Molecular and behavioral analysis of the intron 2 repeat polymorphism in the canine dopamine D4 receptor gene

Genes, Brain and Behavior

Volumn 8, Issue 3, 2009, Pages 330-336

  Hejjas, K ^a,b   Kubinyi, E ^b   Ronai, Z ^a   Szekely, A ^b   Vas, J ^b   Miklosi A ^b   Sasvari Szekely, M ^a   Kereszturi, E ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Canine; Dopamine D4 receptor; Endophenotype; Exon 3 VNTR; German shepherd; Intron 2 VNTR; Social impulsivity

Indexed keywords

DOPAMINE 4 RECEPTOR;

ALLELE; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; EXON; EXPERIMENTAL DOG; GENE ACTIVITY; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC IDENTIFICATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMPULSIVENESS; INTRON; MOLECULAR CLONING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SOCIAL BEHAVIOR; VARIABLE NUMBER OF TANDEM REPEAT; WOLF;

ALLELES; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; DOGS; DOPAMINE; EXONS; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC VARIATION; IMPULSIVE BEHAVIOR; INTRONS; PHENOTYPE; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; QUANTITATIVE TRAIT, HERITABLE; RECEPTORS, DOPAMINE D4; TRANSCRIPTIONAL ACTIVATION; WOLVES;

CANIDAE; CANIS FAMILIARIS;

EID: 65249131805     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2008.00475.x     Document Type: Article

References (33)

