Adoptive transfer of dendritic cells pulsed with Fasciola hepatica antigens and lipopolysaccharides confers protection against fasciolosis in mice

Journal of Infectious Diseases

Volumn 205, Issue 3, 2012, Pages 506-514

  Falcón, Cristian R ^a   Carranza, Franco A ^a   Aoki, Pilar ^a   Motrán, Claudia C ^a   Cervi, Laura ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

DENDRITIC CELL VACCINE; LIPOPOLYSACCHARIDE; PARASITE ANTIGEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL MATURATION; CONTROLLED STUDY; FASCIOLA HEPATICA; FASCIOLIASIS; FEMALE; INFECTION CONTROL; INFECTION PREVENTION; MOUSE; NONHUMAN; PARASITE LOAD; PHENOTYPIC VARIATION; PRIORITY JOURNAL; TH1 CELL; VACCINATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, HELMINTH; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FASCIOLA HEPATICA; FASCIOLIASIS; FEMALE; HISTOCYTOCHEMISTRY; LIPOPOLYSACCHARIDES; LIVER; MICE; MICE, INBRED BALB C; MICROSCOPY; TH1 CELLS; VACCINATION;

EID: 84855876395     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir606     Document Type: Article

References (30)

1. McManus DP, Dalton JP. Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica. Parasitology 2006;133 Suppl: S43-61. (Pubitemid 46208030)
2. Mera y Sierra R, Artigas P, Cuervo P, et al. Fascioliasis transmission by Lymnaea neotropica confirmed by nuclear rDNA and mtDNA sequencing in Argentina. Vet Parasitol 2009;166:73-9.
3. Mulcahy G, O'Connor F, Clery D, et al. Immune responses of cattle to experimental anti-Fasciola hepatica vaccines. Res Vet Sci 1999;67:27-33. (Pubitemid 29389582)
4. Cervi L, Borgonovo J, Egea M, Chiapello L, Masih D. Immunization of rats against Fasciola hepatica using crude antigens conjugated with Freund's adjuvant or oligodeoxynucleotides. Vet Immunol Immunopathol 2004;97:97-104. (Pubitemid 38041257)
5. Hillyer GV. Fasciola antigens as vaccines against fascioliasis and schistosomiasis. J Helminthol 2005;79:241-7. (Pubitemid 41192538)
6. Espino AM, Torres D, Morales A, Delgado B, Quetel J, Osuna A. Fasciola hepatica: identification of CD4+ T-helper epitopes from the 11.5 kDa saposin-like protein SAP-2 using synthetic peptides. Exp Parasitol 2007;117:65-73. (Pubitemid 47411507)
7. Fajardo-Moser M, Berzel S, Moll H. Mechanisms of dendritic cell-based vaccination against infection. Int J Med Microbiol 2008;298:11-20. (Pubitemid 350216547)
8. Ramirez-Pineda JR, Frohlich A, Berberich C, Moll H. Dendritic cells (DC) activated by CpG DNA ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of IL-12 derived from the immunizing DC. J Immunol 2004;172:6281-9. (Pubitemid 38621235)
9. Remer KA, Apetrei C, Schwarz T, Linden C, Moll H. Vaccination with plasmacytoid dendritic cells induces protection against infection with Leishmania major in mice. Eur J Immunol 2007;37:2463-73. (Pubitemid 47430432)
10. Walsh KP, Brady MT, Finlay CM, Boon L, Mills KH. Infection with a helminth parasite attenuates autoimmunity through TGF-betamediated suppression of Th17 and Th1 responses. J Immunol 2009;183:1577-86.
11. Hamilton CM, Dowling DJ, Loscher CE, Morphew RM, Brophy PM, O'Neill SM. The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function. Infect Immun 2009;77:2488-98.
12. Falcon C, Carranza F, Martinez FF, et al. Excretory-secretory products (ESP) from Fasciola hepatica induce tolerogenic properties in myeloid dendritic cells. Vet Immunol Immunopathol 2010;137:36-46.
