechanisms of Wnt signaling in development. Annu. Rev. Cell Dev. Biol. 1998, 14:59-88.
41. Wong H.C., Bourdelas A., Krauss A., Lee H.J., Shao Y., Wu D., Mlodzik M., Shi D.L., Zheng J. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol. Cell 2003, 12:1251-1260.
42. Yang S.A., Carpenter C.L., Abrams C.S. Rho and Rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in platelets. J.Biol. Chem. 2004, 279:42331-42336.
43. Zeng X., Huang H., Tamai K., Zhang X., Harada Y., Yokota C., Almeida K., Wang J., Doble B., Woodgett J., et al. Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development 2008, 135:367-375.