1. Abecasis, G.R., Cardon, L.R. Cookson, W.O 2000) A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66, 279 292.
2. Bailey, J.N., Breidenthal, S.E., Jorgensen, M.J., McCracken, J.T. Fairbanks, L.A 2007) The association of DRD4 and novelty seeking is found in a nonhuman primate model. Psychiatr Genet 17, 23 27.
3. Bjornerfeldt, S., Hailer, F., Nord, M. Vila, C 2008) Assortative mating and fragmentation within dog breeds. BMC Evol Biol 8, 28.
4. D'Souza, U.M., Lammers, C.H., Hwang, C.K., Yajima, S. Mouradian, M.M 2002) Developmental expression of the zinc finger transcription factor DRRF (dopamine receptor regulating factor). Mech Dev 110, 197 201.
5. D'Souza, U.M., Russ, C., Tahir, E., Mill, J., McGuffin, P., Asherson, P.J. Craig, I.W 2004) Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene. Biol Psychiatry 56, 691 697.
6. Ebstein, R.P 2006) The molecular genetic architecture of human personality: beyond self-report questionnaires. Mol Psychiatry 11, 427 445.
7. Ebstein, R.P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E.R., Nemanov, L., Katz, M. Belmaker, R.H 1996) Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 12, 78 80.
8. Fairbanks, L.A 2001) Individual differences in response to a stranger: social impulsivity as a dimension of temperament in vervet monkeys (Cercopithecus aethiops sabaeus). J Comp Psychol 115, 22 28.
9. Faraone, S.V. Khan, S.A 2006) Candidate gene studies of attention-deficit/hyperactivity disorder. J Clin Psychiatry 67 (Suppl. 8 13 20.
10. Hamer, D. Sirota, L 2000) Beware the chopsticks gene. Mol Psychiatry 5, 11 13.
11. Hare, B. Tomasello, M 2005) The emotional reactivity hypothesis and cognitive evolution. Trends Cogn Sci 10, 464 465.
12. Hasegawa, T., Sato, F. Ishida, N 2002) Determination and variability of nucleotide sequences for D4 dopamine receptor genes (DRD4) in genus Equus. J Equine Sci 13, 57 62.
13. Hejjas, K., Vas, J., Topal, J., Szantai, E., Ronai, Z., Szekely, A., Kubinyi, E., Horvath, Z., Sasvari-Szekely, M. Miklosi, A 2007) Association of polymorphisms in the dopamine D4 receptor gene and the activity-impulsivity endophenotype in dogs. Anim Genet 38, 629 633.
14. Hwang, C.K., D'Souza, U.M., Eisch, A.J., Yajima, S., Lammers, C.H., Yang, Y., Lee, S.H., Kim, Y.M., Nestler, E.J. Mouradian, M.M 2001) Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor. Proc Natl Acad Sci USA 98, 7558 7563.
15. Ito, H., Nara, H., Inoue-Murayama, M., Shimada, M.K., Koshimura, A., Ueda, Y., Kitagawa, H., Takeuchi, Y., Mori, Y., Murayama, Y., Morita, M., Iwasaki, T., Ota, K., Tanabe, Y. Ito, S 2004) Allele frequency distribution of the canine dopamine receptor D4 gene exon III and I in 23 breeds. J Vet Med Sci 66, 815 820.
16. Kereszturi, E., Kiraly, O., Csapo, Z., Tarnok, Z., Gadoros, J., Sasvari-Szekely, M. Nemoda, Z 2007) Association between the 120-bp duplication of the dopamine D4 receptor gene and attention deficit hyperactivity disorder: genetic and molecular analyses. Am J Med Genet B Neuropsychiatr Genet 144B, 231 236.
17. Kustanovich, V., Ishii, J., Crawford, L., Yang, M., McGough, J.J., McCracken, J.T., Smalley, S.L. Nelson, S.F 2004) Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5. Mol Psychiatry 9, 711 717.
18. Livak, K.J., Rogers, J. Lichter, J.B 1995) Variability of dopamine D4 receptor (DRD4) gene sequence within and among nonhuman primate species. Proc Natl Acad Sci U S A 92, 427 431.
19. Matsumoto, M., Hidaka, K., Tada, S., Tasaki, Y. Yamaguchi, T 1996) Low levels of mRNA for dopamine D4 receptor in human cerebral cortex and striatum. J Neurochem 66, 915 919.
20. Miklósi, Á 2007) Dog Behaviour, Evolution, and Cognition. Oxford University Press, Oxford, United Kingdom.
21. Miklósi, Á, Topál, J. Csányi, V 2004) Comparative social cognition: what can dogs teach us? Anim Behav 67, 995 1004.
22. Momozawa, Y., Takeuchi, Y., Kusunose, R., Kikusui, T. Mori, Y. (2005) Association between equine temperament and polymorphisms in dopamine D4 receptor gene. Mamm Genome 16, 538 544.
23. Nara, H., Inoue-Murayama, M., Koshimura, A., Sugiyama, A., Murayama, Y., Maejima, M., Ueda, Y., Ito, H., Randi, E., Kim, H.S., Ha, J.H., Kitagawa, H., Takeuchi, Y., Mori, Y., Iwasaki, T., Morita, M., Ota, K. Ito, S 2005) Novel polymorphism of the canine dopamine receptor D4 gene intron II region. Anim Sci J 76, 81 86.
24. Niimi, Y., Inoue-Murayama, M., Murayama, Y., Ito, S. Iwasaki, T 1999) Allelic variation of the D4 dopamine receptor polymorphic region in two dog breeds, golden retriever and Shiba. J Vet Med Sci 61, 1281 1286.
25. Overall, K.L 2000) Natural animal models of human psychiatric conditions: assessment of mechanism and validity. Prog Neuropsychopharmacol Biol Psychiatry 24, 727 776.
26. Ruefenacht, S., Gebhardt-Heinrich, S., Miyake, T. Gaillard, C 2002) A behaviour test on German shepherd dogs: heritability of seven different traits. Appl Anim Behav Sci 79, 113 132.
27. Saetre, P., Strandberg, E., Sundgren, P.E., Pettersson, U., Jazin, E. Bergstrom, T.F 2006) The genetic contribution to canine personality. Genes Brain Behav 5, 240 248.
28. Spady, T.C. Ostrander, E.A 2008) Canine behavioral genetics: pointing out the phenotypes and herding up the genes. Am J Hum Genet 82, 10 18.
29. Svartberg, K 2005) A comparison of behaviour in test and in everyday life: evidence of three consistent boldness-related personality traits in dogs. Appl Anim Behav Sci 91, 103 128.
30. Tenhunen, J., Salminen, M., Lundstrom, K., Kiviluoto, T., Savolainen, R. Ulmanen, I 1994) Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters. Eur J Biochem 223, 1049 1059.
31. Todd, R.D. O'Malley, K.L 2001) The dopamine receptor DRD4 gene: are duplications distracting? Trends Pharmacol Sci 22, 55 56.
32. Van Tol, H.H., Bunzow, J.R., Guan, H.C., Sunahara, R.K., Seeman, P., Niznik, H.B. Civelli, O 1991) Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350, 610 614.
33. Vas, J., Topal, J., Pech, E. Miklosi, A 2007) Measuring attention deficit and activity in dogs: a new application and validation of a human ADHD questionnaire. Appl Anim Behav Sci 103, 105 107.