Modulation of host cell nucleocytoplasmic trafficking during picornavirus infection

Infectious Disorders - Drug Targets

Volumn 12, Issue 1, 2012, Pages 59-67

  Younessi, Parisa ^a   Jans, David A ^b   Ghildyal, Reena ^a  

^a UNIVERSITY OF CANBERRA   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Cardiovirus; Nucleocytoplasmic trafficking; Nucleoporins; Picornavirus; Poliovirus; Rhinovirus

Indexed keywords

CELL PROTEIN; INTERFERON; NUCLEAR PROTEIN; NUCLEOPORIN; VIRUS PROTEIN;

HOST CELL; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PATHOGENESIS; PICORNAVIRUS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; REVIEW; RHINOVIRUS; SIGNAL TRANSDUCTION; VIRUS INFECTION;

EID: 84855833888     PISSN: 18715265     EISSN: 18755852     Source Type: Journal    
DOI: 10.2174/187152612798994993     Document Type: Review

References (59)

1. Bedard, K. M.; Semler, B. L. Regulation of picornavirus gene expression. Microb. Infect., 2004, 6(7), 702-713.
2. Mueller, S.; Wimmer, E.; Cello, J. Poliovirus and poliomyelitis: A tale of guts, brains, and an accidental event. Virus Res., 2005, 111(2), 175-193.
3. Lee, W. M.; Wang, W.; Rueckert, R. R. Complete sequence of the RNA genome of human rhinovirus 16, a clinically useful common cold virus belonging to the ICAM-1 receptor group. Virus Genes, 1995, 9(2), 177-181.
4. Baxter, A.; Chambers, M.; Edfeldt, F.; Edman, K.; Freeman, A.; Johansson, C.; King, S.; Morley, A.; Petersen, J.; Rawlins, P.; Spadola, L.; Thong, B.; Van de Poel, H.; Williams, N. Non-covalent inhibitors of rhinovirus 3C protease. Bioorg. Med. Chem. Lett., 2010, 21(2), 777-780.
5. Racaniello, V. R. In: Picornaviridae: the viruses and their replication., Fields Virology, 4th ed., Knipe, D. M.; Howley, P. M. Eds., Lippincott/Raven: Philadelphia, PA, 2001; pp 685-722.
6. Grubman, M. J.; Baxt, B. Foot-and-mouth disease. Clin. Microbiol. Rev., 2004, 17(2), 465-493.
7. Hughes, A. L. Phylogeny of the Picornaviridae and differential evolutionary divergence of picornavirus proteins. Infect. Genet. Evolution, 2004, 4(2), 143-152.
8. Nagy, P. D.; Wang, R. Y.; Pogany, J.; Hafren, A.; Makinen, K. Emerging picture of host chaperone and cyclophilin roles in RNA virus replication. Virology, 2011, 411(2), 374-382.
9. Belov, G. A.; Lidsky, P. V.; Mikitas, O. V.; Egger, D.; Lukyanov, K. A.; Bienz, K.; Agol, V. I. Bidirectional increase in permeability of nuclear envelope upon poliovirus infection and accompanying alterations of nuclear pores. J. Virol., 2004, 78(18), 10166-10177.
10. Brunel, F.; Zakin, M. M.; Buc, H.; Buckle, M. The polypyrimidine tract binding (PTB) protein interacts with single-stranded DNA in a sequence-specific manner. Nuc. Acids Res., 1996, 24(9), 1608-1615.
11. Niepmann, M. Internal translation initiation of picornaviruses and hepatitis C virus. Biochim. Biophys. Acta-Gene Reg. Mech., 2010, 1789(9-10), 529-541.
12. Gustin, K. E.; Sarnow, P. Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus. J. Virol., 2002, 76(17), 8787-8796.
13. Gustin, K. E.; Sarnow, P. Effects of poliovirus infection on nucleocytoplasmic trafficking and nuclear pore complex composition. Embo. J., 2001, 20(1-2), 240-249.
14. Ghildyal, R.; Ho, A.; Jans, D. A. Central role of the respiratory syncytial virus matrix protein in infection. FEMS Microbiol. Rev., 2006, 30(5), 692-705.
15. Ghildyal, R.; Ho, A.; Wagstaff, K. M.; Dias, M. M.; Barton, C. L.; Jans, P.; Bardin, P.; Jans, D. A. Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha. Biochemistry, 2005, 44(38), 12887-12895.
16. Ghildyal, R.; Jordan, B.; Li, D.; Dagher, H.; Bardin, P. G.; Gern, J. E.; Jans, D. A. Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport. J. Virol., 2009, 83(14), 7349-7352.
17. Cohen, S.; Au, S.; Pante, N. How viruses access the nucleus. Biochim. Biophys. Acta, 2011, 1813(9),1634-1645.
18. Cardarelli, F.; Serresi, M.; Bizzarri, R.; Beltram, F. Tuning the transport properties of HIV-1 Tat arginine-rich motif in living cells. Traffic, 2008, 9(4), 528-539.
