The complex interactions between Clostridium perfringens enterotoxin and epithelial tight junctions

Toxicon

Volumn 39, Issue 11, 2001, Pages 1781-1791

  McClane, Bruce A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Claudin; Clostridium perfringens; Enterotoxin; Occludin; Plasma membrane permeability; Tight junctions

Indexed keywords

ANTIBIOTIC AGENT; CLAUDIN; ENTEROTOXIN; OCCLUDIN;

AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CELL DAMAGE; CELL MEMBRANE PERMEABILITY; CLOSTRIDIUM PERFRINGENS; CYTOTOXICITY; DIARRHEA; DRUG INDUCED DISEASE; FOOD POISONING; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RABBIT; RECEPTOR BINDING; REVIEW; TIGHT JUNCTION;

CLOSTRIDIUM PERFRINGENS;

EID: 0034868507     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(01)00164-7     Document Type: Short Survey

References (63)

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4. Phenotypic characterization of enterotoxigenic Clostridium perfringens isolates from non-foodborne human gastrointestinal diseases
5. The enterotoxin gene (cpe) of Clostridium perfringens can be chromosomal or plasmid-borne
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7. Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction membrane protein
8. Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
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10. Chymotrypsin treatment increases the activity of Clostridium perfringens enterotoxin
11. Trypsin activation of enterotoxin from Clostridium perfringens type A
12. Molecular cloning of the 3′ half of the Clostridium perfringens enterotoxin gene and demonstration that this region encodes receptor-binding activity
13. Localization of the receptor-binding region of Clostridium perfringens enterotoxin utilizing cloned toxin fragments and synthetic peptides. The 30 C-terminal amino acids define a functional binding region
14. Mapping functional regions of Clostridium perfringens type A enterotoxin
15. Cationic currents induced by Clostridium perfringens type A enterotoxin in human intestinal Caco-2 cells
16. Organization of the botulinum neurotoxin C1 gene and its non-toxic protein genes in Clostridium botulinum C 468
17. The relationship between cytotoxic effects and binding to mammalian cultures cells of Clostridium perfringens enterotoxin
18. Isolation and function of a Clostridium perfringens enterotoxin fragment
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20. Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin
21. Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo
22. Evidence that region(s) of the Clostridium perfringens enterotoxin molecule remain exposed on the external surface of the mammalian plasma membrane when the toxin is sequestered in small or large complex
23. Deletion analysis of the Clostridium perfringens enterotoxin
24. Identification of a Clostridium perfringens enterotoxin region required for large complex formation and cytotoxicity by random mutagenesis
25. Primary action of Clostridium perfringens type A enterotoxin on HeLa and Vero cells in the absence of extracellular calcium: Rapid and characteristic changes in membrane permeability
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32. Studies of Clostridium perfringens enterotoxin action at different temperatures demonstrate a correlation between complex formation and cytotoxicity
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38. In vivo effects of enterotoxin from Clostridium perfringens type A in rabbit colon: Binding vs. biologic activity
39. Histopathological effect of Clostridium perfringens enterotoxin in the rabbit ileum
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41. Binding vs. biological activity of Clostridium perfringens enterotoxin in Vero cells
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44. Surveillance for foodborne-disease outbreaks - United States, 1993-97
45. Clostridium perfringens enterotoxin impairs bile flow in the isolated perfused rat liver and induces fragmentation of tight junction fibrils
46. Inactivation of the gene (cpe) encoding Clostridium perfringens enterotoxin eliminates the ability of two cpe-positive C. perfringens type A human gastrointestinal disease isolates to affect rabbit ileal loops
47. Comparative experiments to examine the effects of heating on vegetative cells and spores of Clostridium perfringens isolates carrying plasmid versus chromosomal enterotoxin genes
48. Clostridium perfringens type A enterotoxin induces concurrent development of tissue damage and fluid accumulation in the rabbit ileum
49. Comarative biochemical and immunoctyochemical studies reveal differences in the effects of Clostridium perfringen enterotoxin on polarized CaCo-2 cells versus Vero cells
50. CaCo-2 cells treated with Clostridium perfringens enterotoxin form multiple large complex species, one of which contains the tight junction protein occludin
51. Experimental diarrhea in human volunteers following oral administration of Clostridium perfringens enterotoxin
52. Clostridial enteric diseases of domestic animals
53. Clostridium perfringens enterotoxin fragments removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier
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55. Identification and isolation of the binding substance for Clostridium perfringens enterotoxin on Vero cells
56. Enterotoxin of Clostridium perfringens type A forms ion-permeable channels in a lipid bilayer membrane
57. Evidence that an ∼50 kDa mammalian plasma membrane protein with receptor-like properties mediates the amphiphilicity of specifically-bound Clostridium perfringens enterotoxin
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59. r protein from rabbit brush boarder membranes that binds Clostridium perfringens enterotoxin
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61. r complex in mammalian membranes
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63. Identification and characterization of sporulation-dependent promoters upstream of the enterotoxin gene (cpe) of Clostridium perfringens