13. MacDonald AS, Straw AD, Bauman B, Pearce EJ. CD8-dendritic cell activation status plays an integral role in influencing Th2 response development. J Immunol 2001;167:1982-8. (Pubitemid 32747504)
14. Barton GM, Medzhitov R. Toll-like receptors and their ligands. Curr Top Microbiol Immunol 2002;270:81-92. (Pubitemid 35448154)
15. Cervi L, Rubinstein H, Masih DT. Involvement of excretion-secretion products from Fasciola hepatica inducing suppression of the cellular immune responses. Vet Parasitol 1996;61:97-111. (Pubitemid 26025847)
16. Trinchieri G, Pflanz S, Kastelein RA. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 2003;19:641-4. (Pubitemid 37490789)
17. Jiang HR, Muckersie E, Robertson M, Xu H, Liversidge J, Forrester JV. Secretion of interleukin-10 or interleukin-12 by LPS-activated dendritic cells is critically dependent on time of stimulus relative to initiation of purified DC culture. J Leukoc Biol 2002;72:978-85. (Pubitemid 35365172)
18. Robinson MW, Menon R, Donnelly SM, Dalton JP, Ranganathan S. An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host. Mol Cell Proteomics 2009;8:1891-907.
19. Almeida MS, Torloni H, Lee-Ho P, et al. Vaccination against Fasciola hepatica infection using a Schistosoma mansoni defined recombinant antigen, Sm14. Parasite Immunol 2003;25:135-7. (Pubitemid 38021351)
20. Dalton JP, McGonigle S, Rolph TP, Andrews SJ. Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin. Infect Immun 1996;64:5066-74. (Pubitemid 26403963)
21. Espino AM, Morales A, Delgado B, Rivera FM, Figueroa O, Suarez E. Partial immunity to Fasciola hepatica in mice after vaccination with FhSAP2 delivered as recombinant protein or DNA construct. Ethn Dis 2010;20:S1-17-23.
22. Taylor MD, Harris A, Nair MG, Maizels RM, Allen JE. F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection. J Immunol 2006;176:6918-27. (Pubitemid 43787872)
23. Piedrafita D, Parsons JC, Sandeman RM, et al. Antibody-dependent cell-mediated cytotoxicity to newly excysted juvenile Fasciola hepatica in vitro is mediated by reactive nitrogen intermediates. Parasite Immunol 2001;23:473-82. (Pubitemid 34205732)
24. Klion AD, Nutman TB. The role of eosinophils in host defense against helminth parasites. J Allergy Clin Immunol 2004;113:30-7. (Pubitemid 38096158)
25. Serradell MC, Guasconi L, Cervi L, Chiapello LS, Masih DT. Excretorysecretory products from Fasciola hepatica induce eosinophil apoptosis by a caspase-dependent mechanism. Vet Immunol Immunopathol 2007;117:197-208. (Pubitemid 46711212)
26. O'Neill SM, Brady MT, Callanan JJ, et al. Fasciola hepatica infection downregulates Th1 responses in mice. Parasite Immunol 2000;22:147-55. (Pubitemid 30137756)
27. Donnelly S, O'Neill SM, Sekiya M, Mulcahy G, Dalton JP. Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages. Infect Immun 2005;73:166-73. (Pubitemid 40041106)
28. Flynn RJ, Irwin JA, Olivier M, Sekiya M, Dalton JP, Mulcahy G. Alternative activation of ruminant macrophages by Fasciola hepatica. Vet Immunol Immunopathol 2007;120:31-40. (Pubitemid 47464611)
29. Hacariz O, Sayers G, Mulcahy G. A preliminary study to understand the effect of Fasciola hepatica tegument on naive macrophages and humoral responses in an ovine model. Vet Immunol Immunopathol 2011;139:245-9.
30. Cervi LA, Rubinstein H, Masih DT. Serological, electrophoretic and biological properties of Fasciola hepatica antigens. Rev Inst Med Trop Sao Paulo 1992;34:517-25.