19. Gorlich, D.; Kutay, U. Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol., 1999, 15, 607-660.
20. Macara, I. G. Transport into and out of the nucleus. Microbiol. Mol. Biol. Rev., 2001, 65(4), 570-594.
21. Conzelmann, K. K. Transcriptional activation of alpha/beta interferon genes: interference by nonsegmented negative-strand RNA viruses. J. Virol., 2005, 79(9), 5241-5248.
22. See, H.; Wark, P. Innate immune response to viral infection of the lungs. Paediatr. Respir. Rev., 2008, 9(4), 243-250.
23. Park, N.; Katikaneni, P.; Skern, T.; Gustin, K. E. Differential targeting of nuclear pore complex proteins in poliovirus-infected cells. J. Virol., 2008, 82(4), 1647-1655.
24. Chahine, M. N.; Pierce, G. N. Therapeutic targeting of nuclear protein import in pathological cell conditions. Pharmacol. Rev., 2009, 61(3), 358-372.
25. Cronshaw, J. M.; Matunis, M. J. The nuclear pore complex: disease associations and functional correlations. Trends Endocrin. Metab., 2004, 15(1), 34-39.
26. Park, N.; Skern, T.; Gustin, K. E. Specific cleavage of the nuclear pore complex protein Nup62 by a viral protease. J. Biol. Chem., 2010, 285(37), 28796-28805.
27. Amineva, S. P.; Aminev, A. G.; Palmenberg, A. C.; Gern, J. E. Rhinovirus 3C protease precursors 3CD and 3CD' localize to the nuclei of infected cells. J. Gen. Virol., 2004, 85(Pt 10), 2969-2979.
28. Liebig, H. D.; Seipelt, J.; Vassilieva, E.; Gradi, A.; Kuechler, E. A thermosensitive mutant of HRV2 2A proteinase: evidence for direct cleavage of eIF4GI and eIF4GII. FEBS Lett., 2002, 523(1-3), 53-57.
29. Gustin, K. E. Inhibition of nucleo-cytoplasmic trafficking by RNA viruses: targeting the nuclear pore complex. Virus Res., 2003, 95(1-2), 35-44.
30. Brunner, J. E.; Ertel, K. J.; Rozovics, J. M.; Semler, B. L. Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins. Virology, 2010, 400(2), 240-247.
31. Shiroki, K.; Isoyama, T.; Kuge, S.; Ishii, T.; Ohmi, S.; Hata, S.; Suzuki, K.; Takasaki, Y.; Nomoto, A. Intracellular redistribution of truncated La protein produced by poliovirus 3Cpro-mediated cleavage. J. Virol., 1999, 73(3), 2193-2200.
32. Belov, G. A.; Lidsky, P. V.; Mikitas, O. V.; Egger, D.; Lukyanov, K. A.; Bienz, K.; Agol, V. I. Bidirectional increase in permeability of nuclear envelope upon poliovirus infection and accompanying alterations of nuclear pores. J. Virol., 2004, 78(18), 10166-10177.
33. Castello, A.; Izquierdo, J. M.; Welnowska, E.; Carrasco, L. RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage. J. Cell Sci., 2009, 122(Pt 20), 3799-3809.
34. Kundu, P.; Raychaudhuri, S.; Tsai, W.; Dasgupta, A. Shutoff of RNA polymerase ii transcription by poliovirus involves 3c protease-mediated cleavage of the TATA-binding protein at an alternative site: incomplete shutoff of transcription interferes with efficient viral replication. J. Virol., 2005, 79(15), 9702-9713.
35. Castello, A.; Izquierdo, J. M.; Welnowska, E.; Carrasco, L. RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage. J. Cell Sci., 2009, 122(20), 3799-3809.
36. Lidsky, P. V.; Hato, S.; Bardina, M. V.; Aminev, A. G.; Palmenberg, A. C.; Sheval, E. V.; Polyakov, V. Y.; van Kuppeveld, F. J.; Agol, V. I. Nucleocytoplasmic traffic disorder induced by cardioviruses. J. Virol., 2006, 80(6), 2705-2717.
37. Donnelly, M.; Gani, D.; Flint, M.; Monaghan, S.; Ryan, M. The cleavage activities of aphthovirus and cardiovirus 2A proteins. J. Gen. Virol., 1997, 78(1), 13-21.
38. Delhaye, S.; van Pesch, V.; Michiels, T. The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins. J. Virol., 2004, 78(8), 4357-4362.
39. Ricour, C.; Delhaye, S.; Hato, S. V.; Olenyik, T. D.; Michel, B.; van Kuppeveld, F. J. M.; Gustin, K. E.; Michiels, T. Inhibition of mRNA export and dimerization of interferon regulatory factor 3 by Theiler's virus leader protein. J. Gen. Virol., 2009, 90(1), 177-186.
