Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Kubinyi, Eniko ^a   Vas, Judit ^a   Hejjas, Krisztina ^b   Ronai, Zsolt ^b   Brúder, Ildikó ^a   Turcsán, Borbála ^a   Sasvari Szekely, Maria ^b   Miklósi, Ádám ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

TYROSINE 3 MONOOXYGENASE;

ACTIVITY IMPULSIVITY BEHAVIOURAL SCALE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DOG; DOG ATTENTION DEFICIT HYPERACTIVITY DISORDER RATING SCALE; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; GERMAN SHEPHERD; IMPULSIVENESS; INTERNAL CONSISTENCY; INTRON; MALE; NONHUMAN; PHENOTYPE; RATING SCALE; RELIABILITY; TEST RETEST RELIABILITY; VALIDITY; ADOLESCENT; ADULT; ANIMAL; ATTENTION DEFICIT DISORDER; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOG DISEASE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETICS; HUMAN; METHODOLOGY; MIDDLE AGED; MOTOR ACTIVITY; ORGANIZATION AND MANAGEMENT; PATHOPHYSIOLOGY; PET ANIMAL; PHYSIOLOGY; PSYCHOLOGICAL RATING SCALE; STANDARD;

CANIS FAMILIARIS;

ADOLESCENT; ADULT; ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOG DISEASES; DOGS; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; IMPULSIVE BEHAVIOR; INTRONS; MALE; MIDDLE AGED; MOTOR ACTIVITY; OWNERSHIP; PETS; PHENOTYPE; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; TYROSINE 3-MONOOXYGENASE; YOUNG ADULT;

EID: 84855849462     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030271     Document Type: Article

References (43)

