메뉴 건너뛰기




Volumn 30, Issue 11, 2011, Pages 839-849

The effect of ITPa polymorphisms on the enzyme kinetic properties of human erythrocyte inosine triphosphatase toward its substrates ITP and 6-thio-ITP

Author keywords

Adverse drug reactions; ITPase; Pharmaco genetics; Substrate specificity; Thiopurines

Indexed keywords

INOSINE TRIPHOSPHATE; MERCAPTOPURINE; PHOSPHATASE;

EID: 84855884329     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770.2011.606789     Document Type: Article
Times cited : (12)

References (25)
  • 2
    • 35348853228 scopus 로고    scopus 로고
    • Pharmacogenetic significance of inosine triphosphatase
    • DOI 10.2217/14622416.8.9.1221
    • Bierau, J.; Lindhout, M.; Bakker, J. A. Pharmacogenetic significance of inosine triphosphatase. Pharmacogenomics 2007, 8, 1221-1228. (Pubitemid 47578231)
    • (2007) Pharmacogenomics , vol.8 , Issue.9 , pp. 1221-1228
    • Bierau, J.1    Lindhout, M.2    Bakker, J.A.3
  • 3
    • 0014958870 scopus 로고
    • Human erythrocyte "ITPase": An ITP pyrophosphohydrolase
    • Vanderheiden, B. S. Human erythrocyte "ITPase": an ITP pyrophosphohydrolase. Biochim. Biophys. Acta 1970, 215, 555-558.
    • (1970) Biochim. Biophys. Acta , vol.215 , pp. 555-558
    • Vanderheiden, B.S.1
  • 4
    • 0025279462 scopus 로고
    • Inosine triphosphate pyrophosphohydrolase deficiency in a kindred with adenosine deaminase deficiency
    • DOI 10.1016/0009-8981(90)90206-8
    • Duley, J. A.; Simmonds, H. A.; Hopkinson, D. A.; Levinsky, R. J. Inosine triphosphate pyrophosphohydrolase deficiency in a kindred with adenosine deaminase deficiency. Clin. Chim. Acta 1990, 188, 243-252. (Pubitemid 20176149)
    • (1990) Clinica Chimica Acta , vol.188 , Issue.3 , pp. 243-252
    • Duley, J.A.1    Simmonds, H.A.2    Hopkinson, D.A.3    Levinsky, R.J.4
  • 6
    • 77953276559 scopus 로고    scopus 로고
    • NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals
    • Abolhassani, N.; Iyama, T.; Tsuchimoto, D.; Sakumi, K.; Ohno, M.; Behmanesh, M.; et al. NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals. Nucleic Acids Res. 2010, 38, 2891-2903.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 2891-2903
    • Abolhassani, N.1    Iyama, T.2    Tsuchimoto, D.3    Sakumi, K.4    Ohno, M.5    Behmanesh, M.6
  • 7
    • 77949773445 scopus 로고    scopus 로고
    • ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    • Fellay, J.; Thompson, A. J.; Ge, D.; Gumbs, C. E.; Urban, T. J.; Shianna, K. V.; et al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature 2010, 464, 405-408.
    • (2010) Nature , vol.464 , pp. 405-408
    • Fellay, J.1    Thompson, A.J.2    Ge, D.3    Gumbs, C.E.4    Urban, T.J.5    Shianna, K.V.6
  • 8
    • 79953208979 scopus 로고    scopus 로고
    • Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by restoring adenylosuccinate synthase function
    • Hitomi, Y.; Cirulli, E. T.; Fellay, J.; McHutchison, J. G.; Thompson, A. J.; Gumbs, C. E.; et al. Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by restoring adenylosuccinate synthase function. Gastroenterology 2011, 140, 1314-1321.
    • (2011) Gastroenterology , vol.140 , pp. 1314-1321
    • Hitomi, Y.1    Cirulli, E.T.2    Fellay, J.3    McHutchison, J.G.4    Thompson, A.J.5    Gumbs, C.E.6
  • 10
    • 52149099443 scopus 로고    scopus 로고
    • Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease
    • Ansari, A.; Arenas, M.; Greenfield, S. M.; Morris, D.; Lindsay, J.; Gilshenan, K.; et al. Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease. Aliment. Pharmacol. Ther. 2008; 28, 973-983.
    • (2008) Aliment. Pharmacol. Ther. , vol.28 , pp. 973-983
    • Ansari, A.1    Arenas, M.2    Greenfield, S.M.3    Morris, D.4    Lindsay, J.5    Gilshenan, K.6
  • 12
    • 51649130245 scopus 로고    scopus 로고
    • Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine
    • Hawwa, A. F.; Millership, J. S.; Collier, P. S.; Vandenbroeck, K.; McCarthy, A.; Dempsey, S.; et al. Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine. Br. J. Clin. Pharmacol. 2008, 66, 517-528.
    • (2008) Br. J. Clin. Pharmacol. , vol.66 , pp. 517-528