40. Ricour, C.; Borghese, F.; Sorgeloos, F.; Hato, S. V.; van Kuppeveld, F. J.; Michiels, T. Random mutagenesis defines a domain of Theiler's virus leader protein that is essential for antagonism of nucleocytoplasmic trafficking and cytokine gene expression. J. Virol., 2009, 83(21), 11223-11232.
41. Porter, F. W.; Palmenberg, A. C., Leader-induced phosphorylation of nucleoporins correlates with nuclear trafficking inhibition by cardioviruses. J. Virol., 2009, 83(4), 1941-1951.
42. Porter, F. W.; Bochkov, Y. A.; Albee, A. J.; Wiese, C.; Palmenberg, A. C., A picornavirus protein interacts with Ran-GTPase and disrupts nucleocytoplasmic transport. Proc. Natl. Acad. Sci. USA, 2006, 103(33), 12417-12422.
43. Porter, F. W.; Brown, B.; Palmenberg, A. C. Nucleoporin phosphorylation triggered by the encephalomyocarditis virus leader protein is mediated by mitogen-activated protein kinases. J. Virol., 2010, 84(24), 12538-12548.
44. Bardina, M. V.; Lidsky, P. V.; Sheval, E. V.; Fominykh, K. V.; van Kuppeveld, F. J.; Polyakov, V. Y.; Agol, V. I. Mengovirus-induced rearrangement of the nuclear pore complex: hijacking cellular phosphorylation machinery. J. Virol., 2009, 83(7), 3150-3161.
45. Groppo, R.; Brown, B. A.; Palmenberg, A. C. Mutational analysis of the EMCV 2A protein identifies a nuclear localization signal and an eIF4E binding site. Virology, 2011, 410(1), 257-267.
46. Weidman, M. K.; Sharma, R.; Raychaudhuri, S.; Kundu, P.; Tsai, W.; Dasgupta, A. The interaction of cytoplasmic RNA viruses with the nucleus. Virus Res., 2003, 95(1-2), 75-85.
47. Tesar, M.; Marquardt, O. Foot-and-mouth disease virus protease 3C inhibits cellular transcription and mediates cleavage of histone H3. Virology, 1990, 174(2), 364-374.
48. Brown, C. C.; Piccone, M. E.; Mason, P. W.; McKenna, T. S.; Grubman, M. J. Pathogenesis of wild-type and leaderless foot-andmouth disease virus in cattle. J. Virol., 1996, 70(8), 5638-5641.
49. de los Santos, T.; de Avila Botton, S.; Weiblen, R.; Grubman, M. J. The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response. J. Virol., 2006, 80(4), 1906-1914.
50. de los Santos, T.; Diaz-San Segundo, F.; Grubman, M. J. Degradation of nuclear factor kappa b during foot-and-mouth disease virus infection. J. Virol., 2007, 81(23), 12803-12815.
51. de los Santos, T.; Segundo, F. D.; Zhu, J.; Koster, M.; Dias, C. C.; Grubman, M. J. A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function. J. Virol., 2009, 83(4), 1800-1810.
52. Aravind, L.; Koonin, E. V. SAP-a putative DNA-binding motif involved in chromosomal organization. Trends Biochem. Sci., 2000, 25(3), 112-114.
53. de los Santos, T.; Diaz-San Segundo, F.; Zhu, J.; Koster, M.; Dias, C. C. A.; Grubman, M. J. A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function. J. Virol., 2009, 83(4), 1800-1810.
54. Norder, H.; De Palma, A. M.; Selisko, B.; Costenaro, L.; Papageorgiou, N.; Arnan, C.; Coutard, B.; Lantez, V.; De Lamballerie, X.; Baronti, C.; Solà, M.; Tan, J.; Neyts, J.; Canard, B.; Coll, M.; Gorbalenya, A. E.; Hilgenfeld, R. Picornavirus non-structural proteins as targets for new anti-virals with broad activity. Antiv. Res., 2011, 89(3),204-218.
55. Bastos, R.; Lin, A.; Enarson, M.; Burke, B. Targeting and function in mRNA export of nuclear pore complex protein Nup153. J. Cell Biol., 1996, 134(5), 1141-1156.
56. Sukarieh, R.; Sonenberg, N.; Pelletier, J. Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection. J. Gen. Virol., 2010, 91(Pt 5), 1224-1228.
57. Kleijn, M.; Vrins, C. L.; Voorma, H. O.; Thomas, A. A. Phosphorylation state of the cap-binding protein eIF4E during viral infection. Virology, 1996, 217(2), 486-494.
58. Porter, F. W.; Palmenberg, A. C. Leader-induced phosphorylation of nucleoporins correlates with nuclear trafficking inhibition by cardioviruses. J. Virol., 2009, 83(4), 1941-1951.
59. Gradi, A.; Foeger, N.; Strong, R.; Svitkin, Y. V.; Sonenberg, N.; Skern, T.; Belsham, G. J. Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro. J. Virol., 2004, 78(7), 3271-3278.