1. Topál J, Miklósi Á, Gácsi M, Dóka A, Pongrácz P, et al. (2009) The Dog as a Model for Understanding Human Social Behavior. Adv Stud Behav 39: 71-116.
2. Sutter NB, Ostrander EA, (2004) Dog star rising: the canine genetic system. Nat Rev Genet 5: 900-10.
3. Spady TC, Ostrander EA, (2008) Canine Behavioral Genetics: Pointing Out the Phenotypes and Herding up the Genes. J Human Genet 82: 10-18.
4. Karlsson EK, Lindblad-Toh K, (2008) Leader of the pack: gene mapping in dogs and other model organisms. Med Biochem 9: 713-725.
5. Overall KL, (2000) Natural animal models of human psychiatric conditions: assessment of mechanism and validity. Prog Neuro-Psychopharmacol Biol Psychiat 24: 727-776.
6. Ostrander EA, Galibert F, Patterson DF, (2000) Canine genetics comes of age. Trends Genet 16: 117-124.
7. Parker HG, Shearin AL, Ostrander EA, (2010) Man's best friend becomes biology's best in show: genome analyses in the domestic dog. Annu Rev Genet 44: 309-336.
8. Jones P, Chase K, Martin A, Davern P, Ostrander EA, et al. (2008) Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes. Genetics 179: 1033-1044.
9. Chase K, Jones P, Ostrander EA, Lark KG, (2009) Genetic Mapping of Fixed Phenotypes: Disease Frequency as a Breed Characteristic. J Hered 1-5.
10. Vas J, Topál J, Péch E, Miklósi Á, (2007) Measuring attention deficit and activity in dogs: A new application and validation of a human ADHD questionnaire. Appl Anim Behav Sci 103: 105-117.
11. DuPaul GJ, Power TJ, Anastopoulos AD, Reid R, (1998) ADHD Rating Scale-IV: Checklist, Norms and Clinical Interpretation. New York Guilford Press.
12. Lit L, Schweitzer JB, Iosif AM, Oberbauer AM, (2010) Owner reports of attention, activity, and impulsivity in dogs: a replication study. Behav Brain Func 6: 1.
13. Hennessy MB, Voith VL, Mazzei SJ, Buttram J, Miller DD, et al. (2001) Behavior and cortisol levels of dogs in a public animal shelter, and an exploration of the ability of these measures to predict problem behavior after adoption. Appl Anim Behav Sci 73: 217-233.
14. Wilsson E, Sundgren P-E, (1997) The use of a behaviour test for the selection of dogs for service and breeding, I: Method of testing and evaluating test results in the adult dog, demands on different kinds of service dogs, sex and breed differences. Appl. Anim. Behav Sci 53: 279-295.
15. Gosling SD, John JP, (1999) Personality Dimensions in Nonhuman Animals: A Cross-Species Review. Curr Dir Psychol Sci 8: 69-75.
16. Jones AC, Gosling SD, (2005) Temperament and personality in dogs (Canis familiaris): A review and evaluation of past research. Appl Anim Behav Sci 95: 1-53.
17. Slabbert J, Odendaal JSD, (1999) Early prediction of adult police dog efficiency-a longitudinal study. ApplAnim Behav Sci 64: 269-288.
18. Ruefenacht S, (2002) A behaviour test on German Shepherd dogs: heritability of seven different traits. Appl Anim Behav Sci 79: 113-132.
19. Hejjas K, Vas J, Topal J, Szantai E, Ronai Z, et al. (2007) Association of polymorphisms in the dopamine D4 receptor gene and the activity-impulsivity endophenotype in dogs. Anim Genet 38: 629-633.
20. Hejjas K, Kubinyi E, Ronai Z, Szekely A, Vas J, et al. (2009) Molecular and behavioral analysis of the intron 2 repeat polymorphism in the canine dopamine D4 receptor gene. Genes Brain Behav 8: 330-336.
21. Nieoullon A, (2002) Dopamine and the regulation of cognition and attention. Progress in Neurobiology 67: 53-83.
22. Gizer IR, Ficks C, Waldman ID, (2009) Candidate gene studies of ADHD: a meta-analytic review. Human Genet 126: 51-90.
23. Persson ML, Wasserman D, Geijer T, Jönsson EG, Terenius L, (1997) Tyrosine hydroxylase allelic distribution in suicide attempters. Psychiat Res 72: 73-80.
24. Serretti A, Macciardi F, Verga M, Cusin C, Pedrini S, et al. (1998) Tyrosine hydroxylase gene associated with depressive symptomatology in mood disorder. Am J of Med Genet 81: 127-130.
25. Persson ML, Wasserman D, Jönsson EG, Bergman H, Terenius L, et al. (2000) Search for the influence of the tyrosine hydroxylase (TCAT)(n) repeat polymorphism on personality traits. Psychiat Res 95: 1-8.
26. Sharma P, Hingorani A, Jia H, Ashby M, Hopper R, et al. (1998) Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension. Hypertension 32: 676-682.
27. Takeuchi Y, Hashizume C, Ha CEM, Momozawa Y, Masuda K, et al. (2005) Canine Tyrosine Hydroxylase (TH) Gene and Dopamine β-Hydroxylase (DBH) Gene: Their Sequences, Genetic Polymorphisms, and Diversities among Five Different Dog Breeds. J Vet Med Sci 67: 861-867.
28. Hejjas K, Vas J, Kubinyi E, Sasvari-Szekely M, Miklósi A, et al. (2007) Novel repeat polymorphisms of the dopaminergic neurotransmitter genes among dogs and wolves. Mamm Genome 18: 871-879.
29. Wan M, Kubinyi E, Miklósi Á, Champagne F, (2009) A cross-cultural comparison of reports by German Shepherd owners in Hungary and the United States of America. Appl Anim Behav Sci 121: 206-213.
30. Diederich C, Giffroy J, (2006) Behavioural testing in dogs: A review of methodology in search for standardisation. Appl Anim Behav Sci 97: 51-72.
31. Gosling SD, Kwan VSY, John OP, (2003) A dog's got personality: a cross-species comparative approach to personality judgments in dogs and humans. J Pers Soc Psychol 85: 1161-1169.
32. Rooney N, Gaines S, Bradshaw J, Penman S, (2007) Validation of a method for assessing the ability of trainee specialist search dogs. Appl Anim Behav Sci 103: 90-104.
33. Kwan VSY, Gosling SD, John OP, (2008) Anthropomorphism as a special case of social perception: A cross-species social relations model analysis of humans and dogs. Soc Cogn 26: 129-142.
34. Tami G, Gallagher A, (2009) Description of the behaviour of domestic dog (Canis familiaris) by experienced and inexperienced people. Appl Anim Behav Sci 120: 159-169.
35. Pongrácz P, Molnár C, Miklósi A, Csányi V, (2005) Human listeners are able to classify dog (Canis familiaris) barks recorded in different situations. J Comp Psychol 119: 136-144.
36. Tochigi M, Otowa T, Hibino H, Kato C, Otani T, et al. (2006) Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes. Neurosci Res 54: 180-185.
37. Whiteside S, Lynam D, (2001) The Five Factor Model and impulsivity: using a structural model of personality to understand impulsivity. Personality and Individual Differences 30: 669-689.
38. Momozawa Y, Takeuchi Y, Kusunose R, Kikusui T, Mori Y, (2005) Association between equine temperament and polymorphisms in dopamine D4 receptor gene. Mamm Genome 16: 538-544.
39. Maejima M, Inoue-murayama M, Tonosaki K, Matsuura N, Kato S, et al. (2007) Traits and genotypes may predict the successful training of drug detection dogs. Appl Anim Behav Sci 107: 287-298.
40. Konno A, Inoue-Murayama M, Hasegawa T, (2011) Androgen receptor gene polymorphisms are associated with aggression in Japanese Akita Inu. Biol Letters Published online 30 March 2011.
41. Korsten P, Mueller JC, Hermannstadter C, Bouwman KM, Dingemanse NJ, et al. (2010) Association between DRD4 gene polymorphism and personality variation in great tits: a test across four wild populations. Mol Ecol 19: 832-843.
42. Schwandt ML, Lindell SG, Sjöberg RL, Chisholm KL, Higley JD, et al. (2010) Gene-Environment Interactions and Response to Social Intrusion in Male and Female Rhesus Macaques. Biol Psychiat 67: 323-330.
43. Bailey JN, Breidenthal SE, Jorgensen MJ, McCracken JT, Fairbanks LA, (2007) The association of DRD4 and novelty seeking is found in a nonhuman primate model. 17: 23-27.