    • Hawwa, A.F.1    Millership, J.S.2    Collier, P.S.3    Vandenbroeck, K.4    McCarthy, A.5    Dempsey, S.6
  • 14
    • 67349087340 scopus 로고    scopus 로고
    • TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients
    • Kurzawski, M.; Dziewanowski, K.; Lener, A.; Drozdzik, M. TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients. Eur. J. Clin. Pharmacol. 2009, 65, 533-540.
    • (2009) Eur. J. Clin. Pharmacol. , vol.65 , pp. 533-540
    • Kurzawski, M.1    Dziewanowski, K.2    Lener, A.3    Drozdzik, M.4
  • 15
    • 27444437058 scopus 로고    scopus 로고
    • ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients [7]
    • van Dieren, J. M.; van Vuuren, A. J.; Kusters, J. G.; Nieuwenhuis, E. E.; Kuipers, E. J.; van der Woude, C. J. ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients. Gut 2005, 54, 1664. (Pubitemid 41531793)
    • (2005) Gut , vol.54 , Issue.11 , pp. 1664
    • Van Dieren, J.M.1    Van Vuuren, A.J.2    Kusters, J.G.3    Nieuwenhuis, E.E.S.4    Kuipers, E.J.5    Van Der Woude, C.J.6
  • 16
    • 33745665758 scopus 로고    scopus 로고
    • Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease
    • DOI 10.1136/gut.2005.074930
    • Hindorf, U.; Lindqvist, M.; Peterson, C.; Soderkvist, P.; Strom, M.; Hjortswang, H.; et al. Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease. Gut 2006, 55, 1423-1431. (Pubitemid 44476786)
    • (2006) Gut , vol.55 , Issue.10 , pp. 1423-1431
    • Hindorf, U.1    Lindqvist, M.2    Peterson, C.3    Soderkvist, P.4    Strom, M.5    Hjortswang, H.6    Pousette, A.7    Almer, S.8
  • 17
    • 34547830873 scopus 로고    scopus 로고
    • Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease
    • DOI 10.1111/j.1365-2036.2007.03412.x
    • van Dieren, J. M.; Hansen, B. E.; Kuipers, E. J.; Nieuwenhuis, E. E.; van der Woude, C. J. Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease. Aliment. Pharmacol. Ther. 2007, 26, 643-652. (Pubitemid 47246201)
    • (2007) Alimentary Pharmacology and Therapeutics , vol.26 , Issue.5 , pp. 643-652
    • Van Dieren, J.M.1    Hansen, B.E.2    Kuipers, E.J.3    Nieuwenhuis, E.E.S.4    Van Der Woude, C.J.5
  • 20
    • 34047247010 scopus 로고    scopus 로고
    • Crystal structure of human inosine triphosphatase: Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T
    • DOI 10.1074/jbc.M609838200
    • Stenmark, P.; Kursula, P.; Flodin, S.; Graslund, S.; Landry, R.; Nordlund, P.; et al. Crystal structure of human inosine triphosphatase: Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T. J. Biol. Chem. 2007, 282, 3182-3187. (Pubitemid 47084319)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.5 , pp. 3182-3187
    • Stenmark, P.1    Kursula, P.2    Flodin, S.3    Graslund, S.4    Landry, R.5    Nordlund, P.6    Schuler, H.7
  • 21
    • 31844455940 scopus 로고    scopus 로고
    • Measurement of erythrocyte inosine triphosphate pyrophosphohydrolase (ITPA) activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasian population
    • DOI 10.1373/clinchem.2005.059501
    • Shipkova, M.; Lorenz, K.; Oellerich, M.; Wieland, E.; von Ahsen, N. Measurement of erythrocyte inosine triphosphate pyrophosphohydrolase (ITPA) activity by HPLC and correlation of ITPA genotypephenotype in a Caucasian population. Clin. Chem. 2006, 52, 240-247. (Pubitemid 43185485)
    • (2006) Clinical Chemistry , vol.52 , Issue.2 , pp. 240-247
    • Shipkova, M.1    Lorenz, K.2    Oellerich, M.3    Wieland, E.4    Von Ansen, N.5
  • 24
    • 33750448011 scopus 로고    scopus 로고
    • Determination of ITPase activity in erythrocyte lysates obtained for determination of TPMT activity
    • DOI 10.1080/15257770600894253, PII QT223077148Q1N63
    • Bierau, J.; Bakker, J. A.; Lindhout, M.; van Gennip, A. H. Determination of ITPase activity in erythrocyte lysates obtained for determination of TPMT activity. Nucleos. Nucleot. Nucl. Acids 2006, 25, 1129-1132. (Pubitemid 44651860)
    • (2006) Nucleosides, Nucleotides and Nucleic Acids , vol.25 , Issue.9-11 , pp. 1129-1132
    • Bierau, J.1    Bakker, J.A.2    Lindhout, M.3    Van Gennip, A.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.